Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_P15
(613 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q922R8|PDIA6_MOUSE Protein disulfide-isomerase A6 precur... 203 2e-52
sp|Q63081|PDIA6_RAT Protein disulfide-isomerase A6 precurso... 201 1e-51
sp|Q15084|PDIA6_HUMAN Protein disulfide-isomerase A6 precur... 197 2e-50
sp|Q5R6T1|PDIA6_PONPY Protein disulfide-isomerase A6 precursor 194 2e-49
sp|P38660|PDIA6_MESAU Protein disulfide-isomerase A6 precur... 192 4e-49
sp|Q11067|PDIA6_CAEEL Probable protein disulfide-isomerase ... 187 2e-47
sp|Q6DD51|CSKI2_XENLA Caskin-2 31 2.2
sp|O54943|PER2_MOUSE Period circadian protein 2 (mPER2) 31 2.8
sp|Q9Z301|PER2_RAT Period circadian protein 2 (rPER2) 31 2.8
sp|Q60629|EPHA5_MOUSE Ephrin type-A receptor 5 precursor (T... 30 4.9
>sp|Q922R8|PDIA6_MOUSE Protein disulfide-isomerase A6 precursor (Thioredoxin
domain-containing protein 7)
Length = 440
Score = 203 bits (517), Expect = 2e-52
Identities = 94/165 (56%), Positives = 122/165 (73%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 PELKEITNQDVLKSTCEDHQLCVIAVLPNILDCQSACRNSYLDTIRVSSDKYKANRWGWC 185
PEL EI N+D+ K TCE+HQLCV+AVLP+ILD +A RNSYL+ + +DKYK WGW
Sbjct: 276 PELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWL 335
Query: 186 WTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRGST 365
WTEA +E A GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST
Sbjct: 336 WTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGST 395
Query: 366 AAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIEE-PKSEL 497
A + G P ITP +PWDGKDGE+P E++IDLS++ +++ K EL
Sbjct: 396 APVGGGSFPTITprePWDGKDGELPVEDDIDLSDVELDDLEKDEL 440
>sp|Q63081|PDIA6_RAT Protein disulfide-isomerase A6 precursor (Protein disulfide
isomerase P5) (Calcium-binding protein 1) (CaBP1)
(Thioredoxin domain-containing protein 7)
Length = 440
Score = 201 bits (511), Expect = 1e-51
Identities = 93/165 (56%), Positives = 121/165 (73%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 PELKEITNQDVLKSTCEDHQLCVIAVLPNILDCQSACRNSYLDTIRVSSDKYKANRWGWC 185
PEL EI N+D+ K TCE+HQLCV+AVLP+ILD + RNSYL+ + +DKYK WGW
Sbjct: 276 PELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLEVLLKLADKYKKKMWGWL 335
Query: 186 WTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRGST 365
WTEA +E A GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST
Sbjct: 336 WTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGST 395
Query: 366 AAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIEE-PKSEL 497
A + G P ITP +PWDGKDGE+P E++IDLS++ +++ K EL
Sbjct: 396 APVGGGSFPNITprePWDGKDGELPVEDDIDLSDVELDDLEKDEL 440
>sp|Q15084|PDIA6_HUMAN Protein disulfide-isomerase A6 precursor (Protein disulfide
isomerase P5) (Thioredoxin domain-containing protein 7)
Length = 440
Score = 197 bits (500), Expect = 2e-50
Identities = 88/159 (55%), Positives = 117/159 (73%)
Frame = +3
Query: 6 PELKEITNQDVLKSTCEDHQLCVIAVLPNILDCQSACRNSYLDTIRVSSDKYKANRWGWC 185
PEL EI N+D+ K TCE+HQLCV+AVLP+ILD +A RNSYL+ + +DKYK WGW
Sbjct: 276 PELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWL 335
Query: 186 WTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRGST 365
WTEA +E A GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST
Sbjct: 336 WTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGST 395
Query: 366 AAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIEE 482
A + G P I +PWDG+DGE+P E++IDLS++ +++
Sbjct: 396 APVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 434
>sp|Q5R6T1|PDIA6_PONPY Protein disulfide-isomerase A6 precursor
Length = 440
Score = 194 bits (492), Expect = 2e-49
Identities = 86/159 (54%), Positives = 117/159 (73%)
Frame = +3
Query: 6 PELKEITNQDVLKSTCEDHQLCVIAVLPNILDCQSACRNSYLDTIRVSSDKYKANRWGWC 185
PEL EI ++D+ K TCE+HQLCV++VLP+ILD +A RNSYL+ + +DKYK WGW
Sbjct: 276 PELLEIISEDIAKRTCEEHQLCVVSVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWL 335
Query: 186 WTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRGST 365
WTEA +E A GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST
Sbjct: 336 WTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGST 395
Query: 366 AAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIEE 482
A + G P I +PWDG+DGE+P E++IDLS++ +++
Sbjct: 396 APVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 434
>sp|P38660|PDIA6_MESAU Protein disulfide-isomerase A6 precursor (Protein disulfide
isomerase P5)
Length = 439
Score = 192 bits (489), Expect = 4e-49
Identities = 92/165 (55%), Positives = 119/165 (72%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 PELKEITNQDVLKSTCEDHQLCVIAVLPNILDCQSACRNSYLDTIRVSSDKYKANRWGWC 185
PEL EI N+DV K CE+HQLCV+AVLP+ILD A RNSYL+ + +DKYK WGW
Sbjct: 276 PELLEIINEDVAKKMCEEHQLCVVAVLPHILDT-GAARNSYLEILLKLADKYKKKMWGWL 334
Query: 186 WTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRGST 365
WTEA +E A GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GR ST
Sbjct: 335 WTEAGAQSELENALGIGGFGYPAMARINARKMKFALLKGSFSEQGINEFLRELSFGRAST 394
Query: 366 AAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIEE-PKSEL 497
A + G PAIT +PWDG+DGE+P E++IDLS++ +++ K EL
Sbjct: 395 APVGGGSFPAITAREPWDGRDGELPVEDDIDLSDVELDDLEKDEL 439
>sp|Q11067|PDIA6_CAEEL Probable protein disulfide-isomerase A6 precursor
Length = 440
Score = 187 bits (475), Expect = 2e-47
Identities = 82/165 (49%), Positives = 118/165 (71%)
Frame = +3
Query: 3 APELKEITNQDVLKSTCEDHQLCVIAVLPNILDCQSACRNSYLDTIRVSSDKYKANRWGW 182
APE+ E NQ V++ C++ QLC+ A LP+ILDCQS CRN+YL ++ S+K+K N WGW
Sbjct: 278 APEVFEGINQQVVEDACKEKQLCIFAFLPHILDCQSECRNNYLAMLKEQSEKFKKNLWGW 337
Query: 183 CWTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRGS 362
W E PA+E++F +GGFGYPA+ +N RK KYA L G F + GI +F+RD+S G+G
Sbjct: 338 IWVEGAAQPALEESFEVGGFGYPAMTALNFRKNKYAVLKGSFGKDGIHEFLRDLSYGKGR 397
Query: 363 TAAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIEEPKSEL 497
T+++ G+G P I + WDGKDG +P E++IDLS++ ++ K+EL
Sbjct: 398 TSSLRGDGFPKIQKTEKWDGKDGALPAEDDIDLSDIDLD--KTEL 440
>sp|Q6DD51|CSKI2_XENLA Caskin-2
Length = 1205
Score = 31.2 bits (69), Expect = 2.2
Identities = 26/100 (26%), Positives = 38/100 (38%)
Frame = +3
Query: 180 WCWTEAMKLPAIEKAFGIGGFGYPALVVVNVRKMKYATLTGPFSQTGIQDFVRDVSLGRG 359
+CW ++ F G+ P ++ V + +T P + I +G+
Sbjct: 474 FCWLRGFQMETYVGNFISAGYDLPTIMRVTPEDLTAIGVTKPGHRKMIS-----TEIGK- 527
Query: 360 STAAIVGEGLPAITPVDPWDGKDGEMPKEEEIDLSELGIE 479
IV +GLP PVD WD E LSE G E
Sbjct: 528 ---LIVADGLPQQIPVDLWDWLSQLGLPEYHKQLSENGYE 564
>sp|O54943|PER2_MOUSE Period circadian protein 2 (mPER2)
Length = 1257
Score = 30.8 bits (68), Expect = 2.8
Identities = 13/29 (44%), Positives = 16/29 (55%)
Frame = +1
Query: 499 KKYHLGSLDPLVHAGGLPTGDDVYSCYCC 585
++ L + P VH GGLPT DV C C
Sbjct: 1185 QRRELREVHPWVHTGGLPTAIDVTGCVYC 1213
>sp|Q9Z301|PER2_RAT Period circadian protein 2 (rPER2)
Length = 1257
Score = 30.8 bits (68), Expect = 2.8
Identities = 13/29 (44%), Positives = 16/29 (55%)
Frame = +1
Query: 499 KKYHLGSLDPLVHAGGLPTGDDVYSCYCC 585
++ L + P VH GGLPT DV C C
Sbjct: 1185 QRRELREVHPWVHTGGLPTAIDVTGCVYC 1213
>sp|Q60629|EPHA5_MOUSE Ephrin type-A receptor 5 precursor (Tyrosine-protein kinase
receptor EHK-1) (EPH homology kinase 1) (Brain-specific
kinase) (CEK-7)
Length = 877
Score = 30.0 bits (66), Expect = 4.9
Identities = 17/41 (41%), Positives = 24/41 (58%), Gaps = 5/41 (12%)
Frame = +3
Query: 18 EITNQDVLKSTCEDHQL-----CVIAVLPNILDCQSACRNS 125
E+TNQDV+K+ E ++L C A+ +LDC RNS
Sbjct: 720 EMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNS 760
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,361,141
Number of Sequences: 369166
Number of extensions: 1394449
Number of successful extensions: 4285
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4138
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4279
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4797864890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)