Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_D02
(689 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 256 4e-68
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 253 3e-67
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 251 1e-66
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 251 1e-66
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 250 2e-66
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 249 4e-66
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 249 6e-66
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 247 2e-65
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 244 2e-64
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 241 1e-63
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 256 bits (654), Expect = 4e-68
Identities = 128/208 (61%), Positives = 146/208 (70%), Gaps = 2/208 (0%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
GYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S LM
Sbjct: 11 GYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLM 70
Query: 183 DNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 359
DNAF+YIK+ G++SE YPY ATD +C P K TGF DI Q E L AVATV
Sbjct: 71 DNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQREKALMKAVATV 129
Query: 360 GPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVT 536
GP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW
Sbjct: 130 GPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPE 189
Query: 537 WGESGYIKMSKDKKNQCGIATMASYPLV 620
WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 190 WGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 253 bits (647), Expect = 3e-67
Identities = 127/211 (60%), Positives = 146/211 (69%), Gaps = 5/211 (2%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
GYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS LM
Sbjct: 124 GYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLM 183
Query: 183 DNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 359
D AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E L AVATV
Sbjct: 184 DYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATV 242
Query: 360 GPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSW 527
GP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG + KYW+VKNSW
Sbjct: 243 GPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSW 302
Query: 528 DVTWGESGYIKMSKDKKNQCGIATMASYPLV 620
WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 303 GEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 251 bits (642), Expect = 1e-66
Identities = 123/211 (58%), Positives = 143/211 (67%), Gaps = 5/211 (2%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
GYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M
Sbjct: 124 GYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFM 183
Query: 183 DNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 359
AF+Y+K+ G ++SE YPY A D CK P V TGFT + E L AVATV
Sbjct: 184 ARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATV 243
Query: 360 GPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSW 527
GP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG KYW+VKNSW
Sbjct: 244 GPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSW 303
Query: 528 DVTWGESGYIKMSKDKKNQCGIATMASYPLV 620
WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 304 GPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 251 bits (642), Expect = 1e-66
Identities = 129/212 (60%), Positives = 145/212 (68%), Gaps = 6/212 (2%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
GYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LM
Sbjct: 124 GYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLM 183
Query: 183 DNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 356
DNAF+YIKD G++SE YPY ATD +C P TGF DI Q E L AVAT
Sbjct: 184 DNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVAT 242
Query: 357 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNS 524
VGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG + K+WIVKNS
Sbjct: 243 VGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNS 302
Query: 525 WDVTWGESGYIKMSKDKKNQCGIATMASYPLV 620
W WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 303 WGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 250 bits (639), Expect = 2e-66
Identities = 127/211 (60%), Positives = 144/211 (68%), Gaps = 5/211 (2%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
GYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LM
Sbjct: 124 GYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLM 183
Query: 183 DNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 356
DNAFRY+KD G++SE YPY D TC P TGF D+ Q E L AVAT
Sbjct: 184 DNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVAT 242
Query: 357 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSW 527
+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT K+WIVKNSW
Sbjct: 243 LGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSW 302
Query: 528 DVTWGESGYIKMSKDKKNQCGIATMASYPLV 620
WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 303 GPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 249 bits (637), Expect = 4e-66
Identities = 117/207 (56%), Positives = 151/207 (72%), Gaps = 1/207 (0%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
G VTPVK+Q QCGSCW+FS TGSLEGQ+F K LIS +EQQLVDCS M
Sbjct: 117 GAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWM 176
Query: 183 DNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 359
++AF YIK + GI++E YPY A DG+C+ + + + C+G T+I S +ET L AV +
Sbjct: 177 NDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDI 236
Query: 360 GPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTW 539
GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +W
Sbjct: 237 GPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSW 296
Query: 540 GESGYIKMSKDKKNQCGIATMASYPLV 620
G++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 297 GDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 249 bits (635), Expect = 6e-66
Identities = 121/208 (58%), Positives = 146/208 (70%), Gaps = 2/208 (0%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
G VT VK+Q CGSCW+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS LM
Sbjct: 134 GAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLM 193
Query: 183 DNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 359
DNAFRYIKD G I++E YPY A D +C N + GFTDI +E +A AVATV
Sbjct: 194 DNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATV 253
Query: 360 GPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVT 536
GPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW T
Sbjct: 254 GPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTT 313
Query: 537 WGESGYIKMSKDKKNQCGIATMASYPLV 620
WG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 314 WGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 247 bits (631), Expect = 2e-65
Identities = 122/208 (58%), Positives = 143/208 (68%), Gaps = 2/208 (0%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS LM
Sbjct: 132 GAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLM 191
Query: 183 DNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 359
DNAFRYIKD G I++E YPY D +C N + I TGF DI +E + AVAT+
Sbjct: 192 DNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATM 251
Query: 360 GPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVT 536
GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT + G YW+VKNSW T
Sbjct: 252 GPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTT 311
Query: 537 WGESGYIKMSKDKKNQCGIATMASYPLV 620
WGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 312 WGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 244 bits (622), Expect = 2e-64
Identities = 118/205 (57%), Positives = 148/205 (72%), Gaps = 1/205 (0%)
Frame = +3
Query: 9 VTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDN 188
VTPVK+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS M +
Sbjct: 118 VTPVKDQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTS 177
Query: 189 AFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGP 365
AF YIKD G I++E YPY A D +C+ + + I CTG ++Q E L AV+ VGP
Sbjct: 178 AFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGP 236
Query: 366 VSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGE 545
+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG+
Sbjct: 237 ISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGD 296
Query: 546 SGYIKMSKDKKNQCGIATMASYPLV 620
+GYIKMS+++ N CGIA+ SYP V
Sbjct: 297 AGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 241 bits (615), Expect = 1e-63
Identities = 122/212 (57%), Positives = 144/212 (67%), Gaps = 6/212 (2%)
Frame = +3
Query: 3 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 182
GYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LM
Sbjct: 124 GYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLM 183
Query: 183 DNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 356
DNAF+Y+KD G+++E YPY + +C P TGF DI Q E L AVAT
Sbjct: 184 DNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVAT 242
Query: 357 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNS 524
VGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNS
Sbjct: 243 VGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNS 302
Query: 525 WDVTWGESGYIKMSKDKKNQCGIATMASYPLV 620
W WG +GY+KM+KD+ N CGI+T ASYP V
Sbjct: 303 WGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,802,883
Number of Sequences: 369166
Number of extensions: 1424699
Number of successful extensions: 4583
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4017
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4137
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5927776870
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)