Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_F10
(800 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70566|TMOD2_RAT Tropomodulin-2 (Neuronal tropomodulin) ... 145 1e-34
sp|Q9JKK7|TMOD2_MOUSE Tropomodulin-2 (Neuronal tropomodulin... 144 2e-34
sp|Q9NZR1|TMOD2_HUMAN Tropomodulin-2 (Neuronal tropomodulin... 141 2e-33
sp|P49813|TMOD1_MOUSE Tropomodulin-1 (Erythrocyte tropomodu... 140 3e-33
sp|P28289|TMOD1_HUMAN Tropomodulin-1 (Erythrocyte tropomodu... 138 2e-32
sp|P70567|TMOD1_RAT Tropomodulin-1 (Erythrocyte tropomoduli... 137 3e-32
sp|Q9NYL9|TMOD3_HUMAN Tropomodulin-3 (Ubiquitous tropomodul... 132 8e-31
sp|Q9JHJ0|TMOD3_MOUSE Tropomodulin-3 (Ubiquitous tropomodul... 131 2e-30
sp|Q9JLH8|TMOD4_MOUSE Tropomodulin-4 (Skeletal muscle tropo... 126 6e-29
sp|Q9NZQ9|TMOD4_HUMAN Tropomodulin-4 (Skeletal muscle tropo... 122 9e-28
>sp|P70566|TMOD2_RAT Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Length = 351
Score = 145 bits (366), Expect = 1e-34
Identities = 83/226 (36%), Positives = 132/226 (58%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCGGFQGVAKYESCKPV 224
D E +EAL +A++ EL DLAAVLG + +LN ++ N + G + V K E KPV
Sbjct: 116 DPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGQGRKGPVRNVVKGEKAKPV 175
Query: 225 PDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLTLNCAN 404
+EP N T+VE+ +++++AND SL+EVNLNN+KNI +K +A N H+ + A
Sbjct: 176 FEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVRKFSLAA 235
Query: 405 IGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQQQ 584
++ F +L+ N L++LN+ESN++ G I+ L+ A+ RE L E+++ NQ+Q
Sbjct: 236 TRSNDPVALAFAEMLKVNKTLKSLNVESNFITGAGILALVEAL-RENDTLTEIKIDNQRQ 294
Query: 585 KVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVD 722
+ LG VE EI ++++EN+ + G R R+ + N D
Sbjct: 295 Q-LGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNND 339
>sp|Q9JKK7|TMOD2_MOUSE Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Length = 351
Score = 144 bits (364), Expect = 2e-34
Identities = 82/226 (36%), Positives = 132/226 (58%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCGGFQGVAKYESCKPV 224
D E +EAL +A++ EL DLAAVLG + +LN ++ N + G + V K E KPV
Sbjct: 116 DPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGQGRKGPVRNVVKGEKAKPV 175
Query: 225 PDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLTLNCAN 404
+EP N T+VE+ +++++AND SL+EVNLNN+KNI +K ++ N H+ + A
Sbjct: 176 FEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKSLETNTHVKKFSLAA 235
Query: 405 IGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQQQ 584
++ F +L+ N L++LN+ESN++ G I+ L+ A+ RE L E+++ NQ+Q
Sbjct: 236 TRSNDPVALAFAEMLKVNKTLKSLNVESNFITGTGILALVEAL-RENDTLTEIKIDNQRQ 294
Query: 585 KVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVD 722
+ LG VE EI ++++EN+ + G R R+ + N D
Sbjct: 295 Q-LGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNND 339
>sp|Q9NZR1|TMOD2_HUMAN Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Length = 351
Score = 141 bits (355), Expect = 2e-33
Identities = 81/226 (35%), Positives = 130/226 (57%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCGGFQGVAKYESCKPV 224
D E +EAL +A++ EL DLAAVLG + +LN ++ N + G + V K E KPV
Sbjct: 116 DPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPV 175
Query: 225 PDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLTLNCAN 404
+EP N T+VE +++++AND SL+EVNLNN+KNI ++ +A N H+ + A
Sbjct: 176 FEEPPNPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAA 235
Query: 405 IGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQQQ 584
++ F +L+ N L +LN+ESN++ G I+ L+ A+ +E L E+++ NQ+Q
Sbjct: 236 TRSNDPVAIAFADMLKVNKTLTSLNIESNFITGTGILALVEAL-KENDTLTEIKIDNQRQ 294
Query: 585 KVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVD 722
+ LG VE EI ++++EN+ + G R R+ + N D
Sbjct: 295 Q-LGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNND 339
>sp|P49813|TMOD1_MOUSE Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Length = 359
Score = 140 bits (354), Expect = 3e-33
Identities = 86/241 (35%), Positives = 137/241 (56%), Gaps = 5/241 (2%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYH-----ASVENKEQMCGGFQGVAKYE 209
+ E +EAL NA++ EL D+AA+LG + +++ QY+ +S+ NKE G V K
Sbjct: 113 EPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKE----GLNSVIKPT 168
Query: 210 SCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLT 389
KPVPDE N TDVE +++++ ND L+EVNLNN++NI +K EA N ++
Sbjct: 169 QYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAEALKENSYVKK 228
Query: 390 LNCANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRV 569
+ ++ +L+ N L+TLN+ESN+++G I++L+ A+ S L+EL++
Sbjct: 229 FSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEALPHNTS-LVELKI 287
Query: 570 VNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNRLV 749
NQ Q LG +VE EI ++++NTTL G R+R + + N D R+ RL
Sbjct: 288 DNQSQP-LGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMSNND-LVRKRRLA 345
Query: 750 N 752
+
Sbjct: 346 D 346
>sp|P28289|TMOD1_HUMAN Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Length = 359
Score = 138 bits (348), Expect = 2e-32
Identities = 84/241 (34%), Positives = 138/241 (57%), Gaps = 5/241 (2%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYH-----ASVENKEQMCGGFQGVAKYE 209
+ E +EAL NA++ EL D+AA+LG + +++ QY+ +S+ NKE G V K
Sbjct: 113 EPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKE----GLNSVIKPT 168
Query: 210 SCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLT 389
KPVPDE N TDVE +++++ ND L+EVNLNN++NI +K EA N ++
Sbjct: 169 QYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKK 228
Query: 390 LNCANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRV 569
+ ++ +L++N L+TLN+ESN+++G I++L+ A+ S L+E+++
Sbjct: 229 FSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTS-LVEMKI 287
Query: 570 VNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNRLV 749
NQ Q LG +VE EI ++++N TL G R+R + + MN + R+ RL
Sbjct: 288 DNQSQP-LGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAM-MNNNDLVRKRRLA 345
Query: 750 N 752
+
Sbjct: 346 D 346
>sp|P70567|TMOD1_RAT Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Length = 359
Score = 137 bits (346), Expect = 3e-32
Identities = 85/241 (35%), Positives = 137/241 (56%), Gaps = 5/241 (2%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYH-----ASVENKEQMCGGFQGVAKYE 209
+ E +EAL NA++ EL D+AA+LG + +++ QY+ +S+ NKE G V K
Sbjct: 113 EPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKE----GLNSVIKPT 168
Query: 210 SCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLT 389
KPVPDE N TDVE +++++ ND L+EVNLNN++NI +K E+ N ++
Sbjct: 169 QYKPVPDEEPNPTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAESLKENSYVKK 228
Query: 390 LNCANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRV 569
+ ++ +L+ N L+TLN+ESN+++G I+ L+ A+ S L+EL++
Sbjct: 229 FSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILCLVEALPHNTS-LVELKI 287
Query: 570 VNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNRLV 749
NQ Q LG +VE EI ++++NTTL G R+R + + MN + R+ RL
Sbjct: 288 DNQSQP-LGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAM-MNNNDLVRKRRLA 345
Query: 750 N 752
+
Sbjct: 346 D 346
>sp|Q9NYL9|TMOD3_HUMAN Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Length = 352
Score = 132 bits (333), Expect = 8e-31
Identities = 85/244 (34%), Positives = 133/244 (54%), Gaps = 3/244 (1%)
Frame = +3
Query: 36 MEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQY---HASVENKEQMCGGFQGVAKY 206
+ D E +EAL +A++ EL DLAA+LG + ++ T++ S +Q F V K
Sbjct: 113 VSLDPELEEALTSASDTELCDLAAILGMHNLITNTKFCNIMGSSNGVDQE--HFSNVVKG 170
Query: 207 ESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLL 386
E PV DEP N T+VE +K+ + ND+ L EVNLNN+KNI +K +A N H+
Sbjct: 171 EKILPVFDEPPNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKDFAKALETNTHVK 230
Query: 387 TLNCANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELR 566
+ A ++ F +L+ N L++LN+ESN++ G I+ LI A+ R+ L EL+
Sbjct: 231 CFSLAATRSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDAL-RDNETLAELK 289
Query: 567 VVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNRL 746
+ NQ+Q+ LG VE E+ ++++ENT + G R R + + N D R+ R+
Sbjct: 290 IDNQRQQ-LGTAVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNND-LVRKRRV 347
Query: 747 VNKH 758
H
Sbjct: 348 EGDH 351
>sp|Q9JHJ0|TMOD3_MOUSE Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Length = 352
Score = 131 bits (329), Expect = 2e-30
Identities = 83/246 (33%), Positives = 135/246 (54%), Gaps = 5/246 (2%)
Frame = +3
Query: 36 MEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQY-----HASVENKEQMCGGFQGVA 200
+ D E +EAL +A++ EL DLAA+LG + ++ T + ++ N+E+ F V
Sbjct: 113 ISLDPELEEALTSASDTELCDLAAILGMHNLIADTPFCDVLGSSNGVNQER----FPNVV 168
Query: 201 KYESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKH 380
K E PV DEP N T+VE +K++ ND+ L EVNLNN+KNI +K + N H
Sbjct: 169 KGEKILPVFDEPPNPTNVEESLKRIRENDARLVEVNLNNIKNIPIPTLKDFAKTLEANTH 228
Query: 381 LLTLNCANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLE 560
+ + A ++ F +L+ N L++LN+ESN++ G ++ LI A+ R+ L+E
Sbjct: 229 VKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDAL-RDNETLME 287
Query: 561 LRVVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQN 740
L++ NQ+Q+ LG VE E+ ++++ENT + G R R + + N D R+
Sbjct: 288 LKIDNQRQQ-LGTSVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNND-LVRKR 345
Query: 741 RLVNKH 758
R+ H
Sbjct: 346 RIEGDH 351
>sp|Q9JLH8|TMOD4_MOUSE Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod)
Length = 345
Score = 126 bits (317), Expect = 6e-29
Identities = 73/235 (31%), Positives = 135/235 (57%), Gaps = 2/235 (0%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCG--GFQGVAKYESCK 218
+ E +EAL +AT+ E+ D+AA+LG +++ QY+ ++ + E +C G V + + K
Sbjct: 113 EPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGE-ICNTEGISSVVQPDKYK 171
Query: 219 PVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLTLNC 398
PVPDEP N T++E ++K++ +ND L+EVNLNN+++I V+ LCEA N ++ + +
Sbjct: 172 PVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCEAMKTNTYVRSFSL 231
Query: 399 ANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQ 578
+ + +L +N L++LN+ESN+++ ++ ++ A+ RE + L ELRV NQ
Sbjct: 232 VATKSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAV-RENATLTELRVDNQ 290
Query: 579 QQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNR 743
+Q G VE E+ ++++ ++ G R R + N + + +Q +
Sbjct: 291 RQWP-GDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAHAMTRNNELRRQQKK 344
>sp|Q9NZQ9|TMOD4_HUMAN Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod)
Length = 345
Score = 122 bits (307), Expect = 9e-28
Identities = 71/235 (30%), Positives = 134/235 (57%), Gaps = 2/235 (0%)
Frame = +3
Query: 45 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCG--GFQGVAKYESCK 218
+ E +EAL +AT+ E+ D+AA+L +++ QY+ ++ + E +C G V + + K
Sbjct: 113 EPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGE-ICNTEGISSVVQPDKYK 171
Query: 219 PVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNINEDVIKRLCEAAANNKHLLTLNC 398
PVPDEP N T++E ++K++ +ND L+EVNLNN+++I ++ LCEA N ++ + +
Sbjct: 172 PVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSL 231
Query: 399 ANIGLSNSGCDYFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQ 578
+ + +L +N L++LN+ESN+++ ++ ++ A+ RE + L ELRV NQ
Sbjct: 232 VATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAV-RENATLTELRVDNQ 290
Query: 579 QQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNR 743
+Q G VE E+ ++++ ++ G R R + N + + +Q +
Sbjct: 291 RQWP-GDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKK 344
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,448,023
Number of Sequences: 369166
Number of extensions: 1362347
Number of successful extensions: 4733
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4570
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4709
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7570361805
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)