Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_F06
(640 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q90734|ACTN4_CHICK Alpha-actinin 4 (Non-muscle alpha-act... 211 1e-54
sp|P57780|ACTN4_MOUSE Alpha-actinin 4 (Non-muscle alpha-act... 211 1e-54
sp|O43707|ACTN4_HUMAN Alpha-actinin 4 (Non-muscle alpha-act... 211 1e-54
sp|Q9Z1P2|ACTN1_RAT Alpha-actinin 1 (Alpha-actinin cytoskel... 210 3e-54
sp|P12814|ACTN1_HUMAN Alpha-actinin 1 (Alpha-actinin cytosk... 209 4e-54
sp|Q7TPR4|ACTN1_MOUSE Alpha-actinin 1 (Alpha-actinin cytosk... 209 4e-54
sp|Q9QXQ0|ACTN4_RAT Alpha-actinin 4 (Non-muscle alpha-actin... 208 1e-53
sp|P05094|ACTN1_CHICK Alpha-actinin 1 (Alpha-actinin cytosk... 207 2e-53
sp|O88990|ACTN3_MOUSE Alpha-actinin 3 (Alpha actinin skelet... 200 3e-51
sp|Q08043|ACTN3_HUMAN Alpha-actinin 3 (Alpha actinin skelet... 198 1e-50
>sp|Q90734|ACTN4_CHICK Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 904
Score = 211 bits (538), Expect = 1e-54
Identities = 105/167 (62%), Positives = 134/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEE 181
R+ +E+E+QILTRD+KGISQ QM EFR FNHFDK+ L P+EFKACL+SLG +++ +
Sbjct: 738 RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHCGALGPEEFKACLISLGYDVEND 797
Query: 182 K-GEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+ G+A+F +IMS VDPN SG VTF AFID+M++ETT+ DT +Q++ SFKVL D++YITA
Sbjct: 798 RQGDAEFNRIMSLVDPNGSGSVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNYITA 857
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
EELRRELP +AEYCIA MAPY PD GALDYK F+++LYG SDL
Sbjct: 858 EELRRELPPEQAEYCIARMAPYRGPDAAPGALDYKSFSTALYGESDL 904
>sp|P57780|ACTN4_MOUSE Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 912
Score = 211 bits (538), Expect = 1e-54
Identities = 104/167 (62%), Positives = 135/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEE 181
R+ +E+E+QILTRD+KGISQ QM EFR FNHFDK+ L P+EFKACL+SLG +++ +
Sbjct: 746 RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVEND 805
Query: 182 K-GEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+ G+A+F +IMS VDPN SG+VTF AFID+M++ETT+ DT +Q++ SFKVL D+++ITA
Sbjct: 806 RQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITA 865
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
EELRRELP +AEYCIA MAPY PD GALDYK F+++LYG SDL
Sbjct: 866 EELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL 912
>sp|O43707|ACTN4_HUMAN Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 911
Score = 211 bits (537), Expect = 1e-54
Identities = 105/167 (62%), Positives = 135/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEE 181
R+ +E+E+QILTRD+KGISQ QM EFR FNHFDK+ L P+EFKACL+SLG +++ +
Sbjct: 745 RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVEND 804
Query: 182 K-GEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+ GEA+F +IMS VDPN SG+VTF AFID+M++ETT+ DT +Q++ SFKVL D+++ITA
Sbjct: 805 RQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITA 864
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
EELRRELP +AEYCIA MAPY PD GALDYK F+++LYG SDL
Sbjct: 865 EELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
>sp|Q9Z1P2|ACTN1_RAT Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 892
Score = 210 bits (534), Expect = 3e-54
Identities = 103/167 (61%), Positives = 135/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNL-KE 178
R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++ + TL P+EFKACL+SLG ++ +
Sbjct: 726 RTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGND 785
Query: 179 EKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+GEA+FA+IMS VDPNR GVVTF AFID+M++ET + DT +Q++ SFK+L D++YIT
Sbjct: 786 PQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITG 845
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
+ELRRELP +AEYCIA MAPY PD GALDY F+++LYG SDL
Sbjct: 846 DELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL 892
>sp|P12814|ACTN1_HUMAN Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 892
Score = 209 bits (533), Expect = 4e-54
Identities = 103/167 (61%), Positives = 135/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNL-KE 178
R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++ + TL P+EFKACL+SLG ++ +
Sbjct: 726 RTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGND 785
Query: 179 EKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+GEA+FA+IMS VDPNR GVVTF AFID+M++ET + DT +Q++ SFK+L D++YIT
Sbjct: 786 PQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITM 845
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
+ELRRELP +AEYCIA MAPY PD GALDY F+++LYG SDL
Sbjct: 846 DELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
>sp|Q7TPR4|ACTN1_MOUSE Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 892
Score = 209 bits (533), Expect = 4e-54
Identities = 103/167 (61%), Positives = 135/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNL-KE 178
R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++ + TL P+EFKACL+SLG ++ +
Sbjct: 726 RTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGND 785
Query: 179 EKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+GEA+FA+IMS VDPNR GVVTF AFID+M++ET + DT +Q++ SFK+L D++YIT
Sbjct: 786 PQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITE 845
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
+ELRRELP +AEYCIA MAPY PD GALDY F+++LYG SDL
Sbjct: 846 DELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL 892
>sp|Q9QXQ0|ACTN4_RAT Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 911
Score = 208 bits (529), Expect = 1e-53
Identities = 102/167 (61%), Positives = 133/167 (79%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEE 181
R+ +E+E+QILTRD+KGISQ QM EFR FNHFDK+ L P+EFK CL+SLG +++ +
Sbjct: 745 RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKGCLISLGYDVEND 804
Query: 182 K-GEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+ G+A+F +IMS VDPN SG+VTF AFID+M+KETT+ DT +Q++ SFKVL D+++IT
Sbjct: 805 RQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSKETTDTDTADQVIGSFKVLAGDKNFITV 864
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
EELR+ELP +AEYCIA MAPY PD GALDYK F+++LYG SDL
Sbjct: 865 EELRKELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL 911
>sp|P05094|ACTN1_CHICK Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 893
Score = 207 bits (526), Expect = 2e-53
Identities = 102/167 (61%), Positives = 134/167 (80%), Gaps = 3/167 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNL-KE 178
R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++ + TL P+EFKACL+SLG ++ +
Sbjct: 727 RTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGND 786
Query: 179 EKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITA 358
+GEA+FA+IMS VDPNR GVVTF AFID+M++ET + DT +Q++ SFK+L D++YIT
Sbjct: 787 AQGEAEFARIMSIVDPNRMGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITV 846
Query: 359 EELRRELPSAEAEYCIANMAPY--PDGGEGALDYKLFASSLYGHSDL 493
+ELRRELP +AEYCIA MAPY D GALDY F+++LYG SDL
Sbjct: 847 DELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALYGESDL 893
>sp|O88990|ACTN3_MOUSE Alpha-actinin 3 (Alpha actinin skeletal muscle isoform 3) (F-actin
cross linking protein)
Length = 900
Score = 200 bits (508), Expect = 3e-51
Identities = 96/166 (57%), Positives = 128/166 (77%), Gaps = 2/166 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEE 181
R+ +E+E+Q+LTRD+KG+SQ Q++EFR FNHFD+ + +EP +F+ACL+S+G +L
Sbjct: 739 RTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDL--- 795
Query: 182 KGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITAE 361
GE +FA+IM+ VDPN +GVVTF AFID+M +ET E DT EQ++ SFK+L D++YIT E
Sbjct: 796 -GEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPE 854
Query: 362 ELRRELPSAEAEYCIANMAPYPDGG--EGALDYKLFASSLYGHSDL 493
ELRRELP+ +AEYCI MAPY G GALDY F+S+LYG SDL
Sbjct: 855 ELRRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL 900
>sp|Q08043|ACTN3_HUMAN Alpha-actinin 3 (Alpha actinin skeletal muscle isoform 3) (F-actin
cross linking protein)
Length = 901
Score = 198 bits (503), Expect = 1e-50
Identities = 95/166 (57%), Positives = 127/166 (76%), Gaps = 2/166 (1%)
Frame = +2
Query: 2 RSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEE 181
R+ +E+E+Q+LTRD+KG+SQ Q++EFR FNHFD+ + +EP +F+ACL+S+G +L
Sbjct: 740 RTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDL--- 796
Query: 182 KGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETTEQDTLEQILQSFKVLCQDRDYITAE 361
GE +FA+IM+ VDPN +GVVTF AFID+M +ET E DT EQ++ SFK+L D++YIT E
Sbjct: 797 -GEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPE 855
Query: 362 ELRRELPSAEAEYCIANMAPYPDGG--EGALDYKLFASSLYGHSDL 493
ELRRELP+ +AEYCI M PY G GALDY F+S+LYG SDL
Sbjct: 856 ELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,033,441
Number of Sequences: 369166
Number of extensions: 1187098
Number of successful extensions: 3582
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3372
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3454
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5169945420
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)