Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_H07
(831 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precur... 295 1e-79
sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precur... 291 2e-78
sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precur... 285 1e-76
sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precurso... 281 2e-75
sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ... 236 4e-62
sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precurso... 205 1e-52
sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precur... 204 2e-52
sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precur... 203 5e-52
sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase ... 182 1e-45
sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (... 163 5e-40
>sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERP60) (58 kDa microsomal protein) (P58) (ERp57)
Length = 505
Score = 295 bits (754), Expect = 1e-79
Identities = 138/239 (57%), Positives = 176/239 (73%), Gaps = 2/239 (0%)
Frame = +2
Query: 11 TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
T N K LL+A Y VDYEKN KG+NYWRNR+M VAKKF+D+G+ +HFA+++ +
Sbjct: 248 TEDNKDLLQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGQKLHFAVASRKTF 307
Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
SHELS+FG+ES + R K +KF M E+F+ + A E+F+ D+ + + YLKS
Sbjct: 308 SHELSDFGLESTTGEIPVVAVRTAKGEKFVMQEEFSRDGKALERFLEDYFDGNLKRYLKS 367
Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
E IPE ND PVKVVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+EL +KL +
Sbjct: 368 EPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLRKDP 427
Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
+IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D + Y+ E+T+
Sbjct: 428 NIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKQNPKKYEGGRELSDFISYLKREATN 486
Score = 72.8 bits (177), Expect = 1e-12
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
Frame = +2
Query: 416 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 586
NF++ + D +L+EF+APWCGHCK LAP+YE A +L G + +AK+D TAN +
Sbjct: 34 NFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91
Query: 587 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
+ Y V+G+PT+ ++ +Y+G R D ++ ++ ++
Sbjct: 92 CNKYGVSGYPTLKIFRDGEESG--AYDGPRTADGIVSHLKKQA 132
>sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(58 kDa glucose regulated protein)
Length = 505
Score = 291 bits (745), Expect = 2e-78
Identities = 138/239 (57%), Positives = 176/239 (73%), Gaps = 2/239 (0%)
Frame = +2
Query: 11 TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
T N K LL+A Y VDYEKN KG+NYWRNR+M VAKKF+D+G ++FA+++ +
Sbjct: 248 TEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTF 307
Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
SHELS+FG+ES + R K +KF M E+F+ + A E+F+ D+ + + YLKS
Sbjct: 308 SHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKS 367
Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
E IPE ND PVKVVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+EL +KLS +
Sbjct: 368 EPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDP 427
Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
+IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D + Y+ E+T+
Sbjct: 428 NIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATN 486
Score = 70.9 bits (172), Expect = 4e-12
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
Frame = +2
Query: 416 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 586
NF++ ++D +L+EF+APWCGHCK LAP+YE A +L G + +AK+D TAN +
Sbjct: 34 NFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91
Query: 587 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
+ Y V+G+PT+ + +Y+G R D ++ ++ ++
Sbjct: 92 CNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIVSHLKKQA 132
>sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
Length = 504
Score = 285 bits (729), Expect = 1e-76
Identities = 135/239 (56%), Positives = 175/239 (73%), Gaps = 2/239 (0%)
Frame = +2
Query: 11 TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
T N K LL A Y VDYEKN KG+NYWRNR+M VAKKF+D+G ++FA+++ +
Sbjct: 247 TEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTF 306
Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
SHELS+F +ES + R K +KF M E+F+ + A E+F+ ++ + + YLKS
Sbjct: 307 SHELSDFSLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKS 366
Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
E IPE N+ PVKVVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+EL +KLS +
Sbjct: 367 EPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDP 426
Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
+IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE++D + Y+ E+T+
Sbjct: 427 NIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATN 485
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/104 (35%), Positives = 63/104 (60%), Gaps = 3/104 (2%)
Frame = +2
Query: 413 KNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-D 583
+NF++ V+D +L+EF+APWCGHCK LAP+YE A +L + +AK+D TAN +
Sbjct: 33 ENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL---KIVPLAKVDCTANTN 89
Query: 584 VPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
+ Y V+G+PT+ + +Y+G R D ++ ++ ++
Sbjct: 90 TCNKYGVSGYPTLKIF--RAGEEAGAYDGPRTADGIVSHLKKQA 131
>sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(HIP-70) (Q-2)
Length = 505
Score = 281 bits (719), Expect = 2e-75
Identities = 134/239 (56%), Positives = 174/239 (72%), Gaps = 2/239 (0%)
Frame = +2
Query: 11 TSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQ 190
T N K LL A Y VDYEKN KG+NYWRNR+M VAK F+D+G ++FA+++ +
Sbjct: 248 TEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTF 307
Query: 191 SHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKS 364
SHELS+FG+ES + R K +KF M E+F+ + A E+F+ ++ + + YLKS
Sbjct: 308 SHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKS 367
Query: 365 ETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES 544
E IPE N+ PVKVVVA++FD +VN KDVLIEFYAPWCGHCK+L PKY+EL +KLS +
Sbjct: 368 EPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDP 427
Query: 545 DIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
+IVIAKMDATANDVPSPYEV GFPTIYF+P N K +PK Y GGRE++D + Y+ E+T+
Sbjct: 428 NIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATN 486
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 3/127 (2%)
Frame = +2
Query: 344 VPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEE 517
V + L S + +D V + +NF++ V+D +L+EF+APWCGHCK LAP+YE
Sbjct: 12 VALLLASALLASASD--VLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69
Query: 518 LAKKLSGESDIVIAKMDATAN-DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDML 694
A +L G + +AK+D TAN + + Y V+G+PT+ + +Y+G R D ++
Sbjct: 70 AATRLKG--IVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIV 125
Query: 695 KYIASES 715
++ ++
Sbjct: 126 SHLKKQA 132
>sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ER-60 precursor (ERP60)
Length = 484
Score = 236 bits (603), Expect = 4e-62
Identities = 117/256 (45%), Positives = 170/256 (66%)
Frame = +2
Query: 2 GLRTSSNMKYFSSKPLLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNS 181
G R+ SN YF + L+V + + P G Y RNR++K K K++ FA S +
Sbjct: 233 GYRSPSNTFYFENSDLVVLYNNQSIDSYPSGVKYLRNRVLKTLKDNPQKFKNLVFAYSFA 292
Query: 182 QEQSHELSEFGIESPDSNKVYIVARDEKNQKFKMAEDFTMEAFEKFINDFLNEQVPVYLK 361
+ S+E+S++GIE+ +K+ V K++K+K+ E F+++AF F+N F + + ++K
Sbjct: 293 DDFSYEISDYGIEA---DKLPAVVIQSKDKKYKL-EKFSLDAFSDFLNKFEDGLLTPHVK 348
Query: 362 SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
SE +P + VK +VA NFD +VN+ KDV++ F+A WCGHCK+L PKYEE A K+ E
Sbjct: 349 SEPLPTDDSSAVKKLVALNFDEIVNNEEKDVMVVFHAGWCGHCKNLMPKYEEAASKVKNE 408
Query: 542 SDIVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 721
++V+A MDATANDVPSPY+V GFPTIYF PK K+SP SY GGR+ +D++KY+A E+T
Sbjct: 409 PNLVLAAMDATANDVPSPYQVRGFPTIYFVPKGKKSSPVSYEGGRDTNDIIKYLAREATE 468
Query: 722 SLKSYDRQGRVRKSDL 769
L YDR G +KS+L
Sbjct: 469 ELIGYDRSGNPKKSEL 484
Score = 67.4 bits (163), Expect = 5e-11
Identities = 32/89 (35%), Positives = 54/89 (60%), Gaps = 2/89 (2%)
Frame = +2
Query: 455 LIEFYAPWCGHCKSLAPKYEELAKKLSGE-SDIVIAKMDATAND-VPSPYEVTGFPTIYF 628
L++FYAPWCGHCK LAP++ A+ +SG+ +D+ + K+D T + + S + V+G+PT+
Sbjct: 38 LVKFYAPWCGHCKKLAPEFTSAAQIISGKTNDVKLVKVDCTTQESICSEFGVSGYPTLKI 97
Query: 629 APKNSKNSPKSYNGGREVDDMLKYIASES 715
+ YNG R + + Y+ S +
Sbjct: 98 FRNGDLDG--EYNGPRNANGIANYMISRA 124
>sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
(Calcium-binding protein 2) (CaBP2)
Length = 643
Score = 205 bits (522), Expect = 1e-52
Identities = 106/241 (43%), Positives = 156/241 (64%), Gaps = 4/241 (1%)
Frame = +2
Query: 8 RTSSNMKYFSSKPLLVALYSVDYEKNPK-GTNYWRNRIMKVAKKFVDSGKSVHFAISNSQ 184
+TS++ K +S +PL+V YSVD+ + + T +WRN++++VAK F + FAI++ +
Sbjct: 399 KTSNDAKRYSKRPLVVVYYSVDFSFDYRTATQFWRNKVLEVAKDFPE----YTFAIADEE 454
Query: 185 EQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLK 361
+ + E+ + G+ S V DE +KF M E+F +A ++F+ F ++ +K
Sbjct: 455 DYATEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDALQEFVMAFKKGKLKPVIK 513
Query: 362 SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
S+ +P+ N PV+VVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y L KK G+
Sbjct: 514 SQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSLGKKYKGQ 573
Query: 542 SDIVIAKMDATANDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASES 715
D+VIAKMDATAND+ + Y+V GFPTIYFAP K +P + GG R+++ + K+I +
Sbjct: 574 KDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHA 633
Query: 716 T 718
T
Sbjct: 634 T 634
Score = 87.0 bits (214), Expect = 6e-17
Identities = 48/111 (43%), Positives = 69/111 (62%), Gaps = 2/111 (1%)
Frame = +2
Query: 389 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 565
E + +NFD +VN+ +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+
Sbjct: 175 EVTLTLTKENFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 233
Query: 566 DAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
DAT D+ ++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 234 DATEQTDLAKRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMVEQS 281
Score = 79.3 bits (194), Expect = 1e-14
Identities = 47/115 (40%), Positives = 69/115 (60%), Gaps = 3/115 (2%)
Frame = +2
Query: 380 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 553
K + V V+ +NFD V D KD VL+EFYAPWCGHCK AP+YE++A L + I
Sbjct: 57 KEENGVWVLNDENFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 114
Query: 554 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
+AK+DAT A+ + S ++V+G+PTI K Y+G R ++++ + S
Sbjct: 115 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 166
>sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 638
Score = 204 bits (520), Expect = 2e-52
Identities = 106/241 (43%), Positives = 154/241 (63%), Gaps = 4/241 (1%)
Frame = +2
Query: 8 RTSSNMKYFSSKPLLVALYSVDYEKNPKG-TNYWRNRIMKVAKKFVDSGKSVHFAISNSQ 184
+TS++ K +S +PL+V YSVD+ + + T +WRN++++VAK F + FAI++ +
Sbjct: 394 KTSNDAKRYSKRPLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDFPE----YTFAIADEE 449
Query: 185 EQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLK 361
+ + E+ + G+ S V DE +KF M E+F + +F+ F ++ +K
Sbjct: 450 DYATEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIK 508
Query: 362 SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
S+ +P+ N PVKVVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y L KK G+
Sbjct: 509 SQPVPKNNKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQ 568
Query: 542 SDIVIAKMDATANDVPS-PYEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASES 715
D+VIAKMDATAND+ + Y+V GFPTIYFAP K +P + GG R+++ + K+I +
Sbjct: 569 KDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHA 628
Query: 716 T 718
T
Sbjct: 629 T 629
Score = 85.9 bits (211), Expect = 1e-16
Identities = 47/102 (46%), Positives = 66/102 (64%), Gaps = 2/102 (1%)
Frame = +2
Query: 416 NFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKMDAT-ANDVP 589
NFD +VN+ +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+DAT D+
Sbjct: 179 NFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLA 237
Query: 590 SPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 238 KRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMIEQS 276
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/115 (40%), Positives = 68/115 (59%), Gaps = 3/115 (2%)
Frame = +2
Query: 380 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 553
K + V V+ NFD V D KD VL+EFYAPWCGHCK AP+YE++A L + I
Sbjct: 52 KEENGVWVLNDGNFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 109
Query: 554 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
+AK+DAT A+ + S ++V+G+PTI K Y+G R ++++ + S
Sbjct: 110 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 161
>sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 645
Score = 203 bits (516), Expect = 5e-52
Identities = 105/241 (43%), Positives = 154/241 (63%), Gaps = 4/241 (1%)
Frame = +2
Query: 8 RTSSNMKYFSSKPLLVALYSVDYEKNPKG-TNYWRNRIMKVAKKFVDSGKSVHFAISNSQ 184
+ S++ K ++ +PL+V YSVD+ + + T +WR+++++VAK F + FAI++ +
Sbjct: 401 KVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPE----YTFAIADEE 456
Query: 185 EQSHELSEFGIESPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLK 361
+ + E+ + G+ S V DE +KF M E+F + +F+ F ++ +K
Sbjct: 457 DYAGEVKDLGL-SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIK 515
Query: 362 SETIPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGE 541
S+ +P+ N PVKVVV K FD++V DP KDVLIEFYAPWCGHCK L P Y LAKK G+
Sbjct: 516 SQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ 575
Query: 542 SDIVIAKMDATANDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASES 715
+VIAKMDATANDVPS Y+V GFPTIYFAP K +P + GG R+++ + K+I +
Sbjct: 576 KGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHA 635
Query: 716 T 718
T
Sbjct: 636 T 636
Score = 92.8 bits (229), Expect = 1e-18
Identities = 51/111 (45%), Positives = 71/111 (63%), Gaps = 2/111 (1%)
Frame = +2
Query: 389 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 565
E V+ +NFD +VND +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+
Sbjct: 177 EVTLVLTKENFDEVVND-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235
Query: 566 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 715
DATA D+ ++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 236 DATAETDLAKRFDVSGYPTLKIF---RKGRPYDYNGpreKYGIVDYMIEQS 283
Score = 76.6 bits (187), Expect = 8e-14
Identities = 47/122 (38%), Positives = 70/122 (57%), Gaps = 3/122 (2%)
Frame = +2
Query: 359 KSETIPEKNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKLS 535
+ + + K + V V+ NFD V D KD VL+EFYAPWCGHCK AP+YE++A L
Sbjct: 52 EEDDLEVKEENGVLVLNDANFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIANILK 109
Query: 536 G-ESDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIAS 709
+ I +AK+DAT A+ + S ++V+G+PTI K Y G R ++++ +
Sbjct: 110 DKDPPIPVAKIDATSASVLASRFDVSGYPTIKIL---KKGQAVDYEGSRTQEEIVAKVRE 166
Query: 710 ES 715
S
Sbjct: 167 VS 168
>sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase A4 precursor (ERp-72 homolog)
Length = 618
Score = 182 bits (461), Expect = 1e-45
Identities = 97/244 (39%), Positives = 146/244 (59%), Gaps = 8/244 (3%)
Frame = +2
Query: 32 FSSKPLLVALYSVDYE-KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSE 208
++ KPL+V Y+ D+ + +G+ YWR++++ +A+K+ FA+++ +E + EL E
Sbjct: 378 YTKKPLVVVYYNADFSVQYREGSEYWRSKVLNIAQKYQKD--KYKFAVADEEEFAKELEE 435
Query: 209 FGI-ESPDSNKVYIVARDEKNQKFKMAE-----DFTMEAFEKFINDFLNEQVPVYLKSET 370
G+ +S + V + D K E D +EAF K I+ + + ++KS
Sbjct: 436 LGLGDSGLEHNVVVFGYDGKKYPMNPDEFDGELDENLEAFMKQIS---SGKAKAHVKSAP 492
Query: 371 IPEKNDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKL-SGESD 547
P+ + PVK VV NFD +VND +KDVLIEFYAPWCGHCKS KY ELA+ L + +
Sbjct: 493 APKDDKGPVKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPN 552
Query: 548 IVIAKMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSL 727
+V+AKMDAT ND PS + V GFPTIYFAP K+ P Y+G R+++D+ K++ S
Sbjct: 553 VVLAKMDATINDAPSQFAVEGFPTIYFAPAGKKSEPIKYSGNRDLEDLKKFMTKHGVKSF 612
Query: 728 KSYD 739
+ D
Sbjct: 613 QKKD 616
Score = 88.2 bits (217), Expect = 3e-17
Identities = 51/131 (38%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Frame = +2
Query: 353 YLKSETIPEKNDEPVKVVV--AKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAK 526
+++S P P +VV +NFD +++ + VL+EFYAPWCGHCK LAP+YE+ A+
Sbjct: 133 WVESRVDPNYKPPPEEVVTLTTENFDDFISN-NELVLVEFYAPWCGHCKKLAPEYEKAAQ 191
Query: 527 KLSGE-SDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPK-SYNGGREVDDMLK 697
KL + S + + K+DAT D+ + Y V+G+PT+ K +N + YNG RE ++K
Sbjct: 192 KLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTM----KIIRNGRRFDYNGpreAAGIIK 247
Query: 698 YIASESTSSLK 730
Y+ +S + K
Sbjct: 248 YMTDQSKPAAK 258
Score = 86.7 bits (213), Expect = 7e-17
Identities = 48/116 (41%), Positives = 73/116 (62%), Gaps = 1/116 (0%)
Frame = +2
Query: 386 DEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKM 565
DE V V+ KNFDA + VL++FYAPWCGHCK LAP+YE+ + K+S I +AK+
Sbjct: 35 DEGVVVLTDKNFDAFLKK-NPSVLVKFYAPWCGHCKHLAPEYEKASSKVS----IPLAKV 89
Query: 566 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSLK 730
DAT ++ +E+ G+PT+ F K+ K P Y+GGR+ +++++ S + K
Sbjct: 90 DATVETELGKRFEIQGYPTLKFW-KDGK-GPNDYDGGRDEAGIVEWVESRVDPNYK 143
>sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (PDI)
Length = 505
Score = 163 bits (413), Expect = 5e-40
Identities = 84/165 (50%), Positives = 111/165 (67%), Gaps = 5/165 (3%)
Frame = +2
Query: 227 DSNKVYIVARDEKNQKFKMAED--FTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 400
D + + KNQKF ++ T EA + F++DF+ ++ +KSE IPEK + PV
Sbjct: 299 DKFPAFAIQEVAKNQKFPFDQEKEITFEAIKAFVDDFVAGKIEPSIKSEPIPEKQEGPVT 358
Query: 401 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELA---KKLSGESDIVIAKMDA 571
VVVAKN++ +V D TKDVLIEFYAPWCGHCK+LAPKYEEL K + +VIAK+DA
Sbjct: 359 VVVAKNYNEIVLDDTKDVLIEFYAPWCGHCKALAPKYEELGALYAKSEFKDRVVIAKVDA 418
Query: 572 TANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIA 706
TANDVP E+ GFPTI P +K P +Y+G R V+D++K+IA
Sbjct: 419 TANDVPD--EIQGFPTIKLYPAGAKGQPVTYSGSRTVEDLIKFIA 461
Score = 68.2 bits (165), Expect = 3e-11
Identities = 44/117 (37%), Positives = 64/117 (54%), Gaps = 3/117 (2%)
Frame = +2
Query: 452 VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDAT-ANDVPSPYEVTGFPTIYF 628
VL EF+APWCGHCK+LAP+YEE A L E +I +AK+D T D+ + V G+PT+
Sbjct: 41 VLAEFFAPWCGHCKALAPEYEEAATTLK-EKNIKLAKVDCTEETDLCQQHGVEGYPTLKV 99
Query: 629 APKNSKNSPKSYNGGREVDDMLKYIASESTSSLK--SYDRQGRVRKSDL*KIKIVEY 793
SP Y G R+ + Y+ +S ++ + D +K+D K +V Y
Sbjct: 100 FRGLDNVSP--YKGQRKAAAITSYMIKQSLPAVSEVTKDNLEEFKKAD--KAVLVAY 152
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,914,380
Number of Sequences: 369166
Number of extensions: 1858823
Number of successful extensions: 6184
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5802
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6074
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)