Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_G08
(757 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 298 8e-81
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 293 3e-79
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 291 1e-78
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 288 8e-78
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 288 8e-78
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 288 8e-78
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 288 1e-77
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 286 4e-77
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 286 5e-77
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 285 7e-77
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 298 bits (764), Expect = 8e-81
Identities = 140/226 (61%), Positives = 176/226 (77%), Gaps = 2/226 (0%)
Frame = +2
Query: 2 IAPENIKSLPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQ 181
I+P ++ +LPKSVDWRT+G VT VKDQ CGSCWAFS+TG+LEGQH RK+GVL+S SEQ
Sbjct: 117 ISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQN 175
Query: 182 LVDCSQSFGNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGF 358
LVDCS +GN GC GGLMD AF YIK GI++E SYPY A + C +NK V A GF
Sbjct: 176 LVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGF 235
Query: 359 IDIPQNNENLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG 538
DIPQ +E +A +VATVGP+S+ IDAS SFQFY G+Y+EPQC + +LDHGVL VG+G
Sbjct: 236 TDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFG 295
Query: 539 T-TNGRNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
T +G ++W+VKNSWGT+WG G+I+M ++K NQCG+A+A+SYPLV
Sbjct: 296 TDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 293 bits (750), Expect = 3e-79
Identities = 135/226 (59%), Positives = 172/226 (76%), Gaps = 2/226 (0%)
Frame = +2
Query: 2 IAPENIKSLPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQ 181
I P ++ ++PKSVDWR G VT VKDQ CGSCWAFS+TG+LEGQH RK GVL+S SEQ
Sbjct: 115 IPPAHV-TVPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQN 173
Query: 182 LVDCSQSFGNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGF 358
LVDCS +GN GC GGLMD AF YIK GI++E SYPY + C +NKA + A TGF
Sbjct: 174 LVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGF 233
Query: 359 IDIPQNNENLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG 538
+DIP+ +E + +VAT+GP+S+ IDAS SFQ Y G+Y+EP+C +LDHGVL VGYG
Sbjct: 234 VDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYG 293
Query: 539 T-TNGRNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
T +G ++W+VKNSWGT+WG GYI+M++++NNQCG+ATA+SYP V
Sbjct: 294 TDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 291 bits (745), Expect = 1e-78
Identities = 141/221 (63%), Positives = 166/221 (75%), Gaps = 5/221 (2%)
Frame = +2
Query: 26 LPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSF 205
+PKSVDWR +GYVTPVK+Q CGSCWAFS TG+LEGQ RKTG L+S SEQ LVDCS++
Sbjct: 114 IPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 206 GNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGE-CSYNKAKVVANCTGFIDIPQNN 379
GNEGC GGLMD AF Y+K G++SE SYPY + E C+Y AN TGF+D+PQ
Sbjct: 174 GNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQRE 233
Query: 380 ENLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGY---GTTNG 550
+ L+ A VAT+GPIS+ IDA SFQFYKSGIY +P CSS LDHGVL VGY GT +
Sbjct: 234 KALMKA-VATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 551 RNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
FWIVKNSWG WG NGY++M+KD+NN CG+ATAASYP V
Sbjct: 293 NKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 288 bits (738), Expect = 8e-78
Identities = 139/221 (62%), Positives = 167/221 (75%), Gaps = 5/221 (2%)
Frame = +2
Query: 26 LPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSF 205
+PKSVDWR +G VTPVK+Q CGSCWAFS +G LEGQ KTG LIS SEQ LVDCS +
Sbjct: 114 IPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQ 173
Query: 206 GNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGFIDIPQNNE 382
GN+GC GGLMD+AF YIK+ G++SE SYPY A +G C Y VAN TGF+DIPQ +
Sbjct: 174 GNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEK 233
Query: 383 NLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG----TTNG 550
L+ A VATVGPIS+ +DAS S QFY SGIY EP CSS +LDHGVL VGYG +N
Sbjct: 234 ALMKA-VATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNK 292
Query: 551 RNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
+W+VKNSWG+ WGM GYI+++KD++N CG+ATAASYP+V
Sbjct: 293 NKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 288 bits (738), Expect = 8e-78
Identities = 141/222 (63%), Positives = 164/222 (73%), Gaps = 6/222 (2%)
Frame = +2
Query: 26 LPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSF 205
+PKSVDW +GYVTPVK+Q CGSCWAFS TG+LEGQ RKTG L+S SEQ LVDCS++
Sbjct: 114 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 206 GNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANE-GECSYNKAKVVANCTGFIDIPQNN 379
GN+GC GGLMD AF YIK G++SE SYPY A + C+Y AN TGF+DIPQ
Sbjct: 174 GNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQRE 233
Query: 380 ENLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG----TTN 547
+ L+ A VATVGPIS+ IDA SFQFYKSGIY +P CS LDHGVL VGYG +N
Sbjct: 234 KALMKA-VATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSN 292
Query: 548 GRNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
FWIVKNSWG WG NGY++M+KD+NN CG+ATAASYP V
Sbjct: 293 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 288 bits (738), Expect = 8e-78
Identities = 139/221 (62%), Positives = 165/221 (74%), Gaps = 5/221 (2%)
Frame = +2
Query: 26 LPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSF 205
+PK+VDWR +G VTPVK+Q CGSCWAFS +G LEGQ KTG LIS SEQ LVDCS
Sbjct: 114 IPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQ 173
Query: 206 GNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGFIDIPQNNE 382
GN+GC GGLMD+AF YIK+ G++SE SYPY A +G C Y VAN TGF+DIPQ +
Sbjct: 174 GNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEK 233
Query: 383 NLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG----TTNG 550
L+ A VATVGPIS+ +DAS S QFY SGIY EP CSS LDHGVL VGYG +N
Sbjct: 234 ALMKA-VATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNK 292
Query: 551 RNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
+W+VKNSWG WGM+GYI+++KD+NN CG+ATAASYP+V
Sbjct: 293 DKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 288 bits (736), Expect = 1e-77
Identities = 138/220 (62%), Positives = 162/220 (73%), Gaps = 5/220 (2%)
Frame = +2
Query: 29 PKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSFG 208
P+SVDWR +GYVTPVK+Q CGSCWAFS TG+LEGQ RKTG LIS SEQ LVDCS G
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 209 NEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGFIDIPQNNEN 385
NEGC GGLMDYAF Y++ G++SE SYPY A E C YN VAN TGF+DIP+ +
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA 234
Query: 386 LLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG----TTNGR 553
L+ A VATVGPIS+ IDA SF FYK GIY EP CSS +DHGVL VGYG ++
Sbjct: 235 LMKA-VATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 554 NFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
+W+VKNSWG WGM GY++M+KD+ N CG+A+AASYP V
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 286 bits (732), Expect = 4e-77
Identities = 139/225 (61%), Positives = 165/225 (73%), Gaps = 6/225 (2%)
Frame = +2
Query: 17 IKSLPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCS 196
+ +PKSVDWR +GYVT VK+Q CGSCWAFS TG+LEGQ RKTG L+S SEQ LVDCS
Sbjct: 111 VLEVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCS 170
Query: 197 QSFGNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANE-GECSYNKAKVVANCTGFIDIP 370
+ GN+GC GGLMD AF Y+K G+++E SYPY E C+Y AN TGF+DIP
Sbjct: 171 RPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIP 230
Query: 371 QNNENLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG---- 538
Q + L+ A VATVGPIS+ IDA +SFQFYKSGIY +P CSS LDHGVL VGYG
Sbjct: 231 QREKALMKA-VATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGT 289
Query: 539 TTNGRNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
+N FWIVKNSWG WG NGY++M+KD+NN CG++TAASYP V
Sbjct: 290 DSNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 286 bits (731), Expect = 5e-77
Identities = 136/221 (61%), Positives = 162/221 (73%), Gaps = 5/221 (2%)
Frame = +2
Query: 26 LPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSF 205
LPKSVDWR +GYVTPVK+Q+ CGSCWAFS TG+LEGQ RKTG L+S SEQ LVDCS+
Sbjct: 114 LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 206 GNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGFIDIPQNNE 382
GN+GC GG M AF Y+K+ G++SE SYPY A + C Y VAN TGF + E
Sbjct: 174 GNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKE 233
Query: 383 NLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYG----TTNG 550
L +VATVGPIS+ +DA +SFQFYKSGIY EP CSS +LDHGVL VGYG +N
Sbjct: 234 KALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNN 293
Query: 551 RNFWIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
+W+VKNSWG WG NGY++++KDKNN CG+ATAASYP V
Sbjct: 294 SKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 285 bits (730), Expect = 7e-77
Identities = 139/218 (63%), Positives = 162/218 (74%), Gaps = 2/218 (0%)
Frame = +2
Query: 26 LPKSVDWRTQGYVTPVKDQQSCGSCWAFSTTGSLEGQHKRKTGVLISFSEQQLVDCSQSF 205
+PKSVDW +GYVTPVK+Q CGSCWAFS TG+LEGQ RKTG L+S SEQ LVD S+
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 206 GNEGCGGGLMDYAFAYIKQY-GIESEASYPYTANEGECSYNKAKVVANCTGFIDIPQNNE 382
GN+GC GGLMD AF YIK+ G++SE SYPY A + C+Y A TGF+DIPQ +
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIPQREK 120
Query: 383 NLLAASVATVGPISIGIDASQASFQFYKSGIYDEPQCSSTSLDHGVLAVGYGTTNGRN-F 559
L+ A VATVGPIS+ IDA +SFQFYKSGIY +P CSS LDHGVL VGYG N F
Sbjct: 121 ALMKA-VATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 560 WIVKNSWGTSWGMNGYIEMSKDKNNQCGVATAASYPLV 673
WIVKNSWG WG GY++M+KD+NN CG+ATAASYP V
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,215,556
Number of Sequences: 369166
Number of extensions: 1850209
Number of successful extensions: 5340
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4601
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4807
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6921714800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)