Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_B05
(742 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5R1W6|TKT_PANTR Transketolase (TK) 289 5e-78
sp|Q60HC7|TKT_MACFA Transketolase (TK) 289 5e-78
sp|P29401|TKT_HUMAN Transketolase (TK) 289 6e-78
sp|P50137|TKT_RAT Transketolase (TK) 288 1e-77
sp|Q6B855|TKT_BOVIN Transketolase (TK) 287 2e-77
sp|P40142|TKT_MOUSE Transketolase (TK) (P68) 286 5e-77
sp|P51854|TKT2_HUMAN Transketolase-like 1 (Transketolase 2)... 247 2e-65
sp|Q58092|TKTC_METJA Putative transketolase C-terminal sect... 139 6e-33
sp|P55573|Y4MN_RHISN Hypothetical transketolase family prot... 106 7e-23
sp|Q88QG7|DXS_PSEPK 1-deoxy-D-xylulose-5-phosphate synthase... 90 7e-18
>sp|Q5R1W6|TKT_PANTR Transketolase (TK)
Length = 623
Score = 289 bits (740), Expect = 5e-78
Identities = 140/224 (62%), Positives = 176/224 (78%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FD IRM A+S+++ N GSH GVSIGEDGPSQMALEDLAMFRS+P STVFYPSD VATEK
Sbjct: 397 FDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEK 456
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEAL 360
+VELAANTKGICFIRT RP +IY N+E F++G+AKV+ S++DQ T++ AGVTL+EAL
Sbjct: 457 AVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVILKSKDDQVTVIGAGVTLHEAL 516
Query: 361 KAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSAL 540
AA+ L K +N+RV+D FTIKP+D +L+ A T+G +LTVEDHY EGG+GEAV+SA+
Sbjct: 517 AAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAV 576
Query: 541 ASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAMV 672
E G+ V LAVN VPRSG+P ELL +F ID +I A+ ++
Sbjct: 577 VGEPGITVTHLAVNRVPRSGKPAELLKMFGIDKDAIAQAVRGLI 620
>sp|Q60HC7|TKT_MACFA Transketolase (TK)
Length = 623
Score = 289 bits (740), Expect = 5e-78
Identities = 140/224 (62%), Positives = 177/224 (79%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FD IRM A+S+++ N GSH GVSIGEDGPSQMALEDLAMFRS+P STVFYPSD VATEK
Sbjct: 397 FDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEK 456
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEAL 360
+VELAANTKGICFIRT RP +IY N+E F++G+AKV+ S++DQ T++ AGVTL+EAL
Sbjct: 457 AVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEAL 516
Query: 361 KAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSAL 540
AA++L K +N+RV+D FTIKP+D +L+ A T+G +LTVEDHY EGG+GEAV+SA+
Sbjct: 517 AAAESLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAV 576
Query: 541 ASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAMV 672
E G+ V LAVN VPRSG+P ELL +F ID +I A+ ++
Sbjct: 577 VGEPGITVTHLAVNRVPRSGKPAELLKMFGIDKDAIAQAVKGLI 620
>sp|P29401|TKT_HUMAN Transketolase (TK)
Length = 623
Score = 289 bits (739), Expect = 6e-78
Identities = 140/224 (62%), Positives = 176/224 (78%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FD IRM A+S+++ N GSH GVSIGEDGPSQMALEDLAMFRS+P STVFYPSD VATEK
Sbjct: 397 FDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEK 456
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEAL 360
+VELAANTKGICFIRT RP +IY N+E F++G+AKV+ S++DQ T++ AGVTL+EAL
Sbjct: 457 AVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEAL 516
Query: 361 KAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSAL 540
AA+ L K +N+RV+D FTIKP+D +L+ A T+G +LTVEDHY EGG+GEAV+SA+
Sbjct: 517 AAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAV 576
Query: 541 ASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAMV 672
E G+ V LAVN VPRSG+P ELL +F ID +I A+ ++
Sbjct: 577 VGEPGITVTHLAVNRVPRSGKPAELLKMFGIDRDAIAQAVRGLI 620
>sp|P50137|TKT_RAT Transketolase (TK)
Length = 623
Score = 288 bits (736), Expect = 1e-77
Identities = 140/224 (62%), Positives = 177/224 (79%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FD IRM A+S+++ N GSH GVSIGEDGPSQMALEDLAMFRS+P STVFYPSD VATEK
Sbjct: 397 FDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEK 456
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEAL 360
+VELAANTKGICFIRT RP +IY N+E F++G+AKV+ S++DQ T++ AGVTL+EAL
Sbjct: 457 AVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEAL 516
Query: 361 KAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSAL 540
AA+ L K + VRV+D FTIKP+D++L+ CA T+G +LTVEDHY EGG+GEAV++ +
Sbjct: 517 AAAEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGRILTVEDHYYEGGIGEAVSAVV 576
Query: 541 ASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAMV 672
E GV V +LAV+ VPRSG+P ELL +F ID +I A+ +V
Sbjct: 577 VGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLV 620
>sp|Q6B855|TKT_BOVIN Transketolase (TK)
Length = 623
Score = 287 bits (735), Expect = 2e-77
Identities = 142/224 (63%), Positives = 176/224 (78%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FD IRM A+S+++ N GSH GVSIGEDGPSQMALEDLAMFRSIP STVFYPSD VATEK
Sbjct: 397 FDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSIPMSTVFYPSDGVATEK 456
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEAL 360
+VELAANTKGICFIRT RP +IYK E F+IG+AKV+ +++DQ T++ AGVTL+EAL
Sbjct: 457 AVELAANTKGICFIRTSRPENAIIYKQHEDFQIGQAKVVLKNKDDQVTVIGAGVTLHEAL 516
Query: 361 KAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSAL 540
AAD L + +N+RV+D FTIKP+D++L+ A T+G +LTVEDHY EGG+GEAV SA+
Sbjct: 517 AAADLLKREKINIRVLDPFTIKPLDKKLILDSARATKGRILTVEDHYYEGGIGEAVASAV 576
Query: 541 ASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAMV 672
E GV V +LAV+ VPRSG+P ELL +F ID +I A+ +V
Sbjct: 577 VGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDRDAIAQAVRGLV 620
>sp|P40142|TKT_MOUSE Transketolase (TK) (P68)
Length = 623
Score = 286 bits (731), Expect = 5e-77
Identities = 139/224 (62%), Positives = 178/224 (79%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FD IRM A+S+++ N GSH GVSIGEDGPSQMALEDLAMFRS+P STVFYPSD VATEK
Sbjct: 397 FDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEK 456
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEAL 360
+VELAANTKGICFIRT RP +IY N+E F++G+AKV+ S++DQ T++ AGVTL+EAL
Sbjct: 457 AVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEAL 516
Query: 361 KAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSAL 540
AA++L K +++RV+D FTIKP+D +L+ A T+G +LTVEDHY EGG+GEAV++A+
Sbjct: 517 AAAESLKKDKISIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSAAV 576
Query: 541 ASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAMV 672
E GV V +LAV+ VPRSG+P ELL +F ID +I A+ +V
Sbjct: 577 VGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLV 620
>sp|P51854|TKT2_HUMAN Transketolase-like 1 (Transketolase 2) (TK 2) (Transketolase related
protein)
Length = 557
Score = 247 bits (631), Expect = 2e-65
Identities = 125/241 (51%), Positives = 168/241 (69%), Gaps = 17/241 (7%)
Frame = +1
Query: 1 FDHIRMGAVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEK 180
FDHIR+G +++++ N GSH GVS+G+DG SQMALED+AMFR+IP T+FYP+DAV+TE
Sbjct: 315 FDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEH 374
Query: 181 SVELAANTKGICFIRTGRPNTPVIYKNDEHFEIGKA-----------------KVLRSSQ 309
+V LAAN KG+CFIRT RP T VIY E FEIG+A KVLR
Sbjct: 375 AVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKGVSMLQDSWSSVISYQKVLRHCV 434
Query: 310 NDQATIVSAGVTLYEALKAADTLHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTV 489
+D+ T++ AG+T+YEAL AAD L K + +RV+DLFTIKP+D + A T G ++TV
Sbjct: 435 SDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITV 494
Query: 490 EDHYPEGGLGEAVTSALASEAGVIVKKLAVNGVPRSGQPEELLALFKIDASSIHDAITAM 669
EDHYP+GG+GEAV +A++ + + V LAV+GVP+SG+ EELL ++ I A I A+ M
Sbjct: 495 EDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCM 554
Query: 670 V 672
+
Sbjct: 555 L 555
>sp|Q58092|TKTC_METJA Putative transketolase C-terminal section (TK)
Length = 316
Score = 139 bits (351), Expect = 6e-33
Identities = 81/215 (37%), Positives = 127/215 (59%), Gaps = 6/215 (2%)
Frame = +1
Query: 22 AVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEKSVELAAN 201
A + + +H G+++GEDG S ED+A+ R+IP V P+D T+ + A
Sbjct: 99 AYPKLNVKIVATHAGITVGEDGASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAE 158
Query: 202 TKGICFIRTGRPNTPVIYKNDEH--FEIGKAKVLRSSQNDQATIVSAGVTLYEALKAADT 375
KG ++R R +T +IY+N+E FEIGK K+L ++ TI++ G + EAL+A +
Sbjct: 159 YKGPVYVRMPRRDTEIIYENEEEATFEIGKGKILVDGED--LTIIATGEEVPEALRAGEI 216
Query: 376 LHKSGVNVRVVDLFTIKPIDEELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSALASEAG 555
L ++G++ +V++ TIKPIDEE+++K ++ V+TVEDH GGLG AV +AS
Sbjct: 217 LKENGISAEIVEMATIKPIDEEIIKK----SKDFVVTVEDHSIIGGLGGAVAEVIASNG- 271
Query: 556 VIVKKLAVNGV----PRSGQPEELLALFKIDASSI 648
+ KKL G+ RSG+ +ELL + +D SI
Sbjct: 272 -LNKKLLRIGINDVFGRSGKADELLKYYGLDGESI 305
>sp|P55573|Y4MN_RHISN Hypothetical transketolase family protein y4mN
Length = 345
Score = 106 bits (264), Expect = 7e-23
Identities = 64/158 (40%), Positives = 96/158 (60%), Gaps = 2/158 (1%)
Frame = +1
Query: 85 GPSQMALEDLAMFRSIPGSTVFYPSDAVATEKSVELAANTKGICFIRTGRPNTPVIYKN- 261
GPS A ED+AMFR +P T+ P DA E++V A +G ++R R N P++ +
Sbjct: 146 GPSHQATEDIAMFRGMPNLTIIDPCDASEIEQAVPAIAAHEGPVYMRLLRGNVPLVLEEY 205
Query: 262 DEHFEIGKAKVLRSSQNDQATIVSAGVTLYEALKAADTLHKSGVNVRVVDLFTIKPIDE- 438
FE+GKAK+LR ++ I+S+G+ AL+AA+ L K+G++ V+ + TIKP+DE
Sbjct: 206 GYRFELGKAKLLRDGRD--TLIISSGLMTMRALEAAEELRKNGIDAGVLHVPTIKPLDEA 263
Query: 439 ELLRKCAHETRGHVLTVEDHYPEGGLGEAVTSALASEA 552
+L +CA + R V+ E+H GGLGEAV + L A
Sbjct: 264 TILAECARQGR-LVVVAENHTVIGGLGEAVAATLMRSA 300
>sp|Q88QG7|DXS_PSEPK 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose-5-phosphate
synthase) (DXP synthase) (DXPS)
Length = 631
Score = 89.7 bits (221), Expect = 7e-18
Identities = 76/224 (33%), Positives = 113/224 (50%), Gaps = 9/224 (4%)
Frame = +1
Query: 22 AVSQTDCNFAGSHVGVSIGEDGPSQMALEDLAMFRSIPGSTVFYPSDAVATEKSVELAAN 201
AV D FA G+ +GEDGP+ DL+ R IPG V PSD K +
Sbjct: 415 AVQNLDVLFAIDRAGL-VGEDGPTHAGSYDLSYLRCIPGMLVMTPSDENELRKMLSTGHL 473
Query: 202 TKGICFIRTGR---PNTPVIYKNDEHFEIGKAKVLRSSQNDQATIVSAGVTLYEALKAAD 372
G +R R PN P I + + EIGK V R Q ++ ++ GV L EA++ A+
Sbjct: 474 YNGPAAVRYPRGTGPNAP-ISGDLQPLEIGKGVVRR--QGEKVALLVFGVQLAEAMQVAE 530
Query: 373 TLHKSGVNVRVVDLFTIKPIDEELLRKCA--HETRGHVLTVEDHYPEGGLGEAVTSALAS 546
+N VVD+ +KP+DE L+ + A HE ++T+E++ GG G AV LAS
Sbjct: 531 Q-----INATVVDMRFVKPLDEALVLELAGSHEL---LVTIEENAIMGGAGAAVGEFLAS 582
Query: 547 EAGVIVKKLAVNGVP----RSGQPEELLALFKIDASSIHDAITA 666
+A ++K L G+P +P ++LA +DA+ I ++ A
Sbjct: 583 QA--VLKPLLHLGLPDIYVEHAKPAQMLAECGLDAAGIEASVKA 624
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,341,631
Number of Sequences: 369166
Number of extensions: 1601020
Number of successful extensions: 4963
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4717
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4855
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6679696800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)