Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_N19
(820 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O18404|HCD2_DROME 3-hydroxyacyl-CoA dehydrogenase type I... 265 1e-70
sp|Q99714|HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type I... 248 1e-65
sp|O02691|HCD2_BOVIN 3-hydroxyacyl-CoA dehydrogenase type I... 246 4e-65
sp|O70351|HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type II ... 246 4e-65
sp|O08756|HCD2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type I... 243 4e-64
sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reduc... 102 2e-21
sp|P51831|FABG_BACSU 3-oxoacyl-[acyl-carrier-protein] reduc... 97 4e-20
sp|P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier-protein] reduc... 93 1e-18
sp|O67610|FABG_AQUAE 3-oxoacyl-[acyl-carrier-protein] reduc... 93 1e-18
sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reduc... 92 2e-18
>sp|O18404|HCD2_DROME 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Scully
protein)
Length = 255
Score = 265 bits (676), Expect = 1e-70
Identities = 133/235 (56%), Positives = 166/235 (70%), Gaps = 7/235 (2%)
Frame = +1
Query: 73 TVERLTKQGCKVAICDL------QEPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKL 234
T ERL KQG V + DL + K L F+ DV+SE DV AL K +L
Sbjct: 20 TAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVTSEKDVSAALQTAKDKFGRL 79
Query: 235 DILVNCAGVGLAVKVFN-RKEIPHPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFD 411
D+ VNCAG AVK FN K + H L DF+R++ +NTVGTFN+IRL + +N PN+
Sbjct: 80 DLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFNVIRLSAGLMGANEPNQDG 139
Query: 412 QRGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPL 591
QRG+++NT+S+AAFDGQ GQ+AYSASKAA+ GMTLP+ARDL+ G+R+ TIAPGLF TP+
Sbjct: 140 QRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPGLFNTPM 199
Query: 592 LEALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTIIENPMLNGEVIRIDGALRMM 756
L ALP V+ L+ ++PFP RLG P E+AHLVQ I ENP+LNGEVIRIDGALRMM
Sbjct: 200 LAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQAIYENPLLNGEVIRIDGALRMM 254
>sp|Q99714|HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein) (Short-chain type dehydrogenase/reductase
XH98G2)
Length = 261
Score = 248 bits (634), Expect = 1e-65
Identities = 130/234 (55%), Positives = 163/234 (69%), Gaps = 7/234 (2%)
Frame = +1
Query: 73 TVERLTKQGCKVAICDLQ------EPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKL 234
T ERL QG + DL + K L +N F DV+SE DV+ AL K ++
Sbjct: 26 TAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRV 85
Query: 235 DILVNCAGVGLAVKVFN-RKEIPHPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFD 411
D+ VNCAG+ +A K +N +K H L DF+R+L VN +GTFN+IRL N P++
Sbjct: 86 DVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGG 145
Query: 412 QRGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPL 591
QRG++INT+S+AAF+GQ GQ+AYSASK I GMTLP+ARDLA +G+RVMTIAPGLF TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPL 205
Query: 592 LEALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTIIENPMLNGEVIRIDGALRM 753
L +LP V L++ VPFPSRLG P E+AHLVQ IIENP LNGEVIR+DGA+RM
Sbjct: 206 LTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRM 259
>sp|O02691|HCD2_BOVIN 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH)
Length = 261
Score = 246 bits (629), Expect = 4e-65
Identities = 128/234 (54%), Positives = 163/234 (69%), Gaps = 7/234 (2%)
Frame = +1
Query: 73 TVERLTKQGCKVAICDLQ------EPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKL 234
T ERL QG + DL + K L + F DV+SE DV+ ALT + ++
Sbjct: 26 TAERLVGQGATAVLLDLPNSDGETQAKKLGKSCAFAPADVTSEKDVQAALTLAREKFGRV 85
Query: 235 DILVNCAGVGLAVKVFN-RKEIPHPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFD 411
D+ VNCAG+ +A K +N +K H L DF+R++ VN +GTFN+IRL N P++
Sbjct: 86 DVAVNCAGIAVASKTYNLKKSQAHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGG 145
Query: 412 QRGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPL 591
QRG++INT+S+AAF+GQ GQ+AYSASK I GMTLP+ARDLA MG+RVMTIAPGLF TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVMTIAPGLFGTPL 205
Query: 592 LEALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTIIENPMLNGEVIRIDGALRM 753
L LP+ V+ L++ VPFPSRLG P E+AHLVQ IIEN LNGEVIR+DGA+RM
Sbjct: 206 LTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQAIIENSFLNGEVIRLDGAIRM 259
>sp|O70351|HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein)
Length = 261
Score = 246 bits (629), Expect = 4e-65
Identities = 124/234 (52%), Positives = 166/234 (70%), Gaps = 7/234 (2%)
Frame = +1
Query: 73 TVERLTKQGCKVAICDLQ------EPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKL 234
T +RL QG + D+ E K L N F +V+SE +V+ ALT K ++
Sbjct: 26 TAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQAALTLAKEKFGRI 85
Query: 235 DILVNCAGVGLAVKVFNRKEIP-HPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFD 411
D+ VNCAG+ +A+K ++ K+ H L DF+R++ VN +GTFN+IRL + N P++
Sbjct: 86 DVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIRLVAGVMGQNEPDQGG 145
Query: 412 QRGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPL 591
QRG++INT+S+AAF+GQ GQ+AYSASK I GMTLP+ARDLA +G+RV+TIAPGLF TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVVTIAPGLFATPL 205
Query: 592 LEALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTIIENPMLNGEVIRIDGALRM 753
L LP+ V+ L++ VPFPSRLG P E+AHLVQ +IENP LNGEVIR+DGA+RM
Sbjct: 206 LTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQMVIENPFLNGEVIRLDGAIRM 259
>sp|O08756|HCD2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein)
Length = 261
Score = 243 bits (621), Expect = 4e-64
Identities = 123/234 (52%), Positives = 165/234 (70%), Gaps = 7/234 (2%)
Frame = +1
Query: 73 TVERLTKQGCKVAICDL------QEPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKL 234
T +RL QG + D+ + K L + F +V+SE +++ ALT K ++
Sbjct: 26 TAKRLVGQGATAVLLDVPDSEGESQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRI 85
Query: 235 DILVNCAGVGLAVKVFNRKEIP-HPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFD 411
D+ VNCAG+ +A+K +++K+ H L DF+R++ VN +GTFN+IRL N P++
Sbjct: 86 DVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGG 145
Query: 412 QRGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPL 591
QRG++INT+S+AAF+GQ GQ+AYSASK I GMTLP+ARDLA G+RV+TIAPGLF TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIDGMTLPIARDLAPTGIRVVTIAPGLFATPL 205
Query: 592 LEALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTIIENPMLNGEVIRIDGALRM 753
L LP V+ L++ VPFPSRLG P E+AHLVQTIIENP LNGEVIR+DGA+RM
Sbjct: 206 LTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRM 259
>sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 102 bits (253), Expect = 2e-21
Identities = 64/212 (30%), Positives = 108/212 (50%), Gaps = 3/212 (1%)
Frame = +1
Query: 121 LQEPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKLDILVNCAGVGLAVKVFNRKEIP 300
++E + LP +V+ + ++ + ++ ++D+LVN AG+ + KE
Sbjct: 46 VKEAEGLPGKVDPYVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKE-- 103
Query: 301 HPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFDQR-GIVINTSSIAAFDGQSGQSA 477
D++ ++ VN G FN+ ++ VP QR G ++N SS+ G GQ+
Sbjct: 104 ---EDWDAVINVNLKGVFNVTQMV-------VPYMIKQRNGSIVNVSSVVGIYGNPGQTN 153
Query: 478 YSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPLLEALPNNVQAHLSTTVPFPSRL 657
Y+ASKA + GMT A++LA +RV +APG TP+ E LP + + +P R
Sbjct: 154 YAASKAGVIGMTKTWAKELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSRIPL-GRF 212
Query: 658 GHPDEFAHLVQTII--ENPMLNGEVIRIDGAL 747
G P+E A ++ + E+ + G+VI IDG L
Sbjct: 213 GKPEEVAQVILFLASDESSYVTGQVIGIDGGL 244
>sp|P51831|FABG_BACSU 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 97.4 bits (241), Expect = 4e-20
Identities = 60/213 (28%), Positives = 105/213 (49%), Gaps = 2/213 (0%)
Frame = +1
Query: 121 LQEPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKLDILVNCAGVGLAVKVFNRKEIP 300
+ E K++ + +K DVS+ DV+N + + S+ +DILVN AG+ + KE
Sbjct: 46 VDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMKE-- 103
Query: 301 HPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFDQRGIVINTSSIAAFDGQSGQSAY 480
+++ ++ +N G FN + + + G +IN SSI G GQ+ Y
Sbjct: 104 ---DEWDDVININLKGVFNCTKAVTRQMMKQ------RSGRIINVSSIVGVSGNPGQANY 154
Query: 481 SASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPLLEALPNNVQAHLSTTVPFPSRLG 660
A+KA + G+T A++LA+ + V IAPG T + + L +VQ + +P +R G
Sbjct: 155 VAAKAGVIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPL-ARFG 213
Query: 661 HPDEFAHLVQTIIEN--PMLNGEVIRIDGALRM 753
P + + +V + + G+ + IDG + M
Sbjct: 214 EPSDVSSVVTFLASEGARYMTGQTLHIDGGMVM 246
>sp|P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplast precursor
(3-ketoacyl-acyl carrier protein reductase)
Length = 320
Score = 92.8 bits (229), Expect = 1e-18
Identities = 66/236 (27%), Positives = 109/236 (46%), Gaps = 13/236 (5%)
Frame = +1
Query: 85 LTKQGCKVAICDLQEPKTLPSNSYFIKT----------DVSSENDVENALTQIKSMAQKL 234
L K GCKV + + K S I+ DVS E DVE + +
Sbjct: 97 LGKAGCKVLVNYARSSKEAEEVSKEIEAFGGQALTFGGDVSKEEDVEAMIKTAVDAWGTV 156
Query: 235 DILVNCAGVGLAVKVFNRKEIPHPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFDQ 414
DILVN AG+ + K+ ++ ++ +N G F + + + +
Sbjct: 157 DILVNNAGITRDGLLMRMKK-----SQWQEVIDLNLTGVFLCTQAAAKIMMKK------K 205
Query: 415 RGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPLL 594
+G +IN +S+ G +GQ+ YSA+KA + G T +AR+ A+ + V +APG + +
Sbjct: 206 KGRIINIASVVGLVGNAGQANYSAAKAGVIGFTKTVAREYASRNINVNAVAPGFISSDMT 265
Query: 595 EALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTIIENP---MLNGEVIRIDGALRM 753
L +++ + T+P R G P+E A LV+ + NP + G+V IDG + M
Sbjct: 266 SKLGDDINKKILETIPL-GRYGQPEEVAGLVEFLAINPASSYVTGQVFTIDGGMTM 320
>sp|O67610|FABG_AQUAE 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 248
Score = 92.8 bits (229), Expect = 1e-18
Identities = 62/198 (31%), Positives = 98/198 (49%), Gaps = 2/198 (1%)
Frame = +1
Query: 160 IKTDVSSENDVENALTQIKSMAQKLDILVNCAGVGLAVKVFNRKEIPHPLHDFERILKVN 339
++ ++ SE + A +I ++ +DILVN AG+ K+F R L D+E +LKVN
Sbjct: 62 VEMNLLSEESINKAFEEIYNLVDGIDILVNNAGI-TRDKLFLRMS----LLDWEEVLKVN 116
Query: 340 TVGTFNMIRLCCSMFISNVPNEFDQRGIVINTSSIAAFDGQSGQSAYSASKAAIAGMTLP 519
GTF + + I + G ++N SS+ F G GQ YS +KA + G T
Sbjct: 117 LTGTFLVTQNSLRKMIK------QRWGRIVNISSVVGFTGNVGQVNYSTTKAGLIGFTKS 170
Query: 520 LARDLAAMGVRVMTIAPGLFLTPLLEALPNNVQAHLSTTVPFPSRLGHPDEFAHLVQTII 699
LA++LA V V +APG T + L ++ +P R G P+E A++V +
Sbjct: 171 LAKELAPRNVLVNAVAPGFIETDMTAVLSEEIKQKYKEQIPL-GRFGSPEEVANVVLFLC 229
Query: 700 EN--PMLNGEVIRIDGAL 747
+ GEVI ++G +
Sbjct: 230 SELASYITGEVIHVNGGM 247
>sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|P0A0I0|FABG_STAAW 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|P0A0H9|FABG_STAAM 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|Q6GHK4|FABG_STAAR 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|Q6G9Y2|FABG_STAAS 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 92.0 bits (227), Expect = 2e-18
Identities = 59/214 (27%), Positives = 110/214 (51%), Gaps = 3/214 (1%)
Frame = +1
Query: 121 LQEPKTLPSNSYFIKTDVSSENDVENALTQIKSMAQKLDILVNCAGVGLAVKVFNRKEIP 300
++E K +S+ I+ +V+ ++V+ + ++ S LD+LVN AG+ + KE
Sbjct: 46 VEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKE-- 103
Query: 301 HPLHDFERILKVNTVGTFNMIRLCCSMFISNVPNEFDQR-GIVINTSSIAAFDGQSGQSA 477
+++ ++ N G FN I+ P QR G +IN SS+ G GQ+
Sbjct: 104 ---QEWDDVIDTNLKGVFNCIQKA-------TPQMLRQRSGAIINLSSVVGAVGNPGQAN 153
Query: 478 YSASKAAIAGMTLPLARDLAAMGVRVMTIAPGLFLTPLLEALPNNVQAHLSTTVPFPSRL 657
Y A+KA + G+T AR+LA+ G+ V +APG ++ + +AL + ++ + T +P +R
Sbjct: 154 YVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPL-ARF 212
Query: 658 GHPDEFAHLVQTIIEN--PMLNGEVIRIDGALRM 753
G + A+ V + + + G+ I ++G + M
Sbjct: 213 GQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM 246
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,565,659
Number of Sequences: 369166
Number of extensions: 1839323
Number of successful extensions: 5509
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5187
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5346
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)