Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_D13
(828 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-alanine-ri... 128 2e-29
sp|Q9Z1W9|STK39_MOUSE STE20/SPS1-related proline-alanine-ri... 120 5e-27
sp|O88506|STK39_RAT STE20/SPS1-related proline-alanine-rich... 118 2e-26
sp|Q6P9R2|OXSR1_MOUSE Serine/threonine-protein kinase OSR1 ... 90 7e-18
sp|Q863I2|OXSR1_PIG Serine/threonine-protein kinase OSR1 (O... 89 1e-17
sp|Q5R495|OXSR1_PONPY Serine/threonine-protein kinase OSR1 ... 89 1e-17
sp|O95747|OXSR1_HUMAN Serine/threonine-protein kinase OSR1 ... 88 3e-17
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 62 2e-09
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 62 3e-09
sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (... 56 1e-07
>sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20
related kinase) (Serine/threonine-protein kinase 39)
(DCHT)
Length = 547
Score = 128 bits (321), Expect = 2e-29
Identities = 89/278 (32%), Positives = 131/278 (47%), Gaps = 42/278 (15%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP++RP
Sbjct: 269 ATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRP 328
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR--------------------- 299
+A ELL+ F + L+ K+L +KVR
Sbjct: 329 TAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSD 388
Query: 300 ---DEKQEKNPKDFSGEWNFDIKGKN----------------XXXXXXEDPPGPKTKTST 422
DEK E+ FS E + +K +N + PP
Sbjct: 389 DEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYRE 448
Query: 423 AENVFYRITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNL 602
A + + LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL
Sbjct: 449 ASSCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANL 506
Query: 603 SELVAEP-TMRERVFALNSP-PASGVINEADLNGYAKV 710
++V +P ++ F L S S + +E L G+A++
Sbjct: 507 QKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 544
>sp|Q9Z1W9|STK39_MOUSE STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20
related kinase) (Serine/threonine-protein kinase 39)
Length = 556
Score = 120 bits (301), Expect = 5e-27
Identities = 91/277 (32%), Positives = 132/277 (47%), Gaps = 41/277 (14%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP++RP
Sbjct: 279 ATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRP 338
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR--------------------- 299
+A ELL+ F + L+ K+L +KVR
Sbjct: 339 TAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSD 398
Query: 300 ---DEKQEKNPKDFSGEWNFDIKGKN-----XXXXXXEDPPGPKTKTSTAE---NVFYR- 443
DEK E+ S E + +K +N E S A+ N YR
Sbjct: 399 DEMDEKSEEGKAAASQEKSRRVKEENSEISVNAGGIPEQIQSLSVHDSQAQPNANEDYRE 458
Query: 444 ------ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLS 605
+ LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL
Sbjct: 459 GPCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQ 516
Query: 606 ELVAEP-TMRERVFALNSP-PASGVINEADLNGYAKV 710
++V +P ++ F L S S + +E L G+A++
Sbjct: 517 KIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 553
>sp|O88506|STK39_RAT STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20
related kinase) (Serine/threonine-protein kinase 39)
(Pancreatic serine/threonine-protein kinase) (PS/TK)
(PSTK1)
Length = 553
Score = 118 bits (295), Expect = 2e-26
Identities = 87/277 (31%), Positives = 132/277 (47%), Gaps = 41/277 (14%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP++RP
Sbjct: 276 ATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRP 335
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR--------------------- 299
+A ELL+ F + L+ K+L +KVR
Sbjct: 336 TAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSD 395
Query: 300 ---DEKQEKNPKDFSGEWNFDIKGKNXXXXXXEDPPGPKTKTSTAE--------NVFYR- 443
DEK E+ S E + +K +N + ++ + N YR
Sbjct: 396 DEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYRE 455
Query: 444 ------ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLS 605
+ LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL
Sbjct: 456 GPCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQ 513
Query: 606 ELVAEP-TMRERVFALNSP-PASGVINEADLNGYAKV 710
++V +P ++ F L S + + +E L G+A++
Sbjct: 514 KIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQL 550
>sp|Q6P9R2|OXSR1_MOUSE Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 527
Score = 90.1 bits (222), Expect = 7e-18
Identities = 51/126 (40%), Positives = 70/126 (55%), Gaps = 9/126 (7%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP
Sbjct: 221 ATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNP---------KDFS 335
+A ELL+ F + K++++E L + +L AP R +K + P +D
Sbjct: 281 TAAELLRHKFFQ-KAKNKEFLQEKILQ----RAPTISERSKKVRRVPGSSGRLHKTEDGG 335
Query: 336 GEWNFD 353
EW+ D
Sbjct: 336 WEWSDD 341
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/117 (34%), Positives = 65/117 (55%), Gaps = 11/117 (9%)
Frame = +3
Query: 393 PPGPKTKTSTAENVFYR---------ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARE 545
PP K + A++ R + LR RN K+ EL DI F + G+D+ + +++E
Sbjct: 410 PPAEPAKPAQAQSSGERSQETKIPISLVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQE 467
Query: 546 LVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNS-PPASGVINEADLNGYAKV 710
L+ A L+DG DL++VA NL ++V EP + R F L S S + ++ L G+A++
Sbjct: 468 LISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
>sp|Q863I2|OXSR1_PIG Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 529
Score = 89.4 bits (220), Expect = 1e-17
Identities = 49/121 (40%), Positives = 62/121 (51%), Gaps = 4/121 (3%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP
Sbjct: 221 ATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR----DEKQEKNPKDFSGEWNF 350
+A ELL+ F + L KIL +KVR + +D EW+
Sbjct: 281 TAAELLRHKFFQKAKNKEYLQEKILQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSD 340
Query: 351 D 353
D
Sbjct: 341 D 341
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/91 (38%), Positives = 58/91 (63%), Gaps = 2/91 (2%)
Frame = +3
Query: 444 ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP 623
+ LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP
Sbjct: 438 LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEP 495
Query: 624 -TMRERVFALNS-PPASGVINEADLNGYAKV 710
+ R F L S S + +++ L G+A++
Sbjct: 496 QSNRSVTFKLASGVEGSDIPDDSKLIGFAQL 526
>sp|Q5R495|OXSR1_PONPY Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 527
Score = 89.4 bits (220), Expect = 1e-17
Identities = 51/126 (40%), Positives = 70/126 (55%), Gaps = 9/126 (7%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP
Sbjct: 221 ATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNP---------KDFS 335
+A ELL+ F + K++++E L + +L AP R +K + P +D
Sbjct: 281 TAAELLRHKFFQ-KAKNKEFLQEKILQ----RAPTISERAKKVRRVPGSSGRLHKTEDGG 335
Query: 336 GEWNFD 353
EW+ D
Sbjct: 336 WEWSDD 341
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/91 (38%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Frame = +3
Query: 444 ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP 623
+ LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP
Sbjct: 436 LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEP 493
Query: 624 -TMRERVFALNS-PPASGVINEADLNGYAKV 710
+ R F L S S + ++ L G+A++
Sbjct: 494 QSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
>sp|O95747|OXSR1_HUMAN Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 527
Score = 88.2 bits (217), Expect = 3e-17
Identities = 51/126 (40%), Positives = 69/126 (54%), Gaps = 9/126 (7%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
ATG APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP
Sbjct: 221 ATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNP---------KDFS 335
+A ELL+ F + K++++E L + L AP R +K + P +D
Sbjct: 281 TAAELLRHKFFQ-KAKNKEFLQEKTLQ----RAPTISERAKKVRRVPGSSGRLHKTEDGG 335
Query: 336 GEWNFD 353
EW+ D
Sbjct: 336 WEWSDD 341
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/91 (38%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Frame = +3
Query: 444 ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP 623
+ LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP
Sbjct: 436 LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEP 493
Query: 624 -TMRERVFALNS-PPASGVINEADLNGYAKV 710
+ R F L S S + ++ L G+A++
Sbjct: 494 QSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 62.0 bits (149), Expect = 2e-09
Identities = 39/131 (29%), Positives = 65/131 (49%), Gaps = 9/131 (6%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
A G+ P+++ PMKVL L +N PP ++ NY ++F + CL K+P+ RP
Sbjct: 225 ARGEPPHSELHPMKVLFLIPKNNPPTLEG---------NYSKPLKEFVEACLNKEPSFRP 275
Query: 183 SAKELLQSPFIKSKSRDRELLSKIL---------LNCDIPPAPDRKVRDEKQEKNPKDFS 335
+AKELL+ FI ++ L++++ + D + D + Q D S
Sbjct: 276 TAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSD-S 334
Query: 336 GEWNFDIKGKN 368
G+W F I+ K+
Sbjct: 335 GDWIFTIREKD 345
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 61.6 bits (148), Expect = 3e-09
Identities = 39/131 (29%), Positives = 66/131 (50%), Gaps = 9/131 (6%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
A G+ P+++ PMKVL L +N PP ++ NY ++F + CL K+P+ RP
Sbjct: 213 AKGEPPHSELHPMKVLFLIPKNNPPTLEG---------NYSKPLKEFVEACLNKEPSFRP 263
Query: 183 SAKELLQSPFIKSKSRDRELLSKIL---------LNCDIPPAPDRKVRDEKQEKNPKDFS 335
+AKELL+ FI ++ L++++ + + + D V + Q D S
Sbjct: 264 TAKELLKHKFIIRNAKKTSYLTELIDRYKRWKAEQSHEDSSSEDSDVETDGQASGGSD-S 322
Query: 336 GEWNFDIKGKN 368
G+W F I+ K+
Sbjct: 323 GDWIFTIREKD 333
>sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
Length = 416
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 2/166 (1%)
Frame = +3
Query: 3 ATGQAPYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRP 182
A G+ P + PM+VL L +N PP + T S +++F CL KDP+ RP
Sbjct: 213 AKGEPPNSDMHPMRVLFLIPKNNPPTLIGDFTKS---------FKEFIDACLNKDPSFRP 263
Query: 183 SAKELLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNPKDFSGEWNFDIKG 362
+AKELL+ FI S+ L++++ DR R + + + ++ D +G
Sbjct: 264 TAKELLKHKFIVKNSKKTSYLTELI---------DRFKRWKAEGHSDEE------SDSEG 308
Query: 363 KNXXXXXXEDPPGPKTKTSTAENVFYRITLRKRNPK--QNNELQDI 494
+ E P P+ +T +K +PK QN E QD+
Sbjct: 309 SDSESSSRESNPHPEWSFTTVR--------KKPDPKKLQNGEEQDL 346
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,469,201
Number of Sequences: 369166
Number of extensions: 1650116
Number of successful extensions: 4577
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4420
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4542
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)