Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_C16
(863 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9XVN3|IASPP_CAEEL Apoptotic enhancer 1 protein (Inhibit... 80 6e-15
sp|Q96KQ4|ASPP1_HUMAN Apoptosis stimulating of p53 protein ... 72 2e-12
sp|Q62415|ASPP1_MOUSE Apoptosis stimulating of p53 protein ... 72 2e-12
sp|Q13625|ASPP2_HUMAN Apoptosis stimulating of p53 protein ... 70 6e-12
sp|Q8CG79|ASPP2_MOUSE Apoptosis stimulating of p53 protein ... 70 6e-12
sp|Q8WUF5|IASPP_HUMAN RelA-associated inhibitor (Inhibitor ... 67 5e-11
sp|Q5I1X5|IASPP_MOUSE RelA-associated inhibitor (Inhibitor ... 66 1e-10
sp|O14974|MYPT1_HUMAN Protein phosphatase 1 regulatory subu... 52 2e-06
sp|Q9DBR7|MYPT1_MOUSE Protein phosphatase 1 regulatory subu... 52 2e-06
sp|Q10728|MYPT1_RAT Protein phosphatase 1 regulatory subuni... 52 2e-06
>sp|Q9XVN3|IASPP_CAEEL Apoptotic enhancer 1 protein (Inhibitor member of the ASPP family)
(Protein iASPP) (Ce-iASPP)
Length = 769
Score = 80.5 bits (197), Expect = 6e-15
Identities = 43/105 (40%), Positives = 65/105 (61%), Gaps = 2/105 (1%)
Frame = +3
Query: 555 RAKDALNINPHHGI--LSVKPLDNSENHKVKKRKAIFDPHILLLDACLEPDFELVKELVP 728
R+ D N+ I +VK + N K+ K + FDP LLLDA LE + +LV+
Sbjct: 515 RSDDGQNLEMEVAIERRTVKGILRRPNEKMNKGRIEFDPLALLLDAALEGELDLVRSSAS 574
Query: 729 KVPNISKKTIDGITALHNAVCSADPKLVLFLLQSGADVNASDADG 863
K+ ++S+ +GITALHNA+C+ ++V FL+++ ADVNA D+DG
Sbjct: 575 KLTDVSQANDEGITALHNAICAGHYEIVRFLIENDADVNAQDSDG 619
>sp|Q96KQ4|ASPP1_HUMAN Apoptosis stimulating of p53 protein 1 (Protein phosphatase 1
regulatory subunit 13B)
Length = 1090
Score = 72.4 bits (176), Expect = 2e-12
Identities = 39/86 (45%), Positives = 55/86 (63%)
Frame = +3
Query: 606 KPLDNSENHKVKKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNA 785
KP H ++ R F+P LLLDA LE +F+LV+ ++ +V + SK +GIT LHNA
Sbjct: 872 KPNSERTGHGLRVR---FNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNA 928
Query: 786 VCSADPKLVLFLLQSGADVNASDADG 863
VC+ +V FLL G +VNA+D+DG
Sbjct: 929 VCAGHHHIVKFLLDFGVNVNAADSDG 954
>sp|Q62415|ASPP1_MOUSE Apoptosis stimulating of p53 protein 1 (Protein phosphatase 1
regulatory subunit 13B)
Length = 1087
Score = 72.4 bits (176), Expect = 2e-12
Identities = 39/86 (45%), Positives = 55/86 (63%)
Frame = +3
Query: 606 KPLDNSENHKVKKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNA 785
KP H ++ R F+P LLLDA LE +F+LV+ ++ +V + SK +GIT LHNA
Sbjct: 869 KPNSERTGHGLRVR---FNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNA 925
Query: 786 VCSADPKLVLFLLQSGADVNASDADG 863
VC+ +V FLL G +VNA+D+DG
Sbjct: 926 VCAGHHHIVKFLLDFGVNVNAADSDG 951
>sp|Q13625|ASPP2_HUMAN Apoptosis stimulating of p53 protein 2 (Tumor suppressor p53-binding
protein 2) (p53-binding protein 2) (53BP2) (Bcl2-binding
protein) (Bbp)
Length = 1128
Score = 70.5 bits (171), Expect = 6e-12
Identities = 34/69 (49%), Positives = 51/69 (73%)
Frame = +3
Query: 657 FDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLVLFLLQSGA 836
F+P LLLD+ LE +F+LV+ ++ +V + S +GITALHNAVC+ ++V FL+Q G
Sbjct: 924 FNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGV 983
Query: 837 DVNASDADG 863
+VNA+D+DG
Sbjct: 984 NVNAADSDG 992
>sp|Q8CG79|ASPP2_MOUSE Apoptosis stimulating of p53 protein 2 (Tumor suppressor p53-binding
protein 2)
Length = 1088
Score = 70.5 bits (171), Expect = 6e-12
Identities = 34/69 (49%), Positives = 51/69 (73%)
Frame = +3
Query: 657 FDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLVLFLLQSGA 836
F+P LLLD+ LE +F+LV+ ++ +V + S +GITALHNAVC+ ++V FL+Q G
Sbjct: 884 FNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGV 943
Query: 837 DVNASDADG 863
+VNA+D+DG
Sbjct: 944 NVNAADSDG 952
>sp|Q8WUF5|IASPP_HUMAN RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein
iASPP) (PPP1R13B-like protein) (NFkB-interacting protein
1)
Length = 828
Score = 67.4 bits (163), Expect = 5e-11
Identities = 33/75 (44%), Positives = 53/75 (70%)
Frame = +3
Query: 639 KKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLVLF 818
K R+A +P +LLLDA L + E+V++ V ++ + S+ +GITALHNA+C A+ +V F
Sbjct: 619 KARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDF 678
Query: 819 LLQSGADVNASDADG 863
L+ +GA+VN+ D+ G
Sbjct: 679 LITAGANVNSPDSHG 693
>sp|Q5I1X5|IASPP_MOUSE RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein
iASPP) (PPP1R13B-like protein) (NFkB-interacting protein
1)
Length = 824
Score = 65.9 bits (159), Expect = 1e-10
Identities = 32/75 (42%), Positives = 53/75 (70%)
Frame = +3
Query: 639 KKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLVLF 818
K R+A +P +LLLDA L + ++V++ V ++ + S+ +GITALHNA+C A+ +V F
Sbjct: 615 KARRARLNPLVLLLDAALTGELDVVQQAVKEMNDPSQPNEEGITALHNAICGANYPIVDF 674
Query: 819 LLQSGADVNASDADG 863
L+ +GA+VN+ D+ G
Sbjct: 675 LIAAGANVNSPDSHG 689
>sp|O14974|MYPT1_HUMAN Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase
targeting subunit 1) (Myosin phosphatase target subunit
1) (Protein phosphatase myosin-binding subunit)
Length = 1030
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/77 (35%), Positives = 45/77 (58%)
Frame = +3
Query: 633 KVKKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLV 812
K +K K FD + L AC D + V +L+ + +I+ +DG+TALH A + +V
Sbjct: 30 KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMV 89
Query: 813 LFLLQSGADVNASDADG 863
FL+++GA++N D +G
Sbjct: 90 KFLVENGANINQPDNEG 106
Score = 30.8 bits (68), Expect = 5.1
Identities = 15/34 (44%), Positives = 20/34 (58%)
Frame = +3
Query: 762 GITALHNAVCSADPKLVLFLLQSGADVNASDADG 863
G TALH A +++ L+Q+G DVN D DG
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 232
>sp|Q9DBR7|MYPT1_MOUSE Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase
targeting subunit 1) (Myosin phosphatase target subunit
1)
Length = 1004
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/77 (35%), Positives = 45/77 (58%)
Frame = +3
Query: 633 KVKKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLV 812
K +K K FD + L AC D + V +L+ + +I+ +DG+TALH A + +V
Sbjct: 30 KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMV 89
Query: 813 LFLLQSGADVNASDADG 863
FL+++GA++N D +G
Sbjct: 90 KFLVENGANINQPDNEG 106
Score = 30.8 bits (68), Expect = 5.1
Identities = 15/34 (44%), Positives = 20/34 (58%)
Frame = +3
Query: 762 GITALHNAVCSADPKLVLFLLQSGADVNASDADG 863
G TALH A +++ L+Q+G DVN D DG
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 232
>sp|Q10728|MYPT1_RAT Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase
targeting subunit 1) (Myosin phosphatase target subunit
1) (Protein phosphatase myosin-binding subunit) (MBSP)
(Serine/threonine protein phosphatase PP1 smooth muscle
regulatory subunit M110) (Protein phosphatase subunit
1M) (PP-1M)
Length = 1032
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/77 (35%), Positives = 45/77 (58%)
Frame = +3
Query: 633 KVKKRKAIFDPHILLLDACLEPDFELVKELVPKVPNISKKTIDGITALHNAVCSADPKLV 812
K +K K FD + L AC D + V +L+ + +I+ +DG+TALH A + +V
Sbjct: 30 KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMV 89
Query: 813 LFLLQSGADVNASDADG 863
FL+++GA++N D +G
Sbjct: 90 KFLVENGANINQPDNEG 106
Score = 30.8 bits (68), Expect = 5.1
Identities = 15/34 (44%), Positives = 20/34 (58%)
Frame = +3
Query: 762 GITALHNAVCSADPKLVLFLLQSGADVNASDADG 863
G TALH A +++ L+Q+G DVN D DG
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 232
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,661,242
Number of Sequences: 369166
Number of extensions: 1560778
Number of successful extensions: 4592
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4182
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4586
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)