Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_M21
(844 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q05793|PGBM_MOUSE Basement membrane-specific heparan sul... 60 6e-09
sp|P98160|PGBM_HUMAN Basement membrane-specific heparan sul... 56 1e-07
sp|Q06561|UNC52_CAEEL Basement membrane proteoglycan precur... 48 4e-05
sp|O60469|DSCAM_HUMAN Down syndrome cell adhesion molecule ... 47 9e-05
sp|Q8TD84|DSCL1_HUMAN Down syndrome cell adhesion molecule-... 47 9e-05
sp|P20241|NRG_DROME Neuroglian precursor 43 0.001
sp|P16419|MYPC2_CHICK Myosin-binding protein C, fast-type (... 41 0.005
sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 ... 41 0.005
sp|P13591|NCA11_HUMAN Neural cell adhesion molecule 1, 140 ... 41 0.005
sp|Q28260|VCAM1_CANFA Vascular cell adhesion protein 1 prec... 40 0.006
>sp|Q05793|PGBM_MOUSE Basement membrane-specific heparan sulfate proteoglycan core protein
precursor (HSPG) (Perlecan) (PLC)
Length = 3707
Score = 60.5 bits (145), Expect = 6e-09
Identities = 65/264 (24%), Positives = 102/264 (38%), Gaps = 7/264 (2%)
Frame = +2
Query: 17 GIYQCIISGRDPSTGQ--TVDLRATFTIQPEFKIGSKIELTEPPGPQIFVR-AGDKRELH 187
G Y+C +S R S V ++ + + P+ I T PQ+ R G E H
Sbjct: 2682 GRYRCQVSNRVGSAEAFAQVLVQGSSSNLPDTSIPGGSTPTVQVTPQLETRNIGASVEFH 2741
Query: 188 CEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECK 367
C + +G + W G + P Q ++ +QN+ Q +G Y C+
Sbjct: 2742 CAV---PNERGTHLRWLKEGGQLPPGHSVQDG----------VLRIQNLDQNCQGTYVCQ 2788
Query: 368 VKGETKEAYI---IVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFM 538
G +A +++ ++ +N V G VEF C G V W
Sbjct: 2789 AHGPWGQAQATAQLIVQALPSVLINVRTSVHSVVVGHSVEFECLALG--DPKPQVTW--- 2843
Query: 539 SKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICTEPDTRDTARS-ILNVI 715
SK G + P + I + EL+DAG Y C + T +S +L ++
Sbjct: 2844 SKVGGHLRP----------GIVQSGTIIRIAHVELADAGQYRCAATNAAGTTQSHVLLLV 2893
Query: 716 SDLRIVVTPPIIKLRAGQTATFQC 787
L + TPP I++ AG A F C
Sbjct: 2894 QALPQISTPPEIRVPAGSAAVFPC 2917
Score = 37.4 bits (85), Expect = 0.052
Identities = 64/282 (22%), Positives = 101/282 (35%), Gaps = 25/282 (8%)
Frame = +2
Query: 17 GIYQCIISGRD-PSTGQTVDLRATFTIQPEFKIGSKIELTEPPGPQIFVRAGDKRELHCE 193
G Y C ++G P + L + F++ S + EPP V+ G C
Sbjct: 2309 GEYVCQVAGSSHPEHEASFKLTVPSSQNSSFRLRSPVISIEPPSST--VQQGQDASFKCL 2366
Query: 194 IGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILP-------RLYVSIMILQNIQQMNEG 352
I + G EW + + N + N I+ + + + N+ M +
Sbjct: 2367 I--HEGAMPIKVEWKIRDQELEDNVHISPNGSIITIVAPGPATMEPTACVASNVYGMAQS 2424
Query: 353 KYECKVKGETKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWT 532
V G T+ V P PV H ++G +D+
Sbjct: 2425 VVNLSVHGPP------------TVSVLPEG---------PV--HVKMG------KDITLE 2455
Query: 533 FMSKETGQITPLESRWSRSDDPTADE-------TSFIILQQAEL--SDAGTYICTEPDTR 685
+S + +P RW+R P E S +L+ A + SDAGTY+C +
Sbjct: 2456 CISSGEPRSSP---RWTRLGIPVKLEPRMFGLMNSHAMLKIASVKPSDAGTYVCQAQNAL 2512
Query: 686 DTARSILNVISDLRIVV--TPPI------IKLRAGQTATFQC 787
TA+ + +I D V TP + + L AG TAT C
Sbjct: 2513 GTAQKQVELIVDTGTVAPGTPQVQVEESELTLEAGHTATLHC 2554
Score = 37.4 bits (85), Expect = 0.052
Identities = 31/122 (25%), Positives = 55/122 (45%), Gaps = 2/122 (1%)
Frame = +2
Query: 311 SIMILQNIQQMNEGKYECKVKGE--TKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFH 484
+I+ + +++ + G+Y C T +++++++ ++ P E RV G F
Sbjct: 2859 TIIRIAHVELADAGQYRCAATNAAGTTQSHVLLLVQALPQISTPPEI--RVPAGSAAVFP 2916
Query: 485 CRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYI 664
C GY T + W SK G + P +SR E + ++L DAGTY+
Sbjct: 2917 CMASGYPTPA--ITW---SKVDGDLPP-DSRL---------ENNMLMLPSVRPEDAGTYV 2961
Query: 665 CT 670
CT
Sbjct: 2962 CT 2963
Score = 37.0 bits (84), Expect = 0.068
Identities = 40/166 (24%), Positives = 70/166 (42%), Gaps = 13/166 (7%)
Frame = +2
Query: 329 NIQQMNEGKYECKVKG-----ETKEAYIIVMAKSRTIEVNPNEE-TRRVGDGRPVEFHCR 490
++Q + G Y C + ++ ++ A S+ I V E+ ++ V G V F C
Sbjct: 1734 SVQPSDAGVYICTCRNLIHTSNSRAELLVAEAPSKPIMVTVEEQRSQSVRPGADVTFICT 1793
Query: 491 IGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICT 670
++ +VWT + L SR D + ++ + SDAGTY+CT
Sbjct: 1794 AKS-KSPAYTLVWTRLHNGK-----LPSR-------AMDFNGILTIRNVQPSDAGTYVCT 1840
Query: 671 EPD--TRDTARSILNV-ISDLRIV----VTPPIIKLRAGQTATFQC 787
+ D + L+V +S + PP + ++ GQ A F+C
Sbjct: 1841 GSNMFAMDQGTATLHVQVSGTSTAPVASIHPPQLTVQPGQQAEFRC 1886
Score = 36.6 bits (83), Expect = 0.089
Identities = 46/180 (25%), Positives = 73/180 (40%), Gaps = 20/180 (11%)
Frame = +2
Query: 323 LQNIQQMNEGKYECKVKGE--TKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIG 496
L + + G+Y C+V G T EA ++V TIE + G +PV
Sbjct: 2202 LNRVSPADSGEYSCQVTGSSGTLEASVLV-----TIEASEPSPIPAPGLAQPVYIESS-S 2255
Query: 497 GYRTKNR--DVVWTFMSKETGQITPLESRWSR--SDDPTADET--SFIILQQAELSDAGT 658
+ T+ + D+ + Q+T W + S P +T S + L Q +D+G
Sbjct: 2256 SHLTEGQTVDLKCVVPGQAHAQVT-----WHKRGSSLPARHQTHGSLLRLYQLSPADSGE 2310
Query: 659 YICT---------EPDTRDTARSILNVISDLR---IVVTPPIIKLRAGQTATFQCYVLNG 802
Y+C E + T S N LR I + PP ++ GQ A+F+C + G
Sbjct: 2311 YVCQVAGSSHPEHEASFKLTVPSSQNSSFRLRSPVISIEPPSSTVQQGQDASFKCLIHEG 2370
Score = 34.3 bits (77), Expect = 0.44
Identities = 41/194 (21%), Positives = 72/194 (37%), Gaps = 5/194 (2%)
Frame = +2
Query: 146 PQIFVRAGDKRELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMIL 325
PQ+ V+ G + E C TG EW P +N I+ L
Sbjct: 1872 PQLTVQPGQQAEFRCSA---TGNPTPMLEWIGGPSGQLPAKAQIHN---------GILRL 1919
Query: 326 QNIQQMNEGKYECKVKGETKEAYIIVMAKSR-----TIEVNPNEETRRVGDGRPVEFHCR 490
I+ ++G+Y C+ + M + ++V+P E +V +GR V +CR
Sbjct: 1920 PAIEPSDQGQYLCRALSSAGQHVARAMLQVHGGSGPRVQVSP--ERTQVHEGRTVRLYCR 1977
Query: 491 IGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICT 670
G + + W KE G + P + S + L ++D+G Y+C
Sbjct: 1978 AAG--VPSASITW---RKEGGSL-PFRHQ---------AHGSRLRLHHMSVADSGEYVCR 2022
Query: 671 EPDTRDTARSILNV 712
+ D + + +
Sbjct: 2023 ANNNIDAQETSIMI 2036
>sp|P98160|PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein
precursor (HSPG) (Perlecan) (PLC)
Length = 4391
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/219 (24%), Positives = 87/219 (39%), Gaps = 5/219 (2%)
Frame = +2
Query: 146 PQIFVRA-GDKRELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMI 322
PQ+ ++ G E HC + + G Q R W+ G + P Q ++
Sbjct: 3406 PQLETKSIGASVEFHCAVPSDRGTQLR---WFKEGGQLPPGHSVQDG----------VLR 3452
Query: 323 LQNIQQMNEGKYECKVKGETKEAYI---IVMAKSRTIEVNPNEETRRVGDGRPVEFHCRI 493
+QN+ Q +G Y C+ G +A +V+ ++ +N + V G VEF C
Sbjct: 3453 IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA 3512
Query: 494 GGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICTE 673
G V W SK G + P + + EL+DAG Y CT
Sbjct: 3513 LG--DPKPQVTW---SKVGGHLRP----------GIVQSGGVVRIAHVELADAGQYRCTA 3557
Query: 674 PDTRDTARS-ILNVISDLRIVVTPPIIKLRAGQTATFQC 787
+ T +S +L ++ L + P +++ AG A F C
Sbjct: 3558 TNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPC 3596
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/248 (21%), Positives = 96/248 (38%), Gaps = 10/248 (4%)
Frame = +2
Query: 80 ATFTIQPEFKIGSKIELTEPPGPQIFVRAGDKRELHCEIGVNTGLQGRNAEWYFNGRLMS 259
AT +Q + + + PP Q+ V+ G E C TG EW
Sbjct: 1853 ATLHVQASGTLSAPVVSIHPP--QLTVQPGQLAEFRCSA---TGSPTPTLEWTGGPGGQL 1907
Query: 260 PNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECKVK---GETKEAYIIVMAKSRTIEV 430
P +++ I+ L ++ ++ +Y C+ G+ ++ + V
Sbjct: 1908 PAK---------AQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRV 1958
Query: 431 NPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADE 610
+ E +V GR V +CR G + + W KE G + P ++R R+D T
Sbjct: 1959 QVSPERTQVHAGRTVRLYCRAAG--VPSATITWR---KEGGSLPP-QARSERTDIAT--- 2009
Query: 611 TSFIILQQAELSDAGTYICTEPDTRDTARSILNVISDLRIVVTPPIIKLRA-------GQ 769
+++ +DAG Y+C TA++ + V+ +PP +K+ + GQ
Sbjct: 2010 ---LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ 2066
Query: 770 TATFQCYV 793
T C V
Sbjct: 2067 TLDLNCVV 2074
Score = 43.5 bits (101), Expect = 7e-04
Identities = 65/261 (24%), Positives = 98/261 (37%), Gaps = 16/261 (6%)
Frame = +2
Query: 53 STGQTVDLRATFTIQPEFKIGSKIELTEP----PGPQIFVRAGDKRELHCEIGVNTGLQG 220
++G + A+FT+ GS L P P V+ G C I + G
Sbjct: 2994 ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI--HDGAAP 3051
Query: 221 RNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECKVKGETKEAYII 400
+ EW + N + N+ I P SI+ + + N G Y C A +
Sbjct: 3052 ISLEW------KTRNQELEDNVHISPN--GSIITIVGTRPSNHGTYRCVASNAYGVAQSV 3103
Query: 401 VMAKSR---TIEVNPNEETRRVGDGRPVEFHCRIGGY-RTKNRDVVWTFMSKETGQITPL 568
V T+ V P E V G+ V C G R+ R WT +S + L
Sbjct: 3104 VNLSVHGPPTVSVLP-EGPVWVKVGKAVTLECVSAGEPRSSAR---WTRISSTPAK---L 3156
Query: 569 ESRWSRSDDPTADETSFIILQQAELSDAGTYICTEPDTRDTARSILNVISDL-------- 724
E R D + + + A+ SDAGTY+C + TA+ + VI D
Sbjct: 3157 EQRTYG----LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAP 3212
Query: 725 RIVVTPPIIKLRAGQTATFQC 787
++ + + AG TAT +C
Sbjct: 3213 QVQAEEAELTVEAGHTATLRC 3233
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/166 (24%), Positives = 71/166 (42%), Gaps = 13/166 (7%)
Frame = +2
Query: 329 NIQQMNEGKYECKVKG----ETKEAYIIVM-AKSRTIEVNPNEE-TRRVGDGRPVEFHCR 490
++Q + G Y C + T A ++V A S+ I V E+ ++ V G V F C
Sbjct: 1735 SVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICT 1794
Query: 491 IGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICT 670
++ +VWT + + D + ++ +LSDAGTY+CT
Sbjct: 1795 AKS-KSPAYTLVWTRLHN------------GKLPTRAMDFNGILTIRNVQLSDAGTYVCT 1841
Query: 671 EPD--TRDTARSILNV-----ISDLRIVVTPPIIKLRAGQTATFQC 787
+ D + L+V +S + + PP + ++ GQ A F+C
Sbjct: 1842 GSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRC 1887
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +2
Query: 314 IMILQNIQQMNEGKYECKVKGE--TKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHC 487
++ + +++ + G+Y C T +++++++ ++ P E RV G F C
Sbjct: 3539 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEV--RVPAGSAAVFPC 3596
Query: 488 RIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYIC 667
GY T D+ W SK G + P +SR E + ++L DAGTY+C
Sbjct: 3597 IASGYPTP--DISW---SKLDGSLPP-DSRL---------ENNMLMLPSVRPQDAGTYVC 3641
Query: 668 TEPDTRDTARSILNVISDLRIV 733
T + + ++ ++ R+V
Sbjct: 3642 TATNRQGKVKAFAHLQVPERVV 3663
Score = 32.7 bits (73), Expect = 1.3
Identities = 27/92 (29%), Positives = 36/92 (39%), Gaps = 6/92 (6%)
Frame = +2
Query: 530 TFMSKETGQITPLESRWSRSDDPTAD----ETSFIILQQAELSDAGTYIC--TEPDTRDT 691
T TG P WS+ P E +I+ + D+G YIC T P
Sbjct: 3230 TLRCSATGSPAPT-IHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAE 3288
Query: 692 ARSILNVISDLRIVVTPPIIKLRAGQTATFQC 787
A IL+V S P ++AG+T QC
Sbjct: 3289 ATIILHVESPPYATTVPEHASVQAGETVQLQC 3320
Score = 31.6 bits (70), Expect = 2.9
Identities = 60/296 (20%), Positives = 108/296 (36%), Gaps = 34/296 (11%)
Frame = +2
Query: 17 GIYQCIISGRDPSTGQTVDLRATFTIQPEFKIGSKIELTEPPG-PQIFVRAGDKR----- 178
G Y C + G S+G L A+ + E S + + P G P I + R
Sbjct: 2789 GEYVCRVMG---SSGP---LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQ 2842
Query: 179 --ELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEG 352
+L C + G W+ G N+ +++ ++ L + + G
Sbjct: 2843 TLDLKCVV---PGQAHAQVTWHKRGG----------NLPARHQVHGPLLRLNQVSPADSG 2889
Query: 353 KYECKVKGE--TKEAYIIVMAKSRTIEVNP----------NEETRRVGDGRPVEFHCRIG 496
+Y C+V G T EA ++V + + P + V +G+ ++ +C +
Sbjct: 2890 EYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVP 2949
Query: 497 GYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADET--SFIILQQAELSDAGTYIC- 667
G + V W K G + P +T S + L +D+G Y+C
Sbjct: 2950 GQA--HAQVTWY---KRGGSL------------PARHQTHGSQLRLHLVSPADSGEYVCR 2992
Query: 668 --TEPDTRDTARSILNV---------ISDLRIVVTPPIIKLRAGQTATFQCYVLNG 802
+ P A + V + I + PP ++ GQ A+F+C + +G
Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048
>sp|Q06561|UNC52_CAEEL Basement membrane proteoglycan precursor (Perlecan homolog)
(Uncoordinated protein 52)
Length = 3375
Score = 47.8 bits (112), Expect = 4e-05
Identities = 78/306 (25%), Positives = 124/306 (40%), Gaps = 30/306 (9%)
Frame = +2
Query: 17 GIYQCIISGRDPSTGQTVDLRATFT----IQPEFKIGSKIELTEPPGPQIFVRAGDKREL 184
G Y+C + D ST + R IQP+ +PP V G+ +
Sbjct: 1477 GEYECTSTEPDGSTQLSPPARLNVNQPQAIQPQ---------VDPPVQT--VNEGEPSRI 1525
Query: 185 HCEIGVNTGLQGRNAEWYFNGRLMSPND--YSQYNMRILPRLYVSIMILQNIQQMNEGKY 358
C + + +Q ++ GR P +SQ N+ I PR S +E +Y
Sbjct: 1526 RCWVPGHPNIQ---LQFVKRGRRPLPAHARFSQGNLEI-PRTLKS----------DEDEY 1571
Query: 359 ECKVKG-------ETKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNR 517
C E+ A +IV + R I ++P E+T V +G P + C + G+ +
Sbjct: 1572 ICIATDPTTNRPVESNPARVIVKSPIRPI-IDPAEQT--VPEGSPFKIRCYVPGHPS--- 1625
Query: 518 DVVWTFMSKETGQITPLESRWSRSDDPTADETSFII-LQQAELSDAGTYICT--EPDTRD 688
V TF + +GQ+ + ADE + ++ +Q+AEL+D G YICT +PDT
Sbjct: 1626 -VQLTFR-RVSGQL-----------NEDADENNGLLAVQRAELTDEGDYICTARDPDTGA 1672
Query: 689 TARS------ILNVISDLRI--------VVTPPIIKLRAGQTATFQCYVLNGGRSADHPD 826
S + N + ++ V+TP + G A QC V +A H
Sbjct: 1673 PIDSTPATVHVTNAAAPPQVEARPPQHPVITPQTQTIPEGDPARIQCTVPGNPSAAQHLS 1732
Query: 827 FFMANG 844
F +G
Sbjct: 1733 FERVDG 1738
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/105 (34%), Positives = 47/105 (44%), Gaps = 6/105 (5%)
Frame = +2
Query: 422 IEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPT 601
I V P+E + V DGR V F CR RT + V T RW+R P
Sbjct: 47 ITVFPSE--KEVRDGRDVSFECRA---RTSDNSVYPTV-------------RWARVGGPL 88
Query: 602 A----DETSFIILQQAELSDAGTYICTEPDTRDT--ARSILNVIS 718
D + + +LSDAGTYIC +T AR+ L+V+S
Sbjct: 89 PSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNTVEARATLSVVS 133
Score = 40.8 bits (94), Expect = 0.005
Identities = 54/255 (21%), Positives = 100/255 (39%), Gaps = 10/255 (3%)
Frame = +2
Query: 59 GQTVDLRATFTIQPEFKIGSKIELTEPPGPQIFVRAGDKRELHCEIGVNTGLQGRNAEWY 238
GQ + TF +P + ++ + EP + GD+ C++ T + + EW
Sbjct: 1113 GQVTNEDITFVQKPHEVL--RVRIMEPK--RQIALPGDRVHWICQVTGYT-TEKIHVEWT 1167
Query: 239 FNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECKVKGETKEAYI-IVMAKS 415
G + P + Y+ ++L+ ++ N G+Y C T+ A ++ S
Sbjct: 1168 KVGEMSLPPNAKAYD---------GYLVLKGVEAENAGQYRCTATTITQYATDDALLTIS 1218
Query: 416 RTIEVNPNEETRR-----VGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRW 580
+ I P + V +G P F C + G D T+ ++ G P
Sbjct: 1219 KRISGRPPQPVIDPPHLVVNEGEPAAFRCWVPGIP----DCQITWHREQLGGPLP----- 1269
Query: 581 SRSDDPTADETSFIILQQAELSDAGTYICTEPDTRDTARSILNVISDLRIVVTPPIIKLR 760
+ + + Q++L AG YIC+ + T +S V+ + V+ P + +R
Sbjct: 1270 ----HGVYQTGNALKIPQSQLHHAGRYICSAANQYGTGQSPPAVLEVKKPVIPPKVDPIR 1325
Query: 761 ----AGQTATFQCYV 793
Q A F+C+V
Sbjct: 1326 QTVDRDQPARFKCWV 1340
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/180 (21%), Positives = 71/180 (39%), Gaps = 22/180 (12%)
Frame = +2
Query: 314 IMILQNIQQMNEGKYECKVKGETKEA---------YIIVMAKSRTIEVNPNE------ET 448
++ +Q + +EG Y C + A ++ A +E P + +T
Sbjct: 1647 LLAVQRAELTDEGDYICTARDPDTGAPIDSTPATVHVTNAAAPPQVEARPPQHPVITPQT 1706
Query: 449 RRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIIL 628
+ + +G P C + G + + + + + G+ P S +D+ + +
Sbjct: 1707 QTIPEGDPARIQCTVPGNPSAAQHLSF---ERVDGKGLPFGS---------SDDRGVLTI 1754
Query: 629 QQAELSDAGTYICT-EPDTRDTAR---SILNVISD---LRIVVTPPIIKLRAGQTATFQC 787
+L DAG Y+C P+ + S LNV + R V TPP++ + G A F C
Sbjct: 1755 PSTQLQDAGEYVCLYSPENSPPVKTNPSTLNVTPEGTPPRPVATPPLLSVAPGSPARFNC 1814
Score = 38.9 bits (89), Expect = 0.018
Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 11/134 (8%)
Frame = +2
Query: 425 EVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSD---- 592
+++P +T V D P +F C + G + +WSR D
Sbjct: 1417 QIDPPNQTVNVND--PAQFRCWVPGQPRA-------------------QLKWSRKDGRPL 1455
Query: 593 -DPTADETSFIILQQAELSDAGTYIC--TEPD----TRDTARSILNVISDLRIVVTPPII 751
+ + F+ + +++L DAG Y C TEPD AR +N ++ V PP+
Sbjct: 1456 PNGILERDGFLRIDKSQLHDAGEYECTSTEPDGSTQLSPPARLNVNQPQAIQPQVDPPVQ 1515
Query: 752 KLRAGQTATFQCYV 793
+ G+ + +C+V
Sbjct: 1516 TVNEGEPSRIRCWV 1529
Score = 33.5 bits (75), Expect = 0.76
Identities = 55/260 (21%), Positives = 88/260 (33%), Gaps = 22/260 (8%)
Frame = +2
Query: 131 TEPPGPQIFVRAGDKRELHCEIGVNTGLQGRNAEWYFN---GRLMSPNDYSQYNMRILPR 301
T PPGP++ V G+ ++ CE G EW + R P+D+
Sbjct: 1979 TNPPGPKLIVTVGEPLQVKCEAFGAPGDPEPEVEWLHDPGPERGDLPDDFKPVT------ 2032
Query: 302 LYVSIMILQNIQQMNEGKYECKVKG----ETKEAYIIVMAKSRTIEVN-PNEETRRVGDG 466
+ + N+ N G Y CK TK YI V+ SR V+ ++ G
Sbjct: 2033 ISEQFIRHPNVGLGNAGVYTCKGSSAHATATKNIYIEVVEPSRIATVSILGGSSQWFDQG 2092
Query: 467 RPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDD--PT----ADETSFIIL 628
E C G +R W + DD PT +E +
Sbjct: 2093 EKGELICTATGSSLVDR------------------LEWEKVDDQLPTDVEEHNEPGLLHF 2134
Query: 629 QQAELSDAGTYICTEPDTRDT-------ARSILNVISDLRIVVTPPIIK-LRAGQTATFQ 784
+ S AG Y C + S N + ++ + PP ++ + G +
Sbjct: 2135 PSFKNSYAGEYRCNGYRNNEIIASAAVHVHSSANADDEPKVEIEPPRVRVVSQGDNIVLK 2194
Query: 785 CYVLNGGRSADHPDFFMANG 844
C V G + +H + + G
Sbjct: 2195 CSV-QGAENGEHFKWALLRG 2213
Score = 31.6 bits (70), Expect = 2.9
Identities = 45/206 (21%), Positives = 65/206 (31%), Gaps = 14/206 (6%)
Frame = +2
Query: 119 KIELTEPPGPQIFV--------RAGDKRELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYS 274
++E+TE P V + G++ + C + TG W P+D +
Sbjct: 1876 RLEVTEDQEPPTAVVEPRTWNGKPGERHQFRC---ITTGSPTPKITWTGPNGSPLPHDVT 1932
Query: 275 QYNMRILPRLYVSIMILQNIQQMNEGKYECKVK---GETKEAYIIVMAKSRTIEVNPNEE 445
IL N + G Y C GE + + + S T++ NP
Sbjct: 1933 PLEPNILD--------FSNGRSELNGDYTCTASNPIGEASDHGNVNIGPSLTVKTNPPGP 1984
Query: 446 TRRVGDGRPVEFHCR-IGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDD--PTADETS 616
V G P++ C G +V W P R DD P
Sbjct: 1985 KLIVTVGEPLQVKCEAFGAPGDPEPEVEWLH--------DPGPERGDLPDDFKPVTISEQ 2036
Query: 617 FIILQQAELSDAGTYICTEPDTRDTA 694
FI L +AG Y C TA
Sbjct: 2037 FIRHPNVGLGNAGVYTCKGSSAHATA 2062
>sp|O60469|DSCAM_HUMAN Down syndrome cell adhesion molecule precursor (CHD2)
Length = 2012
Score = 46.6 bits (109), Expect = 9e-05
Identities = 38/170 (22%), Positives = 75/170 (44%), Gaps = 2/170 (1%)
Frame = +2
Query: 167 GDKRELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMN 346
G + L C + TG + + WY NG +++P N+RI + + +I+ ++ + +
Sbjct: 328 GSQVSLSCSV---TGTEDQELSWYRNGEILNPGK----NVRITGINHEN-LIMDHMVKSD 379
Query: 347 EGKYECKVKGETKEA--YIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRD 520
G Y+C V+ + A Y+ V+ + T ++ + V PV C + G T
Sbjct: 380 GGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKG--TPLPT 437
Query: 521 VVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICT 670
+ WT + + R S+ + S++ + +++ D G Y CT
Sbjct: 438 ITWTL--DDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
>sp|Q8TD84|DSCL1_HUMAN Down syndrome cell adhesion molecule-like protein 1 precursor (Down
syndrome cell adhesion molecule 2)
Length = 2053
Score = 46.6 bits (109), Expect = 9e-05
Identities = 52/226 (23%), Positives = 95/226 (42%), Gaps = 16/226 (7%)
Frame = +2
Query: 158 VRAGDKRELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILP--RLYVSI---MI 322
VR D+R + + V L + + Y +S + + + I+P R +++ +
Sbjct: 129 VRVEDQRSMRGNVAVFKCLIPSSVQEY-----VSVVSWEKDTVSIIPEHRFFITYHGGLY 183
Query: 323 LQNIQQMNE-GKYEC----KVKGETKEAYIIVMAKSRTIEVNPNE----ETRRVGDGRPV 475
+ ++Q+ + Y C K GET+++ ++ + E P ++ V G V
Sbjct: 184 ISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTV 243
Query: 476 EFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAG 655
E C GY + W + G+ P +SRW++ + + + D+G
Sbjct: 244 ELPCTASGYPIPA--IRWL----KDGRPLPADSRWTK-------RITGLTISDLRTEDSG 290
Query: 656 TYICTEPDTRDTARS--ILNVISDLRIVVTPPIIKLRAGQTATFQC 787
TYIC +T +A + IL VI L + +TP +K G T C
Sbjct: 291 TYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSC 336
>sp|P20241|NRG_DROME Neuroglian precursor
Length = 1302
Score = 42.7 bits (99), Expect = 0.001
Identities = 52/201 (25%), Positives = 74/201 (36%), Gaps = 8/201 (3%)
Frame = +2
Query: 209 GLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQ--NIQQMNEGKYECKVKGET 382
G+ W NG+ P + S N PR V+ ++ N+ + + G Y C
Sbjct: 364 GVPEPKISWIHNGK---PIEQSTPN----PRRTVTDNTIRIINLVKGDTGNYGCNATNSL 416
Query: 383 ----KEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKET 550
K+ Y+ V A+ TI P + DGR V CR+ G + V W
Sbjct: 417 GYVYKDVYLNVQAEPPTISEAPAAVS--TVDGRNVTIKCRVNG--SPKPLVKWL------ 466
Query: 551 GQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICTEPDT--RDTARSILNVISDL 724
S W + +Q SDAG Y C + A L V
Sbjct: 467 -----RASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHT 521
Query: 725 RIVVTPPIIKLRAGQTATFQC 787
RI P ++ AGQ+ATF+C
Sbjct: 522 RITQEPQNYEVAAGQSATFRC 542
Score = 34.3 bits (77), Expect = 0.44
Identities = 58/276 (21%), Positives = 95/276 (34%), Gaps = 23/276 (8%)
Frame = +2
Query: 35 ISGRDPSTGQTVDLRATFTIQPEFKIGSKIEL------------TEPPGPQIFVR----- 163
++ D S+ AT + E+KIG+K+ L PP Q R
Sbjct: 199 VTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSLA 258
Query: 164 -AGDKRELHCEIGVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQ 340
G + EL C G G W +G+ + Q++ RI Y ++++
Sbjct: 259 LRGKRMELFCIYG---GTPLPQTVWSKDGQRI------QWSDRITQGHYGKSLVIRQTNF 309
Query: 341 MNEGKYECKVKG--ETKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKN 514
+ G Y C V +++ I++ + E + V F CR G
Sbjct: 310 DDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAG--VPE 367
Query: 515 RDVVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICTEPDTRDTA 694
+ W K Q TP R T + + I+ + D G Y C ++
Sbjct: 368 PKISWIHNGKPIEQSTPNPRR-------TVTDNTIRIINLVK-GDTGNYGCNATNSLGYV 419
Query: 695 RS--ILNVISD-LRIVVTPPIIKLRAGQTATFQCYV 793
LNV ++ I P + G+ T +C V
Sbjct: 420 YKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRV 455
>sp|P16419|MYPC2_CHICK Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein,
skeletal muscle fast-isoform)
Length = 1132
Score = 40.8 bits (94), Expect = 0.005
Identities = 41/189 (21%), Positives = 78/189 (41%), Gaps = 1/189 (0%)
Frame = +2
Query: 230 EWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECKVKGETKEAYIIVMA 409
+WY NG+L+ P+ + L R I+ + ++ YEC+V E + + V
Sbjct: 282 KWYKNGQLLKPSTKYVFENVGLKR----ILTIHKCSLADDAAYECRVNDE--KCFTEVFV 335
Query: 410 KSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLESRWSRS 589
K + V E ++V G V + + V+W + + + R+ +
Sbjct: 336 KEPPVTVVRGLEDQQVVVGDRVVLEAEVS---EEGAQVMWLKDGVDVTRDDAFKYRFKKD 392
Query: 590 DDPTADETSFIILQQAELSDAGTY-ICTEPDTRDTARSILNVISDLRIVVTPPIIKLRAG 766
+ F+I+ +AELSD+ Y I T + S+ L ++ + ++A
Sbjct: 393 G-----KKHFLIINEAELSDSAHYKIMTNGGESEAELSVEE--KQLEVLQDMADLTVKAS 445
Query: 767 QTATFQCYV 793
+ A F+C V
Sbjct: 446 EQAVFKCEV 454
>sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM
120) (NCAM-120) (CD56 antigen)
Length = 761
Score = 40.8 bits (94), Expect = 0.005
Identities = 56/226 (24%), Positives = 92/226 (40%), Gaps = 9/226 (3%)
Frame = +2
Query: 17 GIYQCIISGRDPSTGQTVDLRATFTIQPEFKIGSKIELTEPPGPQIFVRAGDKRELHCEI 196
GIY+C+++G D S + AT + KI K+ P PQ F R G+ + C++
Sbjct: 92 GIYKCVVTGEDGSESE-----ATVNV----KIFQKLMFKNAPTPQEF-REGEDAVIVCDV 141
Query: 197 GVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECK--- 367
W GR + +L Y+ I + I++ +EG Y C+
Sbjct: 142 ---VSSLPPTIIWKHKGRDVILK--KDVRFIVLSNNYLQI---RGIKKTDEGTYRCEGRI 193
Query: 368 -VKGET--KEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFM 538
+GE K+ +IV TI+ N G+ V C G+ + WT
Sbjct: 194 LARGEINFKDIQVIVNVPP-TIQARQNIVNATANLGQSVTLVCDAEGF--PEPTMSWT-- 248
Query: 539 SKETGQITPLESRWSRSDDPT---ADETSFIILQQAELSDAGTYIC 667
K+ QI E DD +D++S + +++ + +D YIC
Sbjct: 249 -KDGEQIEQEE------DDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Score = 38.1 bits (87), Expect = 0.031
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 3/139 (2%)
Frame = +2
Query: 392 YIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLE 571
+ + A S +++ P++ VG+ + F C++ G K++D+ W S ++TP +
Sbjct: 12 FFLGTAVSLQVDIVPSQGEISVGESK--FFLCQVAG-DAKDKDISW--FSPNGEKLTPNQ 66
Query: 572 SRWSRSDDPTADETSFIILQQAELSDAGTYICT---EPDTRDTARSILNVISDLRIVVTP 742
R S + D +S + + A + DAG Y C E + A + + L P
Sbjct: 67 QRISVVWND--DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAP 124
Query: 743 PIIKLRAGQTATFQCYVLN 799
+ R G+ A C V++
Sbjct: 125 TPQEFREGEDAVIVCDVVS 143
>sp|P13591|NCA11_HUMAN Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140) (CD56 antigen)
Length = 848
Score = 40.8 bits (94), Expect = 0.005
Identities = 56/226 (24%), Positives = 92/226 (40%), Gaps = 9/226 (3%)
Frame = +2
Query: 17 GIYQCIISGRDPSTGQTVDLRATFTIQPEFKIGSKIELTEPPGPQIFVRAGDKRELHCEI 196
GIY+C+++G D S + AT + KI K+ P PQ F R G+ + C++
Sbjct: 92 GIYKCVVTGEDGSESE-----ATVNV----KIFQKLMFKNAPTPQEF-REGEDAVIVCDV 141
Query: 197 GVNTGLQGRNAEWYFNGRLMSPNDYSQYNMRILPRLYVSIMILQNIQQMNEGKYECK--- 367
W GR + +L Y+ I + I++ +EG Y C+
Sbjct: 142 ---VSSLPPTIIWKHKGRDVILK--KDVRFIVLSNNYLQI---RGIKKTDEGTYRCEGRI 193
Query: 368 -VKGET--KEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFM 538
+GE K+ +IV TI+ N G+ V C G+ + WT
Sbjct: 194 LARGEINFKDIQVIVNVPP-TIQARQNIVNATANLGQSVTLVCDAEGF--PEPTMSWT-- 248
Query: 539 SKETGQITPLESRWSRSDDPT---ADETSFIILQQAELSDAGTYIC 667
K+ QI E DD +D++S + +++ + +D YIC
Sbjct: 249 -KDGEQIEQEE------DDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Score = 38.1 bits (87), Expect = 0.031
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 3/139 (2%)
Frame = +2
Query: 392 YIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRDVVWTFMSKETGQITPLE 571
+ + A S +++ P++ VG+ + F C++ G K++D+ W S ++TP +
Sbjct: 12 FFLGTAVSLQVDIVPSQGEISVGESK--FFLCQVAG-DAKDKDISW--FSPNGEKLTPNQ 66
Query: 572 SRWSRSDDPTADETSFIILQQAELSDAGTYICT---EPDTRDTARSILNVISDLRIVVTP 742
R S + D +S + + A + DAG Y C E + A + + L P
Sbjct: 67 QRISVVWND--DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAP 124
Query: 743 PIIKLRAGQTATFQCYVLN 799
+ R G+ A C V++
Sbjct: 125 TPQEFREGEDAVIVCDVVS 143
>sp|Q28260|VCAM1_CANFA Vascular cell adhesion protein 1 precursor (V-CAM 1)
Length = 739
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/154 (22%), Positives = 68/154 (44%), Gaps = 5/154 (3%)
Frame = +2
Query: 341 MNEGKYECKVKGETKEAYIIVMAKSRTIEVNPNEETRRVGDGRPVEFHCRIGGYRTKNRD 520
++E ++E K + T+ Y+ V + T+ V+P+ V +G PV C G N
Sbjct: 489 IDEMEFEPKQRQSTQTLYVNVAPRDTTVVVSPSSI---VEEGSPVNMTCSSDGLPAPN-- 543
Query: 521 VVWTFMSKETGQITPLESRWSRSDDPTADETSFIILQQAELSDAGTYICTEPDTRDTARS 700
++W+ G++ L S+DP + L A++ D+G Y+C + +R
Sbjct: 544 ILWS-RRLSNGRLQSL------SEDP------ILTLTSAKMEDSGIYVCEGINQAGISRK 590
Query: 701 ILNVI-----SDLRIVVTPPIIKLRAGQTATFQC 787
+ +I D++++ P ++ G T C
Sbjct: 591 EVELIIQVAPKDIQLIAFPS-ESVKEGDTVIISC 623
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,146,359
Number of Sequences: 369166
Number of extensions: 2061022
Number of successful extensions: 6036
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5580
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5990
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8245425915
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)