Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_C22
(614 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P29508|SCCA1_HUMAN Squamous cell carcinoma antigen 1 (SC... 124 2e-28
sp|P48594|SCCA2_HUMAN Squamous cell carcinoma antigen 2 (SC... 123 4e-28
sp|Q9UIV8|SPB13_HUMAN Serpin B13 (Hurpin) (HaCaT UV-repress... 113 3e-25
sp|Q8CDC0|SPB13_MOUSE Serpin B13 109 6e-24
sp|O02739|SPB6_BOVIN Serine proteinase inhibitor B-43 (Serp... 106 4e-23
sp|Q96P63|SPB12_HUMAN Serpin B12 103 5e-22
sp|P80229|ILEU_PIG Leukocyte elastase inhibitor (LEI) (Serp... 101 2e-21
sp|P35237|SPB6_HUMAN Placental thrombin inhibitor (Cytoplas... 99 9e-21
sp|P01014|OVALY_CHICK Gene Y protein (Ovalbumin-related) 98 2e-20
sp|P05619|ILEU_HORSE Leukocyte elastase inhibitor (LEI) (Se... 97 3e-20
>sp|P29508|SCCA1_HUMAN Squamous cell carcinoma antigen 1 (SCCA-1) (Protein T4-A)
Length = 390
Score = 124 bits (311), Expect = 2e-28
Identities = 71/179 (39%), Positives = 102/179 (56%), Gaps = 5/179 (2%)
Frame = +1
Query: 76 DIGAIKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTN 255
D +KIANKLF E Y L Y+ AI + Y+ +E +DF + P++S K+IN WVE QTN
Sbjct: 97 DAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTN 156
Query: 256 GKIKDLLHSGNINEATKLILVNAIYFKGSWINKFNL--IGQKSFHLLNGTNKSTEMMCNT 429
KIK+L+ GNI T L+LVNAIYFKG W KFN ++ F T KS +MM
Sbjct: 157 EKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQY 216
Query: 430 ESYKYLNNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSLPDIEKKIFQHK---WDSI 597
S+ + + + ++IP+ K S++++LPN L +E+K+ K W S+
Sbjct: 217 TSFHFASLEDVQAKVLEIPY---KGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSL 272
>sp|P48594|SCCA2_HUMAN Squamous cell carcinoma antigen 2 (SCCA-2) (Leupin)
Length = 390
Score = 123 bits (308), Expect = 4e-28
Identities = 72/179 (40%), Positives = 98/179 (54%), Gaps = 5/179 (2%)
Frame = +1
Query: 76 DIGAIKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTN 255
D +KIANKLF E YQ L Y+ AI + Y+ +E DF + P++S K+IN WVE QTN
Sbjct: 97 DAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEESRKKINSWVESQTN 156
Query: 256 GKIKDLLHSGNINEATKLILVNAIYFKGSWINKFNLIGQK--SFHLLNGTNKSTEMMCNT 429
KIK+L G I T L+LVNAIYFKG W NKF K F T KS +MM
Sbjct: 157 EKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQY 216
Query: 430 ESYKYLNNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSLPDIEKKIFQHK---WDSI 597
S+ + + ++IP+ K S++++LPN L +E+K+ K W S+
Sbjct: 217 NSFNFALLEDVQAKVLEIPY---KGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSL 272
>sp|Q9UIV8|SPB13_HUMAN Serpin B13 (Hurpin) (HaCaT UV-repressible serpin) (Protease
inhibitor 13) (Headpin)
Length = 391
Score = 113 bits (283), Expect = 3e-25
Identities = 68/197 (34%), Positives = 106/197 (53%), Gaps = 6/197 (3%)
Frame = +1
Query: 13 NPDSFHQE----LSDCVKTSNVDDADIGAIKIANKLFLENHYQLLDSYIKAIDQLYKGGI 180
N ++ HQ+ L++ K +N + + I N+LF E Y L Y+ +++ Y +
Sbjct: 78 NTEAVHQQFQKFLTEISKLTNDYE-----LNITNRLFGEKTYLFLQKYLDYVEKYYHASL 132
Query: 181 EKMDFISNPDKSCKEINHWVEQQTNGKIKDLLHSGNINEATKLILVNAIYFKGSWINKFN 360
E +DF++ D+S K+IN WVE +TN KIKDL G+I+ +TKL+LVN +YFKG W +F
Sbjct: 133 EPVDFVNAADESRKKINSWVESKTNEKIKDLFPDGSISSSTKLVLVNMVYFKGQWDREFK 192
Query: 361 LIGQK--SFHLLNGTNKSTEMMCNTESYKYLNNSKIGFCAVQIPFKRIKNVVYSLMIILP 534
K F + T+KS +MM + S+ + + + IP+ KN S+ ++LP
Sbjct: 193 KENTKEEKFWMNKSTSKSVQMMTQSHSFSFTFLEDLQAKILGIPY---KNNDLSMFVLLP 249
Query: 535 NHSKSLPDIEKKIFQHK 585
N L I KI K
Sbjct: 250 NDIDGLEKIIDKISPEK 266
>sp|Q8CDC0|SPB13_MOUSE Serpin B13
Length = 389
Score = 109 bits (272), Expect = 6e-24
Identities = 60/166 (36%), Positives = 91/166 (54%), Gaps = 2/166 (1%)
Frame = +1
Query: 94 IANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTNGKIKDL 273
I+N+LF E Y L YI +++ Y +E +DF++ D+S K+IN WVE QTN K+KDL
Sbjct: 103 ISNRLFGEKTYLFLQKYIDYVEKYYHASLEPVDFVNAADESRKKINSWVESQTNVKVKDL 162
Query: 274 LHSGNINEATKLILVNAIYFKGSWINKFNL--IGQKSFHLLNGTNKSTEMMCNTESYKYL 447
G++N +TKL+L+N +YFKG W +F ++ F L +K +MM S+ +
Sbjct: 163 FPEGSLNSSTKLVLINTVYFKGLWDREFKKEHTKEEDFWLNKNLSKPVQMMALCSSFNFT 222
Query: 448 NNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSLPDIEKKIFQHK 585
+ V IP+ KN S+ ++LPN L I K+ K
Sbjct: 223 FLEDLQAKIVGIPY---KNNDISMFVLLPNDIDGLEKIMDKMSPEK 265
>sp|O02739|SPB6_BOVIN Serine proteinase inhibitor B-43 (Serpin B6)
Length = 378
Score = 106 bits (265), Expect = 4e-23
Identities = 62/192 (32%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
Frame = +1
Query: 19 DSFHQELSDCVKTSNVDDADIGAIKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFI 198
+ HQ + + N D ++ AN+LF E Y L S+ + + Y+ +E++DF+
Sbjct: 67 EDVHQGFQNLLSEVNRRDTQY-LLRTANRLFGEKTYDFLSSFKDSCHKFYQAEMEELDFV 125
Query: 199 SNPDKSCKEINHWVEQQTNGKIKDLLHSGNINEATKLILVNAIYFKGSWINKFNL--IGQ 372
S ++S K IN WV ++T GKI+DLL + ++N T+L+LVNAIYFKG+W +FN +
Sbjct: 126 SATEQSRKHINTWVAEKTEGKIRDLLPANSVNPMTRLVLVNAIYFKGNWDTQFNKEHTEE 185
Query: 373 KSFHLLNGTNKSTEMMCNTESYKYLNNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSL 552
+ F + K +MM + K + IG + QI +++I+LP+ S L
Sbjct: 186 RPFRVSKNVEKPVQMMFKKSTCKI---TYIGEISTQILVLPYVGQELNMVILLPSESTDL 242
Query: 553 PDIEKKIFQHKW 588
+EK + K+
Sbjct: 243 NTVEKALTYEKF 254
>sp|Q96P63|SPB12_HUMAN Serpin B12
Length = 405
Score = 103 bits (256), Expect = 5e-22
Identities = 69/182 (37%), Positives = 93/182 (51%), Gaps = 13/182 (7%)
Frame = +1
Query: 88 IKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTNGKIK 267
+ IAN+L+ E + + Y+ + Q Y IE +DF NP+KS +EIN WVE Q+ GKIK
Sbjct: 112 LSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIK 171
Query: 268 DLLHSGNINEATKLILVNAIYFKGSWINKF---NLIGQKSFHLLNGTNKSTEMMCNTESY 438
+L IN T L+LVNA+YFK W F N + F L NKS +MM Y
Sbjct: 172 ELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTV-DAPFCLNANENKSVKMMTQKGLY 230
Query: 439 KYLNNSKIGF---CAVQIPFKRIKNVVYSLMIILPNHS----KSLPDIEKKIFQHK---W 588
+IGF QI R S+ ++LP+HS K L ++E+KI K W
Sbjct: 231 ------RIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAW 284
Query: 589 DS 594
S
Sbjct: 285 SS 286
>sp|P80229|ILEU_PIG Leukocyte elastase inhibitor (LEI) (Serpin B1) (Leucocyte neutral
proteinase inhibitor) (LNPI)
Length = 378
Score = 101 bits (251), Expect = 2e-21
Identities = 61/179 (34%), Positives = 99/179 (55%), Gaps = 5/179 (2%)
Frame = +1
Query: 61 NVDDADIGA---IKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEIN 231
N D GA +K+AN+LF E Y L ++ + + Y + +DF+ +++ K IN
Sbjct: 74 NADINKCGASYILKLANRLFGEKTYHFLPEFLASTQKTYGAELASVDFLRASEEARKAIN 133
Query: 232 HWVEQQTNGKIKDLLHSGNINEATKLILVNAIYFKGSWINKFNLIGQKS--FHLLNGTNK 405
WV++QT GKI +LL SG ++ ATKL+LVNAIYFKGSW KF K F L +K
Sbjct: 134 EWVKEQTEGKIPELLASGVVDSATKLVLVNAIYFKGSWQEKFMTEATKDAPFRLNKKDSK 193
Query: 406 STEMMCNTESYKYLNNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSLPDIEKKIFQH 582
+ +MM + + + ++ +++P+ + S++I+LP+ + +KI QH
Sbjct: 194 TVKMMYQKKKFPFGYIKELKCRVLELPY---QGKDLSMVILLPDSIEDESTGLRKIEQH 249
>sp|P35237|SPB6_HUMAN Placental thrombin inhibitor (Cytoplasmic antiproteinase) (CAP)
(Protease inhibitor 6) (PI-6) (Serpin B6)
Length = 376
Score = 99.0 bits (245), Expect = 9e-21
Identities = 54/169 (31%), Positives = 96/169 (56%), Gaps = 2/169 (1%)
Frame = +1
Query: 88 IKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTNGKIK 267
+++AN+LF E L S+ + + Y+ +E++DFIS +KS K IN WV ++T GKI
Sbjct: 88 LRVANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIA 147
Query: 268 DLLHSGNINEATKLILVNAIYFKGSWINKFNL--IGQKSFHLLNGTNKSTEMMCNTESYK 441
+LL G+++ T+L+LVNA+YF+G+W +F+ ++ F + K +MM ++K
Sbjct: 148 ELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFK 207
Query: 442 YLNNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSLPDIEKKIFQHKW 588
+ IG QI +++I+LP+ + L +EK++ K+
Sbjct: 208 ---KTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKF 253
>sp|P01014|OVALY_CHICK Gene Y protein (Ovalbumin-related)
Length = 388
Score = 97.8 bits (242), Expect = 2e-20
Identities = 51/165 (30%), Positives = 94/165 (56%), Gaps = 2/165 (1%)
Frame = +1
Query: 85 AIKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTNGKI 264
+++IA+KL+++ + +L Y+ + Y GG+E+++F + +++ + IN WVE++TNG+I
Sbjct: 99 SLEIADKLYVDKTFSVLPEYLSCARKFYTGGVEEVNFKTAAEEARQLINSWVEKETNGQI 158
Query: 265 KDLLHSGNINEATKLILVNAIYFKGSWINKFNL--IGQKSFHLLNGTNKSTEMMCNTESY 438
KDLL S +I+ T ++ +N IYFKG W FN + F + +K +MMC S+
Sbjct: 159 KDLLVSSSIDFGTTMVFINTIYFKGIWKIAFNTEDTREMPFSMTKEESKPVQMMCMNNSF 218
Query: 439 KYLNNSKIGFCAVQIPFKRIKNVVYSLMIILPNHSKSLPDIEKKI 573
+++P+ + S++++LP+ L IEK I
Sbjct: 219 NVATLPAEKMKILELPY---ASGDLSMLVLLPDEVSGLERIEKTI 260
>sp|P05619|ILEU_HORSE Leukocyte elastase inhibitor (LEI) (Serpin B1)
Length = 379
Score = 97.4 bits (241), Expect = 3e-20
Identities = 57/172 (33%), Positives = 92/172 (53%), Gaps = 6/172 (3%)
Frame = +1
Query: 88 IKIANKLFLENHYQLLDSYIKAIDQLYKGGIEKMDFISNPDKSCKEINHWVEQQTNGKIK 267
+K+AN+L+ E Y L ++ + ++Y + +DF P+ + KEIN WV+ QT GKI
Sbjct: 86 LKLANRLYGEKTYNFLADFLASTQKMYGAELASVDFQQAPEDARKEINEWVKGQTEGKIP 145
Query: 268 DLLHSGNINEATKLILVNAIYFKGSWINKF--NLIGQKSFHLLNGTNKSTEMMCNTESYK 441
+LL G ++ TKL+LVNAIYFKG+W KF F L K+ +MM + +
Sbjct: 146 ELLVKGMVDNMTKLVLVNAIYFKGNWQEKFMKEATRDAPFRLNKKDTKTVKMMYQKKKFP 205
Query: 442 YLNNSKIGFCAVQIPFKRIKNVVYSLMIILP----NHSKSLPDIEKKIFQHK 585
Y + +++P+ + S++I+LP + S L IEK++ K
Sbjct: 206 YNYIEDLKCRVLELPY---QGKELSMIILLPDDIEDESTGLEKIEKQLTLEK 254
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,149,383
Number of Sequences: 369166
Number of extensions: 1307861
Number of successful extensions: 3607
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3406
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3472
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4846822695
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)