Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_H12
(740 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase 249 5e-66
sp|Q9Z2W0|DNPEP_MOUSE Aspartyl aminopeptidase 240 3e-63
sp|Q19087|DNPEP_CAEEL Putative aspartyl aminopeptidase 217 3e-56
sp|O36014|DNPEP_SCHPO Putative aspartyl aminopeptidase 203 3e-52
sp|P38821|DNPEP_YEAST Putative aspartyl aminopeptidase 187 2e-47
sp|Q87YC5|APEB_PSESM Probable M18-family aminopeptidase 2 187 3e-47
sp|Q9HYZ3|APEB_PSEAE Probable M18-family aminopeptidase 2 184 2e-46
sp|Q88M44|APEB_PSEPK Probable M18-family aminopeptidase 2 178 1e-44
sp|Q50022|APEB_MYCLE Probable M18-family aminopeptidase 2 155 1e-37
sp|Q97LF4|APEB_CLOAB Probable M18-family aminopeptidase 2 148 1e-35
>sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase
Length = 475
Score = 249 bits (636), Expect = 5e-66
Identities = 120/219 (54%), Positives = 169/219 (77%), Gaps = 3/219 (1%)
Frame = +3
Query: 15 EDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLE---SVSDDTNI 185
+DIV++ELCLAD QP+ +GG + EF+FAPRLDNL +C+ ++QAL++S S++ + ++
Sbjct: 233 KDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNLHSCFCALQALIDSCAGPGSLATEPHV 292
Query: 186 RAVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISAD 365
R V L+DNEE+GS+SAQGAQS TEL+LRR+ + CQ+ + +E AI S +ISAD
Sbjct: 293 RMVTLYDNEEVGSESAQGAQSLLTELVLRRI-SASCQHP-----TAFEEAIPKSFMISAD 346
Query: 366 QAHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFV 545
AH VHPNY +KHE H+PL H+G V+K+NS QRYASNA++ +++REVANK +VPLQ+ +
Sbjct: 347 MAHAVHPNYLDKHEENHRPLFHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPLQDLM 406
Query: 546 VRQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
VR D CG+TIGPI+++ +GL +D+G PQL+MHS REM
Sbjct: 407 VRNDTPCGTTIGPILASRLGLRVLDLGSPQLAMHSIREM 445
>sp|Q9Z2W0|DNPEP_MOUSE Aspartyl aminopeptidase
Length = 473
Score = 240 bits (612), Expect = 3e-63
Identities = 115/218 (52%), Positives = 162/218 (74%), Gaps = 3/218 (1%)
Frame = +3
Query: 15 EDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLES---VSDDTNI 185
+ I+++ELCLAD QP+ +GG ++EF+FAPRLDNL +C+ ++QAL++S S ++ D ++
Sbjct: 231 DSIMEMELCLADTQPAVLGGAYEEFIFAPRLDNLHSCFCALQALIDSCASPASLARDPHV 290
Query: 186 RAVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISAD 365
R V L+DNEE+GS+SAQGAQS TELILRR+ + + +E AI S +ISAD
Sbjct: 291 RMVTLYDNEEVGSESAQGAQSLLTELILRRI------SASPQRLTAFEEAIPKSFMISAD 344
Query: 366 QAHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFV 545
AH VHPNY +KHE H+P H+G V+K+NS QRYASNA++ S++REVA + VPLQ+ +
Sbjct: 345 MAHAVHPNYSDKHEENHRPSFHKGPVIKVNSKQRYASNAVSESMIREVAGQVGVPLQDLM 404
Query: 546 VRQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCRE 659
VR D CG+TIGPI+++ +GL +D+G PQL+MHS RE
Sbjct: 405 VRNDSPCGTTIGPILASRLGLRVLDLGSPQLAMHSIRE 442
>sp|Q19087|DNPEP_CAEEL Putative aspartyl aminopeptidase
Length = 470
Score = 217 bits (552), Expect = 3e-56
Identities = 112/220 (50%), Positives = 145/220 (65%), Gaps = 2/220 (0%)
Frame = +3
Query: 15 EDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESL--ESVSDDTNIR 188
EDIVD++L L D + I G+ EF+ RLDN YT++ L+ESL ES +D IR
Sbjct: 232 EDIVDLDLYLYDTNKAAIVGMEDEFISGARLDNQVGTYTAISGLLESLTGESFKNDPQIR 291
Query: 189 AVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQ 368
FDNEE+GS SA GA S+FTE +LRR+ S + +E AI S+LISADQ
Sbjct: 292 IAACFDNEEVGSDSAMGASSSFTEFVLRRL-------SAGGSTTAFEEAIGKSMLISADQ 344
Query: 369 AHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVV 548
AH HPNY KHE H+P H G+V+K+N NQRYA+ + T + L++VA +++VPLQ VV
Sbjct: 345 AHATHPNYSAKHEENHRPAFHGGVVVKVNVNQRYATTSTTHAALKQVAFEAQVPLQVVVV 404
Query: 549 RQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREMTD 668
R D CGST+GPI++ +GL TVDVG PQL+MHS RE D
Sbjct: 405 RNDSPCGSTVGPILATKLGLQTVDVGCPQLAMHSIREFAD 444
>sp|O36014|DNPEP_SCHPO Putative aspartyl aminopeptidase
Length = 467
Score = 203 bits (517), Expect = 3e-52
Identities = 106/216 (49%), Positives = 151/216 (69%), Gaps = 2/216 (0%)
Frame = +3
Query: 21 IVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLE--SVSDDTNIRAV 194
IVD EL L D + + +GGIH+EFVF+PRLDNL + + QAL +SLE S+ +++ +R V
Sbjct: 227 IVDFELILGDAEKARLGGIHEEFVFSPRLDNLGMTFCASQALTKSLENNSLDNESCVRVV 286
Query: 195 CLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAH 374
FD+EEIGS SAQGA+S F +L+R IC+ G S S + ++ S L+SAD AH
Sbjct: 287 PSFDHEEIGSVSAQGAESTFLPAVLQR----ICE-LGKES-SLFSISMVKSFLVSADMAH 340
Query: 375 GVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQ 554
+HPNY ++E + P ++G V+K+N+NQRY +N+ +L++VA ++VP+Q+FVVR
Sbjct: 341 AMHPNYSSRYENSNTPFLNKGTVIKVNANQRYTTNSAGIVLLKKVAQLADVPIQSFVVRN 400
Query: 555 DMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
D CGSTIGP ++A G+ T+D+G P LSMHSCREM
Sbjct: 401 DSPCGSTIGPKLAAMTGMRTLDLGNPMLSMHSCREM 436
>sp|P38821|DNPEP_YEAST Putative aspartyl aminopeptidase
Length = 490
Score = 187 bits (476), Expect = 2e-47
Identities = 106/222 (47%), Positives = 143/222 (64%), Gaps = 6/222 (2%)
Frame = +3
Query: 12 VEDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSD-DTNIR 188
+EDI D EL L D ST+GG + EFVF+ RLDNL +C+TS+ L + ++ D ++ IR
Sbjct: 241 IEDIEDFELILYDHNASTLGGFNDEFVFSGRLDNLTSCFTSMHGLTLAADTEIDRESGIR 300
Query: 189 AVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSH-YERAI----ANSLL 353
+ FD+EEIGS SAQGA S F IL R+ +I + G + AI A S
Sbjct: 301 LMACFDHEEIGSSSAQGADSNFLPNILERL--SILKGDGSDQTKPLFHSAILETSAKSFF 358
Query: 354 ISADQAHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPL 533
+S+D AH VHPNY K+E QHKPL G V+KIN+NQRY +N+ +++ +A ++VPL
Sbjct: 359 LSSDVAHAVHPNYANKYESQHKPLLGGGPVIKINANQRYMTNSPGLVLVKRLAEAAKVPL 418
Query: 534 QNFVVRQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCRE 659
Q FVV D CGSTIGPI+++ G+ T+D+G P LSMHS RE
Sbjct: 419 QLFVVANDSPCGSTIGPILASKTGIRTLDLGNPVLSMHSIRE 460
>sp|Q87YC5|APEB_PSESM Probable M18-family aminopeptidase 2
Length = 429
Score = 187 bits (474), Expect = 3e-47
Identities = 99/214 (46%), Positives = 138/214 (64%)
Frame = +3
Query: 21 IVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRAVCL 200
++D EL D Q + + G++ +F+ RLDNL +C+ +QAL L + SD+T + VC
Sbjct: 207 VLDYELSFYDTQSAAVVGLNGDFLAGARLDNLLSCFAGMQAL---LNTESDETAL-LVCT 262
Query: 201 FDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGV 380
D+EE+GS SA GA A E I++R++ S Y R I SLLISAD AHG+
Sbjct: 263 -DHEEVGSSSACGADGAMLEQIVQRLL---------PSSEDYVRTIQKSLLISADNAHGI 312
Query: 381 HPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDM 560
HPNY +KH+ H P + G V+K+NSNQRYA+N+ T R + EVP+Q+FVVR DM
Sbjct: 313 HPNYADKHDANHGPKLNAGPVIKVNSNQRYATNSETAGFFRHLCMAEEVPVQSFVVRSDM 372
Query: 561 ACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
CGSTIGPI ++++G+ TVD+G P +MHS RE+
Sbjct: 373 GCGSTIGPITASHLGIRTVDIGLPTFAMHSIREL 406
>sp|Q9HYZ3|APEB_PSEAE Probable M18-family aminopeptidase 2
Length = 429
Score = 184 bits (468), Expect = 2e-46
Identities = 96/219 (43%), Positives = 135/219 (61%)
Frame = +3
Query: 6 VKVEDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNI 185
+ + ++D EL D Q + + G++ EF+ RLDNL +C+ ++AL+ + D N
Sbjct: 202 ITADVVLDYELSFYDTQSAAVVGLNDEFIAGARLDNLLSCHAGLEALLNA----EGDENC 257
Query: 186 RAVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISAD 365
VC D+EE+GS S GA F E +LRR++ + RAI SLL+SAD
Sbjct: 258 ILVCT-DHEEVGSCSHCGADGPFLEQVLRRLL---------PEGDAFSRAIQRSLLVSAD 307
Query: 366 QAHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFV 545
AHGVHPNY ++H+ H P + G V+KINSNQRYA+N+ T R + SEVP+Q+FV
Sbjct: 308 NAHGVHPNYADRHDANHGPALNGGPVIKINSNQRYATNSETAGFFRHLCQDSEVPVQSFV 367
Query: 546 VRQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
R DM CGSTIGPI ++ +G+ TVD+G P +MHS RE+
Sbjct: 368 TRSDMGCGSTIGPITASQVGVRTVDIGLPTFAMHSIREL 406
>sp|Q88M44|APEB_PSEPK Probable M18-family aminopeptidase 2
Length = 429
Score = 178 bits (452), Expect = 1e-44
Identities = 96/220 (43%), Positives = 138/220 (62%)
Frame = +3
Query: 3 EVKVEDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTN 182
E+ + ++D EL D Q + + G++ +F+ RLDNL +CY +QAL L + SD+T
Sbjct: 201 ELIADVVLDYELSFYDTQDAALIGLNGDFIAGARLDNLLSCYAGLQAL---LAADSDETC 257
Query: 183 IRAVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISA 362
+ VC D+EE+GS SA GA E L+R++ Y R + SL++SA
Sbjct: 258 V-LVCN-DHEEVGSCSACGADGPMLEQTLQRLL---------PDGDTYVRTVQRSLMVSA 306
Query: 363 DQAHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNF 542
D AHGVHPNY +KH+ H P + G V+K+N+NQRYA+N+ T R + EVP+Q+F
Sbjct: 307 DNAHGVHPNYADKHDGNHGPKLNAGPVIKVNNNQRYATNSETAGFFRHLCMAEEVPVQSF 366
Query: 543 VVRQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
VVR DM CGSTIGPI ++++G+ TVD+G P +MHS RE+
Sbjct: 367 VVRSDMGCGSTIGPITASHLGVRTVDIGLPTFAMHSIREL 406
>sp|Q50022|APEB_MYCLE Probable M18-family aminopeptidase 2
Length = 426
Score = 155 bits (391), Expect = 1e-37
Identities = 91/219 (41%), Positives = 122/219 (55%)
Frame = +3
Query: 6 VKVEDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNI 185
V V D++ V+L D PS + G + APRLDN +CY ++AL L SV D +
Sbjct: 195 VAVADVLAVDLMTHDLVPSMVIGADANLLSAPRLDNQVSCYAGMEAL---LASVPHDC-L 250
Query: 186 RAVCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISAD 365
+ LFD+EE+GS S +GA+S +L R+V Y R + SLL+SAD
Sbjct: 251 PVLALFDHEEVGSTSDRGARSNLLSTVLERIVLA-----AGGGRDDYLRRLPASLLVSAD 305
Query: 366 QAHGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFV 545
AH HPNY E HE H + G VLK++ N RYA++ T + ++ V LQ +
Sbjct: 306 MAHATHPNYPECHEPSHLIEVNAGPVLKVHPNLRYATDGRTAAAFEVACQQAGVRLQRYE 365
Query: 546 VRQDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
R D CGSTIGP+ SA G+ TVDVG QL+MHS RE+
Sbjct: 366 HRADRPCGSTIGPLASARTGIPTVDVGAAQLAMHSAREL 404
>sp|Q97LF4|APEB_CLOAB Probable M18-family aminopeptidase 2
Length = 433
Score = 148 bits (374), Expect = 1e-35
Identities = 88/217 (40%), Positives = 129/217 (59%)
Frame = +3
Query: 12 VEDIVDVELCLADCQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRA 191
+E+I+D +L L + I GI+ EF+ + RLD++ + + ALV + S+ TN+ A
Sbjct: 207 IENIIDFDLFLYEYDKGCIMGINNEFISSSRLDDMEMVHAGLNALVNA--KCSEATNVLA 264
Query: 192 VCLFDNEEIGSQSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQA 371
FDNEEIGS + QGA S F IL R+V + + RA+ NS +IS+D A
Sbjct: 265 C--FDNEEIGSATKQGADSQFLSDILERIVLSFG-----GDREDFFRALHNSFMISSDSA 317
Query: 372 HGVHPNYEEKHERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVR 551
H VHPN EK + +P ++G V+KI++ Q+Y S++ + ++ EV S VP Q FV R
Sbjct: 318 HAVHPNKGEKADPITRPHINEGPVIKISAAQKYTSDSNSIAVYEEVCRLSGVPYQKFVNR 377
Query: 552 QDMACGSTIGPIMSANMGLATVDVGGPQLSMHSCREM 662
D GSTIGPI + + + TVD+G P L+MHS RE+
Sbjct: 378 SDERGGSTIGPITATHTAIRTVDIGTPLLAMHSIREL 414
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,584,940
Number of Sequences: 369166
Number of extensions: 1831866
Number of successful extensions: 4867
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4620
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4837
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6679696800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)