Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_K03
(832 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 300 3e-81
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 297 3e-80
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 295 8e-80
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 287 2e-77
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 279 8e-75
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 273 3e-73
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 256 7e-68
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 226 8e-59
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 207 4e-53
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 205 1e-52
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 300 bits (768), Expect = 3e-81
Identities = 143/244 (58%), Positives = 173/244 (70%), Gaps = 1/244 (0%)
Frame = +2
Query: 104 PLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLNRVRL 280
PLS +L+N+VN TTWKAG +S ++K+ G ++ P KLP+R V L
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGP---KLPQRDAFAADVVL 80
Query: 281 PTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLT 460
P +FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 81 PESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLT 140
Query: 461 CCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTG 640
CCG CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTG
Sbjct: 141 CCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTG 200
Query: 641 EFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFP 820
E TPKC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE AFSVY+DF
Sbjct: 201 EGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFL 260
Query: 821 NYKS 832
YKS
Sbjct: 261 LYKS 264
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 297 bits (760), Expect = 3e-80
Identities = 139/248 (56%), Positives = 172/248 (69%), Gaps = 1/248 (0%)
Frame = +2
Query: 92 PIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 268
P PLS D+INY+N TTW+AG IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 269 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 448
+ LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 449 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 628
DLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRP 196
Query: 629 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 808
CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVF 256
Query: 809 ADFPNYKS 832
+DF YKS
Sbjct: 257 SDFLTYKS 264
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 295 bits (756), Expect = 8e-80
Identities = 141/248 (56%), Positives = 172/248 (69%), Gaps = 1/248 (0%)
Frame = +2
Query: 92 PIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 268
P PLS DLINY+N TTW+AG IS ++K+ G V+ P KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGP---KLPGRVAFGE 76
Query: 269 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 448
+ LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAE
Sbjct: 77 DIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAE 136
Query: 449 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 628
DLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRP 196
Query: 629 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 808
CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVF 256
Query: 809 ADFPNYKS 832
+DF YKS
Sbjct: 257 SDFLTYKS 264
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 287 bits (735), Expect = 2e-77
Identities = 135/247 (54%), Positives = 171/247 (69%)
Frame = +2
Query: 92 PIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR 271
P PLS +L+NYVN TTW+AG +S ++++ G K P+R
Sbjct: 21 PSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFTED 77
Query: 272 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 451
++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SAED
Sbjct: 78 LKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAED 137
Query: 452 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 631
LLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P
Sbjct: 138 LLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 632 CTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 811
CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE AFSVY+
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYS 257
Query: 812 DFPNYKS 832
DF YKS
Sbjct: 258 DFLLYKS 264
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 279 bits (713), Expect = 8e-75
Identities = 132/249 (53%), Positives = 165/249 (66%), Gaps = 1/249 (0%)
Frame = +2
Query: 89 IPIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLN 268
IP + PLS DL+N++N + TT +AG +S ++K+ G K P+R
Sbjct: 20 IPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFAE 76
Query: 269 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 448
+ LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SAE
Sbjct: 77 DMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAE 136
Query: 449 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 628
DLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P
Sbjct: 137 DLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRP 196
Query: 629 NCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSV 805
CTGE TP+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE AF V
Sbjct: 197 PCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIV 256
Query: 806 YADFPNYKS 832
Y DF YKS
Sbjct: 257 YEDFLMYKS 265
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 273 bits (699), Expect = 3e-73
Identities = 129/248 (52%), Positives = 164/248 (66%), Gaps = 5/248 (2%)
Frame = +2
Query: 104 PLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 271
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 272 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 451
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 452 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 631
L++CC CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 632 C-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 808
C T + TP+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEAAF VY
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVY 266
Query: 809 ADFPNYKS 832
DF NYKS
Sbjct: 267 EDFLNYKS 274
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 256 bits (653), Expect = 7e-68
Identities = 122/248 (49%), Positives = 161/248 (64%), Gaps = 5/248 (2%)
Frame = +2
Query: 104 PLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 271
PLS D+I+Y+N W+A + RF S+ D R +G ++ + + KR+P ++
Sbjct: 28 PLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWN 86
Query: 272 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 451
V +P+ FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S G Q +SA D
Sbjct: 87 VEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVD 146
Query: 452 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 631
LLTCC CG GC GG AW YWV +G+VT H GC+ Y FPKC HH G YP
Sbjct: 147 LLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPP 205
Query: 632 CTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 808
C + + TP+CK+ CQ Y Y +DK GKSSY+V ++++AI +EI+ GPVEA+F+VY
Sbjct: 206 CGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVY 265
Query: 809 ADFPNYKS 832
DF NYKS
Sbjct: 266 EDFLNYKS 273
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 226 bits (575), Expect = 8e-59
Identities = 121/249 (48%), Positives = 158/249 (63%), Gaps = 12/249 (4%)
Frame = +2
Query: 116 DLINYVNYVAQTTWKAGPTTRFQSI-SDIRKVLGVMKDPNNFKLP-KRKPLLNRVR---- 277
DLI+YVN Q W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 278 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDL 454
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 455 LTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGP 622
L+CC CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P
Sbjct: 164 LSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDP 222
Query: 623 YPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAF 799
P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+GP+E AF
Sbjct: 223 CPH--DLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAF 280
Query: 800 SVYADFPNY 826
VY DF NY
Sbjct: 281 EVYEDFLNY 289
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 207 bits (526), Expect = 4e-53
Identities = 99/185 (53%), Positives = 122/185 (65%)
Frame = +2
Query: 278 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 457
+P TFD+R QW +CKSI IRDQ+ CGSCWAFGA E I+DR CI + G Q P IS +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 458 TCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCT 637
+CCG CG+GC GG+P A +W + G+VTGG+Y GC+ Y C+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 638 GEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADF 817
E TP C +CQ+GYS YA+DK +G S+Y+V N +I EI NGPVEAAFSVY DF
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256
Query: 818 PNYKS 832
YKS
Sbjct: 257 YKYKS 261
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 205 bits (521), Expect = 1e-52
Identities = 110/245 (44%), Positives = 141/245 (57%), Gaps = 9/245 (3%)
Frame = +2
Query: 119 LINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV---RLPTT 289
LI+YVN AQ W AG + K+ + D K + ++ +P
Sbjct: 32 LIDYVNS-AQKLWTAG-----HQVIPKEKITKKLMDVKYLVPHKDEDIVATEVSDAIPDH 85
Query: 290 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 469
FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL+CC
Sbjct: 86 FDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCT 145
Query: 470 --FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTG 640
F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C
Sbjct: 146 GMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPE 205
Query: 641 EF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 811
+ PTPKC +C + Y+ Y +DK +G ++Y+V + I EILTNGP+E AF+VY
Sbjct: 206 DTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYE 265
Query: 812 DFPNY 826
DF Y
Sbjct: 266 DFYQY 270
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,352,002
Number of Sequences: 369166
Number of extensions: 2204425
Number of successful extensions: 6771
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6260
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6605
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)