Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_E19
(827 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 182 7e-46
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 179 1e-44
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 178 2e-44
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 174 3e-43
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 169 1e-41
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 166 9e-41
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 164 4e-40
sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor 163 6e-40
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 162 1e-39
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 162 1e-39
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 182 bits (463), Expect = 7e-46
Identities = 90/190 (47%), Positives = 124/190 (65%), Gaps = 2/190 (1%)
Frame = +2
Query: 59 FVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEE 238
F+ P L VDWR KG VT VK+Q C + WAF++TG+ EG++ ++GVL+S SE+
Sbjct: 116 FISPAHVTL-PKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQ 174
Query: 239 QLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GMNNEVTYPYFGIKDRCKYNNNSVIAHVVS 415
L+DCS YGN+GC GG DN+F Y K G++ E +YPY I D C +N +V A
Sbjct: 175 NLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRG 234
Query: 416 FIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGY 595
F D+ + +E ++A AV+ GP++ IDAS SFQFY EG+YN+P C + +H VL+VG+
Sbjct: 235 FTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGF 294
Query: 596 GESE-GEDYW 622
G E GEDYW
Sbjct: 295 GTDESGEDYW 304
Score = 55.1 bits (131), Expect = 2e-07
Identities = 21/32 (65%), Positives = 27/32 (84%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WGD G+IKM+R+ NQCGIAS++S+P
Sbjct: 308 NSWGTTWGDKGFIKMLRNKENQCGIASASSYP 339
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 179 bits (453), Expect = 1e-44
Identities = 84/177 (47%), Positives = 118/177 (66%), Gaps = 2/177 (1%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWR+ G VT VK+Q C + WAF++TG+ EG++ + GVL+S SE+ L+DCS YGN+G
Sbjct: 126 VDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNG 185
Query: 278 CKGGSPDNSFNYYKPY-GMNNEVTYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 454
C GG DN+F Y K G++ E +YPY GI D C +N ++ A F+D+ +E ++
Sbjct: 186 CNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMK 245
Query: 455 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESE-GEDYW 622
AV+ GP++ IDAS SFQ Y EG+YN+P C + + +H VL+VGYG E G DYW
Sbjct: 246 KAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYW 302
Score = 55.5 bits (132), Expect = 2e-07
Identities = 21/32 (65%), Positives = 27/32 (84%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WG+ GYIKM R+ NNQCGIA+++S+P
Sbjct: 306 NSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 178 bits (451), Expect = 2e-44
Identities = 88/220 (40%), Positives = 126/220 (57%), Gaps = 2/220 (0%)
Frame = +2
Query: 2 FRSKYLSKNLMSRSQINSKFVMPYKT--KLNDDEVDWRKKGVVTPVKNQYGCNAGWAFAA 175
F++KYL++ MSR+ +PY+ + D++DWR+ G VT VK+Q C + WAF+
Sbjct: 80 FKAKYLTE--MSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFST 137
Query: 176 TGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYGMNNEVTYPY 355
TG+ EG+Y +SFSE+QL+DCS +GN+GC GG +N++ Y K +G+ E +YPY
Sbjct: 138 TGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPY 197
Query: 356 FGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGI 535
++ +C+YN +A V + V +E+++ V A P +D F YR GI
Sbjct: 198 TAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVE-SDFMMYRSGI 256
Query: 536 YNDPTCSKTSPNHAVLIVGYGESEGEDYWDSKK*LGGYVG 655
Y TCS NHAVL VGYG G DYW K G Y G
Sbjct: 257 YQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWG 296
Score = 48.5 bits (114), Expect = 2e-05
Identities = 19/32 (59%), Positives = 22/32 (68%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WG+ GYI+M R+ N CGIAS S P
Sbjct: 289 NSWGTYWGERGYIRMARNRGNMCGIASLASLP 320
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 174 bits (441), Expect = 3e-43
Identities = 87/200 (43%), Positives = 124/200 (62%), Gaps = 1/200 (0%)
Frame = +2
Query: 26 NLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAM 205
N+ RS S F +T EVDWR KG VTPVK+Q C + WAF+ TGS EG++ +
Sbjct: 87 NIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFL 146
Query: 206 QTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKP-YGMNNEVTYPYFGIKDRCKY 382
+TG L+S +E+QL+DCS YG GC GG +++F+Y K G++ E YPY C++
Sbjct: 147 KTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRF 206
Query: 383 NNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKT 562
++NSV A ++A +E + AV GP++ IDA+ SFQFY G+Y +P+CS +
Sbjct: 207 DSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPS 266
Query: 563 SPNHAVLIVGYGESEGEDYW 622
+HAVL VGYG G+D+W
Sbjct: 267 YLDHAVLAVGYGSEGGQDFW 286
Score = 50.1 bits (118), Expect = 8e-06
Identities = 20/32 (62%), Positives = 23/32 (71%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSW WGD GYIKM R+ NN CGIA+ S+P
Sbjct: 290 NSWATSWGDAGYIKMSRNRNNNCGIATVASYP 321
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 169 bits (427), Expect = 1e-41
Identities = 88/196 (44%), Positives = 120/196 (61%), Gaps = 11/196 (5%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWR+KG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN G
Sbjct: 118 VDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEG 177
Query: 278 CKGGSPDNSFNYYKPY-GMNNEVTYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 454
C GG D +F Y + G+++E +YPY ++ CKYN +A+ F+D+ + E +
Sbjct: 178 CNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALM 236
Query: 455 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 622
AV+ GP++ IDA SF FY+EGIY +P CS +H VL+VGYG ES+ YW
Sbjct: 237 KAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYW 296
Query: 623 DSKK------*LGGYV 652
K +GGYV
Sbjct: 297 LVKNSWGEEWGMGGYV 312
Score = 48.9 bits (115), Expect = 2e-05
Identities = 19/32 (59%), Positives = 23/32 (71%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WG GY+KM +D N CGIAS+ S+P
Sbjct: 300 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 166 bits (419), Expect = 9e-41
Identities = 82/180 (45%), Positives = 110/180 (61%), Gaps = 5/180 (2%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWRKKG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN G
Sbjct: 118 VDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQG 177
Query: 278 CKGGSPDNSFNYYKPY-GMNNEVTYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 454
C GG +F Y K G+++E +YPY + + CKY + +A+ F VA E +
Sbjct: 178 CNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALM 237
Query: 455 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 622
AV+ GP++ +DA SFQFY+ GIY +P CS + +H VL+VGYG S YW
Sbjct: 238 KAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYW 297
Score = 51.2 bits (121), Expect = 3e-06
Identities = 18/33 (54%), Positives = 26/33 (78%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPD 731
NSWG WG +GY+K+ +D NN CGIA++ S+P+
Sbjct: 301 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPN 333
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 164 bits (414), Expect = 4e-40
Identities = 82/180 (45%), Positives = 112/180 (62%), Gaps = 5/180 (2%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWR+KG VTPVKNQ C + WAF+A+G EG+ ++TG L+S SE+ L+DCS A GN G
Sbjct: 118 VDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQG 177
Query: 278 CKGGSPDNSFNYYKPY-GMNNEVTYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 454
C GG D +F Y K G+++E +YPY CKY +A+ F+D+ + E +
Sbjct: 178 CNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALM 236
Query: 455 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 622
AV+ GP++ +DAS PS QFY GIY +P CS + +H VL+VGYG +S YW
Sbjct: 237 KAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYW 296
Score = 47.8 bits (112), Expect = 4e-05
Identities = 17/32 (53%), Positives = 25/32 (78%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG+ WG GYIK+ +D +N CG+A++ S+P
Sbjct: 300 NSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
>sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor
Length = 334
Score = 163 bits (412), Expect = 6e-40
Identities = 83/180 (46%), Positives = 112/180 (62%), Gaps = 5/180 (2%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWRKKG VTPV+ Q C+A WAFA TG+ E + QTG L S + L+DCS GN+G
Sbjct: 119 VDWRKKGYVTPVRRQGDCDACWAFAVTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNG 178
Query: 278 CKGGSPDNSFNY-YKPYGMNNEVTYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 454
C GG N+F Y G+ +E TYPY G C+YN + A + F+ + ++ +I +
Sbjct: 179 CLGGDTYNAFQYVLHNGGLESEATYPYEGKDGPCRYNPKNSKAEITGFVSLPQSEDI-LM 237
Query: 455 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 622
AAV+ GP+TA IDAS SF+ Y+ GIY++P CS + H VL+VGYG E++G YW
Sbjct: 238 AAVATIGPITAGIDASHESFKNYKGGIYHEPNCSSDTVTHGVLVVGYGFKGIETDGNHYW 297
Score = 47.4 bits (111), Expect = 5e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WG GY+K+ +D NN CGIAS +P
Sbjct: 301 NSWGKRWGIRGYMKLAKDKNNHCGIASYAHYP 332
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 162 bits (410), Expect = 1e-39
Identities = 85/175 (48%), Positives = 111/175 (63%), Gaps = 2/175 (1%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWR+KG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS A GN G
Sbjct: 118 VDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEG 177
Query: 278 CKGGSPDNSFNYYKPY-GMNNEVTYPYFG-IKDRCKYNNNSVIAHVVSFIDVARNNEIQV 451
C GG DN+F Y K G+++E +YPY G + C Y A+ F+D+ + E +
Sbjct: 178 CNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKAL 236
Query: 452 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGED 616
AV+ GP++ IDA SFQFY+ GIY DP CS +H VL+VGYG EG D
Sbjct: 237 MKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYG-FEGTD 290
Score = 50.8 bits (120), Expect = 4e-06
Identities = 19/32 (59%), Positives = 25/32 (78%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WG +GY+KM +D NN CGIA++ S+P
Sbjct: 300 NSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 331
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 162 bits (410), Expect = 1e-39
Identities = 81/180 (45%), Positives = 111/180 (61%), Gaps = 5/180 (2%)
Frame = +2
Query: 98 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 277
VDWR+KG VTPVKNQ C + WAF+A+G EG+ ++TG L+S SE+ L+DCS GN G
Sbjct: 118 VDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQG 177
Query: 278 CKGGSPDNSFNYYKPY-GMNNEVTYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 454
C GG D +F Y K G+++E +YPY CKY +A+ F+D+ + E +
Sbjct: 178 CNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEKALM 236
Query: 455 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 622
AV+ GP++ +DAS PS QFY GIY +P CS +H VL+VGYG +S + YW
Sbjct: 237 KAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYW 296
Score = 48.5 bits (114), Expect = 2e-05
Identities = 18/32 (56%), Positives = 24/32 (75%)
Frame = +3
Query: 633 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 728
NSWG WG GYIK+ +D NN CG+A++ S+P
Sbjct: 300 NSWGKEWGMDGYIKIAKDRNNHCGLATAASYP 331
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,948,778
Number of Sequences: 369166
Number of extensions: 1790272
Number of successful extensions: 5490
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4818
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5153
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)