Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_A24
(303 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 59 3e-09
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 58 8e-09
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 57 1e-08
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 57 2e-08
sp|P81013|GRN1_CYPCA Granulin-1 55 4e-08
sp|P81015|GRN3_CYPCA Granulin-3 54 1e-07
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 54 1e-07
sp|P81014|GRN2_CYPCA Granulin-2 49 4e-06
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 49 4e-06
sp|P25777|ORYB_ORYSA Oryzain beta chain precursor 44 2e-04
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 59.3 bits (142), Expect = 3e-09
Identities = 24/49 (48%), Positives = 27/49 (55%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
C D C QTCC G + CCPF GVCC D R CC G+HC + G
Sbjct: 518 CGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQG 566
Score = 52.4 bits (124), Expect = 3e-07
Identities = 21/48 (43%), Positives = 27/48 (56%)
Frame = +2
Query: 65 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 208
+CP+G QTCC + +G +GCCPF VCC D CC + C T
Sbjct: 288 SCPEG------QTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHT 329
Score = 52.0 bits (123), Expect = 4e-07
Identities = 21/46 (45%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Frame = +2
Query: 68 CPDG-GQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
CPD QC TCCL+ +G YGCCP +CC D CC C
Sbjct: 208 CPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 48.1 bits (113), Expect = 6e-06
Identities = 20/46 (43%), Positives = 22/46 (47%), Gaps = 1/46 (2%)
Frame = +2
Query: 68 CPDGG-QCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
CP G +C TCC M G +GCCP CC D CC G C
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASC 157
Score = 46.6 bits (109), Expect = 2e-05
Identities = 21/50 (42%), Positives = 24/50 (48%)
Frame = +2
Query: 65 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
NCP G +C L G CCPFS + C D CC G+HC T G
Sbjct: 52 NCPIG------HSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDG 95
Score = 45.8 bits (107), Expect = 3e-05
Identities = 18/45 (40%), Positives = 20/45 (44%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
C C QTCC G + CC VCC D + CC GY C
Sbjct: 441 CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 33.1 bits (74), Expect = 0.21
Identities = 12/33 (36%), Positives = 17/33 (51%)
Frame = +2
Query: 65 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCC 163
+C + C CC + +G +GCCP S G C
Sbjct: 377 SCDEVVSCRPGNICCRLASGEWGCCPSSEGYLC 409
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 57.8 bits (138), Expect = 8e-09
Identities = 25/56 (44%), Positives = 31/56 (55%)
Frame = +2
Query: 47 KIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
K+G+ C +G C QTCC G + CCP+ GVCC D R CC G+HC G
Sbjct: 511 KVGNVE-CGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARG 565
Score = 55.1 bits (131), Expect = 5e-08
Identities = 23/55 (41%), Positives = 31/55 (56%)
Frame = +2
Query: 44 IKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 208
+K + +CP+G TCC + TG +GCCPF+ VCC D CC G+ C T
Sbjct: 280 VKCDMEVSCPEG------YTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHT 328
Score = 54.3 bits (129), Expect = 9e-08
Identities = 20/49 (40%), Positives = 27/49 (55%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
C D +C TCC + +G +GCCP VCC D + CC G+ C+ G
Sbjct: 364 CDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQG 412
Score = 51.2 bits (121), Expect = 7e-07
Identities = 21/50 (42%), Positives = 25/50 (50%)
Frame = +2
Query: 65 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
+C G C +C L +G CCPFS GV C D CC G+HC G
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADG 109
Score = 49.7 bits (117), Expect = 2e-06
Identities = 21/46 (45%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Frame = +2
Query: 68 CPDGG-QCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
CPD QC TCC + TG YGCCP +CC D CC C
Sbjct: 207 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 252
Score = 48.1 bits (113), Expect = 6e-06
Identities = 20/50 (40%), Positives = 23/50 (46%)
Frame = +2
Query: 53 GDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
G + CPD TCC+M G +GCCP CC D CC G C
Sbjct: 127 GSQFECPDSA------TCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 47.4 bits (111), Expect = 1e-05
Identities = 21/53 (39%), Positives = 25/53 (47%)
Frame = +2
Query: 44 IKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
++IGD C C QTCC G + CC VCC D + CC GY C
Sbjct: 435 LQIGDIG-CDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 486
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 57.4 bits (137), Expect = 1e-08
Identities = 23/55 (41%), Positives = 28/55 (50%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGGCA*LGS 232
C + C TCC + +G +GCCP VCC D + CC GY CV G GS
Sbjct: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS 420
Score = 54.7 bits (130), Expect = 7e-08
Identities = 23/55 (41%), Positives = 31/55 (56%)
Frame = +2
Query: 44 IKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 208
+K + +CPDG TCC + +G +GCCPF+ VCC D CC G+ C T
Sbjct: 282 VKCDMEVSCPDG------YTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDT 330
Score = 53.9 bits (128), Expect = 1e-07
Identities = 21/49 (42%), Positives = 25/49 (51%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
C +G C QTCC + CCP+ GVCC D R CC G+ C G
Sbjct: 521 CGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
Score = 50.8 bits (120), Expect = 1e-06
Identities = 20/46 (43%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Frame = +2
Query: 68 CPDGG-QCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
CPD +C TCC+M G +GCCP CC D CC G C
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 46.2 bits (108), Expect = 2e-05
Identities = 19/48 (39%), Positives = 23/48 (47%)
Frame = +2
Query: 59 KNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
++ CPDG TCC + +G YGCCP CC D CC C
Sbjct: 212 RSRCPDG------STCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
Score = 45.4 bits (106), Expect = 4e-05
Identities = 18/45 (40%), Positives = 20/45 (44%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
C C QTCC G + CC VCC D + CC GY C
Sbjct: 444 CDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTC 488
Score = 43.9 bits (102), Expect = 1e-04
Identities = 17/49 (34%), Positives = 21/49 (42%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
C C+ +C +G CCPF V C D CC G+HC G
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADG 109
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 56.6 bits (135), Expect = 2e-08
Identities = 25/53 (47%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Frame = +2
Query: 65 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC--VTGGC 217
+CPDG TCC + TG +GCCPF+ VCC D CC G+ C TG C
Sbjct: 286 SCPDG------YTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC 332
Score = 55.1 bits (131), Expect = 5e-08
Identities = 27/68 (39%), Positives = 35/68 (51%)
Frame = +2
Query: 11 TVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAP 190
+V+ S F K+G+ C G C Q+CC G + CCP+ GVCC D R CC
Sbjct: 498 SVQPSMDLTFGSKVGNVE-CGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPI 556
Query: 191 GYHCVTGG 214
G+HC G
Sbjct: 557 GFHCSAKG 564
Score = 54.7 bits (130), Expect = 7e-08
Identities = 20/49 (40%), Positives = 26/49 (53%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
C D C TCC + +G +GCCP VCC D + CC G+ C+ G
Sbjct: 363 CDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKCMDEG 411
Score = 51.6 bits (122), Expect = 6e-07
Identities = 22/52 (42%), Positives = 29/52 (55%)
Frame = +2
Query: 59 KNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 214
+++CPDG +C L +G CCPFS GV C D + CC G+HC G
Sbjct: 64 RDHCPDG------YSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADG 109
Score = 49.7 bits (117), Expect = 2e-06
Identities = 21/46 (45%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Frame = +2
Query: 68 CPDGG-QCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
CPD QC TCC + TG YGCCP +CC D CC C
Sbjct: 206 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 251
Score = 48.1 bits (113), Expect = 6e-06
Identities = 20/50 (40%), Positives = 23/50 (46%)
Frame = +2
Query: 53 GDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
G + CPD TCC+M G +GCCP CC D CC G C
Sbjct: 127 GSQFECPDSA------TCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 46.2 bits (108), Expect = 2e-05
Identities = 20/63 (31%), Positives = 27/63 (42%)
Frame = +2
Query: 14 VERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPG 193
+E+ +R+ + C C QTCC G + CC VCC D + CC G
Sbjct: 423 LEKMPVRQTTLLQHGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAG 482
Query: 194 YHC 202
Y C
Sbjct: 483 YTC 485
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 55.5 bits (132), Expect = 4e-08
Identities = 24/45 (53%), Positives = 26/45 (57%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
CPDG TCCL G + CCPFS+G CC D CC GYHC
Sbjct: 10 CPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 53.9 bits (128), Expect = 1e-07
Identities = 22/45 (48%), Positives = 24/45 (53%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
C G C TCC G + CCPF +G CC D R CC GYHC
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 53.9 bits (128), Expect = 1e-07
Identities = 21/43 (48%), Positives = 24/43 (55%)
Frame = +2
Query: 68 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 196
C +G C QTCC G CCP+S GVCC D R CC G+
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +2
Query: 86 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
C TCC G + CCPF +G CC D R CC GY C
Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +2
Query: 86 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 202
C G +TCC G GCCP+ GVCC D CC G C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P25777|ORYB_ORYSA Oryzain beta chain precursor
Length = 471
Score = 43.5 bits (101), Expect = 2e-04
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 3/50 (6%)
Frame = +2
Query: 56 DKNNCPDGGQCA---GLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 196
D +CP G C G + CL++ GCCP CC D +CC P Y
Sbjct: 387 DNFSCPAGSTCCCAFGFRNLCLVW----GCCPVEGATCCKDHASCCPPDY 432
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,454,588
Number of Sequences: 369166
Number of extensions: 784215
Number of successful extensions: 2503
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2282
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2475
length of database: 68,354,980
effective HSP length: 69
effective length of database: 55,608,265
effective search space used: 1723856215
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)