Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_B18
(820 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O70352|CD82_RAT CD82 antigen (Metastasis suppressor homo... 60 7e-09
sp|P40237|CD82_MOUSE CD82 antigen (Inducible membrane prote... 60 9e-09
sp|Q80WR1|TSN18_MOUSE Tetraspanin-18 (Tspan-18) 56 1e-07
sp|Q58CY8|TSN18_BOVIN Tetraspanin-18 (Tspan-18) 55 3e-07
sp|P28648|CD63_RAT CD63 antigen (AD1 antigen) 53 9e-07
sp|Q96SJ8|TSN18_HUMAN Tetraspanin-18 (Tspan-18) 52 1e-06
sp|P41731|CD63_MOUSE CD63 antigen 51 4e-06
sp|O60635|TSN1_HUMAN Tetraspanin-1 (Tspan-1) (Tetraspan NET... 51 4e-06
sp|Q5RC27|TSN1_PONPY Tetraspanin-1 (Tspan-1) 49 2e-05
sp|O75954|TSN9_HUMAN Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) 48 4e-05
>sp|O70352|CD82_RAT CD82 antigen (Metastasis suppressor homolog)
Length = 266
Score = 60.1 bits (144), Expect = 7e-09
Identities = 56/257 (21%), Positives = 104/257 (40%), Gaps = 2/257 (0%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GAVILG G+W+ DKS+ V++ T+S+ L V A V I
Sbjct: 24 GAVILGFGVWILADKSSFISVLQ-------------TSSSSLQVGAYVFIGVGAITMLMG 70
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTNVLEKDFN 401
A+ E +CLL Y + NK ++ +G ++ ++++ N
Sbjct: 71 FLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVEVLFYFNANKLKQEMGNTVMDIIQ---N 127
Query: 402 GILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNW--KSTSSSGTKQIYPVGCCKLK 575
+N +++ + + + ++KCCG + S NW + TK YP C K K
Sbjct: 128 YSVNASSSR-EEAWDYVQAQVKCCG------WVSPSNWTRNPVLKNSTKTTYPCSCEKTK 180
Query: 576 EKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXXX 755
E+ KK + ++ + ++N P D ++ GC+ +++N
Sbjct: 181 EEDNQLIVKK-GFCESDNSTASENSPED---WPVHPEGCMEKAQAWLQENFGILLGVCAG 236
Query: 756 XXXFEIMCIVFACCVMR 806
E++ + + C+ R
Sbjct: 237 VAVIELLGLFLSICLCR 253
>sp|P40237|CD82_MOUSE CD82 antigen (Inducible membrane protein R2) (C33 antigen) (IA4)
Length = 266
Score = 59.7 bits (143), Expect = 9e-09
Identities = 58/258 (22%), Positives = 100/258 (38%), Gaps = 3/258 (1%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GAVILG G+W+ DK++ V++ T+S+ L V A V I
Sbjct: 24 GAVILGFGVWILADKNSFISVLQ-------------TSSSSLQVGAYVFIGVGAITIVMG 70
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTNVLEKDFN 401
A+ E +CLL Y + +K +K +G ++ +++
Sbjct: 71 FLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVGVLFYFNADKLKKEMGNTVMDIIRN--- 127
Query: 402 GILNTNATLF-TKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSS--SGTKQIYPVGCCKL 572
NAT + + + ++KCCG + S NW TK YP C K+
Sbjct: 128 --YTANATSSREEAWDYVQAQVKCCG------WVSHYNWTENEELMGFTKTTYPCSCEKI 179
Query: 573 KEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXX 752
KE+ KK + +A + ++N P D +N GC+ +++N
Sbjct: 180 KEEDNQLIVKK-GFCEADNSTVSENNPED---WPVNTEGCMEKAQAWLQENFGILLGVCA 235
Query: 753 XXXXFEIMCIVFACCVMR 806
E++ + + C+ R
Sbjct: 236 GVAVIELLGLFLSICLCR 253
>sp|Q80WR1|TSN18_MOUSE Tetraspanin-18 (Tspan-18)
Length = 248
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/256 (20%), Positives = 100/256 (39%), Gaps = 1/256 (0%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GA +LGVGIWV VD + E++ + +L A +++
Sbjct: 24 GACLLGVGIWVLVDPTGFREIV--------------ATNPLLTTGAYIVLAMGGLLFLLG 69
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS-LTNVLEKDF 398
A++EN+CLL+ + + F+++L + T L K +
Sbjct: 70 FLGCCGAVRENRCLLLFFFLFILIIFLVELSAAILAFI----FREHLTREFFTKELTKHY 125
Query: 399 NGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKE 578
G + + +F+ + ++M CCGVN DF ++ + T+++ P CC+
Sbjct: 126 QG--DNDTDVFSATWNSVMITFGCCGVNGPEDFKLASVFRLLTLD-TEEV-PKACCR--- 178
Query: 579 KYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXXXX 758
+P + +++ + PF IN GC +++ E +
Sbjct: 179 ---REPQTRDGVVLSREECQLGRNPF------INKQGCYTVILNTFETYVYLAGAFAIGV 229
Query: 759 XXFEIMCIVFACCVMR 806
E+ +VFA C+ R
Sbjct: 230 LAIELFLMVFAMCLFR 245
>sp|Q58CY8|TSN18_BOVIN Tetraspanin-18 (Tspan-18)
Length = 249
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/256 (21%), Positives = 94/256 (36%), Gaps = 1/256 (0%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GA +LG+GIWV VD + E++ + +L A +L+
Sbjct: 24 GACLLGIGIWVMVDPTGFREIV--------------AANPLLITGAYILLAMGGLLFLLG 69
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS-LTNVLEKDF 398
A++ENKCLL+ + + F+ NL + T L K +
Sbjct: 70 FLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFI----FRGNLTREFFTKELTKHY 125
Query: 399 NGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKE 578
G +T+ +F+ + ++M CCGVN DF ++ + + P CC+ +E
Sbjct: 126 QGSNDTD--VFSATWNSVMITFGCCGVNGPEDFKYASVFRLLTLDSDE--VPEACCR-RE 180
Query: 579 KYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXXXX 758
D + C D +N GC +++ E +
Sbjct: 181 PQSRD----------GVLLSREECLLGRD-LFLNKQGCYTVILNAFETYVYLAGALAIGV 229
Query: 759 XXFEIMCIVFACCVMR 806
E+ ++FA C+ R
Sbjct: 230 LAIELFAMIFAMCLFR 245
>sp|P28648|CD63_RAT CD63 antigen (AD1 antigen)
Length = 238
Score = 53.1 bits (126), Expect = 9e-07
Identities = 46/193 (23%), Positives = 74/193 (38%), Gaps = 4/193 (2%)
Frame = +3
Query: 240 AIKENKCLLITY----SILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTNVLEKDFNGI 407
A KEN CL+IT+ S++ K++F K+ K + N L
Sbjct: 75 ACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFSKSFQKQMQNYLTD----- 129
Query: 408 LNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKEKYQ 587
N AT+ K+ E KCCG +N TD++ + K P CC
Sbjct: 130 -NKTATILDKL----QKENKCCGASNYTDWERIPGM-------AKDRVPDSCC------- 170
Query: 588 YDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXXXXXXF 767
N C D +STI+ GC+ ++ + KN+
Sbjct: 171 -------------INI-TVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFV 216
Query: 768 EIMCIVFACCVMR 806
E++ I+F+CC+++
Sbjct: 217 EVLGIIFSCCLVK 229
>sp|Q96SJ8|TSN18_HUMAN Tetraspanin-18 (Tspan-18)
Length = 248
Score = 52.4 bits (124), Expect = 1e-06
Identities = 52/256 (20%), Positives = 92/256 (35%), Gaps = 1/256 (0%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GA +L +GIWV VD + E++ + +L A +L+
Sbjct: 24 GACLLAIGIWVMVDPTGFREIV--------------AANPLLLTGAYILLAMGGLLFLLG 69
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSL-TNVLEKDF 398
A++ENKCLL+ + + F++NL + T L K +
Sbjct: 70 FLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFI----FRENLTREFFTKELTKHY 125
Query: 399 NGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKE 578
G N + +F+ + ++M CCGVN DF ++ + + P CC+ +E
Sbjct: 126 QG--NNDTDVFSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSEE--VPEACCR-RE 180
Query: 579 KYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXXXX 758
D + C +N GC +++ E +
Sbjct: 181 PQSRD----------GVLLSREECLLGR-SLFLNKQGCYTVILNTFETYVYLAGALAIGV 229
Query: 759 XXFEIMCIVFACCVMR 806
E+ ++FA C+ R
Sbjct: 230 LAIELFAMIFAMCLFR 245
>sp|P41731|CD63_MOUSE CD63 antigen
Length = 238
Score = 50.8 bits (120), Expect = 4e-06
Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 4/193 (2%)
Frame = +3
Query: 240 AIKENKCLLITY----SILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTNVLEKDFNGI 407
A KEN CL+IT+ S++ K++F K+ + + N L+
Sbjct: 75 ACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKD----- 129
Query: 408 LNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKEKYQ 587
N AT+ K+ E CCG +N TD++++ K P CC
Sbjct: 130 -NKTATILDKL----QKENNCCGASNYTDWENIPGM-------AKDRVPDSCC------- 170
Query: 588 YDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMXXXXXXXXXXXXF 767
N C D +STI+ GC+ ++ + KN+
Sbjct: 171 -------------INI-TVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFV 216
Query: 768 EIMCIVFACCVMR 806
E++ I+F+CC+++
Sbjct: 217 EVLGIIFSCCLVK 229
>sp|O60635|TSN1_HUMAN Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
Length = 241
Score = 50.8 bits (120), Expect = 4e-06
Identities = 49/228 (21%), Positives = 80/228 (35%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GA +L VGIWV +D ++ ++ L + F N ++ +V +
Sbjct: 22 GAALLAVGIWVSIDGASFLKIFG--PLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYG-- 77
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTNVLEKDFN 401
A E+KC L+T+ + + L + ++KD+
Sbjct: 78 ------AKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYG 131
Query: 402 GILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKEK 581
+ FT+++ M LKCCG N TDF+ +K S+ +P CC
Sbjct: 132 SQED-----FTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSA------FPPFCC----- 175
Query: 582 YQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKN 725
ND N N+ C + GC L+ I N
Sbjct: 176 -----------NDNVTNTANETCTKQKAHDQ-KVEGCFNQLLYDIRTN 211
>sp|Q5RC27|TSN1_PONPY Tetraspanin-1 (Tspan-1)
Length = 241
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/228 (21%), Positives = 79/228 (34%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
GA +L VGIWV +D ++ ++ L + F N ++ +V +
Sbjct: 22 GAALLAVGIWVSIDGASFLKIFG--PLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYG-- 77
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTNVLEKDFN 401
A E+KC L+T+ + + L + ++KD+
Sbjct: 78 ------AKTESKCALMTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYG 131
Query: 402 GILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYPVGCCKLKEK 581
+ FT+++ M LKCCG N TDF+ K + +P CC
Sbjct: 132 SQED-----FTQVWNTTMKGLKCCGFTNYTDFEDSPYLKENHA------FPPFCC----- 175
Query: 582 YQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKN 725
ND N ND C + + GC L+ I N
Sbjct: 176 -----------NDNITNTANDTCTKQKAEDQ-KVEGCFNQLLYDIRTN 211
>sp|O75954|TSN9_HUMAN Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)
Length = 239
Score = 47.8 bits (112), Expect = 4e-05
Identities = 52/201 (25%), Positives = 80/201 (39%), Gaps = 14/201 (6%)
Frame = +3
Query: 42 GAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLIIXXXXXXXXX 221
G +LGVGIW+ V + N + SF + ++ L V+AI I+
Sbjct: 24 GCGLLGVGIWLSVSQGNFATF---------SPSFPSLSAANL-VIAIGTIVMVTGFLGCL 73
Query: 222 XXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSLTN--VLEKD 395
AIKENKCLL+++ I+ +K +N K L +L
Sbjct: 74 G-----AIKENKCLLLSFFIVLLVILLAELILLILFFVYMDKVNENAKKDLKEGLLLYHT 128
Query: 396 FNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSV------------RNWKSTSSSGT 539
N + NA + I E++CCGV + TD+ V N + + T
Sbjct: 129 ENNVGLKNA------WNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNAT 182
Query: 540 KQIYPVGCCKLKEKYQYDPNK 602
++ GC + K K +D NK
Sbjct: 183 TPLWRTGCYE-KVKMWFDDNK 202
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,109,839
Number of Sequences: 369166
Number of extensions: 1633666
Number of successful extensions: 4241
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4054
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4204
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)