Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_I07
(627 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 194 2e-49
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 192 6e-49
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 188 1e-47
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 186 4e-47
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 185 9e-47
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 184 1e-46
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 177 2e-44
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 176 3e-44
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 174 2e-43
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 173 3e-43
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 194 bits (493), Expect = 2e-49
Identities = 100/207 (48%), Positives = 127/207 (61%), Gaps = 1/207 (0%)
Frame = +3
Query: 3 FGTRVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHN 182
F T + + I + KF + LN +W +K T R Y + RR +WE+N+K I+ HN
Sbjct: 6 FLTALCLGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHN 63
Query: 183 LEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWR 362
EY GKH +++ +N F DMTNEEF+ G K +G + P +P SVDWR
Sbjct: 64 REYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWR 121
Query: 363 QKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX 542
+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 122 EKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGG 181
Query: 543 LMDNAFRYIKDQ-GIESEGDYPYTATD 620
LMDNAFRY+KD G++SE YPY D
Sbjct: 182 LMDNAFRYVKDNGGLDSEESYPYLGRD 208
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 192 bits (488), Expect = 6e-49
Identities = 91/182 (50%), Positives = 118/182 (64%)
Frame = +3
Query: 78 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 257
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 258 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 437
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 438 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQGIESEGDYPYTAT 617
+EGQY + ISFSEQQLVDCS LM+NA++Y+K G+E+E YPYTA
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAV 200
Query: 618 DG 623
+G
Sbjct: 201 EG 202
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 188 bits (477), Expect = 1e-47
Identities = 100/207 (48%), Positives = 124/207 (59%), Gaps = 1/207 (0%)
Frame = +3
Query: 3 FGTRVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHN 182
F T + + + + K N L+ W +K T R Y + RR +WE+N K I HN
Sbjct: 6 FLTVLCLGVASAAPKLDPN--LDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHN 63
Query: 183 LEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWR 362
EY GKH + + +N F DMTNEEF+ G K +G + P + V P SVDW
Sbjct: 64 QEYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWT 121
Query: 363 QKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX 542
+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 122 KKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGG 181
Query: 543 LMDNAFRYIKDQ-GIESEGDYPYTATD 620
LMDNAF+YIKD G++SE YPY ATD
Sbjct: 182 LMDNAFQYIKDNGGLDSEESYPYLATD 208
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 186 bits (472), Expect = 4e-47
Identities = 96/198 (48%), Positives = 128/198 (64%), Gaps = 1/198 (0%)
Frame = +3
Query: 30 TAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHT 209
+AVP KF N L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH
Sbjct: 16 SAVP-KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHG 72
Query: 210 YSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVK 389
+++ +N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVK
Sbjct: 73 FTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVK 130
Query: 390 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 569
NQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+
Sbjct: 131 NQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYV 190
Query: 570 KDQ-GIESEGDYPYTATD 620
K+ G++SE YPY A D
Sbjct: 191 KENGGLDSEESYPYVAVD 208
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 185 bits (469), Expect = 9e-47
Identities = 97/203 (47%), Positives = 125/203 (61%), Gaps = 1/203 (0%)
Frame = +3
Query: 3 FGTRVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHN 182
F T + + I + K N L+ +W +K T GR Y + RR +WE+N+K I+ HN
Sbjct: 6 FLTALCLGIASAAPKLDQN--LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHN 63
Query: 183 LEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWR 362
EY GKH +S+ +N F DMTNEEF+ G K +G + + V P SVDWR
Sbjct: 64 QEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWR 121
Query: 363 QKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX 542
+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 122 EKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGG 181
Query: 543 LMDNAFRYIKDQ-GIESEGDYPY 608
LMDNAF+Y+KD G+++E YPY
Sbjct: 182 LMDNAFQYVKDNGGLDTEESYPY 204
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 184 bits (468), Expect = 1e-46
Identities = 93/186 (50%), Positives = 118/186 (63%), Gaps = 1/186 (0%)
Frame = +3
Query: 66 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 245
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 246 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 425
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 426 ATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDY 602
ATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G++SE Y
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESY 202
Query: 603 PYTATD 620
PY AT+
Sbjct: 203 PYEATE 208
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 177 bits (449), Expect = 2e-44
Identities = 93/185 (50%), Positives = 117/185 (63%), Gaps = 1/185 (0%)
Frame = +3
Query: 75 EWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEE 254
EW +K+T R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEE
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 255 FKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATG 434
F+ G K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G
Sbjct: 88 FRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASG 145
Query: 435 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYT 611
LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY
Sbjct: 146 CLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYE 205
Query: 612 ATDGT 626
A DG+
Sbjct: 206 AKDGS 210
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 176 bits (447), Expect = 3e-44
Identities = 91/187 (48%), Positives = 118/187 (63%), Gaps = 1/187 (0%)
Frame = +3
Query: 69 NEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTN 248
N +W +K+T R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTN
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 249 EEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSA 428
EEF+ G K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA
Sbjct: 86 EEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSA 143
Query: 429 TGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYP 605
+G LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YP
Sbjct: 144 SGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYP 203
Query: 606 YTATDGT 626
Y A DG+
Sbjct: 204 YEAKDGS 210
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 174 bits (440), Expect = 2e-43
Identities = 94/210 (44%), Positives = 129/210 (61%), Gaps = 4/210 (1%)
Frame = +3
Query: 3 FGTRVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKH 179
+G +VV+ + + L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I H
Sbjct: 2 WGLKVVLLLPVMSSALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIH 61
Query: 180 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASV 353
NLE LG HTY L +N DMT+EE K G+ K P+ S T P+ G P S+
Sbjct: 62 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGL-KVPPSHSRSNDTLYIPDWEGRTPDSI 120
Query: 354 DWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXX 533
D+R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 121 DYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENDGC 178
Query: 534 XXXLMDNAFRYI-KDQGIESEGDYPYTATD 620
M NAF+Y+ K++GI+SE YPY D
Sbjct: 179 GGGYMTNAFQYVQKNRGIDSEDAYPYVGQD 208
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 173 bits (439), Expect = 3e-43
Identities = 96/210 (45%), Positives = 128/210 (60%), Gaps = 9/210 (4%)
Frame = +3
Query: 18 VVAITAVPQKFSVNSELNEEWETYKTTFGRKY-DELTDITRRLIWEQNLKYIQKHNLEYD 194
++A+ A+ Q S + EEW TYK + Y +E+ + R I+ +N I KHN +
Sbjct: 8 LLALVALTQAISPLDLIKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFA 67
Query: 195 LGKHTYSLGLNQFADMTNEEFKAKYLG-------IMKTKPTLEGSTYMAPENIGVLPASV 353
GK +Y LGLN++ADM + EFK G +M+ + L G+TY+ P ++ V P SV
Sbjct: 68 QGKVSYKLGLNKYADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHVTV-PKSV 126
Query: 354 DWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXX 533
DWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 127 DWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGC 186
Query: 534 XXXLMDNAFRYIKDQ-GIESEGDYPYTATD 620
LMDNAFRYIKD GI++E YPY D
Sbjct: 187 NGGLMDNAFRYIKDNGGIDTEKSYPYEGID 216
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,891,046
Number of Sequences: 369166
Number of extensions: 1256451
Number of successful extensions: 3658
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3331
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3435
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4974853140
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)