Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_B09
(764 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31689|DNJA1_HUMAN DnaJ homolog subfamily A member 1 (He... 326 5e-89
sp|P63036|DNJA1_RAT DnaJ homolog subfamily A member 1 (DnaJ... 326 5e-89
sp|Q8WW22|DNJA4_HUMAN DnaJ homolog subfamily A member 4 326 5e-89
sp|Q9JMC3|DNJA4_MOUSE DnaJ homolog subfamily A member 4 (Mm... 323 4e-88
sp|O60884|DNJA2_HUMAN DnaJ homolog subfamily A member 2 (HI... 299 6e-81
sp|Q9QYJ0|DNJA2_MOUSE DnaJ homolog subfamily A member 2 (mDj3) 298 1e-80
sp|O35824|DNJA2_RAT DnaJ homolog subfamily A member 2 (RDJ2) 296 4e-80
sp|Q03363|DNJH1_ALLPO DnaJ protein homolog 1 (DNAJ-1) 274 2e-73
sp|P42824|DNJH2_ALLPO DnaJ protein homolog 2 268 1e-71
sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1 259 4e-69
>sp|P31689|DNJA1_HUMAN DnaJ homolog subfamily A member 1 (Heat shock 40 kDa protein 4)
(DnaJ protein homolog 2) (HSJ-2) (HSDJ)
Length = 397
Score = 326 bits (835), Expect = 5e-89
Identities = 149/253 (58%), Positives = 198/253 (78%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
+V+HQL+VTL++LY G TRKLA+QKNVICDKC GRGGK+GAV+ C +CRG G+++ I Q+
Sbjct: 106 NVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQI 165
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GPGMVQQ+Q+ C C+G E I+ +DRCK C G+K+VREKK+LEVHIDKGM DGQ+I F+
Sbjct: 166 GPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFH 225
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GEGDQEPGLEPGDI IVL++K H VFTR+ DL M + LV++LCGF++ I+TLDNR +
Sbjct: 226 GEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTI 285
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
V+ + PG+++K+ + + + NEGMP Y+ P+E+GRLII+F V FPEN FL DKL+ L +
Sbjct: 286 VITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKL 345
Query: 722 LPPSQFSSSLDNM 760
LP + D M
Sbjct: 346 LPERKEVEETDEM 358
>sp|P63036|DNJA1_RAT DnaJ homolog subfamily A member 1 (DnaJ-like protein 1)
sp|P63037|DNJA1_MOUSE DnaJ homolog subfamily A member 1 (Heat shock 40 kDa protein 4)
(DnaJ protein homolog 2) (HSJ-2)
Length = 397
Score = 326 bits (835), Expect = 5e-89
Identities = 149/253 (58%), Positives = 198/253 (78%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
+V+HQL+VTL++LY G TRKLA+QKNVICDKC GRGGK+GAV+ C +CRG G+++ I Q+
Sbjct: 106 NVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQI 165
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GPGMVQQ+Q+ C C+G E I+ +DRCK C G+K+VREKK+LEVHIDKGM DGQ+I F+
Sbjct: 166 GPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFH 225
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GEGDQEPGLEPGDI IVL++K H VFTR+ DL M + LV++LCGF++ I+TLDNR +
Sbjct: 226 GEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTI 285
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
V+ + PG+++K+ + + + NEGMP Y+ P+E+GRLII+F V FPEN FL DKL+ L +
Sbjct: 286 VITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKL 345
Query: 722 LPPSQFSSSLDNM 760
LP + D M
Sbjct: 346 LPERKEVEETDEM 358
>sp|Q8WW22|DNJA4_HUMAN DnaJ homolog subfamily A member 4
Length = 397
Score = 326 bits (835), Expect = 5e-89
Identities = 150/253 (59%), Positives = 203/253 (80%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
+V+HQL+VTL++LY G T+KLA+QKNVIC+KC G GGK+G+V+KC C+G G+++HI+Q+
Sbjct: 107 NVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQI 166
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GPGMVQQ+QT C CKG+ E IN +DRC+ C G KV+REKK++EVH++KGM DGQ+I F+
Sbjct: 167 GPGMVQQIQTVCIECKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFH 226
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GEGDQEP LEPGD+ IVL++K H+VF R+ DLI MK+ L ++LCGFK+TI TLDNRIL
Sbjct: 227 GEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRIL 286
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
V+ +K GEVIK+ + R + +EGMP YK+P E+G LIIQF V+FPE ++L +KL +L ++
Sbjct: 287 VITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEAL 346
Query: 722 LPPSQFSSSLDNM 760
LPP Q D+M
Sbjct: 347 LPPRQKVRITDDM 359
>sp|Q9JMC3|DNJA4_MOUSE DnaJ homolog subfamily A member 4 (MmDjA4)
Length = 397
Score = 323 bits (827), Expect = 4e-88
Identities = 149/253 (58%), Positives = 201/253 (79%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
+V+HQL+VTL++LY G T+KLA+QKNVIC+KC G GGK+G+V+KC C+G G++VHI+Q+
Sbjct: 107 NVVHQLSVTLEDLYNGITKKLALQKNVICEKCEGIGGKKGSVEKCPLCKGRGMQVHIQQI 166
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GPGMVQQ+QT C CKG+ E IN +DRC+ C G KV REKK++EVH++KGM DGQ+I F+
Sbjct: 167 GPGMVQQIQTVCIECKGQGERINPKDRCENCSGAKVTREKKIIEVHVEKGMKDGQKILFH 226
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GEGDQEP L+PGD+ IVL++K H+VF R+ DLI MK+ L ++LCGFK+TI TLD+R+L
Sbjct: 227 GEGDQEPELDPGDVIIVLDQKDHSVFQRRGQDLIMKMKIQLSEALCGFKKTIKTLDDRVL 286
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
V+ +K GEVIK+ + + I NEGMP YK+P E+G +IIQF VVFPE +L +KL +L ++
Sbjct: 287 VISSKSGEVIKHGDLKCIRNEGMPIYKAPLEKGVMIIQFLVVFPEKQWLSQEKLPQLEAL 346
Query: 722 LPPSQFSSSLDNM 760
LPP Q D+M
Sbjct: 347 LPPRQKVRITDDM 359
>sp|O60884|DNJA2_HUMAN DnaJ homolog subfamily A member 2 (HIRA interacting protein 4)
(Cell cycle progression restoration gene 3 protein)
(Dnj3)
Length = 412
Score = 299 bits (765), Expect = 6e-81
Identities = 139/242 (57%), Positives = 182/242 (75%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
D++H L V+L++LY G T KL + KNV+C C+G+GGK GAVQKC++CRG GV + IRQL
Sbjct: 115 DMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRGVRIMIRQL 174
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
PGMVQQMQ+ C C GE EVINE+DRCKKCEG+KV++E K+LEVH+DKGM GQ+I F
Sbjct: 175 APGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRITFT 234
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GE DQ PG+EPGDI ++L+EK H VF R DL K+ LV++LCGF+ T LD R +
Sbjct: 235 GEADQAPGVEPGDIVLLLQEKEHEVFQRDGNDLHMTYKIGLVEALCGFQFTFKHLDGRQI 294
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
VV+ PG+VI+ R + EGMP+Y++PFE+G L I+FDV FPENN++ DKL++L +
Sbjct: 295 VVKYPPGKVIEPGCVRVVRGEGMPQYRNPFEKGDLYIKFDVQFPENNWINPDKLSELEDL 354
Query: 722 LP 727
LP
Sbjct: 355 LP 356
>sp|Q9QYJ0|DNJA2_MOUSE DnaJ homolog subfamily A member 2 (mDj3)
Length = 412
Score = 298 bits (763), Expect = 1e-80
Identities = 139/242 (57%), Positives = 182/242 (75%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
D++H L V+L++LY G T KL + KNV+C C+G+GGK GAVQKC++CRG GV + IRQL
Sbjct: 115 DMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRGVRIMIRQL 174
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
PGMVQQMQ+ C C GE EVINE+DRCKKCEG+KV++E K+LEVH+DKGM GQ+I F
Sbjct: 175 APGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRITFT 234
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GE DQ PG+EPGDI ++L+EK H VF R DL K+ LV++LCGF+ T LD R +
Sbjct: 235 GEADQAPGVEPGDIVLLLQEKEHEVFQRDGNDLHMTYKIGLVEALCGFQFTFKHLDARQI 294
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
VV+ PG+VI+ R + EGMP+Y++PFE+G L I+FDV FPENN++ DKL++L +
Sbjct: 295 VVKYPPGKVIEPGCVRVVRGEGMPQYRNPFEKGDLYIKFDVQFPENNWINPDKLSELEDL 354
Query: 722 LP 727
LP
Sbjct: 355 LP 356
>sp|O35824|DNJA2_RAT DnaJ homolog subfamily A member 2 (RDJ2)
Length = 412
Score = 296 bits (758), Expect = 4e-80
Identities = 138/242 (57%), Positives = 181/242 (74%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
D++H L V+L++LY G T KL + KNV+C C+G+GGK GAVQKC++CRG GV + IRQL
Sbjct: 115 DMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRGVRIMIRQL 174
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
PGMVQQMQ+ C C GE EVINE+DRCKKCEG+KV++E K+LEVH+DKGM GQ+I F
Sbjct: 175 APGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRITFT 234
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GE DQ PG+EPGDI + ++EK H VF R DL K+ LV++LCGF+ T LD R +
Sbjct: 235 GEADQAPGVEPGDIVLFVQEKEHEVFQRDGNDLHMTYKIGLVEALCGFQFTFKHLDARQI 294
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
VV+ PG+VI+ R + EGMP+Y++PFE+G L I+FDV FPENN++ DKL++L +
Sbjct: 295 VVKYPPGKVIEPGCVRVVRGEGMPQYRNPFEKGDLYIKFDVQFPENNWINPDKLSELEDL 354
Query: 722 LP 727
LP
Sbjct: 355 LP 356
>sp|Q03363|DNJH1_ALLPO DnaJ protein homolog 1 (DNAJ-1)
Length = 397
Score = 274 bits (701), Expect = 2e-73
Identities = 132/254 (51%), Positives = 183/254 (72%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
DV+H L V+L+ELY G ++KL++ +NVIC KCNG+G K GA +C SC+G G++V IRQL
Sbjct: 99 DVVHPLKVSLEELYNGTSKKLSLSRNVICSKCNGKGSKSGASMRCASCQGSGMKVSIRQL 158
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GPGM+QQMQ C CKG E+IN++DRC C+G+KVV+EKKVLEVH++KGM +GQ+I F
Sbjct: 159 GPGMIQQMQHPCNDCKGTGEMINDKDRCPLCKGEKVVQEKKVLEVHVEKGMQNGQRITFP 218
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GE D+ P GDI VL++K H F RK DL Y L L ++LCGF+ +T LD R L
Sbjct: 219 GEADEAPDTVTGDIVFVLQQKEHPKFQRKGDDLFYKHTLSLTEALCGFQFVLTHLDGRQL 278
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
++++ PGEV+K +++AI++EGMP Y+ PF +G+L IQF V FP++ L D+ + S+
Sbjct: 279 LIKSNPGEVVKPDQFKAINDEGMPMYQRPFMRGKLYIQFLVDFPDS--LTPDQCKVIESV 336
Query: 722 LPPSQFSSSLDNMK 763
LP S SS L +M+
Sbjct: 337 LPRSA-SSQLTDME 349
>sp|P42824|DNJH2_ALLPO DnaJ protein homolog 2
Length = 418
Score = 268 bits (685), Expect = 1e-71
Identities = 127/254 (50%), Positives = 182/254 (71%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
DV+H L V+L++LY G ++KL++ +NV+C KC G+G K GA C SC+G G++V IRQL
Sbjct: 120 DVVHPLKVSLEDLYNGTSKKLSLSRNVLCTKCKGKGSKSGASMNCASCQGSGMKVSIRQL 179
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GPGM+QQMQ C CKG E+I+++DRC +C+G+KVV++KKVLEVH++KGM +GQ+I F
Sbjct: 180 GPGMIQQMQHPCNECKGTGEMISDKDRCPQCKGEKVVQQKKVLEVHVEKGMQNGQKITFP 239
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GE D+ P GDI VL++K H F RK DL Y L L ++LCGF+ +T LDNR L
Sbjct: 240 GEADEAPDTVTGDIVFVLQQKEHPKFKRKGDDLFYEHSLSLTEALCGFQFVLTHLDNRQL 299
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
++++ PGEVIK +++ I++EGMP Y+ PF +G+L I F V FP++ L D+ L S+
Sbjct: 300 LIKSNPGEVIKPDQFKGINDEGMPMYQRPFMRGKLYIHFSVDFPDS--LTPDQCKALESV 357
Query: 722 LPPSQFSSSLDNMK 763
L PS+ +S L +M+
Sbjct: 358 L-PSRNASRLTDME 370
>sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1
Length = 417
Score = 259 bits (663), Expect = 4e-69
Identities = 125/254 (49%), Positives = 176/254 (69%)
Frame = +2
Query: 2 DVIHQLNVTLDELYKGNTRKLAIQKNVICDKCNGRGGKEGAVQKCNSCRGMGVEVHIRQL 181
DV+H L V+L++L+ G T+KL++ +NVIC KC G+G K GA KC+ C+G G++V IR L
Sbjct: 120 DVVHPLKVSLEDLFTGTTKKLSLSRNVICSKCTGKGSKSGASMKCSGCQGTGMKVSIRHL 179
Query: 182 GPGMVQQMQTTCRTCKGEREVINERDRCKKCEGQKVVREKKVLEVHIDKGMTDGQQIKFN 361
GP M+QQMQ C CKG E IN++DRC +C+G+KVV+EKKVLEV ++KGM GQ+I F
Sbjct: 180 GPSMIQQMQHPCNECKGTGETINDKDRCPQCKGEKVVQEKKVLEVVVEKGMQHGQKITFP 239
Query: 362 GEGDQEPGLEPGDICIVLEEKPHNVFTRKKADLIYNMKLDLVDSLCGFKRTITTLDNRIL 541
GE D+ P GDI VL++K H F RK DL Y L L ++LCGF+ +T LD R L
Sbjct: 240 GEADEAPDTVTGDIVFVLQQKEHPKFKRKGEDLFYEHTLSLTEALCGFRFVLTHLDGRQL 299
Query: 542 VVETKPGEVIKNLEYRAIDNEGMPKYKSPFEQGRLIIQFDVVFPENNFLPTDKLNKLRSI 721
++++ GEV+K +++AI++EGMP Y+ PF +G++ I F V FP++ L D++ L +I
Sbjct: 300 LIKSNLGEVVKPDQFKAIEDEGMPIYQRPFMKGKMYIHFTVEFPDS--LNPDQVKSLEAI 357
Query: 722 LPPSQFSSSLDNMK 763
LPP S SL M+
Sbjct: 358 LPPKP-SMSLTYME 370
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,250,412
Number of Sequences: 369166
Number of extensions: 1601948
Number of successful extensions: 5417
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4691
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4866
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)