Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_A12
(488 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 67 2e-11
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 67 2e-11
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 66 5e-11
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 60 3e-09
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 59 8e-09
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 57 2e-08
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 57 2e-08
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 55 9e-08
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 54 1e-07
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 54 2e-07
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 67.4 bits (163), Expect = 2e-11
Identities = 41/131 (31%), Positives = 70/131 (53%), Gaps = 2/131 (1%)
Frame = +3
Query: 18 NVYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIAL 191
++YS+PFY+ FGYKM R L+ G+ T+LS++F ++ GE D L WP ++++++ L
Sbjct: 439 SLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLML 498
Query: 192 MDQRNNTIHTCKTYCVNTVAENFKEIFQKPAFRKLGEDYYYGSETLININSIMNNAKLYK 371
MDQ ++ H + + + +FK KP GE + +++ N K
Sbjct: 499 MDQGSSRRHLGDAFKPDPNSSSFK----KPT----GEMNIASGCPVFVAQTVLENGTYIK 550
Query: 372 KDSIVIKCFVE 404
D+I IK V+
Sbjct: 551 DDTIFIKVIVD 561
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 67.4 bits (163), Expect = 2e-11
Identities = 41/131 (31%), Positives = 70/131 (53%), Gaps = 2/131 (1%)
Frame = +3
Query: 18 NVYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIAL 191
++YS+PFY+ FGYKM R L+ G+ T+LS++F ++ GE D L WP ++++++ L
Sbjct: 438 SLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLML 497
Query: 192 MDQRNNTIHTCKTYCVNTVAENFKEIFQKPAFRKLGEDYYYGSETLININSIMNNAKLYK 371
MDQ ++ H + + + +FK KP GE + +++ N K
Sbjct: 498 MDQGSSRRHLGDAFKPDPNSSSFK----KPT----GEMNIASGCPVFVAQTVLENGTYIK 549
Query: 372 KDSIVIKCFVE 404
D+I IK V+
Sbjct: 550 DDTIFIKVIVD 560
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 65.9 bits (159), Expect = 5e-11
Identities = 40/133 (30%), Positives = 74/133 (55%), Gaps = 4/133 (3%)
Frame = +3
Query: 18 NVYSKPFYSF--GYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIAL 191
+V+S+PFY+ GY++ RA L+ +G+ T+LS+YF ++ GE D L WP +R+++ L
Sbjct: 427 SVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLML 486
Query: 192 MDQRNNTIHTCKTYCVNTVAENFKEIFQKPAFRKLGE-DYYYGSETLININSIMNNAKLY 368
+DQ H +T+ + + +FK R GE + G ++ +++ N+ Y
Sbjct: 487 LDQSGKKNHIVETFKADPNSSSFK--------RPDGEMNIASGCPRFVSHSTLENSKNTY 538
Query: 369 -KKDSIVIKCFVE 404
K D++ +K V+
Sbjct: 539 IKDDTLFLKVAVD 551
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 60.1 bits (144), Expect = 3e-09
Identities = 30/91 (32%), Positives = 57/91 (62%), Gaps = 6/91 (6%)
Frame = +3
Query: 12 NTNVYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISI 185
N +S FY+ +GYK+++ A+L+ + +GE T+LS+Y +L G D+ L WP+ RR++
Sbjct: 329 NLECFSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTF 388
Query: 186 ALMDQRNNTI----HTCKTYCVNTVAENFKE 266
+L+DQ + + H +T+ + +NF++
Sbjct: 389 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQK 419
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 58.5 bits (140), Expect = 8e-09
Identities = 28/83 (33%), Positives = 50/83 (60%), Gaps = 2/83 (2%)
Frame = +3
Query: 21 VYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIALM 194
++S FY+ +GYKM LR L+ G T+LS++F +++G ND L WP +++++ L+
Sbjct: 376 IFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLL 435
Query: 195 DQRNNTIHTCKTYCVNTVAENFK 263
DQ NN H + + + +F+
Sbjct: 436 DQ-NNREHVIDAFRPDVTSSSFQ 457
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 57.0 bits (136), Expect = 2e-08
Identities = 30/91 (32%), Positives = 55/91 (60%), Gaps = 6/91 (6%)
Frame = +3
Query: 12 NTNVYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISI 185
N +S FY+ +GYK+++ A L+ + +GE T+LS+Y +L G D+ L WP RR++
Sbjct: 329 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF 388
Query: 186 ALMDQRNNTI----HTCKTYCVNTVAENFKE 266
+L+DQ + + H +T+ + +NF++
Sbjct: 389 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQK 419
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 57.0 bits (136), Expect = 2e-08
Identities = 27/83 (32%), Positives = 49/83 (59%), Gaps = 2/83 (2%)
Frame = +3
Query: 21 VYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIALM 194
++S FY+ +GYKM LR L+ G T+LS++F +++G ND L WP +++++ L+
Sbjct: 376 IFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLL 435
Query: 195 DQRNNTIHTCKTYCVNTVAENFK 263
D NN H + + + +F+
Sbjct: 436 D-HNNREHVIDAFRPDVTSSSFQ 457
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 55.1 bits (131), Expect = 9e-08
Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 5/134 (3%)
Frame = +3
Query: 18 NVYSKPFYSF--GYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIAL 191
+++S+ FY+ GY++ RA L+ +G ++LS+YF ++ GE D L WP +R+++ L
Sbjct: 427 SIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLML 486
Query: 192 MDQRNNTIHTCKTYCVNTVAENFKEIFQKPAFRKL-GEDYYYGSETLININSIMNNAK-- 362
+DQ + E FK +F++ GE +S++ NAK
Sbjct: 487 LDQSGK----------KNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNA 536
Query: 363 LYKKDSIVIKCFVE 404
K D++ +K V+
Sbjct: 537 YIKDDTLFLKVAVD 550
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 3/132 (2%)
Frame = +3
Query: 18 NVYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIAL 191
+++S FY+ +GYK+ LR L+ G+ T+LS++ ++ GE D L WP +++ L
Sbjct: 290 SLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFML 349
Query: 192 MDQRNNTIHTCKTYCVNTVAENFKEIFQKPAFRKLGEDYYYGSETLININSIMNNAKLY- 368
+DQ NN H + + + + FQ+P + + G ++ + + Y
Sbjct: 350 LDQ-NNREHAIDAFRPDLSSAS----FQRP---QSETNVASGCPLFFPLSKLQSPKHAYV 401
Query: 369 KKDSIVIKCFVE 404
K D++ +KC VE
Sbjct: 402 KDDTMFLKCIVE 413
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/132 (26%), Positives = 68/132 (51%), Gaps = 3/132 (2%)
Frame = +3
Query: 18 NVYSKPFYS--FGYKMRLRANLSRHQNGESTYLSVYFSLLEGENDDTLLWPMERRISIAL 191
+++S FY+ +GYK+ LR L+ +G+ T+LS++ ++ GE D L WP +++ L
Sbjct: 283 SLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFML 342
Query: 192 MDQRNNTIHTCKTYCVNTVAENFKEIFQKPAFRKLGEDYYYGSETLININSIMNNAKLY- 368
+DQ NN H + + + + FQ+P + + G ++ + + Y
Sbjct: 343 LDQ-NNREHAIDAFRPDLSSAS----FQRP---QSETNVASGCPLFFPLSKLQSPKHAYV 394
Query: 369 KKDSIVIKCFVE 404
K D++ +KC V+
Sbjct: 395 KDDTMFLKCIVD 406
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,818,411
Number of Sequences: 369166
Number of extensions: 1028733
Number of successful extensions: 2725
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2681
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2721
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2970720600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)