Planarian EST Database


Dr_sW_021_H07

BLASTX 2.2.12 [Aug-07-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Dr_sW_021_H07
         (831 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|P38657|PDIA3_BOVIN  Protein disulfide-isomerase A3 precur...   295   1e-79
sp|P30101|PDIA3_HUMAN  Protein disulfide-isomerase A3 precur...   291   2e-78
sp|P27773|PDIA3_MOUSE  Protein disulfide-isomerase A3 precur...   285   1e-76
sp|P11598|PDIA3_RAT  Protein disulfide-isomerase A3 precurso...   281   2e-75
sp|P38658|ERP60_SCHMA  Probable protein disulfide-isomerase ...   236   4e-62
sp|P38659|PDIA4_RAT  Protein disulfide-isomerase A4 precurso...   205   1e-52
sp|P08003|PDIA4_MOUSE  Protein disulfide-isomerase A4 precur...   204   2e-52
sp|P13667|PDIA4_HUMAN  Protein disulfide-isomerase A4 precur...   203   5e-52
sp|P34329|PDIA4_CAEEL  Probable protein disulfide-isomerase ...   182   1e-45
sp|P55059|PDI_HUMIN  Protein disulfide-isomerase precursor (...   163   5e-40
>sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
           ER-60) (ERP60) (58 kDa microsomal protein) (P58) (ERp57)
          Length = 505

 Score =  295 bits (754), Expect = 1e-79
 Identities = 138/239 (57%), Positives = 176/239 (73%), Gaps = 2/239 (0%)
 Frame = +2

Query: 11  TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
           T  N      K LL+A Y VDYEKN KG+NYWRNR+M VAKKF+D+G+ +HFA+++ +  
Sbjct: 248 TEDNKDLLQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGQKLHFAVASRKTF 307

Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
           SHELS+FG+ES       +  R  K +KF M E+F+ +  A E+F+ D+ +  +  YLKS
Sbjct: 308 SHELSDFGLESTTGEIPVVAVRTAKGEKFVMQEEFSRDGKALERFLEDYFDGNLKRYLKS 367

Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
           E IPE ND PVKVVVA+NFD +VN+  KDVLIEFYAPWCGHCK+L PKY+EL +KL  + 
Sbjct: 368 EPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLRKDP 427

Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
           +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D + Y+  E+T+
Sbjct: 428 NIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKQNPKKYEGGRELSDFISYLKREATN 486

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
 Frame = +2

Query: 416 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 586
           NF++ + D      +L+EF+APWCGHCK LAP+YE  A +L G   + +AK+D TAN + 
Sbjct: 34  NFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91

Query: 587 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
            + Y V+G+PT+       ++   +Y+G R  D ++ ++  ++
Sbjct: 92  CNKYGVSGYPTLKIFRDGEESG--AYDGPRTADGIVSHLKKQA 132
>sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
           ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
           (58 kDa glucose regulated protein)
          Length = 505

 Score =  291 bits (745), Expect = 2e-78
 Identities = 138/239 (57%), Positives = 176/239 (73%), Gaps = 2/239 (0%)
 Frame = +2

Query: 11  TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
           T  N      K LL+A Y VDYEKN KG+NYWRNR+M VAKKF+D+G  ++FA+++ +  
Sbjct: 248 TEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTF 307

Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
           SHELS+FG+ES       +  R  K +KF M E+F+ +  A E+F+ D+ +  +  YLKS
Sbjct: 308 SHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKS 367

Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
           E IPE ND PVKVVVA+NFD +VN+  KDVLIEFYAPWCGHCK+L PKY+EL +KLS + 
Sbjct: 368 EPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDP 427

Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
           +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D + Y+  E+T+
Sbjct: 428 NIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATN 486

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
 Frame = +2

Query: 416 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 586
           NF++ ++D      +L+EF+APWCGHCK LAP+YE  A +L G   + +AK+D TAN + 
Sbjct: 34  NFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91

Query: 587 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
            + Y V+G+PT+       +    +Y+G R  D ++ ++  ++
Sbjct: 92  CNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIVSHLKKQA 132
>sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precursor (Disulfide isomerase
           ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
          Length = 504

 Score =  285 bits (729), Expect = 1e-76
 Identities = 135/239 (56%), Positives = 175/239 (73%), Gaps = 2/239 (0%)
 Frame = +2

Query: 11  TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
           T  N      K LL A Y VDYEKN KG+NYWRNR+M VAKKF+D+G  ++FA+++ +  
Sbjct: 247 TEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTF 306

Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
           SHELS+F +ES       +  R  K +KF M E+F+ +  A E+F+ ++ +  +  YLKS
Sbjct: 307 SHELSDFSLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKS 366

Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
           E IPE N+ PVKVVVA+NFD +VN+  KDVLIEFYAPWCGHCK+L PKY+EL +KLS + 
Sbjct: 367 EPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDP 426

Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
           +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE++D + Y+  E+T+
Sbjct: 427 NIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATN 485

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 37/104 (35%), Positives = 63/104 (60%), Gaps = 3/104 (2%)
 Frame = +2

Query: 413 KNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-D 583
           +NF++ V+D      +L+EF+APWCGHCK LAP+YE  A +L     + +AK+D TAN +
Sbjct: 33  ENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL---KIVPLAKVDCTANTN 89

Query: 584 VPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
             + Y V+G+PT+      +     +Y+G R  D ++ ++  ++
Sbjct: 90  TCNKYGVSGYPTLKIF--RAGEEAGAYDGPRTADGIVSHLKKQA 131
>sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precursor (Disulfide isomerase
           ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
           (HIP-70) (Q-2)
          Length = 505

 Score =  281 bits (719), Expect = 2e-75
 Identities = 134/239 (56%), Positives = 174/239 (72%), Gaps = 2/239 (0%)
 Frame = +2

Query: 11  TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
           T  N      K LL A Y VDYEKN KG+NYWRNR+M VAK F+D+G  ++FA+++ +  
Sbjct: 248 TEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTF 307

Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
           SHELS+FG+ES       +  R  K +KF M E+F+ +  A E+F+ ++ +  +  YLKS
Sbjct: 308 SHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKS 367

Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
           E IPE N+ PVKVVVA++FD +VN   KDVLIEFYAPWCGHCK+L PKY+EL +KLS + 
Sbjct: 368 EPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDP 427

Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
           +IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE++D + Y+  E+T+
Sbjct: 428 NIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATN 486

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 3/127 (2%)
 Frame = +2

Query: 344 VPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEE 517
           V + L S  +   +D  V  +  +NF++ V+D      +L+EF+APWCGHCK LAP+YE 
Sbjct: 12  VALLLASALLASASD--VLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69

Query: 518 LAKKLSGESDIVIAKMDATAN-DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDML 694
            A +L G   + +AK+D TAN +  + Y V+G+PT+       +    +Y+G R  D ++
Sbjct: 70  AATRLKG--IVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIV 125

Query: 695 KYIASES 715
            ++  ++
Sbjct: 126 SHLKKQA 132
>sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ER-60 precursor (ERP60)
          Length = 484

 Score =  236 bits (603), Expect = 4e-62
 Identities = 117/256 (45%), Positives = 170/256 (66%)
 Frame = +2

Query: 2   GLRTSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNS 181
           G R+ SN  YF +  L+V   +   +  P G  Y RNR++K  K      K++ FA S +
Sbjct: 233 GYRSPSNTFYFENSDLVVLYNNQSIDSYPSGVKYLRNRVLKTLKDNPQKFKNLVFAYSFA 292

Query: 182 QEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTMEAFEKFINDFLNEQVPVYLK 361
            + S+E+S++GIE+   +K+  V    K++K+K+ E F+++AF  F+N F +  +  ++K
Sbjct: 293 DDFSYEISDYGIEA---DKLPAVVIQSKDKKYKL-EKFSLDAFSDFLNKFEDGLLTPHVK 348

Query: 362 SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
           SE +P  +   VK +VA NFD +VN+  KDV++ F+A WCGHCK+L PKYEE A K+  E
Sbjct: 349 SEPLPTDDSSAVKKLVALNFDEIVNNEEKDVMVVFHAGWCGHCKNLMPKYEEAASKVKNE 408

Query: 542 SDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
            ++V+A MDATANDVPSPY+V GFPTIYF PK  K+SP SY GGR+ +D++KY+A E+T 
Sbjct: 409 PNLVLAAMDATANDVPSPYQVRGFPTIYFVPKGKKSSPVSYEGGRDTNDIIKYLAREATE 468

Query: 722 SLKSYDRQGRVRKSDL 769
            L  YDR G  +KS+L
Sbjct: 469 ELIGYDRSGNPKKSEL 484

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 32/89 (35%), Positives = 54/89 (60%), Gaps = 2/89 (2%)
 Frame = +2

Query: 455 LIEFYAPWCGHCKSLAPKYEELAKKLSGE-SDIVIAKMDATAND-VPSPYEVTGFPTIYF 628
           L++FYAPWCGHCK LAP++   A+ +SG+ +D+ + K+D T  + + S + V+G+PT+  
Sbjct: 38  LVKFYAPWCGHCKKLAPEFTSAAQIISGKTNDVKLVKVDCTTQESICSEFGVSGYPTLKI 97

Query: 629 APKNSKNSPKSYNGGREVDDMLKYIASES 715
                 +    YNG R  + +  Y+ S +
Sbjct: 98  FRNGDLDG--EYNGPRNANGIANYMISRA 124
>sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
            (Calcium-binding protein 2) (CaBP2)
          Length = 643

 Score =  205 bits (522), Expect = 1e-52
 Identities = 106/241 (43%), Positives = 156/241 (64%), Gaps = 4/241 (1%)
 Frame = +2

Query: 8    RTSSNMKYFSSKPLLVALYSVDYEKNPK-GTNYWRNRIMKVAKKFVDSGKSVHFAISNSQ 184
            +TS++ K +S +PL+V  YSVD+  + +  T +WRN++++VAK F +      FAI++ +
Sbjct: 399  KTSNDAKRYSKRPLVVVYYSVDFSFDYRTATQFWRNKVLEVAKDFPE----YTFAIADEE 454

Query: 185  EQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLK 361
            + + E+ + G+ S     V     DE  +KF M  E+F  +A ++F+  F   ++   +K
Sbjct: 455  DYATEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDALQEFVMAFKKGKLKPVIK 513

Query: 362  SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
            S+ +P+ N  PV+VVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y  L KK  G+
Sbjct: 514  SQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSLGKKYKGQ 573

Query: 542  SDIVIAKMDATANDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASES 715
             D+VIAKMDATAND+ +  Y+V GFPTIYFAP   K +P  + GG R+++ + K+I   +
Sbjct: 574  KDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHA 633

Query: 716  T 718
            T
Sbjct: 634  T 634

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 48/111 (43%), Positives = 69/111 (62%), Gaps = 2/111 (1%)
 Frame = +2

Query: 389 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 565
           E    +  +NFD +VN+    +L+EFYAPWCGHCK LAP+YE+ AK+LS  S  I +AK+
Sbjct: 175 EVTLTLTKENFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 233

Query: 566 DAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
           DAT   D+   ++V+G+PT+       K  P  YNG RE   ++ Y+  +S
Sbjct: 234 DATEQTDLAKRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMVEQS 281

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 47/115 (40%), Positives = 69/115 (60%), Gaps = 3/115 (2%)
 Frame = +2

Query: 380 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 553
           K +  V V+  +NFD  V D  KD VL+EFYAPWCGHCK  AP+YE++A  L   +  I 
Sbjct: 57  KEENGVWVLNDENFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 114

Query: 554 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
           +AK+DAT A+ + S ++V+G+PTI       K     Y+G R  ++++  +   S
Sbjct: 115 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 166
>sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
          Length = 638

 Score =  204 bits (520), Expect = 2e-52
 Identities = 106/241 (43%), Positives = 154/241 (63%), Gaps = 4/241 (1%)
 Frame = +2

Query: 8    RTSSNMKYFSSKPLLVALYSVDYEKNPKG-TNYWRNRIMKVAKKFVDSGKSVHFAISNSQ 184
            +TS++ K +S +PL+V  YSVD+  + +  T +WRN++++VAK F +      FAI++ +
Sbjct: 394  KTSNDAKRYSKRPLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDFPE----YTFAIADEE 449

Query: 185  EQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLK 361
            + + E+ + G+ S     V     DE  +KF M  E+F  +   +F+  F   ++   +K
Sbjct: 450  DYATEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIK 508

Query: 362  SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
            S+ +P+ N  PVKVVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y  L KK  G+
Sbjct: 509  SQPVPKNNKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQ 568

Query: 542  SDIVIAKMDATANDVPS-PYEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASES 715
             D+VIAKMDATAND+ +  Y+V GFPTIYFAP   K +P  + GG R+++ + K+I   +
Sbjct: 569  KDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHA 628

Query: 716  T 718
            T
Sbjct: 629  T 629

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 47/102 (46%), Positives = 66/102 (64%), Gaps = 2/102 (1%)
 Frame = +2

Query: 416 NFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKMDAT-ANDVP 589
           NFD +VN+    +L+EFYAPWCGHCK LAP+YE+ AK+LS  S  I +AK+DAT   D+ 
Sbjct: 179 NFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLA 237

Query: 590 SPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
             ++V+G+PT+       K  P  YNG RE   ++ Y+  +S
Sbjct: 238 KRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMIEQS 276

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 47/115 (40%), Positives = 68/115 (59%), Gaps = 3/115 (2%)
 Frame = +2

Query: 380 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 553
           K +  V V+   NFD  V D  KD VL+EFYAPWCGHCK  AP+YE++A  L   +  I 
Sbjct: 52  KEENGVWVLNDGNFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 109

Query: 554 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
           +AK+DAT A+ + S ++V+G+PTI       K     Y+G R  ++++  +   S
Sbjct: 110 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 161
>sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
          Length = 645

 Score =  203 bits (516), Expect = 5e-52
 Identities = 105/241 (43%), Positives = 154/241 (63%), Gaps = 4/241 (1%)
 Frame = +2

Query: 8    RTSSNMKYFSSKPLLVALYSVDYEKNPKG-TNYWRNRIMKVAKKFVDSGKSVHFAISNSQ 184
            + S++ K ++ +PL+V  YSVD+  + +  T +WR+++++VAK F +      FAI++ +
Sbjct: 401  KVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPE----YTFAIADEE 456

Query: 185  EQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLK 361
            + + E+ + G+ S     V     DE  +KF M  E+F  +   +F+  F   ++   +K
Sbjct: 457  DYAGEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIK 515

Query: 362  SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
            S+ +P+ N  PVKVVV K FD++V DP KDVLIEFYAPWCGHCK L P Y  LAKK  G+
Sbjct: 516  SQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ 575

Query: 542  SDIVIAKMDATANDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASES 715
              +VIAKMDATANDVPS  Y+V GFPTIYFAP   K +P  + GG R+++ + K+I   +
Sbjct: 576  KGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHA 635

Query: 716  T 718
            T
Sbjct: 636  T 636

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 51/111 (45%), Positives = 71/111 (63%), Gaps = 2/111 (1%)
 Frame = +2

Query: 389 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 565
           E   V+  +NFD +VND    +L+EFYAPWCGHCK LAP+YE+ AK+LS  S  I +AK+
Sbjct: 177 EVTLVLTKENFDEVVND-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235

Query: 566 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
           DATA  D+   ++V+G+PT+       K  P  YNG RE   ++ Y+  +S
Sbjct: 236 DATAETDLAKRFDVSGYPTLKIF---RKGRPYDYNGpreKYGIVDYMIEQS 283

 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 47/122 (38%), Positives = 70/122 (57%), Gaps = 3/122 (2%)
 Frame = +2

Query: 359 KSETIPEKNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKLS 535
           + + +  K +  V V+   NFD  V D  KD VL+EFYAPWCGHCK  AP+YE++A  L 
Sbjct: 52  EEDDLEVKEENGVLVLNDANFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIANILK 109

Query: 536 G-ESDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIAS 709
             +  I +AK+DAT A+ + S ++V+G+PTI       K     Y G R  ++++  +  
Sbjct: 110 DKDPPIPVAKIDATSASVLASRFDVSGYPTIKIL---KKGQAVDYEGSRTQEEIVAKVRE 166

Query: 710 ES 715
            S
Sbjct: 167 VS 168
>sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase A4 precursor (ERp-72 homolog)
          Length = 618

 Score =  182 bits (461), Expect = 1e-45
 Identities = 97/244 (39%), Positives = 146/244 (59%), Gaps = 8/244 (3%)
 Frame = +2

Query: 32   FSSKPLLVALYSVDYE-KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSE 208
            ++ KPL+V  Y+ D+  +  +G+ YWR++++ +A+K+        FA+++ +E + EL E
Sbjct: 378  YTKKPLVVVYYNADFSVQYREGSEYWRSKVLNIAQKYQKD--KYKFAVADEEEFAKELEE 435

Query: 209  FGI-ESPDSNKVYIVARDEKNQKFKMAE-----DFTMEAFEKFINDFLNEQVPVYLKSET 370
             G+ +S   + V +   D K       E     D  +EAF K I+   + +   ++KS  
Sbjct: 436  LGLGDSGLEHNVVVFGYDGKKYPMNPDEFDGELDENLEAFMKQIS---SGKAKAHVKSAP 492

Query: 371  IPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKL-SGESD 547
             P+ +  PVK VV  NFD +VND +KDVLIEFYAPWCGHCKS   KY ELA+ L   + +
Sbjct: 493  APKDDKGPVKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPN 552

Query: 548  IVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSL 727
            +V+AKMDAT ND PS + V GFPTIYFAP   K+ P  Y+G R+++D+ K++      S 
Sbjct: 553  VVLAKMDATINDAPSQFAVEGFPTIYFAPAGKKSEPIKYSGNRDLEDLKKFMTKHGVKSF 612

Query: 728  KSYD 739
            +  D
Sbjct: 613  QKKD 616

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 51/131 (38%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
 Frame = +2

Query: 353 YLKSETIPEKNDEPVKVVV--AKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAK 526
           +++S   P     P +VV    +NFD  +++  + VL+EFYAPWCGHCK LAP+YE+ A+
Sbjct: 133 WVESRVDPNYKPPPEEVVTLTTENFDDFISN-NELVLVEFYAPWCGHCKKLAPEYEKAAQ 191

Query: 527 KLSGE-SDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPK-SYNGGREVDDMLK 697
           KL  + S + + K+DAT   D+ + Y V+G+PT+    K  +N  +  YNG RE   ++K
Sbjct: 192 KLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTM----KIIRNGRRFDYNGpreAAGIIK 247

Query: 698 YIASESTSSLK 730
           Y+  +S  + K
Sbjct: 248 YMTDQSKPAAK 258

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 48/116 (41%), Positives = 73/116 (62%), Gaps = 1/116 (0%)
 Frame = +2

Query: 386 DEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKM 565
           DE V V+  KNFDA +      VL++FYAPWCGHCK LAP+YE+ + K+S    I +AK+
Sbjct: 35  DEGVVVLTDKNFDAFLKK-NPSVLVKFYAPWCGHCKHLAPEYEKASSKVS----IPLAKV 89

Query: 566 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSLK 730
           DAT   ++   +E+ G+PT+ F  K+ K  P  Y+GGR+   +++++ S    + K
Sbjct: 90  DATVETELGKRFEIQGYPTLKFW-KDGK-GPNDYDGGRDEAGIVEWVESRVDPNYK 143
>sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (PDI)
          Length = 505

 Score =  163 bits (413), Expect = 5e-40
 Identities = 84/165 (50%), Positives = 111/165 (67%), Gaps = 5/165 (3%)
 Frame = +2

Query: 227 DSNKVYIVARDEKNQKFKMAED--FTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 400
           D    + +    KNQKF   ++   T EA + F++DF+  ++   +KSE IPEK + PV 
Sbjct: 299 DKFPAFAIQEVAKNQKFPFDQEKEITFEAIKAFVDDFVAGKIEPSIKSEPIPEKQEGPVT 358

Query: 401 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELA---KKLSGESDIVIAKMDA 571
           VVVAKN++ +V D TKDVLIEFYAPWCGHCK+LAPKYEEL     K   +  +VIAK+DA
Sbjct: 359 VVVAKNYNEIVLDDTKDVLIEFYAPWCGHCKALAPKYEELGALYAKSEFKDRVVIAKVDA 418

Query: 572 TANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIA 706
           TANDVP   E+ GFPTI   P  +K  P +Y+G R V+D++K+IA
Sbjct: 419 TANDVPD--EIQGFPTIKLYPAGAKGQPVTYSGSRTVEDLIKFIA 461

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 44/117 (37%), Positives = 64/117 (54%), Gaps = 3/117 (2%)
 Frame = +2

Query: 452 VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDAT-ANDVPSPYEVTGFPTIYF 628
           VL EF+APWCGHCK+LAP+YEE A  L  E +I +AK+D T   D+   + V G+PT+  
Sbjct: 41  VLAEFFAPWCGHCKALAPEYEEAATTLK-EKNIKLAKVDCTEETDLCQQHGVEGYPTLKV 99

Query: 629 APKNSKNSPKSYNGGREVDDMLKYIASESTSSLK--SYDRQGRVRKSDL*KIKIVEY 793
                  SP  Y G R+   +  Y+  +S  ++   + D     +K+D  K  +V Y
Sbjct: 100 FRGLDNVSP--YKGQRKAAAITSYMIKQSLPAVSEVTKDNLEEFKKAD--KAVLVAY 152
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,914,380
Number of Sequences: 369166
Number of extensions: 1858823
Number of successful extensions: 6184
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5802
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6074
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)