Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_P07
(664 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 224 2e-58
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 223 3e-58
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 221 1e-57
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 220 3e-57
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 218 9e-57
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 216 3e-56
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 215 7e-56
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 215 7e-56
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 214 2e-55
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 209 5e-54
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 224 bits (571), Expect = 2e-58
Identities = 110/192 (57%), Positives = 134/192 (69%), Gaps = 2/192 (1%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS LMDNAFRYIKD G I++E
Sbjct: 150 AFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTE 209
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY A D +C N + GFTDI +E +A AVATVGPVSVAIDA H SFQ
Sbjct: 210 KSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQF 269
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQ 559
Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQ
Sbjct: 270 YSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQ 329
Query: 560 CGIATMASYPLV 595
CGIA+ +SYPLV
Sbjct: 330 CGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 223 bits (568), Expect = 3e-58
Identities = 111/192 (57%), Positives = 131/192 (68%), Gaps = 2/192 (1%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FS+TG+LEGQ+FRK L+S SEQ LVDCS LMDNAFRYIKD G I++E
Sbjct: 148 AFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTE 207
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY D +C N + I TGF DI +E + AVAT+GPVSVAIDA H SFQL
Sbjct: 208 KSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQL 267
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQ 559
Y G+YNE C LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQ
Sbjct: 268 YSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQ 327
Query: 560 CGIATMASYPLV 595
CGIAT +SYP V
Sbjct: 328 CGIATASSYPTV 339
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 221 bits (563), Expect = 1e-57
Identities = 113/192 (58%), Positives = 131/192 (68%), Gaps = 2/192 (1%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ FRK +L+S SEQ LVD S LMDNAF+YIK+ G ++SE
Sbjct: 27 AFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSE 86
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY ATD +C P K TGF DI Q E L AVATVGP+SVAIDAGH+SFQ
Sbjct: 87 ESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQF 145
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQ 559
YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG GY+KM+KD+ N
Sbjct: 146 YKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNH 205
Query: 560 CGIATMASYPLV 595
CGIAT ASYP V
Sbjct: 206 CGIATAASYPTV 217
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 220 bits (560), Expect = 3e-57
Identities = 104/191 (54%), Positives = 137/191 (71%), Gaps = 1/191 (0%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESE 202
+FS TGSLEGQ+F K LIS +EQQLVDCS M++AF YIK + GI++E
Sbjct: 133 AFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTE 192
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY A DG+C+ + + + C+G T+I S +ET L AV +GP+SV IDA H+SFQ
Sbjct: 193 AAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQF 252
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQC 562
Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++ N C
Sbjct: 253 YSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNC 312
Query: 563 GIATMASYPLV 595
GIAT+ASYPLV
Sbjct: 313 GIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 218 bits (556), Expect = 9e-57
Identities = 112/195 (57%), Positives = 131/195 (67%), Gaps = 5/195 (2%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G ++SE
Sbjct: 140 AFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSE 199
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 200 ESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLF 258
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMSKDK 550
YK GIY E CS+ +DHGVL VGYG + KYW+VKNSW WG GY+KM+KD+
Sbjct: 259 YKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDR 318
Query: 551 KNQCGIATMASYPLV 595
+N CGIA+ ASYP V
Sbjct: 319 RNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 216 bits (551), Expect = 3e-56
Identities = 114/196 (58%), Positives = 130/196 (66%), Gaps = 6/196 (3%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G ++SE
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSE 199
Query: 203 GDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 379
YPY ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SFQ
Sbjct: 200 ESYPYLATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSFQ 258
Query: 380 LYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSKD 547
YKSGIY + CS LDHGVL VGYG + K+WIVKNSW WG +GY+KM+KD
Sbjct: 259 FYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKD 318
Query: 548 KKNQCGIATMASYPLV 595
+ N CGIAT ASYP V
Sbjct: 319 QNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 215 bits (548), Expect = 7e-56
Identities = 108/195 (55%), Positives = 127/195 (65%), Gaps = 5/195 (2%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+K+ G ++SE
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSE 199
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY A D CK P V TGFT + E L AVATVGP+SVA+DAGH+SFQ
Sbjct: 200 ESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQF 259
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKDK 550
YKSGIY E CS+ LDHGVL VGYG KYW+VKNSW WG +GY+K++KDK
Sbjct: 260 YKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDK 319
Query: 551 KNQCGIATMASYPLV 595
N CGIAT ASYP V
Sbjct: 320 NNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 215 bits (548), Expect = 7e-56
Identities = 112/195 (57%), Positives = 129/195 (66%), Gaps = 5/195 (2%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD G ++SE
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSE 199
Query: 203 GDYPYTATDG-TCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 379
YPY D TC P TGF D+ Q E L AVAT+GP+SVAIDAGH SFQ
Sbjct: 200 ESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSFQ 258
Query: 380 LYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGYIKMSKDK 550
YKSGIY + CS+ LDHGVL VGY GT K+WIVKNSW WG +GY+KM+KD+
Sbjct: 259 FYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQ 318
Query: 551 KNQCGIATMASYPLV 595
N CGIAT ASYP V
Sbjct: 319 NNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 214 bits (545), Expect = 2e-55
Identities = 106/191 (55%), Positives = 134/191 (70%), Gaps = 1/191 (0%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ+F KN+ L+S SEQQLVDCS M +AF YIKD G I++E
Sbjct: 132 AFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTE 191
Query: 203 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQL 382
YPY A D +C+ + + I CTG ++Q E L AV+ VGP+SVAIDA H SFQ
Sbjct: 192 SSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQF 250
Query: 383 YKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQC 562
Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++ N C
Sbjct: 251 YSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNC 310
Query: 563 GIATMASYPLV 595
GIA+ SYP V
Sbjct: 311 GIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 209 bits (532), Expect = 5e-54
Identities = 108/196 (55%), Positives = 130/196 (66%), Gaps = 6/196 (3%)
Frame = +2
Query: 26 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESE 202
+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G +++E
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTE 199
Query: 203 GDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 379
YPY + +C P TGF DI Q E L AVATVGP+SVAIDAGH+SFQ
Sbjct: 200 ESYPYLGRETNSCTYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQ 258
Query: 380 LYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSKD 547
YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG +GY+KM+KD
Sbjct: 259 FYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAKD 318
Query: 548 KKNQCGIATMASYPLV 595
+ N CGI+T ASYP V
Sbjct: 319 QNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,490,993
Number of Sequences: 369166
Number of extensions: 1380432
Number of successful extensions: 4353
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3855
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3941
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5560129980
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)