Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_A18
(926 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BW91|NUDT9_HUMAN ADP-ribose pyrophosphatase, mitochond... 197 3e-50
sp|Q8BVU5|NUDT9_MOUSE ADP-ribose pyrophosphatase, mitochond... 196 1e-49
sp|Q5XIG0|NUDT9_RAT ADP-ribose pyrophosphatase, mitochondri... 196 1e-49
sp|Q09297|NDX6_CAEEL Putative nudix hydrolase 6 140 4e-33
sp|Q8N2Z3|NUD9P_HUMAN Hypothetical nucleoside diphosphate-l... 121 2e-27
sp|O94759|TRPM2_HUMAN Transient receptor potential cation c... 104 3e-22
sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation c... 102 1e-21
sp|P34641|CED11_CAEEL Ced-11 protein 39 0.021
sp|Q58549|ADPP_METJA ADP-ribose pyrophosphatase (ADP-ribose... 39 0.027
sp|P35942|RRPO_ROTGI RNA-directed RNA polymerase subunit VP... 38 0.035
>sp|Q9BW91|NUDT9_HUMAN ADP-ribose pyrophosphatase, mitochondrial precursor (ADP-ribose
diphosphatase) (Adenosine diphosphoribose
pyrophosphatase) (ADPR-PPase) (ADP-ribose
phosphohydrolase) (Nucleoside diphosphate-linked moiety
X motif 9) (Nudix motif 9)
Length = 350
Score = 197 bits (501), Expect = 3e-50
Identities = 94/165 (56%), Positives = 119/165 (72%), Gaps = 1/165 (0%)
Frame = +1
Query: 364 MTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEE 543
+T WKRD + I VS K IL+FV I RK EWA+PGGMVDPGE ++AT+KREF EE
Sbjct: 175 ITRWKRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEE 234
Query: 544 ALNTLIKTTQEKKELYEKIDYLFVNG-TTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDS 720
ALN+L KT+ EK+E+ EK+ LF IY GYVDDPRNTDNAW+ET AVN+HD+ G+
Sbjct: 235 ALNSLQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEI 294
Query: 721 LAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILKKLVNKHGAHW 855
+ + LEAGDDA ++W+D+N +LKLYASH +K + K AHW
Sbjct: 295 MDNLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHW 339
Score = 103 bits (256), Expect = 9e-22
Identities = 50/114 (43%), Positives = 70/114 (61%)
Frame = +2
Query: 23 HIRCREEFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNKILTSNLTDDDILKNPFA 202
H + R YP K ++R V +E V W V++ +Y+P YT+ +L D +
Sbjct: 62 HNKARTSPYPGSK-VERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNF 120
Query: 203 DINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPV 364
FNE DG ++R+S +G+Y+I +G PRNP GRTG+VGRG L WGPNHAADP+
Sbjct: 121 SPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPI 174
>sp|Q8BVU5|NUDT9_MOUSE ADP-ribose pyrophosphatase, mitochondrial precursor (ADP-ribose
diphosphatase) (Adenosine diphosphoribose
pyrophosphatase) (ADPR-PPase) (ADP-ribose
phosphohydrolase) (Nucleoside diphosphate-linked moiety
X motif 9) (Nudix motif 9)
Length = 350
Score = 196 bits (497), Expect = 1e-49
Identities = 93/165 (56%), Positives = 121/165 (73%), Gaps = 1/165 (0%)
Frame = +1
Query: 364 MTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEE 543
+T WKRDE+ I VS K IL+FV I RK EWA+PGGMVDPGE ++AT+KREF EE
Sbjct: 175 ITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEE 234
Query: 544 ALNTLIKTTQEKKELYEKIDYLFVNG-TTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDS 720
ALN+L K++ EK+E+ EK+ LF IY GYVDDPRNTDNAW+ET AVN+HD+ G++
Sbjct: 235 ALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGET 294
Query: 721 LAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILKKLVNKHGAHW 855
+ + LEAGDDA ++W+D++ +LKLYASH +K + K AHW
Sbjct: 295 MDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEKRDAHW 339
Score = 103 bits (256), Expect = 9e-22
Identities = 50/114 (43%), Positives = 69/114 (60%)
Frame = +2
Query: 23 HIRCREEFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNKILTSNLTDDDILKNPFA 202
H + R YP K ++R V +E V W V++ +Y P YT+ +L D +
Sbjct: 62 HNKARTSPYPGSK-VERSQVPNEKVGWLVEWQDYNPVEYTAVSVLAGPQWADPQISESNF 120
Query: 203 DINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPV 364
FNE DG ++R+S +G+Y+I +G PRNP GRTG+VGRG L WGPNHAADP+
Sbjct: 121 SPKFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPI 174
>sp|Q5XIG0|NUDT9_RAT ADP-ribose pyrophosphatase, mitochondrial precursor (ADP-ribose
diphosphatase) (Adenosine diphosphoribose
pyrophosphatase) (ADPR-PPase) (ADP-ribose
phosphohydrolase) (Nucleoside diphosphate-linked moiety
X motif 9) (Nudix motif 9)
Length = 350
Score = 196 bits (497), Expect = 1e-49
Identities = 93/165 (56%), Positives = 121/165 (73%), Gaps = 1/165 (0%)
Frame = +1
Query: 364 MTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEE 543
+T WKRDE+ I VS K IL+FV I RK EWA+PGGMVDPGE ++AT+KREF EE
Sbjct: 175 ITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEE 234
Query: 544 ALNTLIKTTQEKKELYEKIDYLFVNG-TTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDS 720
ALN+L K++ EK+E+ EK+ LF IY GYVDDPRNTDNAW+ET AVN+HD+ G++
Sbjct: 235 ALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGET 294
Query: 721 LAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILKKLVNKHGAHW 855
+ + LEAGDDA ++W+D++ +LKLYASH +K + K AHW
Sbjct: 295 MDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEKRDAHW 339
Score = 103 bits (256), Expect = 9e-22
Identities = 50/114 (43%), Positives = 69/114 (60%)
Frame = +2
Query: 23 HIRCREEFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNKILTSNLTDDDILKNPFA 202
H + R YP K ++R V +E V W V++ +Y P YT+ +L D +
Sbjct: 62 HNKARTSPYPGSK-VERSKVPNEKVGWLVEWQDYNPVEYTAVSVLAGPQWADPQISESSF 120
Query: 203 DINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPV 364
FNE DG ++R+S +G+Y+I +G PRNP GRTG+VGRG L WGPNHAADP+
Sbjct: 121 SPRFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPI 174
>sp|Q09297|NDX6_CAEEL Putative nudix hydrolase 6
Length = 260
Score = 140 bits (354), Expect = 4e-33
Identities = 71/157 (45%), Positives = 97/157 (61%)
Frame = +1
Query: 373 WKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEEALN 552
W + + I + + L+FV + R + EWA+PGGMVD GE V+ T++REF+EEA++
Sbjct: 111 WGPNHAADPIVSRTNDNGDLEFVAVQRHDNGEWAIPGGMVDAGEHVSQTLRREFAEEAMH 170
Query: 553 TLIKTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDSLAQI 732
++ + E +D L+ NG +Y GYVDDPRNTDNAW+ETV NFHD G L +
Sbjct: 171 GIVDS--------ENLDELWNNGKELYRGYVDDPRNTDNAWMETVVFNFHDSKG-LLKNV 221
Query: 733 KLEAGDDAAAIRWIDLNKELKLYASHLSILKKLVNKH 843
L+AGDDA A+RWI +N LYASH + L H
Sbjct: 222 ALQAGDDAKALRWIAVNSNEPLYASHSHFIDLLKESH 258
Score = 80.5 bits (197), Expect = 6e-15
Identities = 47/118 (39%), Positives = 66/118 (55%), Gaps = 3/118 (2%)
Frame = +2
Query: 20 IHIRCRE-EFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNKILTSNLTDDDILKNP 196
+H +CR + NI R +V D V W+ ++ Y P +T K+ + D +I +
Sbjct: 4 VHQKCRNIDTVYLGSNIHRLNVPDNLVKWSQEWSGYNPPAHTDPKVDGAVWADPEIDEKT 63
Query: 197 FADINFNELDGKIDRRSHHGMY--DIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPV 364
F ++N +DGKI+R S+ Y D V P NP GRTG+ GRG L WGPNHAADP+
Sbjct: 64 FQP-SWNAIDGKINRVSYVCQYSFDPVTLRPLNPIGRTGLSGRGLLGRWGPNHAADPI 120
>sp|Q8N2Z3|NUD9P_HUMAN Hypothetical nucleoside diphosphate-linked moiety X motif 9P1
Length = 120
Score = 121 bits (304), Expect = 2e-27
Identities = 62/123 (50%), Positives = 84/123 (68%), Gaps = 1/123 (0%)
Frame = +1
Query: 487 MVDPGELVTATIKREFSEEALNTLIKTTQEKKELYEKIDYLFVNGT-TIYTGYVDDPRNT 663
MVDPGE ++AT+KREF EEA+N+L K+ +E +EL ++ L +Y GYVDD RNT
Sbjct: 1 MVDPGEKISATLKREFGEEAMNSLQKSRKEMQELERQLHKLLSQEHFEVYKGYVDDSRNT 60
Query: 664 DNAWIETVAVNFHDKDGDSLAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILKKLVNKH 843
DN WIET AVN+ D+ D L LEAGDDA ++W+D+N +L+LYAS ++ + K
Sbjct: 61 DNCWIETEAVNYRDEIMDHL---PLEAGDDAKKVKWVDINDKLELYASLSQFIQLVAEKR 117
Query: 844 GAH 852
GAH
Sbjct: 118 GAH 120
>sp|O94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2
(Long transient receptor potential channel 2) (LTrpC2)
(LTrpC-2) (Transient receptor potential channel 7)
(TrpC7) (Estrogen-responsive element associated gene
protein 1)
Length = 1503
Score = 104 bits (260), Expect = 3e-22
Identities = 59/168 (35%), Positives = 93/168 (55%), Gaps = 4/168 (2%)
Frame = +1
Query: 364 MTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEE 543
+T W+R+E+ I + S K +L+ + + WALPGG +PGE++ +KR
Sbjct: 1352 VTRWRRNEDGAIC--RKSIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRIL--- 1406
Query: 544 ALNTLIKTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDSL 723
++E + + L G +Y GY+DDPRNTDNAWIETVAV+ H +D + +
Sbjct: 1407 -----------RQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDV 1455
Query: 724 ----AQIKLEAGDDAAAIRWIDLNKELKLYASHLSILKKLVNKHGAHW 855
L A D A+IRW +++ + LYA+H ++L+K + GAH+
Sbjct: 1456 ELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY 1503
Score = 89.7 bits (221), Expect = 1e-17
Identities = 46/114 (40%), Positives = 62/114 (54%)
Frame = +2
Query: 23 HIRCREEFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNKILTSNLTDDDILKNPFA 202
H+ R YP + RF V +E VPW +F Y+P YT+ + + + P +
Sbjct: 1239 HVNARHLLYPNCP-VTRFPVPNEKVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLS 1297
Query: 203 DINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPV 364
I +N +DG DRRS HG Y + GLP NP GRTG+ GRG L +GPNH P+
Sbjct: 1298 TIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPM 1351
>sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation channel subfamily M member 2
(Long transient receptor potential channel 2) (LTrpC2)
(LTrpC-2) (Transient receptor potential channel 7)
(TrpC7)
Length = 1507
Score = 102 bits (255), Expect = 1e-21
Identities = 58/175 (33%), Positives = 93/175 (53%), Gaps = 11/175 (6%)
Frame = +1
Query: 364 MTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEE 543
+T WKR++ I + S + +L+ + + WALPGG +PGE++ +KR
Sbjct: 1349 VTRWKRNQGGAIC--RKSVRKMLEVLVMKLPRSEHWALPGGSREPGEMLPRKLKRVL--- 1403
Query: 544 ALNTLIKTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDSL 723
++E + + L + GT +Y GYVDDPRNTDNAWIETVAV+ H +D + +
Sbjct: 1404 -----------RQEFWVAFETLLMQGTEVYKGYVDDPRNTDNAWIETVAVSIHFQDQNDM 1452
Query: 724 AQIKLEAG-----------DDAAAIRWIDLNKELKLYASHLSILKKLVNKHGAHW 855
+LE D + W +++ + LYA+H +IL+K+ + GAH+
Sbjct: 1453 ELKRLEENLHTHDPKELTRDLKLSTEWQVVDRRIPLYANHKTILQKVASLFGAHF 1507
Score = 97.4 bits (241), Expect = 5e-20
Identities = 51/116 (43%), Positives = 67/116 (57%), Gaps = 2/116 (1%)
Frame = +2
Query: 23 HIRCREEFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNK--ILTSNLTDDDILKNP 196
H+ R YP + I RF V +E VPW +F Y+P YT+ K LT + D P
Sbjct: 1237 HVSARHLLYPNAR-IMRFPVPNEKVPWAAEFLIYDPPFYTAEKDVALTDPVGDT---AEP 1292
Query: 197 FADINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPV 364
+ I++N +DG DRRS HG+Y + G P NP GRTG+ GRG L ++GPNH PV
Sbjct: 1293 LSKISYNVVDGPTDRRSFHGVYVVEYGFPLNPMGRTGLRGRGSLSWFGPNHTLQPV 1348
>sp|P34641|CED11_CAEEL Ced-11 protein
Length = 1418
Score = 38.9 bits (89), Expect = 0.021
Identities = 36/114 (31%), Positives = 48/114 (42%), Gaps = 12/114 (10%)
Frame = +2
Query: 41 EFYpreKNIKRFHVSDEYVPWTVDFPEYEPTIYTSNKILTSNLTDDDILKNPFADINFNE 220
E YP E NI + V+ PWTV P Y P Y + D+ K + DI +
Sbjct: 1162 EKYP-ESNILKISVNMVSKPWTVLVPRYNPPFYCK----PAEDFPSDVQK--YVDIATEQ 1214
Query: 221 LDGKIDR----RSHHGMYDIVD--------GLPRNPYGRTGIVGRGCLYYWGPN 346
G++ R R + + D G P NP GRTG+ GRG +G N
Sbjct: 1215 NVGELKRIWRSRQANDVTSSNDKCWKLSAAGFPLNPNGRTGMAGRGNHPRFGAN 1268
>sp|Q58549|ADPP_METJA ADP-ribose pyrophosphatase (ADP-ribose diphosphatase) (Adenosine
diphosphoribose pyrophosphatase) (ADPR-PPase)
(ADP-ribose phosphohydrolase)
Length = 169
Score = 38.5 bits (88), Expect = 0.027
Identities = 44/149 (29%), Positives = 61/149 (40%), Gaps = 1/149 (0%)
Frame = +1
Query: 382 DENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEEALNTLI 561
+++N+I+ K P F G F ALPGG V+ GE V + RE EE
Sbjct: 50 EKDNKILLIKRKNNP---FKGCF-------ALPGGFVECGETVEEAVVREIKEET----- 94
Query: 562 KTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNF-HDKDGDSLAQIKL 738
L K+ L +Y+ DPR +++ F D G +L
Sbjct: 95 -------GLIPKVKSLL----GVYSSPDRDPRG------HVISIVFILDVIGG-----EL 132
Query: 739 EAGDDAAAIRWIDLNKELKLYASHLSILK 825
+AGDDA + DLN KL H I+K
Sbjct: 133 KAGDDAKEAEFFDLNNLPKLAFDHEKIIK 161
>sp|P35942|RRPO_ROTGI RNA-directed RNA polymerase subunit VP1 (Inner layer protein VP1)
(Core protein VP1)
Length = 1159
Score = 38.1 bits (87), Expect = 0.035
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Frame = +1
Query: 541 EALNTLIKTTQEKKELYEKIDYLF-VNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGD 717
E L TL KT E L EKI+ L + T+Y G D RN +W+ T + ++
Sbjct: 56 ELLLTLKKTLDECSTLDEKIETLLRIRYFTVYVGDKSDKRNIIRSWLSTTINRLNVEEYA 115
Query: 718 SLAQIKLEA 744
S+ +I+L+A
Sbjct: 116 SIQEIELQA 124
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,508,957
Number of Sequences: 369166
Number of extensions: 2112065
Number of successful extensions: 6399
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6098
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6380
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9510757740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)