Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_M06
(811 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P41570|6PGD_CERCA 6-phosphogluconate dehydrogenase, deca... 314 2e-85
sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, deca... 313 3e-85
sp|P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, deca... 313 4e-85
sp|Q9DCD0|6PGD_MOUSE 6-phosphogluconate dehydrogenase, deca... 310 2e-84
sp|P41572|6PGD_DROME 6-phosphogluconate dehydrogenase, deca... 307 3e-83
sp|O60037|6PGD_CUNEL 6-phosphogluconate dehydrogenase, deca... 306 3e-83
sp|P41573|6PGD_DROSI 6-phosphogluconate dehydrogenase, deca... 305 1e-82
sp|P14332|6PGD_PIG 6-phosphogluconate dehydrogenase, decarb... 300 2e-81
sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, deca... 300 4e-81
sp|P78812|6PGD_SCHPO 6-phosphogluconate dehydrogenase, deca... 283 5e-76
>sp|P41570|6PGD_CERCA 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 314 bits (805), Expect = 2e-85
Identities = 164/254 (64%), Positives = 189/254 (74%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT I ++ + G YL+E I D+AGQKGTGKWTAI+AL +GVPVTLI E+VF+R
Sbjct: 229 SFLIEITRDILNYQDDRG-YLLERIRDTAGQKGTGKWTAISALQYGVPVTLIGEAVFSRC 287
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LSALK RV ASK+ N+ D KFLN IK+ALY SKI+SY QGFM+M+ A+ E
Sbjct: 288 LSALKDERVAASKQLKGPNVNAKVEDLPKFLNHIKHALYCSKIVSYAQGFMLMREAAKEN 347
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
WNL+ G IALMWRGGCIIRS FL NIKDAY +N LS LL D FF+ I Q SWR V
Sbjct: 348 NWNLNYGGIALMWRGGCIIRSVFLGNIKDAYTRNPQLSNLLLDDFFKKAIEVGQNSWRQV 407
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
VANA L GIP PA S AL+FYDG RTEKLPANL+QAQRD FGAH Y+LL G + HT+W
Sbjct: 408 VANAFLWGIPVPALSTALSFYDGYRTEKLPANLLQAQRDYFGAHTYELLGAEGKFVHTNW 467
Query: 723 TGHGGNAAASTYQA 764
TG GGN +ASTYQA
Sbjct: 468 TGTGGNVSASTYQA 481
>sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 313 bits (803), Expect = 3e-85
Identities = 153/254 (60%), Positives = 188/254 (74%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT++I KF+ DG +L+ I DSAGQKGTGKWTAI+AL++GVPVTLI E+VFAR
Sbjct: 230 SFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARC 289
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LS+LK R++ASK+ F GDK FL I+ ALYASKIISY QGFM+++ A+ EF
Sbjct: 290 LSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEF 349
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
W L+ G IALMWRGGCIIRS FL IKDA+++N L LL D FF+S + CQ+SWR
Sbjct: 350 GWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRA 409
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
V+ GIP P F+ AL+FYDG R E LPA+LIQAQRD FGAH Y+LL PG + HT+W
Sbjct: 410 VSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNW 469
Query: 723 TGHGGNAAASTYQA 764
TGHGG ++S+Y A
Sbjct: 470 TGHGGTVSSSSYNA 483
>sp|P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 313 bits (802), Expect = 4e-85
Identities = 153/254 (60%), Positives = 189/254 (74%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT+SI KF+ DG +L+ I DSAGQKGTGKWTAI+AL++GVPVTLI E+VFAR
Sbjct: 230 SFLIEITASILKFQDADGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARC 289
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LS+LK R++ASK+ + F GDK FL I+ ALYASKIISY QGFM+++ A+ EF
Sbjct: 290 LSSLKDERIQASKKLKGPQNIPFEGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEF 349
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
W L+ G IALMWRGGCIIRS FL IKDA+++N L LL D FF+S + CQ+SWR
Sbjct: 350 GWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVENCQDSWRRA 409
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
++ GIP P F+ AL+FYDG R LPANLIQAQRD FGAH Y+LL PG + HT+W
Sbjct: 410 ISTGVQAGIPMPCFTTALSFYDGYRHAMLPANLIQAQRDYFGAHTYELLAKPGQFIHTNW 469
Query: 723 TGHGGNAAASTYQA 764
TGHGG+ ++S+Y A
Sbjct: 470 TGHGGSVSSSSYNA 483
>sp|Q9DCD0|6PGD_MOUSE 6-phosphogluconate dehydrogenase, decarboxylating
Length = 483
Score = 310 bits (795), Expect = 2e-84
Identities = 151/254 (59%), Positives = 189/254 (74%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT++I K++ DG L+ I DSAGQKGTGKWTAI+AL++G+PVTLI E+VFAR
Sbjct: 230 SFLIEITANILKYRDTDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARC 289
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LS+LK RV+AS++ ++ G K FL I+ ALYASKIISY QGFM+++ A+ EF
Sbjct: 290 LSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQGFMLLRQAATEF 349
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
W L+ G IALMWRGGCIIRS FL IKDA+E+N L LL D FF+S + CQ+SWR V
Sbjct: 350 GWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRV 409
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
++ GIP P F+ AL+FYDG R E LPANLIQAQRD FGAH Y+LL PG + HT+W
Sbjct: 410 ISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFIHTNW 469
Query: 723 TGHGGNAAASTYQA 764
TGHGG+ ++S+Y A
Sbjct: 470 TGHGGSVSSSSYNA 483
>sp|P41572|6PGD_DROME 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 307 bits (786), Expect = 3e-83
Identities = 159/254 (62%), Positives = 185/254 (72%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT I K+K G YL+E I D+AGQKGTGKWTAI AL +GVPVTLI E+VF+R
Sbjct: 229 SFLIEITRDILKYKDGKG-YLLERIRDTAGQKGTGKWTAIAALQYGVPVTLIGEAVFSRC 287
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LSALK RV+AS + + TKFL+ IK+ALY +KI+SY QGFM+M+ A+ E
Sbjct: 288 LSALKDERVQASSVLKGPSTKAQVANLTKFLDDIKHALYCAKIVSYAQGFMLMREAAREN 347
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
KW L+ G IALMWRGGCIIRS FL NIKDAY LS LL D FF+ I + Q+SWR V
Sbjct: 348 KWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLLDDFFKKAIERGQDSWREV 407
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
VANA GIP PA S AL+FYDG RT KLPANL+QAQRD FGAH Y+LL G + HT+W
Sbjct: 408 VANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYELLGQEGQFHHTNW 467
Query: 723 TGHGGNAAASTYQA 764
TG GGN +ASTYQA
Sbjct: 468 TGTGGNVSASTYQA 481
>sp|O60037|6PGD_CUNEL 6-phosphogluconate dehydrogenase, decarboxylating
Length = 485
Score = 306 bits (785), Expect = 3e-83
Identities = 154/254 (60%), Positives = 185/254 (72%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT I +FK DG LV I D+AGQKGTGKWTAI +LD G+PVTLI E+V++R
Sbjct: 232 SFLIEITRDILRFKDTDGQPLVTKIRDTAGQKGTGKWTAIDSLDRGIPVTLIGEAVYSRC 291
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LS+LK RV ASK + FTGDK F+ Q+ ALYA+KI+SY QG+M+M+ A+ ++
Sbjct: 292 LSSLKDERVRASKILQGPSSSKFTGDKKTFIAQLGQALYAAKIVSYAQGYMLMRQAAKDY 351
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
+W L+ IALMWRGGCIIRS FL I+DAY KN L LLFD FF+ K Q++WR+V
Sbjct: 352 EWKLNNAGIALMWRGGCIIRSVFLGKIRDAYTKNPELENLLFDDFFKDATAKAQDAWRNV 411
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
A A L GIPTPA S AL FYDGLR E LPANL+QAQRD FGAH Y+LL PG + HT+W
Sbjct: 412 TAQAVLMGIPTPALSTALNFYDGLRHEILPANLLQAQRDYFGAHTYELLHTPGKWVHTNW 471
Query: 723 TGHGGNAAASTYQA 764
TG GGN +ASTY A
Sbjct: 472 TGRGGNVSASTYDA 485
>sp|P41573|6PGD_DROSI 6-phosphogluconate dehydrogenase, decarboxylating
Length = 481
Score = 305 bits (781), Expect = 1e-82
Identities = 158/254 (62%), Positives = 185/254 (72%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT I K+K G +L+E I D+AGQKGTGKWTAI AL +GVPVTLI E+VF+R
Sbjct: 229 SFLIEITRDILKYKDGKG-HLLERIRDTAGQKGTGKWTAIAALQYGVPVTLIGEAVFSRC 287
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LSALK RV+AS + + TKFL+ IK+ALY +KI+SY QGFM+M+ A+ E
Sbjct: 288 LSALKDERVQASSVLKGPSTKAEVANLTKFLDDIKHALYCAKIVSYAQGFMLMREAAREN 347
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
KW L+ G IALMWRGGCIIRS FL NIKDAY LS LL D FF+ I + Q+SWR V
Sbjct: 348 KWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPQLSNLLLDDFFKKAIERGQDSWREV 407
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDW 722
VANA GIP PA S AL+FYDG RT KLPANL+QAQRD FGAH Y+LL G + HT+W
Sbjct: 408 VANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYELLGQEGQFHHTNW 467
Query: 723 TGHGGNAAASTYQA 764
TG GGN +ASTYQA
Sbjct: 468 TGTGGNVSASTYQA 481
>sp|P14332|6PGD_PIG 6-phosphogluconate dehydrogenase, decarboxylating
Length = 250
Score = 300 bits (769), Expect = 2e-81
Identities = 149/251 (59%), Positives = 186/251 (74%)
Frame = +3
Query: 12 IEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARSLSA 191
IEIT++I KF+ DG +L+ I DSAGQKGTGKWTAI+AL++GVPVTLI E+VFAR LS+
Sbjct: 1 IEITANILKFQDADGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSS 60
Query: 192 LKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEFKWN 371
LK RV+ASK+ + F+GDK FL I+ ALYASKIISYTQGFM+++ A+ EF W+
Sbjct: 61 LKDERVQASKKLKGPQKIQFSGDKKSFLEDIRKALYASKIISYTQGFMLLRQAAAEFGWS 120
Query: 372 LDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHVVAN 551
+ LMWRGGCIIRS FL IKDA+++N L LL D FF+S + CQ+SWR V+
Sbjct: 121 -STTEHRLMWRGGCIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVEDCQDSWRRAVST 179
Query: 552 AALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHTDWTGH 731
GIP P F+ AL+FYDG R E LPANLIQAQRD FGAH Y+LL PG + HT+WTGH
Sbjct: 180 GVQTGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLAKPGHFVHTNWTGH 239
Query: 732 GGNAAASTYQA 764
GG+ ++S+Y A
Sbjct: 240 GGSVSSSSYNA 250
>sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, decarboxylating
Length = 484
Score = 300 bits (767), Expect = 4e-81
Identities = 153/256 (59%), Positives = 184/256 (71%), Gaps = 2/256 (0%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT++I K++ G +V I DSAGQKGTGKWT AL++G+PVTLI E+VFAR
Sbjct: 229 SFLIEITANILKYRDEQGEPIVPKIRDSAGQKGTGKWTCFAALEYGLPVTLIGEAVFARC 288
Query: 183 LSALKSLRVEASKRFPSNNLLNFT--GDKTKFLNQIKYALYASKIISYTQGFMMMKSASH 356
LSALK RV ASK+ P + T DK F+ QI ALYASKI+SY QGFM++ AS
Sbjct: 289 LSALKDERVRASKQLPRPQVSPDTVVQDKRVFIKQISKALYASKIVSYAQGFMLLAEASK 348
Query: 357 EFKWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWR 536
+F WNL+ G IALMWRGGCIIRSRFL +I+ A++KNK LS LL D FF I + Q+SWR
Sbjct: 349 QFNWNLNFGAIALMWRGGCIIRSRFLGDIEHAFQKNKQLSNLLLDDFFTKAITEAQDSWR 408
Query: 537 HVVANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYEHT 716
VV A GIP PAFS ALAFYDG +E +PANL+QAQRD FGAH Y+LL PGT+ HT
Sbjct: 409 VVVCAAVRLGIPVPAFSSALAFYDGYTSEVVPANLLQAQRDYFGAHTYELLAKPGTWVHT 468
Query: 717 DWTGHGGNAAASTYQA 764
+WTG GG ++ Y A
Sbjct: 469 NWTGTGGRVTSNAYNA 484
>sp|P78812|6PGD_SCHPO 6-phosphogluconate dehydrogenase, decarboxylating
Length = 492
Score = 283 bits (723), Expect = 5e-76
Identities = 145/261 (55%), Positives = 184/261 (70%), Gaps = 7/261 (2%)
Frame = +3
Query: 3 SFLIEITSSITKFKANDGTYLVEDIYDSAGQKGTGKWTAITALDFGVPVTLIAESVFARS 182
SFLIEIT + ++KA+DG LVE I D+AGQKGTGKWTA AL+ G PV+LI E+VFAR
Sbjct: 233 SFLIEITRDVLRYKADDGKPLVEKILDAAGQKGTGKWTAQNALEMGTPVSLITEAVFARC 292
Query: 183 LSALKSLRVEASKRFPSNNLLNFTGDKTKFLNQIKYALYASKIISYTQGFMMMKSASHEF 362
LS+LKS RV ASK+ N FTGDK + ++ ++ ALYASKIISY QGFM+M+ A+ E+
Sbjct: 293 LSSLKSERVRASKKLTGPNT-KFTGDKKQLIDDLEDALYASKIISYAQGFMLMREAAKEY 351
Query: 363 KWNLDLGKIALMWRGGCIIRSRFLQNIKDAYEKNKNLSILLFDKFFQSEILKCQESWRHV 542
W L+ IALMWRGGCIIRS FL++I +A+ ++ NL +LF FF + + K Q WR V
Sbjct: 352 GWKLNNAGIALMWRGGCIIRSVFLKDITEAFREDPNLESILFHPFFTNGVEKAQAGWRRV 411
Query: 543 VANAALHGIPTPAFSCALAFYDGLRTEKLPANLIQAQRDLFGAHQYQLLDHPGTYE---- 710
VA AA+ GIP PA S L+FYDG R+ LPANL+QAQRD FGAH +++L
Sbjct: 412 VAQAAMLGIPVPATSTGLSFYDGYRSAVLPANLLQAQRDYFGAHTFRVLPEAADKSLPAD 471
Query: 711 ---HTDWTGHGGNAAASTYQA 764
H +WTGHGGN +A+TY A
Sbjct: 472 KDIHINWTGHGGNISATTYDA 492
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,678,388
Number of Sequences: 369166
Number of extensions: 2004204
Number of successful extensions: 5064
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4848
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5002
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)