Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_P21
(838 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q92122|KPYK_XENLA Pyruvate kinase, muscle isozyme (Cytos... 261 2e-69
sp|O62619|KPYK_DROME Pyruvate kinase (PK) 260 3e-69
sp|Q29536|KPYR_CANFA Pyruvate kinase, isozyme R 256 5e-68
sp|P11974|KPYM_RABIT Pyruvate kinase, isozymes M1/M2 (Pyruv... 254 2e-67
sp|P11980|KPYM_RAT Pyruvate kinase, isozymes M1/M2 (Pyruvat... 254 3e-67
sp|P30613|KPYR_HUMAN Pyruvate kinase, isozymes R/L (R-type/... 253 5e-67
sp|P11979|KPYM_FELCA Pyruvate kinase, isozyme M1 (Pyruvate ... 252 8e-67
sp|P14618|KPYM_HUMAN Pyruvate kinase, isozymes M1/M2 (Pyruv... 251 1e-66
sp|P00548|KPYK_CHICK Pyruvate kinase, muscle isozyme 251 1e-66
sp|P53657|KPYR_MOUSE Pyruvate kinase, isozymes R/L (L-PK) 249 7e-66
>sp|Q92122|KPYK_XENLA Pyruvate kinase, muscle isozyme (Cytosolic thyroid hormone binding
protein) (CTHBP)
Length = 527
Score = 261 bits (666), Expect = 2e-69
Identities = 140/270 (51%), Positives = 180/270 (66%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
+E GG LGS K LP A+ A S Q+L F +E VDM+F+SFI ADV ++E
Sbjct: 193 IENGGMLGSKKGVNLPGAAVDLPAVSSKDIQDLQFGVEQDVDMVFASFIRKAADVHEVRE 252
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
V+G G+ IK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 253 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 312
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++
Sbjct: 313 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 372
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+A+FHRQLF +L+ S DPT+ T IIV+T S
Sbjct: 373 MQHAIAREAEAAIFHRQLFEELR--RVSPLTRDPTEATAVGAVEASFKCSSGAIIVLTKS 430
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA L++ YRP+ P+I+VTR Q ARQ H
Sbjct: 431 GRSAHLLSRYRPRAPIISVTRNGQTARQAH 460
>sp|O62619|KPYK_DROME Pyruvate kinase (PK)
Length = 533
Score = 260 bits (665), Expect = 3e-69
Identities = 139/276 (50%), Positives = 187/276 (67%)
Frame = +3
Query: 9 ESARCLVEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKAD 188
+S C VE GG LGS K LP + A S + +LLF +E +VDMIF+SFI + A
Sbjct: 194 DSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAA 253
Query: 189 VQRIKEVIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQ 368
+ I++V+G G+ IK+++KIE + G+ +LDEI+E D IM+ RGDLG+E+P EKVF+AQ
Sbjct: 254 LTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQ 313
Query: 369 KSIIARCQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMY 548
K++IARC A KPV+ TQMLESM KPR TRAEISDVANAVLDGAD ++LS ET++G Y
Sbjct: 314 KAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEY 373
Query: 549 PVETLQTMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCI 728
P+E + TM + C+EAE+A++H+ LF DL + ID + I
Sbjct: 374 PLECVLTMAKTCKEAEAALWHQNLFNDL---VRGAGTIDASHAAAIAAVEAATKAKASAI 430
Query: 729 IVVTTSGRSATLIASYRPQCPVITVTRQAQVARQCH 836
+V+TTSG+SA ++ YRP+CP+I VTR AQ ARQ H
Sbjct: 431 VVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAH 466
>sp|Q29536|KPYR_CANFA Pyruvate kinase, isozyme R
Length = 519
Score = 256 bits (654), Expect = 5e-68
Identities = 137/270 (50%), Positives = 180/270 (66%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP + S Q+L F +E+ VD++F+SF+ +DV I+
Sbjct: 185 VENGGLLGSRKGVNLPGAEVDLPGLSEQDAQDLRFGVEHNVDIVFASFVRKASDVAAIRA 244
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
+GP GR IK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 245 ALGPEGRTIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR 304
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C +A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G +PVE ++
Sbjct: 305 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGKFPVEAVK 364
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
HR+ REAE+A++HRQLF +L+ A+ DPT+ T IIV+T +
Sbjct: 365 MQHRIAREAEAAVYHRQLFEELR--RAAPLSRDPTEVTAIATVEAAFKCCAAAIIVLTKT 422
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA L++ YRP+ VI VTR AQ ARQ H
Sbjct: 423 GRSAQLLSRYRPRAAVIAVTRSAQAARQAH 452
>sp|P11974|KPYM_RABIT Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme)
Length = 531
Score = 254 bits (649), Expect = 2e-67
Identities = 138/270 (51%), Positives = 177/270 (65%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP A+ A S Q+L F +E VDM+F+SFI ADV +++
Sbjct: 197 VENGGFLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRK 256
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
++G G+ IK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK II R
Sbjct: 257 ILGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGR 316
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++
Sbjct: 317 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 376
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+AMFHR+LF +L +SSH D + +IV+T S
Sbjct: 377 MQHLIAREAEAAMFHRKLFEELA--RSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTES 434
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA +A YRP+ P+I VTR Q ARQ H
Sbjct: 435 GRSAHQVARYRPRAPIIAVTRNHQTARQAH 464
>sp|P11980|KPYM_RAT Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme)
Length = 531
Score = 254 bits (648), Expect = 3e-67
Identities = 138/270 (51%), Positives = 176/270 (65%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP A+ A S Q+L F +E VDM+F+SFI ADV +++
Sbjct: 197 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRK 256
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
V+G G+ IK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 257 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 316
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++
Sbjct: 317 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 376
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+A+FHR LF +L ASS DP + +IV+T S
Sbjct: 377 MQHLIAREAEAAVFHRLLFEELA--RASSQSTDPLEAMAMGSVEASYKCLAAALIVLTES 434
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA +A YRP+ P+I VTR Q ARQ H
Sbjct: 435 GRSAHQVARYRPRAPIIAVTRNPQTARQAH 464
>sp|P30613|KPYR_HUMAN Pyruvate kinase, isozymes R/L (R-type/L-type pyruvate kinase) (Red
cell/liver pyruvate kinase)
Length = 574
Score = 253 bits (646), Expect = 5e-67
Identities = 135/270 (50%), Positives = 180/270 (66%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP + S ++L F +E+ VD++F+SF+ +DV ++
Sbjct: 240 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA 299
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
+GP G GIK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 300 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR 359
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C +A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G +PVE ++
Sbjct: 360 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK 419
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+A++HRQLF +L+ A+ DPT+ T IIV+TT+
Sbjct: 420 MQHAIAREAEAAVYHRQLFEELR--RAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTT 477
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA L++ YRP+ VI VTR AQ ARQ H
Sbjct: 478 GRSAQLLSRYRPRAAVIAVTRSAQAARQVH 507
>sp|P11979|KPYM_FELCA Pyruvate kinase, isozyme M1 (Pyruvate kinase muscle isozyme)
Length = 531
Score = 252 bits (644), Expect = 8e-67
Identities = 137/270 (50%), Positives = 176/270 (65%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP A+ A S Q+L F +E VDM+F+SFI +DV +++
Sbjct: 197 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK 256
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
V+G G+ IK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 257 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 316
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++
Sbjct: 317 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 376
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+AMFHR+LF +L SSH D + +IV+T S
Sbjct: 377 MQHLIAREAEAAMFHRKLFEELV--RGSSHSTDLMEAMAMGSVEASYKCLAAALIVLTES 434
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA +A YRP+ P+I VTR Q ARQ H
Sbjct: 435 GRSAHQVARYRPRAPIIAVTRNHQTARQAH 464
>sp|P14618|KPYM_HUMAN Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme)
(Cytosolic thyroid hormone-binding protein) (CTHBP)
(THBP1)
Length = 531
Score = 251 bits (642), Expect = 1e-66
Identities = 136/270 (50%), Positives = 177/270 (65%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP A+ A S Q+L F +E VDM+F+SFI +DV +++
Sbjct: 197 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK 256
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
V+G G+ IK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 257 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 316
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C A KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++
Sbjct: 317 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 376
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+A++H QLF +L+ + DPT+ T IIV+T S
Sbjct: 377 MQHLIAREAEAAIYHLQLFEELR--RLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKS 434
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA +A YRP+ P+I VTR Q ARQ H
Sbjct: 435 GRSAHQVARYRPRAPIIAVTRNPQTARQAH 464
>sp|P00548|KPYK_CHICK Pyruvate kinase, muscle isozyme
Length = 530
Score = 251 bits (642), Expect = 1e-66
Identities = 135/270 (50%), Positives = 176/270 (65%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LGS K LP A+ A S Q+L F +E VDM+F+SFI ADV +++
Sbjct: 196 VENGGMLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQNVDMVFASFIRKAADVHAVRK 255
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
V+G G+ IK+++KIE G+ DEI+E +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 256 VLGEKGKHIKIISKIENHEGVRRFDEIMEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 315
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C A KP++ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++
Sbjct: 316 CNRAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 375
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+AMFHRQ F ++ H S H +P +IV+T S
Sbjct: 376 MQHAIAREAEAAMFHRQQFEEILRH--SVHHREPADAMAAGAVEASFKCLAAALIVMTES 433
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA L++ YRP+ P+I VTR Q ARQ H
Sbjct: 434 GRSAHLVSRYRPRAPIIAVTRNDQTARQAH 463
>sp|P53657|KPYR_MOUSE Pyruvate kinase, isozymes R/L (L-PK)
Length = 574
Score = 249 bits (636), Expect = 7e-66
Identities = 134/270 (49%), Positives = 179/270 (66%)
Frame = +3
Query: 27 VEQGGRLGSSKRCILPRNALLKHAFSVSFRQNLLFALENQVDMIFSSFIDSKADVQRIKE 206
VE GG LG+ K LP + S +L F +E+ VD+IF+SF+ +DV +++
Sbjct: 240 VEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHYVDIIFASFVRKASDVVAVRD 299
Query: 207 VIGPVGRGIKLVAKIETKNGIVHLDEILEEADAIMIGRGDLGLELPIEKVFVAQKSIIAR 386
+GP GRGIK+++KIE G+ DEILE +D IM+ RGDLG+E+P EKVF+AQK +I R
Sbjct: 300 ALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMMARGDLGIEIPAEKVFLAQKMMIGR 359
Query: 387 CQMAKKPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQ 566
C +A KPV+ TQMLESM K R TRAE SDVANAVLDGAD ++LS ET++G +PVE ++
Sbjct: 360 CNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVK 419
Query: 567 TMHRVCREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTS 746
H + REAE+A++HRQLF +L+ A+ DPT+ T IIV+T +
Sbjct: 420 MQHAIAREAEAAVYHRQLFEELR--RAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKT 477
Query: 747 GRSATLIASYRPQCPVITVTRQAQVARQCH 836
GRSA L++ YRP+ VI VTR AQ ARQ H
Sbjct: 478 GRSAQLLSRYRPRAAVIAVTRSAQAARQVH 507
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,480,636
Number of Sequences: 369166
Number of extensions: 1716416
Number of successful extensions: 4808
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4566
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4736
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8148988185
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)