Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_C06
(698 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 265 7e-71
sp|Q26563|CATC_SCHMA Cathepsin C precursor 261 2e-69
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 260 3e-69
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 257 2e-68
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 257 2e-68
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 256 3e-68
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 117 3e-26
sp|P80884|ANAN_ANACO Ananain precursor 110 3e-24
sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4... 110 4e-24
sp|P92133|CATB3_GIALA Cathepsin B-like CP3 precursor (Cathe... 110 4e-24
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 265 bits (678), Expect = 7e-71
Identities = 120/195 (61%), Positives = 151/195 (77%), Gaps = 1/195 (0%)
Frame = +1
Query: 1 VLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK 180
+LEAR RI +NN+ PILSPQ+VV CS Y+QGC+GGFPYLIAGK+A+DFG+ +E+C PY
Sbjct: 266 MLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYT 325
Query: 181 GMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSG 360
G + C +DC RY+++ Y Y+GG+YG NE LM++ELV +GP+AV FEVYDDF+ Y
Sbjct: 326 GTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKK 385
Query: 361 GVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWRENGY 537
G+YHH T + FNPFELTNHAVL+VGYG +++SG +WIVKNSWG GW ENGY
Sbjct: 386 GIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGY 438
Query: 538 FRIRRGNDECGIESL 582
FRIRRG DEC IES+
Sbjct: 439 FRIRRGTDECAIESI 453
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 261 bits (666), Expect = 2e-69
Identities = 122/195 (62%), Positives = 149/195 (76%), Gaps = 2/195 (1%)
Frame = +1
Query: 4 LEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKG 183
LEAR R+ SN + +PILSPQ VV+CSPYS+GC+GGFP+LIAGK+ EDFG+ Q+ PY G
Sbjct: 256 LEARIRLVSNFSEQPILSPQTVVDCSPYSEGCNGGFPFLIAGKYGEDFGLPQKIVIPYTG 315
Query: 184 MN-GKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSG 360
+ GKC+ +K+C RY+ T+Y YIGGYYGATNE LM++EL+ NGP VGFEVY+DF Y
Sbjct: 316 EDTGKCTVSKNCTRYYTTDYSYIGGYYGATNEKLMQLELISNGPFPVGFEVYEDFQFYKE 375
Query: 361 GVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWRENGY 537
G+YHH + T + FNPFELTNHAVL+VGYG + SGE +W VKNSWG W E GY
Sbjct: 376 GIYHHT----TVQTDHYNFNPFELTNHAVLLVGYGVDKLSGEPYWKVKNSWGVEWGEQGY 431
Query: 538 FRIRRGNDECGIESL 582
FRI RG DECG+ESL
Sbjct: 432 FRILRGTDECGVESL 446
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 260 bits (664), Expect = 3e-69
Identities = 117/195 (60%), Positives = 151/195 (77%), Gaps = 1/195 (0%)
Frame = +1
Query: 1 VLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK 180
+LEAR RI +NN+ PILSPQ+VV CSPY+QGCDGGFPYLIAGK+A+DFG+ +ESC PY
Sbjct: 265 MLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYT 324
Query: 181 GMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSG 360
+ C ++C RY++++Y Y+GG+YG NE LM++ELVK+GP+AV FEV+DDF+ Y
Sbjct: 325 AKDSPCKpreNCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHS 384
Query: 361 GVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWRENGY 537
G+YHH T FNPFELTNHAVL+VGYG + +G ++WI+KNSWG+ W E+GY
Sbjct: 385 GIYHH-------TGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGY 437
Query: 538 FRIRRGNDECGIESL 582
FRIRRG DEC IES+
Sbjct: 438 FRIRRGTDECAIESI 452
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 257 bits (657), Expect = 2e-68
Identities = 117/195 (60%), Positives = 149/195 (76%), Gaps = 1/195 (0%)
Frame = +1
Query: 1 VLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK 180
+LEAR RI +NN+ PILSPQ+VV CSPY+QGCDGGFPYLIAGK+A+DFG+ +E+C PY
Sbjct: 265 MLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEENCFPYT 324
Query: 181 GMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSG 360
+ C ++C RY+++ Y Y+GG+YG NE LM++ELVK+GP+AV FEV+DDF+ Y
Sbjct: 325 ATDAPCKPKENCLRYYSSEYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHS 384
Query: 361 GVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWRENGY 537
G+YHH T FNPFELTNHAVL+VGYG + +G +WIVKNSWG+ W E+GY
Sbjct: 385 GIYHH-------TGLSDPFNPFELTNHAVLLVGYGKDPVTGLDYWIVKNSWGSQWGESGY 437
Query: 538 FRIRRGNDECGIESL 582
FRIRRG DEC IES+
Sbjct: 438 FRIRRGTDECAIESI 452
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 257 bits (656), Expect = 2e-68
Identities = 116/195 (59%), Positives = 148/195 (75%), Gaps = 1/195 (0%)
Frame = +1
Query: 1 VLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK 180
+LEAR RI +NN+ PILS Q+VV CS Y+QGC+GGFPYL AGK+A+DFG+ +E+C PY
Sbjct: 266 MLEARIRILTNNSQTPILSSQEVVSCSQYAQGCEGGFPYLTAGKYAQDFGLVEEACFPYT 325
Query: 181 GMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSG 360
G + C +DC RY+++ Y Y+GG+YG NE LM++ELV +GP+AV FEVYDDF+ Y
Sbjct: 326 GTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVYHGPLAVAFEVYDDFLHYQN 385
Query: 361 GVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWRENGY 537
G+YHH T + FNPFELTNHAVL+VGYG +++SG +WIVKNSWG W E+GY
Sbjct: 386 GIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTSWGEDGY 438
Query: 538 FRIRRGNDECGIESL 582
FRIRRG DEC IES+
Sbjct: 439 FRIRRGTDECAIESI 453
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 256 bits (655), Expect = 3e-68
Identities = 118/195 (60%), Positives = 151/195 (77%), Gaps = 1/195 (0%)
Frame = +1
Query: 1 VLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK 180
+LEAR RI +NNT PILSPQ++V CS Y+QGC+GGFPYLIAGK+A+DFG+ +E+C PY
Sbjct: 239 MLEARIRILTNNTQTPILSPQEIVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYA 298
Query: 181 GMNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSG 360
G + C DC RY+++ Y Y+GG+YGA NE LM++ELV++GP+AV FEVYDDF Y
Sbjct: 299 GSDSPCK-PNDCFRYYSSEYYYVGGFYGACNEALMKLELVRHGPMAVAFEVYDDFFHYQK 357
Query: 361 GVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWRENGY 537
G+Y+H T + FNPFELTNHAVL+VGYG +++SG +WIVKNSWG+ W E+GY
Sbjct: 358 GIYYH-------TGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGSRWGEDGY 410
Query: 538 FRIRRGNDECGIESL 582
FRIRRG DEC IES+
Sbjct: 411 FRIRRGTDECAIESI 425
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 117 bits (293), Expect = 3e-26
Identities = 73/217 (33%), Positives = 110/217 (50%), Gaps = 22/217 (10%)
Frame = +1
Query: 1 VLEARYRIRSNNTVRPILSPQDVVEC--SPYSQGCDGGFPYLIAGKFAEDFGMAQ----- 159
++ R I + +PI+SP D++ C S GC+GG+P + A ++ + G+
Sbjct: 121 MISDRTCIETKGAQQPIISPDDLLSCCGSSCGNGCEGGYP-IQALRWWDSKGVVTGGDYH 179
Query: 160 -ESCNPYK---GMNGKCSTTK------DCKRYFATNY---KYIG--GYYGATNEPLMRME 294
C PY +G C +K C+ ++T Y K+ G Y N ++ E
Sbjct: 180 GAGCKPYPIAPCTSGNCPESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAE 239
Query: 295 LVKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETS 474
+ NGP+ F VY+DF Y GVY H T K+ L HA+ ++G+G T
Sbjct: 240 IYANGPVEAAFSVYEDFYKYKSGVYKH-------TAGKY------LGGHAIKIIGWG-TE 285
Query: 475 SGEKFWIVKNSWGNGWRENGYFRIRRGNDECGIESLV 585
SG +W+V NSWG W E+G+F+I RG+D+CGIES V
Sbjct: 286 SGSPYWLVANSWGVNWGESGFFKIYRGDDQCGIESAV 322
>sp|P80884|ANAN_ANACO Ananain precursor
Length = 345
Score = 110 bits (276), Expect = 3e-24
Identities = 65/183 (35%), Positives = 89/183 (48%)
Frame = +1
Query: 4 LEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKG 183
+E+ Y+I+ N V LS Q V++C+ S GC GG+ + G+A + PYK
Sbjct: 156 VESIYKIKRGNLVS--LSEQQVLDCA-VSYGCKGGWINKAYSFIISNKGVASAAIYPYKA 212
Query: 184 MNGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGG 363
G C T + T Y Y+ N M V N PIA + +F Y G
Sbjct: 213 AKGTCKTNGVPNSAYITRYTYV-----QRNNERNMMYAVSNQPIAAALDASGNFQHYKRG 267
Query: 364 VYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWRENGYFR 543
V+ GTR NHA++++GYG+ SSG+KFWIV+NSWG GW E GY R
Sbjct: 268 VFTGPCGTR--------------LNHAIVIIGYGQDSSGKKFWIVRNSWGAGWGEGGYIR 313
Query: 544 IRR 552
+ R
Sbjct: 314 LAR 316
>sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 precursor (Cysteine
protease-related 4)
Length = 335
Score = 110 bits (275), Expect = 4e-24
Identities = 73/222 (32%), Positives = 101/222 (45%), Gaps = 31/222 (13%)
Frame = +1
Query: 13 RYRIRSNNTVRPILSPQDVVEC-SPYSQGCDGGFP-----YLIAGKFAEDFGM-AQESCN 171
R+ I SN V +LS +DV+ C S GC+GG+P YL+ F AQ C
Sbjct: 121 RFCIASNGAVNTLLSAEDVLSCCSNCGYGCEGGYPINAWKYLVKSGFCTGGSYEAQFGCK 180
Query: 172 PYK-------------------GMNGKCSTTKDCKRYFATNY---KYIGGYYGATNEPLM 285
PY G + K + + Y K+ G A + +
Sbjct: 181 PYSLAPCGETVGNVTWPSCPDDGYDTPACVNKCTNKNYNVAYTADKHFGSTAYAVGKKVS 240
Query: 286 RM--ELVKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVG 459
++ E++ +GP+ F VY+DF Y GVY H G EL HA+ ++G
Sbjct: 241 QIQAEIIAHGPVEAAFTVYEDFYQYKTGVYVHTTGQ-------------ELGGHAIRILG 287
Query: 460 YGETSSGEKFWIVKNSWGNGWRENGYFRIRRGNDECGIESLV 585
+G T +G +W+V NSW W ENGYFRI RG +ECGIE V
Sbjct: 288 WG-TDNGTPYWLVANSWNVNWGENGYFRIIRGTNECGIEHAV 328
>sp|P92133|CATB3_GIALA Cathepsin B-like CP3 precursor (Cathepsin B-like protease B3)
Length = 299
Score = 110 bits (275), Expect = 4e-24
Identities = 66/181 (36%), Positives = 81/181 (44%), Gaps = 4/181 (2%)
Frame = +1
Query: 55 SPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK----GMNGKCSTTKDCKR 222
SPQ VV C CDGG+ + +F G + C PY+ G G C T
Sbjct: 126 SPQYVVSCDRGDMACDGGWLPSV-WRFLTKTGTTTDECVPYQSGSTGARGTCPTKCADGS 184
Query: 223 YFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTT 402
YK + P + L GP+ F VY DFM Y GVY H +G +
Sbjct: 185 DLPHLYKATKAVDYGLDAPAIMKALATGGPLQTAFTVYSDFMYYESGVYQHTYGRVE--- 241
Query: 403 SKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWRENGYFRIRRGNDECGIESL 582
HAV +VGYG G +WI+KNSWG W E+GYFRI R +ECGIE
Sbjct: 242 ----------GGHAVDMVGYGTDDDGVDYWIIKNSWGPDWGEDGYFRIIRMTNECGIEEQ 291
Query: 583 V 585
V
Sbjct: 292 V 292
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,148,856
Number of Sequences: 369166
Number of extensions: 1852293
Number of successful extensions: 5177
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4699
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4872
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6073541875
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)