Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_H11
(889 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NYB9|ABI2_HUMAN Abl-interactor 2 (Abelson interactor 2... 95 3e-19
sp|P62484|ABI2_MOUSE Abl-interactor 2 (Abelson interactor 2... 94 4e-19
sp|Q8IZP0|ABI1_HUMAN Abl-interactor 1 (Abelson interactor 1... 89 1e-17
sp|Q8CBW3|ABI1_MOUSE Abl-interactor 1 (Abelson interactor 1... 87 5e-17
sp|Q9QZM5|ABI1_RAT Abl-interactor 1 (Abelson interactor 1) ... 87 5e-17
sp|Q9P2A4|ABI3_HUMAN ABI gene family member 3 (New molecule... 76 1e-13
sp|Q8BYZ1|ABI3_MOUSE ABI gene family member 3 (New molecule... 68 3e-11
sp|Q9NZM3|ITSN2_HUMAN Intersectin-2 (SH3 domain-containing ... 65 3e-10
sp|Q9Z0R6|ITSN2_MOUSE Intersectin-2 (SH3 domain-containing ... 64 4e-10
sp|Q15811|ITSN1_HUMAN Intersectin 1 (SH3 domain-containing ... 58 4e-08
>sp|Q9NYB9|ABI2_HUMAN Abl-interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding
protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Length = 513
Score = 94.7 bits (234), Expect = 3e-19
Identities = 52/116 (44%), Positives = 67/116 (57%)
Frame = +2
Query: 452 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQY 631
PPPP VE+ P +E Y + + PY ++ D WAP Y
Sbjct: 403 PPPPPVEE---PVFDESPPPPPPPEDYEEEEAAVVEYSD-PY------AEEDPPWAPRSY 452
Query: 632 ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENL 799
+ KVV +Y Y ++KEDELSF E +IYV +KNDDG +EGVMNG GLFPGNYVE++
Sbjct: 453 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESI 508
>sp|P62484|ABI2_MOUSE Abl-interactor 2 (Abelson interactor 2) (Abi-2)
Length = 446
Score = 94.4 bits (233), Expect = 4e-19
Identities = 52/116 (44%), Positives = 67/116 (57%)
Frame = +2
Query: 452 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQY 631
PPPP VE+ P +E Y + + PY ++ D WAP Y
Sbjct: 336 PPPPPVEE---PVFDESPPPPPPPEDYEEEEAAVVEYSD-PY------AEEDPPWAPRAY 385
Query: 632 ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENL 799
+ KVV +Y Y ++KEDELSF E +IYV +KNDDG +EGVMNG GLFPGNYVE++
Sbjct: 386 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESI 441
>sp|Q8IZP0|ABI1_HUMAN Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3
domain-binding protein 1) (Eps8 SH3 domain-binding
protein) (Eps8-binding protein) (e3B1) (Nap1-binding
protein) (Nap1BP) (Abl-binding protein 4) (AblBP4)
Length = 508
Score = 89.4 bits (220), Expect = 1e-17
Identities = 49/117 (41%), Positives = 65/117 (55%), Gaps = 1/117 (0%)
Frame = +2
Query: 452 PPPPNVEQFQ-RPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQ 628
PPP ++ F PP +D Y + + PY + D WAP
Sbjct: 399 PPPDDIPMFDDSPPPPPPPPVD-----YEDEEAAVVQYND-PY------ADGDPAWAPKN 446
Query: 629 YICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENL 799
YI KVV +Y Y ++K+DELSF+E +IYV +KNDDG +EGV N GLFPGNYVE++
Sbjct: 447 YIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 503
>sp|Q8CBW3|ABI1_MOUSE Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3
domain-binding protein 1) (Eps8 SH3 domain-binding
protein) (Eps8-binding protein) (e3B1) (Ablphilin-1)
Length = 481
Score = 87.4 bits (215), Expect = 5e-17
Identities = 48/119 (40%), Positives = 65/119 (54%), Gaps = 3/119 (2%)
Frame = +2
Query: 452 PPPPNVEQFQR---PPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAP 622
PPP ++ F PP ++ + + + S PY + D WAP
Sbjct: 372 PPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYS--------DPY------ADGDPAWAP 417
Query: 623 SQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENL 799
YI KVV +Y Y ++K+DELSF E +IYV +KNDDG +EGV N GLFPGNYVE++
Sbjct: 418 KNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESI 476
>sp|Q9QZM5|ABI1_RAT Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain
binding protein) (Eps8 binding protein) (e3B1)
Length = 476
Score = 87.4 bits (215), Expect = 5e-17
Identities = 48/119 (40%), Positives = 65/119 (54%), Gaps = 3/119 (2%)
Frame = +2
Query: 452 PPPPNVEQFQR---PPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAP 622
PPP ++ F PP ++ + + + S PY + D WAP
Sbjct: 367 PPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYS--------DPY------ADGDPAWAP 412
Query: 623 SQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENL 799
YI KVV +Y Y ++K+DELSF E +IYV +KNDDG +EGV N GLFPGNYVE++
Sbjct: 413 KNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESI 471
>sp|Q9P2A4|ABI3_HUMAN ABI gene family member 3 (New molecule including SH3) (Nesh)
Length = 366
Score = 75.9 bits (185), Expect = 1e-13
Identities = 45/120 (37%), Positives = 63/120 (52%), Gaps = 6/120 (5%)
Frame = +2
Query: 452 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIK------SQSDEV 613
PPP VE FQRPP+ E+++ + + + + P D L + +
Sbjct: 245 PPPAAVEVFQRPPTLEELS-PPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPS 303
Query: 614 WAPSQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVE 793
W P+ Y+ KVVTLY Y K++ELSF E +I V ++ DG EGV + G FPGNYVE
Sbjct: 304 WVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVE 363
>sp|Q8BYZ1|ABI3_MOUSE ABI gene family member 3 (New molecule including SH3) (Nesh)
Length = 367
Score = 68.2 bits (165), Expect = 3e-11
Identities = 41/115 (35%), Positives = 59/115 (51%)
Frame = +2
Query: 449 LPPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQ 628
LPPPP + +PP ++ + D +G+ P + + W P+
Sbjct: 259 LPPPPL--EVSQPPLEAELPLPPPP-ALEGDELGLLPPPPPGF------GPDEPSWVPAS 309
Query: 629 YICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVE 793
Y+ KVVTLY Y + K++ELSF E +I V ++ DG EGV + G FPGNYVE
Sbjct: 310 YLEKVVTLYPYTRQKDNELSFSEGTVICVIRRYSDGWCEGVSSEGTGFFPGNYVE 364
>sp|Q9NZM3|ITSN2_HUMAN Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18)
(SH3P18-like WASP associated protein)
Length = 1696
Score = 65.1 bits (157), Expect = 3e-10
Identities = 31/75 (41%), Positives = 46/75 (61%), Gaps = 1/75 (1%)
Frame = +2
Query: 572 PYDVLRIKSQSDEVWAPSQY-ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEG 748
P +++ S E P+ + +C+V+ +Y Y N EDELSF + +LI V K+D W+G
Sbjct: 1107 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1166
Query: 749 VMNGKAGLFPGNYVE 793
+NG GLFP NYV+
Sbjct: 1167 EINGVTGLFPSNYVK 1181
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/53 (37%), Positives = 31/53 (58%)
Frame = +2
Query: 644 VTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENLD 802
+ LY Y + +L+F E E I V QK+ + W G + ++G+FP NYV+ D
Sbjct: 986 IALYPYSSVEPGDLTFTEGEEILVTQKDGEW-WTGSIGDRSGIFPSNYVKPKD 1037
Score = 32.0 bits (71), Expect = 2.4
Identities = 15/52 (28%), Positives = 28/52 (53%), Gaps = 5/52 (9%)
Frame = +2
Query: 659 YLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKA-----GLFPGNYVENL 799
Y+ + ++LS +LI + +KN G W+G + + G FP ++V+ L
Sbjct: 1063 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1114
Score = 31.2 bits (69), Expect = 4.0
Identities = 15/52 (28%), Positives = 31/52 (59%)
Frame = +2
Query: 638 KVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVE 793
K L + K++ L+F ++++I V ++ ++ W G ++G G FP +YV+
Sbjct: 901 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENW-WFGEVHGGRGWFPKSYVK 951
>sp|Q9Z0R6|ITSN2_MOUSE Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains
protein 2) (EH domain and SH3 domain regulator of
endocytosis 2)
Length = 1658
Score = 64.3 bits (155), Expect = 4e-10
Identities = 30/75 (40%), Positives = 46/75 (61%), Gaps = 1/75 (1%)
Frame = +2
Query: 572 PYDVLRIKSQSDEVWAPSQY-ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEG 748
P +++ S E P+ + +C+V+ +Y Y+ N EDEL+F + +LI V K+D W+G
Sbjct: 1068 PASHVKLLGPSSERTMPTFHAVCQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQG 1127
Query: 749 VMNGKAGLFPGNYVE 793
NG GLFP NYV+
Sbjct: 1128 ETNGLTGLFPSNYVK 1142
Score = 40.4 bits (93), Expect = 0.007
Identities = 20/53 (37%), Positives = 29/53 (54%)
Frame = +2
Query: 644 VTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENLD 802
+ LY Y + +L+F E E I V QK+ + W G + + G+FP NYV D
Sbjct: 947 IALYSYSSVEPGDLTFTEGEEILVTQKDGEW-WTGSIGERTGIFPSNYVRPKD 998
Score = 32.0 bits (71), Expect = 2.4
Identities = 16/52 (30%), Positives = 31/52 (59%)
Frame = +2
Query: 638 KVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVE 793
K L + KE+ L+F ++++I V ++ ++ W G ++G G FP +YV+
Sbjct: 855 KAQALCSWTAKKENHLNFSKHDVITVLEQQENW-WFGEVHGGRGWFPKSYVK 905
Score = 30.8 bits (68), Expect = 5.3
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Frame = +2
Query: 659 YLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKA-----GLFPGNYVENL 799
Y + ++LS +LI + +KN G W+G + + G FP ++V+ L
Sbjct: 1024 YAASGTEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1075
>sp|Q15811|ITSN1_HUMAN Intersectin 1 (SH3 domain-containing protein 1A) (SH3P17)
Length = 1721
Score = 57.8 bits (138), Expect = 4e-08
Identities = 23/54 (42%), Positives = 36/54 (66%)
Frame = +2
Query: 632 ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVE 793
+C+V+ +Y Y +DEL+F + ++I V K D W+G +NG+ GLFP NYV+
Sbjct: 1157 VCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 43.5 bits (101), Expect = 8e-04
Identities = 19/53 (35%), Positives = 33/53 (62%)
Frame = +2
Query: 644 VTLYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVENLD 802
+ +Y Y +++ +L+F + ++I V +K+ D W G + KAG+FP NYV D
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKDGDW-WTGTVGDKAGVFPSNYVRLKD 1059
Score = 35.4 bits (80), Expect = 0.21
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Frame = +2
Query: 659 YLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKA-----GLFPGNYVENL 799
Y ++L+ +LI +++KN G WEG + + G FP NYV+ L
Sbjct: 1085 YTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 34.7 bits (78), Expect = 0.37
Identities = 17/48 (35%), Positives = 30/48 (62%)
Frame = +2
Query: 650 LYKYLQNKEDELSFLENELIYVKQKNDDGRWEGVMNGKAGLFPGNYVE 793
LY + K++ L+F +N++I V ++ D W G + G+ G FP +YV+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDMW-WFGEVQGQKGWFPKSYVK 967
Score = 33.9 bits (76), Expect = 0.62
Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 7/57 (12%)
Frame = +2
Query: 650 LYKYLQNKEDELSFLENELIYVK-------QKNDDGRWEGVMNGKAGLFPGNYVENL 799
LY + DE++ +++ VK Q + G G + GK G FP NY E +
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,110,588
Number of Sequences: 369166
Number of extensions: 1587441
Number of successful extensions: 4815
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4468
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4754
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8886314050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)