Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_J09
(856 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 97 7e-20
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 96 1e-19
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 96 1e-19
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 96 2e-19
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 95 2e-19
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 91 4e-18
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 90 7e-18
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 90 9e-18
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 90 9e-18
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 81 4e-15
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 96.7 bits (239), Expect = 7e-20
Identities = 61/206 (29%), Positives = 94/206 (45%), Gaps = 10/206 (4%)
Frame = +3
Query: 141 KKNFPFNISDNLKCIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLTEGCGDI--- 311
K+ F + D KC C +L + QT+CG R+C+ C+ + KC C +
Sbjct: 40 KEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA--CQESIVK 97
Query: 312 SRTISDNAVNREIGQLKVKCLFSA--CKYEGLLRDIGDHL-DSCVHQLVSC--PECNEEL 476
+ DN REI L++ C + C + L + HL + C + + C P+C E++
Sbjct: 98 DKVFKDNCCKREILALQIYCRNESRGCAEQLTLGHLLVHLKNDCHFEELPCVRPDCKEKV 157
Query: 477 PKNDLKDHLEKNCQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKK 656
+ DL+DH+EK C+ R C HC + L K + CP + CP+KC +
Sbjct: 158 LRKDLRDHVEKACKYREATCSHCKSQVPMIALQK-----HEDTDCPCVVVSCPHKCSVQT 212
Query: 657 IV--NLLNHRKECSKKPITCPFSVIG 728
++ L H EC P TC F G
Sbjct: 213 LLRSELSAHLSECVNAPSTCSFKRYG 238
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 95.9 bits (237), Expect = 1e-19
Identities = 62/194 (31%), Positives = 89/194 (45%), Gaps = 5/194 (2%)
Frame = +3
Query: 162 ISDNLKCIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLTEGCGDI---SRTISDN 332
+ +C IC L A+QT CG R+C+ C+ + + KC + +I ++ DN
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDN--EILLENQLFPDN 121
Query: 333 AVNREIGQLKVKCLFSACKYEGLLRDIGDHLDSCVHQLVSCPECNEELPKNDLKDHLEKN 512
REI L VKC C ++ LR + DH C L+ CP+C K + H+ K+
Sbjct: 122 FAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKD 181
Query: 513 CQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKKI-VNLLNHRK-E 686
C R V+C +C MA++ DK D CP C Y C+ I + NH +
Sbjct: 182 CPRRQVSCDNCAASMAFE--DKEIHDQN----CPLANVICEY-CNTILIREQMPNHYDLD 234
Query: 687 CSKKPITCPFSVIG 728
C PI C FS G
Sbjct: 235 CPTAPIPCTFSTFG 248
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 95.9 bits (237), Expect = 1e-19
Identities = 62/206 (30%), Positives = 92/206 (44%), Gaps = 10/206 (4%)
Frame = +3
Query: 141 KKNFPFNISDNLKCIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLTEGCGDI--- 311
K+ F + D KC C +L N QT+CG R+C+ C+ + KC C +
Sbjct: 39 KEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKC--TACQESIIK 96
Query: 312 SRTISDNAVNREIGQLKVKCLFS--ACKYEGLLRDIGDHL-DSCVHQLVSC--PECNEEL 476
+ DN REI L+V C C + L + HL + C + + C +C E++
Sbjct: 97 DKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKV 156
Query: 477 PKNDLKDHLEKNCQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKK 656
+ DL+DH+EK C+ R C HC + L K + CP + CP+KC +
Sbjct: 157 LRKDLRDHVEKACKYREATCSHCKSQVPMIKLQK-----HEDTDCPCVVVSCPHKCSVQT 211
Query: 657 IV--NLLNHRKECSKKPITCPFSVIG 728
++ L H EC P TC F G
Sbjct: 212 LLRSELSAHLSECVNAPSTCSFKRYG 237
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 95.5 bits (236), Expect = 2e-19
Identities = 61/194 (31%), Positives = 89/194 (45%), Gaps = 5/194 (2%)
Frame = +3
Query: 162 ISDNLKCIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLTEGCGDI---SRTISDN 332
+ +C IC L A+QT CG R+C+ C+ + + KC + +I ++ DN
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDN--EILLENQLFPDN 121
Query: 333 AVNREIGQLKVKCLFSACKYEGLLRDIGDHLDSCVHQLVSCPECNEELPKNDLKDHLEKN 512
REI L VKC C + LR + DH C LV+CP+C K + H+ ++
Sbjct: 122 FAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIED 181
Query: 513 CQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKKI-VNLLNHRK-E 686
C R V+C +C MAY+ + ++ CP C Y C I + NH +
Sbjct: 182 CPRRQVSCVNCAVSMAYEEKE------IHDQSCPLANIICEY-CGTILIREQMPNHYDLD 234
Query: 687 CSKKPITCPFSVIG 728
C PI C FSV G
Sbjct: 235 CPTAPIPCTFSVFG 248
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 95.1 bits (235), Expect = 2e-19
Identities = 55/196 (28%), Positives = 97/196 (49%), Gaps = 7/196 (3%)
Frame = +3
Query: 150 FPFNISDNLKCIICTQLLLNALQTD-CGCRYCQICLDEYMGQGKKKCLTEGCG-DISRTI 323
FP L C +C + + ++++ CG RYC CL E++ +G KC + D ++
Sbjct: 8 FPEKPKRRLLCPLCGKPMRDSVEVSTCGHRYCDNCLQEFLSEGVFKCPEDQLPLDYAKIY 67
Query: 324 SDNAVNREIGQLKVKCLFS--ACKYEGLLRDIGDHLDSCVHQLVSCP-ECNEELPKNDLK 494
D + ++ L ++C+ S C++ G LR + HL++C +V CP C +L + DL
Sbjct: 68 PDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCPAKLSRRDLP 127
Query: 495 DHLEKNCQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKKIVNLL- 671
HL+ +C R + C+ CG + + + +E +CP+ FC KC + + LL
Sbjct: 128 AHLQHDCPKRRLKCEFCGCDFSGEAYE------SHEGVCPQESVFCENKCGARMMRRLLA 181
Query: 672 -NHRKECSKKPITCPF 716
+ EC K+ C +
Sbjct: 182 QHATSECPKRTQPCAY 197
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 90.9 bits (224), Expect = 4e-18
Identities = 67/250 (26%), Positives = 107/250 (42%), Gaps = 13/250 (5%)
Frame = +3
Query: 54 NKFLGLSYLQDRKMASLNTDLPKNIKRYRKKNFPFNISDNLKCIICTQLLLNALQTDCGC 233
+K + +++ S++ D +I+ F + + KC C +L N QT CG
Sbjct: 7 HKGMPCGFIRQNSGNSISLDFEPSIEY----QFVERLEERYKCAFCHSVLHNPHQTGCGH 62
Query: 234 RYCQICLDEYMGQGKKKCLTEGCGDISRTI-------SDNAVNREIGQLKVKCLFS-ACK 389
R+CQ C+ ++ T + + + DN RE+ L V C + C
Sbjct: 63 RFCQHCI-----LSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCN 117
Query: 390 YEGLLRDIGDHLDSCVHQLVSC--PECNEELPKNDLKDHLEKNCQMRLVNCKHCGEIMAY 563
+ +L DHL C+ Q V C +C E + + DLK+HL +CQ R C +C + +
Sbjct: 118 AKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVV 177
Query: 564 QTLDKSHLDPKNENICPKLEGFCPYKCDNKKIV---NLLNHRKECSKKPITCPFSVIGL* 734
+L EN+CP+ FCP C KI+ + H C + CPF G
Sbjct: 178 -----INLQNHEENLCPEYPVFCPNNC--AKIILKTEVDEHLAVCPEAEQDCPFKHYGCA 230
Query: 735 QSDDERKSEQ 764
+D R +Q
Sbjct: 231 VTDKRRNLQQ 240
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 90.1 bits (222), Expect = 7e-18
Identities = 58/208 (27%), Positives = 82/208 (39%), Gaps = 13/208 (6%)
Frame = +3
Query: 180 CIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLT--------EGCG--DISRTISD 329
C C +L Q CG RYC CL + G + C EG + S D
Sbjct: 34 CSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPD 93
Query: 330 NAVNREIGQLKVKCLFSACKYEGLLRDIGD-HLDSCVHQLVSCPECNEELPKNDLKDHLE 506
NA RE+ L C C ++G L++ H C L CP C + + + HLE
Sbjct: 94 NAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLE 153
Query: 507 KNCQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKKI--VNLLNHR 680
C R ++C+HC + H +CPK C C KKI +H
Sbjct: 154 HECPERSLSCRHCRAPCCGADVKAHH------EVCPKFPLTCD-GCGKKKIpreKFQDHV 206
Query: 681 KECSKKPITCPFSVIGL*QSDDERKSEQ 764
K C K + C F IG ++ + K ++
Sbjct: 207 KTCGKCRVPCRFHAIGCLETVEGEKQQE 234
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 89.7 bits (221), Expect = 9e-18
Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 7/188 (3%)
Frame = +3
Query: 174 LKCIICTQLLLNALQTD-CGCRYCQICLDEYMGQGKKKCLTEGCG-DISRTISDNAVNRE 347
L C +C + + +Q CG R+C CL E++ +G KC + D ++ D + +
Sbjct: 16 LLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQ 75
Query: 348 IGQLKVKCLFS--ACKYEGLLRDIGDHLDSCVHQLVSCP-ECNEELPKNDLKDHLEKNCQ 518
+ L ++C+ S C++ G LR + HL++C ++ CP C +L + DL HL+ +C
Sbjct: 76 VLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCP 135
Query: 519 MRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKKIVNLL--NHRKECS 692
R + C+ CG + + + +E +CP+ +C KC + + LL + EC
Sbjct: 136 KRRLKCEFCGCDFSGEAYE------SHEGMCPQESVYCENKCGARMMRRLLAQHATSECP 189
Query: 693 KKPITCPF 716
K+ C +
Sbjct: 190 KRTQPCTY 197
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 89.7 bits (221), Expect = 9e-18
Identities = 55/196 (28%), Positives = 81/196 (41%), Gaps = 13/196 (6%)
Frame = +3
Query: 180 CIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLT--------EGCG--DISRTISD 329
C C +L Q CG RYC CL + G + C EG + S D
Sbjct: 34 CSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPD 93
Query: 330 NAVNREIGQLKVKCLFSACKYEGLLRDIGD-HLDSCVHQLVSCPECNEELPKNDLKDHLE 506
NA RE+ L C C ++G L++ H C L CP C + ++ + H E
Sbjct: 94 NAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTE 153
Query: 507 KNCQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKCDNKKI--VNLLNHR 680
+ C R ++C+HC ++ L+ + +CPK C C KKI +H
Sbjct: 154 QECPKRSLSCQHCRAPCSHVDLEVHY------EVCPKFPLTCD-GCGKKKIpreTFQDHV 206
Query: 681 KECSKKPITCPFSVIG 728
+ CSK + C F +G
Sbjct: 207 RACSKCRVLCRFHTVG 222
Score = 32.0 bits (71), Expect = 2.2
Identities = 16/58 (27%), Positives = 29/58 (50%)
Frame = +1
Query: 679 VRNALRNQSLVRFR*LGCNKVMTKENLNSHNNEESFQHSSLLMKEITTMKSDISELKQ 852
VR + + L RF +GC++++ ENL H + +H +LL+ ++ L Q
Sbjct: 206 VRACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQ 263
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 80.9 bits (198), Expect = 4e-15
Identities = 56/199 (28%), Positives = 77/199 (38%), Gaps = 6/199 (3%)
Frame = +3
Query: 150 FPFNISDNLKCIICTQLLLNALQTDCGCRYCQICLDEYMGQGKKKCLTEGCGDI--SRTI 323
F + + KC C +L N QT CG R+CQ C+ I
Sbjct: 35 FVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVF 94
Query: 324 SDNAVNREIGQLKVKCLFS-ACKYEGLLRDIGDHLDSCVHQLVSCP--ECNEELPKNDLK 494
DN RE+ L V C + C +L DHL C Q V CP C E + + D+K
Sbjct: 95 KDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCPNESCREAMLRKDVK 154
Query: 495 DHLEKNCQMRLVNCKHCGEIMAYQTLDKSHLDPKNENICPKLEGFCPYKC-DNKKIVNLL 671
+HL C+ R C +C + + ++L EN CP CP +C +
Sbjct: 155 EHLSAYCRFREEKCLYC-----KRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIPRARVN 209
Query: 672 NHRKECSKKPITCPFSVIG 728
H C + CPF G
Sbjct: 210 EHLTVCPEAEQDCPFKHYG 228
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,559,680
Number of Sequences: 369166
Number of extensions: 2192281
Number of successful extensions: 6201
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5708
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6132
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)