Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_B22
(776 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 240 4e-63
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 237 2e-62
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 237 2e-62
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 234 2e-61
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 229 5e-60
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 224 3e-58
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 223 6e-58
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 222 8e-58
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 221 1e-57
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 221 2e-57
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 240 bits (612), Expect = 4e-63
Identities = 129/263 (49%), Positives = 166/263 (63%), Gaps = 6/263 (2%)
Frame = +2
Query: 5 LSLVVVAI-----TAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYI 169
LSLV+ A +AVP KF N L+ +W +K T R Y + RR +WE+N+K I
Sbjct: 3 LSLVLAAFCLGIASAVP-KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMI 59
Query: 170 QKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPAS 349
+ HN EY GKH +++ +N F DMTNEEF+ + +G + + +G + P + LP S
Sbjct: 60 ELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKS 117
Query: 350 VDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXX 529
VDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 118 VDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQG 177
Query: 530 XXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLA 706
M AF+Y+K+ G++SE YPY A D CK P V TGFT + E L
Sbjct: 178 CNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALM 237
Query: 707 NAVATVGPVSVAIDAGHASFQLY 775
AVATVGP+SVA+DAGH+SFQ Y
Sbjct: 238 KAVATVGPISVAMDAGHSSFQFY 260
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 237 bits (605), Expect = 2e-62
Identities = 126/258 (48%), Positives = 156/258 (60%), Gaps = 1/258 (0%)
Frame = +2
Query: 5 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 184
L L + + + L +W +K R Y + RR +WE+N+K I+ HN
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQ 64
Query: 185 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 364
EY GKH++++ +N F DMT+EEF+ G KP +G + P P SVDWR+
Sbjct: 65 EYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWRE 122
Query: 365 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 544
KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS L
Sbjct: 123 KGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGL 182
Query: 545 MDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 721
MD AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E L AVAT
Sbjct: 183 MDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVAT 241
Query: 722 VGPVSVAIDAGHASFQLY 775
VGP+SVAIDAGH SF Y
Sbjct: 242 VGPISVAIDAGHESFLFY 259
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 237 bits (605), Expect = 2e-62
Identities = 127/259 (49%), Positives = 158/259 (61%), Gaps = 2/259 (0%)
Frame = +2
Query: 5 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 184
L+ + + I + KF + LN +W +K T R Y + RR +WE+N+K I+ HN
Sbjct: 7 LTALCLGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNR 64
Query: 185 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 364
EY GKH +++ +N F DMTNEEF+ G K +G + P +P SVDWR+
Sbjct: 65 EYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWRE 122
Query: 365 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 544
KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS L
Sbjct: 123 KGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGL 182
Query: 545 MDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 718
MDNAFRY+KD G++SE YPY D TC P TGF D+ Q E L AVA
Sbjct: 183 MDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVA 241
Query: 719 TVGPVSVAIDAGHASFQLY 775
T+GP+SVAIDAGH SFQ Y
Sbjct: 242 TLGPISVAIDAGHQSFQFY 260
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 234 bits (597), Expect = 2e-61
Identities = 128/259 (49%), Positives = 156/259 (60%), Gaps = 2/259 (0%)
Frame = +2
Query: 5 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 184
L+++ + + + K N L+ W +K T R Y + RR +WE+N K I HN
Sbjct: 7 LTVLCLGVASAAPKLDPN--LDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQ 64
Query: 185 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 364
EY GKH + + +N F DMTNEEF+ G K +G + P + V P SVDW +
Sbjct: 65 EYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTK 122
Query: 365 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 544
KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS L
Sbjct: 123 KGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGL 182
Query: 545 MDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 718
MDNAF+YIKD G++SE YPY ATD +C P TGF DI Q E L AVA
Sbjct: 183 MDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVA 241
Query: 719 TVGPVSVAIDAGHASFQLY 775
TVGP+SVAIDAGH SFQ Y
Sbjct: 242 TVGPISVAIDAGHTSFQFY 260
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 229 bits (585), Expect = 5e-60
Identities = 125/259 (48%), Positives = 158/259 (61%), Gaps = 2/259 (0%)
Frame = +2
Query: 5 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 184
L+ + + I + K N L+ +W +K T GR Y + RR +WE+N+K I+ HN
Sbjct: 7 LTALCLGIASAAPKLDQN--LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQ 64
Query: 185 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 364
EY GKH +S+ +N F DMTNEEF+ G K +G + + V P SVDWR+
Sbjct: 65 EYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWRE 122
Query: 365 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 544
KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS L
Sbjct: 123 KGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGL 182
Query: 545 MDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 718
MDNAF+Y+KD G+++E YPY + +C P TGF DI Q E L AVA
Sbjct: 183 MDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVA 241
Query: 719 TVGPVSVAIDAGHASFQLY 775
TVGP+SVAIDAGH+SFQ Y
Sbjct: 242 TVGPISVAIDAGHSSFQFY 260
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 224 bits (570), Expect = 3e-58
Identities = 124/264 (46%), Positives = 162/264 (61%), Gaps = 9/264 (3%)
Frame = +2
Query: 11 LVVVAITAVPQKFSVNSELNEEWETYKTTFGRKY-DELTDITRRLIWEQNLKYIQKHNLE 187
+ ++A+ A+ Q S + EEW TYK + Y +E+ + R I+ +N I KHN
Sbjct: 6 VALLALVALTQAISPLDLIKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQL 65
Query: 188 YDLGKHTYSLGLNQFADMTNEEFKAKYLG-------IMKTKPTLEGSTYMAPENIGVLPA 346
+ GK +Y LGLN++ADM + EFK G +M+ + L G+TY+ P ++ V P
Sbjct: 66 FAQGKVSYKLGLNKYADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHVTV-PK 124
Query: 347 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 526
SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 125 SVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNN 184
Query: 527 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 703
LMDNAFRYIKD GI++E YPY D +C N + I TGF DI +E +
Sbjct: 185 GCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKM 244
Query: 704 ANAVATVGPVSVAIDAGHASFQLY 775
AVAT+GPVSVAIDA H SFQLY
Sbjct: 245 KKAVATMGPVSVAIDASHESFQLY 268
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 223 bits (567), Expect = 6e-58
Identities = 123/259 (47%), Positives = 156/259 (60%), Gaps = 1/259 (0%)
Frame = +2
Query: 2 ILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHN 181
+L+++ + KF + + EW +K+T R Y + RR IWE+N++ IQ HN
Sbjct: 6 LLAVLCLGTALATPKF--DQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHN 63
Query: 182 LEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWR 361
EY G+H +S+ +N F DMTNEEF+ G K +G + P + + P SVDWR
Sbjct: 64 GEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWR 121
Query: 362 QKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX 541
+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ LVDCS
Sbjct: 122 EKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGG 181
Query: 542 LMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 718
LMD AF+YIK+ G++SE YPY A DG+CK V TGF DI Q E L AVA
Sbjct: 182 LMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDI-PQQEKALMKAVA 240
Query: 719 TVGPVSVAIDAGHASFQLY 775
TVGP+SVA+DA H S Q Y
Sbjct: 241 TVGPISVAMDASHPSLQFY 259
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 222 bits (566), Expect = 8e-58
Identities = 121/259 (46%), Positives = 156/259 (60%), Gaps = 1/259 (0%)
Frame = +2
Query: 2 ILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHN 181
+L+++ + KF + N +W +K+T R Y + RR +WE+N++ IQ HN
Sbjct: 6 LLAVLCLGTALATPKF--DQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHN 63
Query: 182 LEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWR 361
EY GKH +++ +N F DMTNEEF+ G K +G + P + + P +VDWR
Sbjct: 64 GEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWR 121
Query: 362 QKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX 541
+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ LVDCS
Sbjct: 122 EKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGG 181
Query: 542 LMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 718
LMD AF+YIK+ G++SE YPY A DG+CK V TGF DI Q E L AVA
Sbjct: 182 LMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDI-PQQEKALMKAVA 240
Query: 719 TVGPVSVAIDAGHASFQLY 775
TVGP+SVA+DA H S Q Y
Sbjct: 241 TVGPISVAMDASHPSLQFY 259
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 221 bits (564), Expect = 1e-57
Identities = 112/257 (43%), Positives = 154/257 (59%)
Frame = +2
Query: 5 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 184
+ L ++A+ V V ++ W +K + ++Y+ D RR IWE+N+K+IQ+HNL
Sbjct: 1 MRLFILAVLTV----GVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNL 56
Query: 185 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 364
+DLG TY+LGLNQF DMT EEFKAKYL M + N +P +DWR+
Sbjct: 57 RHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRE 116
Query: 365 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 544
GYVT VK+Q CGSCW+FS TG++EGQY + ISFSEQQLVDCS L
Sbjct: 117 SGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGL 176
Query: 545 MDNAFRYIKDQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 724
M+NA++Y+K G+E+E YPYTA +G C+ N V K TG+ + S +E +L N V
Sbjct: 177 MENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGAR 236
Query: 725 GPVSVAIDAGHASFQLY 775
P +VA+D + F +Y
Sbjct: 237 RPAAVAVDV-ESDFMMY 252
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 221 bits (563), Expect = 2e-57
Identities = 122/262 (46%), Positives = 161/262 (61%), Gaps = 4/262 (1%)
Frame = +2
Query: 2 ILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKH 178
+L L VV+ P++ L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I H
Sbjct: 6 VLLLPVVSFALHPEEI-----LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH 60
Query: 179 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASV 352
NLE LG HTY L +N DMT+EE K G+ K P+ S T P+ G P S+
Sbjct: 61 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSI 119
Query: 353 DWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXX 532
D+R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 120 DYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGC 177
Query: 533 XXXLMDNAFRYI-KDQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLAN 709
M NAF+Y+ +++GI+SE YPY D +C NP+ KC G+ +I NE L
Sbjct: 178 GGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKR 237
Query: 710 AVATVGPVSVAIDAGHASFQLY 775
AVA VGPVSVAIDA SFQ Y
Sbjct: 238 AVARVGPVSVAIDASLTSFQFY 259
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,600,913
Number of Sequences: 369166
Number of extensions: 1598444
Number of successful extensions: 4723
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4253
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4388
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7260540000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)