Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_A01
(865 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9V7P1|WDR50_DROME Hypothetical WD-repeat protein l(2)k0... 105 1e-22
sp|Q5SSI6|WDR50_MOUSE WD-repeat protein 50 103 5e-22
sp|Q9Y5J1|WDR50_HUMAN WD-repeat protein 50 100 5e-21
sp|Q9FMU5|WDR50_ARATH WD-repeat protein At5g14050 98 3e-20
sp|P78750|UTP18_SCHPO Probable U3 small nucleolar RNA-assoc... 83 9e-16
sp|P42000|WDR50_CAEEL Hypothetical WD-repeat protein B0280.... 74 7e-13
sp|P40362|UTP18_YEAST U3 small nucleolar RNA-associated pro... 70 1e-11
sp|Q8BU03|PWP2_MOUSE Periodic tryptophan protein 2 homolog 41 0.004
sp|Q5ABA6|ATG18_CANAL Autophagy-related protein 18 41 0.004
sp|P73594|Y1409_SYNY3 Hypothetical WD-repeat protein slr1409 40 0.006
>sp|Q9V7P1|WDR50_DROME Hypothetical WD-repeat protein l(2)k07824
Length = 506
Score = 105 bits (263), Expect = 1e-22
Identities = 69/213 (32%), Positives = 111/213 (52%), Gaps = 2/213 (0%)
Frame = +3
Query: 96 IRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVKSMAFSHNGKYLHVFEVQ 275
+ R EVSP G ++V + + +I +++ +T + H + G VK +S + K + V
Sbjct: 295 MHRFEVSPCGKFIVTAGKFGAIHLLTAKTNELLHSFKQEGKVKGFTWSSDSKRILVCGST 354
Query: 276 GQISVFEFKENIFSRPVFLRRWTDYGCVNAVKITISPDNKYVACGS-SGVVNIYKFTDTW 452
+SV ++N+ +F+ D GC++ I +SP+ + +A GS GVVNIY + +
Sbjct: 355 SNVSVLNLRQNLIEH-IFM----DDGCIHGESIQLSPNQRLLATGSQEGVVNIYDYESIF 409
Query: 453 QTKFPKPIKEIQYQEGRINQLLFNNSSKILAVGYCLTNDMNNGRFKLIHMDSLTVFSNFP 632
+K P+P K I L FN+SS++LA+ C + N FKL H S TV+SNFP
Sbjct: 410 ASKAPQPEKRFMNLRTAITDLQFNHSSELLAM--CSSEAPN--AFKLAHFPSATVYSNFP 465
Query: 633 GP-VGTSRPTSLSFSPNDKYLAVGRFNGKVTTF 728
TS++FSP+ +LA +V F
Sbjct: 466 AQNEKVGFVTSMAFSPHSSFLAFATKGKQVPLF 498
>sp|Q5SSI6|WDR50_MOUSE WD-repeat protein 50
Length = 552
Score = 103 bits (258), Expect = 5e-22
Identities = 69/218 (31%), Positives = 113/218 (51%), Gaps = 3/218 (1%)
Frame = +3
Query: 84 KTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVKSMAFSHNGKYLHV 263
K +++ EVSP G +++ S ++S +T + ++++G + + FS + K ++
Sbjct: 336 KEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKINGRIAASTFSSDSKRIYT 395
Query: 264 FEVQGQISVFEFKENIFSRPVFLRRWTDYGCVNAVKITISPDNKYVACGS-SGVVNIYKF 440
+ G++ V++ + SR + R+ D G + + I S + +YVACGS SGVVNIY
Sbjct: 396 YSENGEVYVWD----VNSRKC-MNRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQ 450
Query: 441 TDTWQTKFPKPIKEIQYQEGRINQLLFNNSSKILAVGYCLTNDMNNGRFKLIHMDSLTVF 620
Q PKPIK I + L FN +++ILAV + M +L+H+ S TVF
Sbjct: 451 DSCLQQTNPKPIKAIMNLVTGVTSLAFNPTTEILAVA---SRKMKEA-VRLVHLPSCTVF 506
Query: 621 SNFP--GPVGTSRPTSLSFSPNDKYLAVGRFNGKVTTF 728
SNFP SR ++ FSP Y A+G G+ +
Sbjct: 507 SNFPVFKKSTLSRVQTMDFSPRGGYFALGNEKGRALMY 544
>sp|Q9Y5J1|WDR50_HUMAN WD-repeat protein 50
Length = 556
Score = 100 bits (249), Expect = 5e-21
Identities = 67/218 (30%), Positives = 111/218 (50%), Gaps = 3/218 (1%)
Frame = +3
Query: 84 KTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVKSMAFSHNGKYLHV 263
K +R EVSP G +++ + + +++ +T + ++++G V + FS + K ++
Sbjct: 340 KEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYA 399
Query: 264 FEVQGQISVFEFKENIFSRPVFLRRWTDYGCVNAVKITISPDNKYVACGSS-GVVNIYKF 440
G++ V++ + SR L R+ D G + + I S + +YVACGS+ GVVNIY
Sbjct: 400 SSGDGEVYVWD----VNSRKC-LNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQ 454
Query: 441 TDTWQTKFPKPIKEIQYQEGRINQLLFNNSSKILAVGYCLTNDMNNGRFKLIHMDSLTVF 620
Q PKPIK I + L FN +++ILA+ ++ +L+H+ S TVF
Sbjct: 455 DSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAI----ASEKMKEAVRLVHLPSCTVF 510
Query: 621 SNFP--GPVGTSRPTSLSFSPNDKYLAVGRFNGKVTTF 728
SNFP S ++ FSP Y A+G GK +
Sbjct: 511 SNFPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMY 548
>sp|Q9FMU5|WDR50_ARATH WD-repeat protein At5g14050
Length = 546
Score = 98.2 bits (243), Expect = 3e-20
Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 2/214 (0%)
Frame = +3
Query: 93 NIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVKSMAFSHNGKYLHVFEV 272
++ EVS + + F I +VST+T + L+++G+V+S+AFS +GK+L
Sbjct: 335 SLEYFEVSQDSNTIAFVGNEGYILLVSTKTKELIGTLKMNGSVRSLAFSEDGKHLLSSGG 394
Query: 273 QGQISVFEFKENIFSRPVFLRRWTDYGCVNAVKITISPDNKYVACGSS-GVVNIYKFTDT 449
GQ+ V++ + L + D G + S + A G+ G+VNIYK ++
Sbjct: 395 DGQVYVWDLR-----TMKCLYKGVDEGSTCGTSLCSSLNGALFASGTDRGIVNIYKKSEF 449
Query: 450 WQTKFPKPIKEIQYQEGRINQLLFNNSSKILAVGYCLTNDMNNGRFKLIHMDSLTVFSNF 629
K KPIK + +I+ + FN+ ++ILA+ + MN KL+H+ SLTVFSN+
Sbjct: 450 VGGK-RKPIKTVDNLTSKIDFMKFNHDAQILAI----VSTMNKNSVKLVHVPSLTVFSNW 504
Query: 630 PGPVGTSR-PTSLSFSPNDKYLAVGRFNGKVTTF 728
P P T P L FSP ++A+G GKV +
Sbjct: 505 PPPNSTMHYPRCLDFSPGSGFMAMGNAAGKVLLY 538
>sp|P78750|UTP18_SCHPO Probable U3 small nucleolar RNA-associated protein 18 (U3
snoRNA-associated protein 18)
Length = 556
Score = 83.2 bits (204), Expect = 9e-16
Identities = 65/250 (26%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Frame = +3
Query: 3 RLVIFTNRSYYKVWHITNGNITDHNISKT-------SNIRRLEVSPAGDYMVFSSENSSI 161
R++ R Y +W + + + +S+ ++ R V P G Y+ + I
Sbjct: 275 RVIAAGRRKYMYIWDLESAQV--QKVSRMYGQENFQPSMERFHVDPTGKYIALEGRSGHI 332
Query: 162 EVVSTQTFLVCHKLQVSGAVKSMAFSHNGKYLHVFEVQGQISVFEFKENIFSRPVFLRRW 341
++ T ++ G + + F+ +G + V ++ F N+ R V +RRW
Sbjct: 333 NLLHALTGQFATSFKIEGVLSDVLFTSDGSEMLVLSYGAEVWHF----NVEQRSV-VRRW 387
Query: 342 TDYGCVNAVKITISPDNKYVACGS-SGVVNIYKFTDTWQTKFPKPIKEIQYQEGRINQLL 518
V+ + P NKY+A GS SG+VNIY + PKP+ + IN +
Sbjct: 388 QVQDGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSNADAAPKPVTTLDNITFSINSMS 447
Query: 519 FNNSSKILAVGYCLTNDMNNGRFKLIHMDSLTVFSNFP---GPVGTSRPTSLSFSPNDKY 689
F+ S++LA+ D +L+H+ S +VF N+P P+G R T L+F +
Sbjct: 448 FSQDSQVLAIASRGKKD----TLRLVHVPSFSVFRNWPTSATPLG--RVTCLAFGKGGE- 500
Query: 690 LAVGRFNGKV 719
L VG G+V
Sbjct: 501 LCVGNEAGRV 510
>sp|P42000|WDR50_CAEEL Hypothetical WD-repeat protein B0280.9 in chromosome III
Length = 429
Score = 73.6 bits (179), Expect = 7e-13
Identities = 54/222 (24%), Positives = 100/222 (45%), Gaps = 4/222 (1%)
Frame = +3
Query: 75 NISKTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVKSMAF--SHNG 248
N IR +S ++ + NS I V+ + + + + F SH+
Sbjct: 207 NTVPKQGIRLFAISHDSQFLAIAGHNSHIYVLHATSMEHITTISLPANASEIKFFPSHSR 266
Query: 249 KYLHVFEVQGQISVFEFKENIFSRPVFLRRWTDYGCVNAVKITISPDNKYVACGS-SGVV 425
+ + E GQI + + +TD G V+ + IS Y A GS +G+V
Sbjct: 267 EIWIICET-GQIVIANI--GLPGTKSSQHTFTDDGAVHGTTLAISQHGDYFATGSDTGIV 323
Query: 426 NIYKFTDTWQTKFPKPIKEIQYQEGRINQLLFNNSSKILAVGYCLTNDMNNGRFKLIHMD 605
N+Y D + P+P+ + ++ + FN+ ++++A+ +++ + +L+H+
Sbjct: 324 NVYSGNDCRNSTNPRPLFNVSNLVTAVSSIAFNSDAQLMAI----CSNVKDNHLRLVHVA 379
Query: 606 SLTVFSNFPGPVG-TSRPTSLSFSPNDKYLAVGRFNGKVTTF 728
S T F NFP G + + FSPN Y+AVG +G++ F
Sbjct: 380 SQTTFKNFPERNGKVTHARCVEFSPNGGYMAVGNDDGRLHVF 421
>sp|P40362|UTP18_YEAST U3 small nucleolar RNA-associated protein 18 (U3 snoRNA-associated
protein 18)
Length = 594
Score = 69.7 bits (169), Expect = 1e-11
Identities = 58/238 (24%), Positives = 104/238 (43%), Gaps = 26/238 (10%)
Frame = +3
Query: 84 KTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVKSMAFSHN----GK 251
K ++++ + + ++ N I ++ + + L ++ G + + GK
Sbjct: 359 KVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGK 418
Query: 252 Y---LHVFEVQGQISVFEFKENIFSRPVFLRRWTDYGCVNAVKITIS------------- 383
+ L G++ F+ +N +RRW D G V KI +
Sbjct: 419 FRTILIAVNAYGEVWEFDLNKNGH----VIRRWKDQGGVGITKIQVGGGTTTTCPALQIS 474
Query: 384 --PDNKYVACGS-SGVVNIYKFTDTWQTKFPKPIKEIQYQEGRINQLLFNNSSKILAVGY 554
N+++A GS SG VN+Y + + P P+ + I+ L F+ +IL
Sbjct: 475 KIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQIL---- 530
Query: 555 CLTNDMNNGRFKLIHMDSLTVFSNFPG---PVGTSRPTSLSFSPNDKYLAVGRFNGKV 719
C+ + +L+H+ S +VFSN+P P+G + TS++FSP+ LAVG GKV
Sbjct: 531 CMASRAVKDALRLVHLPSCSVFSNWPTSGTPLG--KVTSVAFSPSGGLLAVGNEQGKV 586
>sp|Q8BU03|PWP2_MOUSE Periodic tryptophan protein 2 homolog
Length = 919
Score = 41.2 bits (95), Expect = 0.004
Identities = 46/212 (21%), Positives = 84/212 (39%), Gaps = 6/212 (2%)
Frame = +3
Query: 105 LEVSPAGDYMVFSSENSSIEVVSTQT-FLVCHKLQVSGAVKSMAFSHNGKYLHVFEVQGQ 281
L SP G Y+V ++ ++V +T + F + S V + F+ G + + G
Sbjct: 379 LAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGT 438
Query: 282 ISVFEFKENIFSRPVFLRRWTDYGCVNAVKITISPDNKYVACGSSGVVNIYKFTDTWQTK 461
+ F+ R R T + CV + + V+ G+ I+ W +
Sbjct: 439 VRAFDLHRYRNFRTFTSPRPTQFSCV-----AVDSSGEIVSAGAQDSFEIF----VWSMQ 489
Query: 462 FPKPIKEIQYQEGRINQLLFNNSSKILAVGYC-----LTNDMNNGRFKLIHMDSLTVFSN 626
+ + + EG ++ L FN ILA L + ++ R K ++LT+
Sbjct: 490 TGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMFDSWRTK----ETLTL--- 542
Query: 627 FPGPVGTSRPTSLSFSPNDKYLAVGRFNGKVT 722
TS +++F P+ LAV N ++T
Sbjct: 543 ------TSDALAVTFRPDGAELAVATLNSQIT 568
Score = 30.4 bits (67), Expect = 6.7
Identities = 18/71 (25%), Positives = 33/71 (46%)
Frame = +3
Query: 39 VWHITNGNITDHNISKTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGA 218
V+ + N ++ NI+ + +SP G + E + +VS V H G+
Sbjct: 39 VFDLKNNRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGS 98
Query: 219 VKSMAFSHNGK 251
V S++FS +G+
Sbjct: 99 VHSVSFSPDGR 109
>sp|Q5ABA6|ATG18_CANAL Autophagy-related protein 18
Length = 558
Score = 41.2 bits (95), Expect = 0.004
Identities = 44/155 (28%), Positives = 71/155 (45%), Gaps = 15/155 (9%)
Frame = +3
Query: 51 TNG--NITDHNISKTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSGAVK 224
TNG N T +NIS SN + GD ++F+ +S++ +S + HK +
Sbjct: 207 TNGGSNSTQNNISSVSNTP----NRVGDVIIFNL--TSLQPISV---IEAHK----STIA 253
Query: 225 SMAFSHNGKYL----------HVFEVQGQISVFEFKENIFSRPVFLRRWTDYGCVNAVKI 374
SMAFS+NG YL +FEV +++F+ + ++ R+
Sbjct: 254 SMAFSNNGLYLATASDKGTIVRIFEVATGTKLYQFRRGTYPTKIYSLRF----------- 302
Query: 375 TISPDNKYV-ACGSSGVVNIYKF--TDTWQTKFPK 470
S D+KYV A SS V+I++ + +TK K
Sbjct: 303 --SADDKYVLATSSSLTVHIFRLGEEEALETKHKK 335
>sp|P73594|Y1409_SYNY3 Hypothetical WD-repeat protein slr1409
Length = 326
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/86 (24%), Positives = 43/86 (50%)
Frame = +3
Query: 36 KVWHITNGNITDHNISKTSNIRRLEVSPAGDYMVFSSENSSIEVVSTQTFLVCHKLQVSG 215
K+W++ I ++ + T + + P G+++ +S++ +I L+ V+
Sbjct: 237 KLWNLAGELIHEYKVVPTGWVNSAQFYPKGEWLATASDDGTIRFWQKDGQLIYELPLVNA 296
Query: 216 AVKSMAFSHNGKYLHVFEVQGQISVF 293
+ S++FS +GK L QGQ+ VF
Sbjct: 297 RLTSLSFSPDGKQLAATSSQGQVWVF 322
Score = 32.3 bits (72), Expect = 1.8
Identities = 21/68 (30%), Positives = 32/68 (47%)
Frame = +3
Query: 525 NSSKILAVGYCLTNDMNNGRFKLIHMDSLTVFSNFPGPVGTSRPTSLSFSPNDKYLAVGR 704
NS++ G L ++G + D ++ P+ +R TSLSFSP+ K LA
Sbjct: 258 NSAQFYPKGEWLATASDDGTIRFWQKDGQLIYEL---PLVNARLTSLSFSPDGKQLAATS 314
Query: 705 FNGKVTTF 728
G+V F
Sbjct: 315 SQGQVWVF 322
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,244,403
Number of Sequences: 369166
Number of extensions: 1855640
Number of successful extensions: 5256
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4939
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5220
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)