Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_P04
(692 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P51159|RB27A_HUMAN Ras-related protein Rab-27A (Rab-27) ... 227 3e-59
sp|P23640|RB27A_RAT Ras-related protein Rab-27A (Rab-27) (G... 226 4e-59
sp|O00194|RB27B_HUMAN Ras-related protein Rab-27B (C25KG) 226 6e-59
sp|Q9ERI2|RB27A_MOUSE Ras-related protein Rab-27A 225 8e-59
sp|Q99P58|RB27B_MOUSE Ras-related protein Rab-27B 224 2e-58
sp|Q99P74|RB27B_RAT Ras-related protein Rab-27B 223 3e-58
sp|Q05974|RAB1A_LYMST Ras-related protein Rab-1A 164 3e-40
sp|Q39571|YPTC1_CHLRE GTP-binding protein YPTC1 162 6e-40
sp|P22125|RAB1_DISOM Ras-related protein ORAB-1 162 6e-40
sp|P62820|RAB1A_HUMAN Ras-related protein Rab-1A (YPT1-rela... 162 8e-40
>sp|P51159|RB27A_HUMAN Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram)
Length = 221
Score = 227 bits (578), Expect = 3e-59
Identities = 107/193 (55%), Positives = 148/193 (76%)
Frame = +2
Query: 5 NNDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGI 184
++ DYDYLIK LALGDS VGKT +L +Y + + F TVG+DF+ KRVVY +G
Sbjct: 2 SDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFRPKRVVYRASGPDGP 61
Query: 185 VEKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINS 364
V + R++LQLWDTAGQERF+SLT +FFRDAMGFLL+FDLT+E SF+NVR+W+ L++++
Sbjct: 62 VGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHA 121
Query: 365 YSESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLV 544
Y E+PDI+L GNK D+ +RVV E A++ A+++ IPY ETSA++G NI +A L+DL+
Sbjct: 122 YCENPDIVLCGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLI 181
Query: 545 MERINRVVDKSFL 583
M+R+ R VDKS++
Sbjct: 182 MKRMERCVDKSWI 194
>sp|P23640|RB27A_RAT Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram) (Ram
p25)
Length = 221
Score = 226 bits (576), Expect = 4e-59
Identities = 106/193 (54%), Positives = 146/193 (75%)
Frame = +2
Query: 5 NNDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGI 184
++ DYDYLIK LALGDS VGKT +L +Y + + F TVG+DF++KRVVY +G
Sbjct: 2 SDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGT 61
Query: 185 VEKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINS 364
V + R++LQLWDTAGQERF+SLT +FFRDAMGFLL+FDLT+E SF+NVR+W+ L++++
Sbjct: 62 VGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHA 121
Query: 365 YSESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLV 544
Y E+PDI+L GNK D+ +R V E A A+++ IPY ETSA++G NI +A L+DL+
Sbjct: 122 YCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISQAIEMLLDLI 181
Query: 545 MERINRVVDKSFL 583
M+R+ R VDKS++
Sbjct: 182 MKRMERCVDKSWI 194
>sp|O00194|RB27B_HUMAN Ras-related protein Rab-27B (C25KG)
Length = 218
Score = 226 bits (575), Expect = 6e-59
Identities = 106/188 (56%), Positives = 144/188 (76%)
Frame = +2
Query: 14 DYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGIVEK 193
DYDYLIKLLALGDS VGKT L RY +N + F TVG+DF++KRVVY + NG K
Sbjct: 5 DYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGK 64
Query: 194 EARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINSYSE 373
+++LQLWDTAGQERF+SLT +FFRDAMGFLL+FDLT + SF+NVR+W+ L+ N+Y E
Sbjct: 65 AFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCE 124
Query: 374 SPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLVMER 553
+PDI+L+GNK D+ +R V+ A A ++ IPY ETSA++G+N++KA TL+DL+M+R
Sbjct: 125 NPDIVLIGNKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKR 184
Query: 554 INRVVDKS 577
+ + V+K+
Sbjct: 185 MEQCVEKT 192
>sp|Q9ERI2|RB27A_MOUSE Ras-related protein Rab-27A
Length = 221
Score = 225 bits (574), Expect = 8e-59
Identities = 106/193 (54%), Positives = 145/193 (75%)
Frame = +2
Query: 5 NNDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGI 184
++ DYDYLIK LALGDS VGKT +L +Y + + F TVG+DF++KRVVY +G
Sbjct: 2 SDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGA 61
Query: 185 VEKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINS 364
V + R++LQLWDTAGQERF+SLT +FFRDAMGFLL+FDLT+E SF+NVR+W+ L++++
Sbjct: 62 VGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHA 121
Query: 365 YSESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLV 544
Y E+PDI+L GNK D+ +R V E A A+++ IPY ETSA++G NI A L+DL+
Sbjct: 122 YCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISHAIEMLLDLI 181
Query: 545 MERINRVVDKSFL 583
M+R+ R VDKS++
Sbjct: 182 MKRMERCVDKSWI 194
>sp|Q99P58|RB27B_MOUSE Ras-related protein Rab-27B
Length = 218
Score = 224 bits (570), Expect = 2e-58
Identities = 104/188 (55%), Positives = 145/188 (77%)
Frame = +2
Query: 14 DYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGIVEK 193
DYDYLIKLLALGDS VGKT L RY +N + F TVG+DF++KRVVY + +G K
Sbjct: 5 DYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGASGK 64
Query: 194 EARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINSYSE 373
+++LQLWDTAGQERF+SLT +FFRDAMGFLL+FDLT + SF+NVR+W+ L+ N+Y E
Sbjct: 65 AFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCE 124
Query: 374 SPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLVMER 553
+PDI+L+GNK D+ +R V+ A A+++ IPY ETSA++G+N++K+ TL+DL+M+R
Sbjct: 125 NPDIVLIGNKADLPDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKR 184
Query: 554 INRVVDKS 577
+ + V+K+
Sbjct: 185 MEKCVEKT 192
>sp|Q99P74|RB27B_RAT Ras-related protein Rab-27B
Length = 218
Score = 223 bits (569), Expect = 3e-58
Identities = 104/188 (55%), Positives = 145/188 (77%)
Frame = +2
Query: 14 DYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGIVEK 193
DYDYLIKLLALGDS VGKT L RY +N + F TVG+DF++KRVVY + +G K
Sbjct: 5 DYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGSSGK 64
Query: 194 EARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINSYSE 373
+++LQLWDTAGQERF+SLT +FFRDAMGFLL+FDLT + SF+NVR+W+ L+ N+Y E
Sbjct: 65 AFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCE 124
Query: 374 SPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLVMER 553
+PDI+L+GNK D+ +R V+ A A+++ IPY ETSA++G+N++K+ TL+DL+M+R
Sbjct: 125 NPDIVLIGNKADLLDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKR 184
Query: 554 INRVVDKS 577
+ + V+K+
Sbjct: 185 MEKCVEKT 192
>sp|Q05974|RAB1A_LYMST Ras-related protein Rab-1A
Length = 205
Score = 164 bits (414), Expect = 3e-40
Identities = 81/191 (42%), Positives = 127/191 (66%), Gaps = 1/191 (0%)
Frame = +2
Query: 8 NDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGIV 187
N DYDYL KLL +GDS VGK+C+L R+ ++ YT + +T+GVDFK + + K
Sbjct: 5 NPDYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT----- 59
Query: 188 EKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINSY 367
+ LQ+WDTAGQERF+++T S++R A G ++V+D+TD+ SF NV+ WL+ +I+ Y
Sbjct: 60 -----IKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQ--EIDRY 112
Query: 368 -SESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLV 544
SE+ + +LVGNK D+TT++VV + A +A + IP++ETSA + N+++AF T+ +
Sbjct: 113 ASENVNKLLVGNKSDLTTKKVVDFTTAKEYADQLGIPFLETSAKNATNVEQAFMTMAAEI 172
Query: 545 MERINRVVDKS 577
R+ + S
Sbjct: 173 KNRMGPITAAS 183
>sp|Q39571|YPTC1_CHLRE GTP-binding protein YPTC1
Length = 203
Score = 162 bits (411), Expect = 6e-40
Identities = 84/184 (45%), Positives = 127/184 (69%), Gaps = 1/184 (0%)
Frame = +2
Query: 8 NDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGIV 187
N +YDYL KLL +GDS VGK+C+L R+ ++ YT + +T+GVDFK + V +G V
Sbjct: 2 NPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTVEL-----DGKV 56
Query: 188 EKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINSY 367
K LQ+WDTAGQERF+++T S++R A G ++V+D+TD+ SF NV+ WL +I+ Y
Sbjct: 57 IK-----LQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLN--EIDRY 109
Query: 368 -SESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLV 544
SE+ + +LVGNK D+T+++VV Y A +FA E IP++ETSA + N+++AF T+ +
Sbjct: 110 ASENVNKLLVGNKSDLTSKKVVEYSVAKAFADEIGIPFLETSAKNATNVEQAFMTMAAEI 169
Query: 545 MERI 556
R+
Sbjct: 170 KNRM 173
>sp|P22125|RAB1_DISOM Ras-related protein ORAB-1
Length = 202
Score = 162 bits (411), Expect = 6e-40
Identities = 81/184 (44%), Positives = 125/184 (67%), Gaps = 1/184 (0%)
Frame = +2
Query: 8 NDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNGIV 187
N +YDYL KLL +GDS VGK+C+L R+ ++ YT + +T+GVDFK + + K
Sbjct: 2 NPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT----- 56
Query: 188 EKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKINSY 367
+ LQ+WDTAGQERF+++T S++R A G ++V+D+TD+ SF NV+ WL+ +I+ Y
Sbjct: 57 -----IKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQ--EIDRY 109
Query: 368 -SESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLIDLV 544
SE+ + +LVGNK D+TT++VV Y A FA IP++ETSA + N+++AF T+ +
Sbjct: 110 ASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEI 169
Query: 545 MERI 556
+R+
Sbjct: 170 KKRM 173
>sp|P62820|RAB1A_HUMAN Ras-related protein Rab-1A (YPT1-related protein)
sp|Q6NYB7|RAB1A_RAT Ras-related protein Rab-1A
sp|P62821|RAB1A_MOUSE Ras-related protein Rab-1A (YPT1-related protein)
sp|P62822|RAB1A_CANFA Ras-related protein Rab-1A
Length = 205
Score = 162 bits (410), Expect = 8e-40
Identities = 81/186 (43%), Positives = 126/186 (67%), Gaps = 1/186 (0%)
Frame = +2
Query: 2 SNNDDYDYLIKLLALGDSSVGKTCILQRYINNAYTHDFGNTVGVDFKQKRVVYLPKNNNG 181
S N +YDYL KLL +GDS VGK+C+L R+ ++ YT + +T+GVDFK + + K
Sbjct: 3 SMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT--- 59
Query: 182 IVEKEARLNLQLWDTAGQERFKSLTVSFFRDAMGFLLVFDLTDENSFINVRDWLRLLKIN 361
+ LQ+WDTAGQERF+++T S++R A G ++V+D+TD+ SF NV+ WL+ +I+
Sbjct: 60 -------IKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQ--EID 110
Query: 362 SY-SESPDIILVGNKKDITTRRVVSYENAMSFAKEFNIPYVETSASSGENIDKAFNTLID 538
Y SE+ + +LVGNK D+TT++VV Y A FA IP++ETSA + N++++F T+
Sbjct: 111 RYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAA 170
Query: 539 LVMERI 556
+ +R+
Sbjct: 171 EIKKRM 176
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,171,413
Number of Sequences: 369166
Number of extensions: 1502453
Number of successful extensions: 5167
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4385
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4473
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5976365205
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)