Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_P03
(833 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 (Preseni... 75 2e-13
sp|Q8JHE9|APH1B_BRARE Gamma-secretase subunit Aph-1b (Anter... 55 3e-07
sp|Q96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A (APH-1... 43 0.001
sp|Q07283|TRHY_HUMAN Trichohyalin 43 0.001
sp|Q8BVF7|APH1A_MOUSE Gamma-secretase subunit APH-1A (APH-1... 42 0.002
sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C 40 0.010
sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B (APH-1... 39 0.014
sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B (APH-1... 39 0.014
sp|Q5RDM3|APH1B_PONPY Gamma-secretase subunit APH-1B (APH-1... 39 0.014
sp|Q87M02|IF2_VIBPA Translation initiation factor IF-2 36 0.15
>sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor)
Length = 238
Score = 75.1 bits (183), Expect = 2e-13
Identities = 60/242 (24%), Positives = 89/242 (36%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXYAVVPLK 212
M E GC +FG P L +FTI P+R+I YA++PLK
Sbjct: 1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLW-YALIPLK 59
Query: 213 SKLAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLIMFDLKSSEPSTDRSLTSNIDIATTS 392
LAFG+VFSV FQEA R++ L ++G+ + D + ++ + S + S
Sbjct: 60 EFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIIS 119
Query: 393 NNINYHRDGEEGNKPLIASDKSTEDIFNVTMFAYVXXXXXXXXXXXXXXXNMLVALRGPG 572
MFA V N+L + GPG
Sbjct: 120 G-----------------------------MFALV---------------NVLADMSGPG 135
Query: 573 TLGYFGQSADFIDFYAAQTXXXXXXXXXXXXXMSKAYQARSLVKFGAILLVHMLYSCLTL 752
T+G G + F AAQ A+ + + G ++ H+ S +TL
Sbjct: 136 TMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVFSHLFVSLITL 195
Query: 753 AN 758
N
Sbjct: 196 LN 197
>sp|Q8JHE9|APH1B_BRARE Gamma-secretase subunit Aph-1b (Anterior-pharynx-defective protein
1b)
Length = 258
Score = 54.7 bits (130), Expect = 3e-07
Identities = 63/270 (23%), Positives = 90/270 (33%), Gaps = 17/270 (6%)
Frame = +3
Query: 54 GCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXYAVVPLKSK----- 218
GC +FG I L +FTI PLRVI + V + +K
Sbjct: 8 GCTFIAFGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQISNKNSATQ 67
Query: 219 ----LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLIMFDLKSSEPSTDRSLTSNIDIAT 386
L FG+V SV+ QEA R+ + L K + G+ +
Sbjct: 68 QRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLLAL----------------------- 104
Query: 387 TSNNINYHRDGEEGNKPLIASDKSTEDIFNVTM--FAYVXXXXXXXXXXXXXXXNMLVAL 560
S ED ++M AYV N+L
Sbjct: 105 -----------------------SQEDTMPISMRQLAYVSGLGFGFMSGAFSVVNILSDS 141
Query: 561 RGPGTLGYFGQSADFIDFYAAQTXXXXXXXXXXXXXMSKAYQARSLVKFGAILLVHMLYS 740
GPGT+G G+S + A T +A + + GA++ H++ S
Sbjct: 142 LGPGTVGIHGESQHYFISSAFMTLAIILLHMFWGVVFFEACERQRWWALGAVVASHLVVS 201
Query: 741 CLTLANNS------PSPAPEIVLAVNAVLC 812
CLT N P+ V+AV A LC
Sbjct: 202 CLTFVNPHYQGSLIPTYIILSVMAVWAYLC 231
>sp|Q96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha)
(Presenilin-stabilization factor)
Length = 265
Score = 42.7 bits (99), Expect = 0.001
Identities = 52/251 (20%), Positives = 73/251 (29%), Gaps = 9/251 (3%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXYAVVPLK 212
M GC +FG L L T+ PLRVI + +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 213 SK---------LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLIMFDLKSSEPSTDRSLT 365
+ L FG SV+ QE RF + L K D G+ +
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASL---------------- 104
Query: 366 SNIDIATTSNNINYHRDGEEGNKPLIASDKSTEDIFNVTMFAYVXXXXXXXXXXXXXXXN 545
E+G P+ ++ AYV N
Sbjct: 105 -----------------SEDGRSPI-----------SIRQMAYVSGLSFGIISGVFSVIN 136
Query: 546 MLVALRGPGTLGYFGQSADFIDFYAAQTXXXXXXXXXXXXXMSKAYQARSLVKFGAILLV 725
+L GPG +G G S + A T A + R G ++
Sbjct: 137 ILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGS 196
Query: 726 HMLYSCLTLAN 758
H+L S LT N
Sbjct: 197 HLLTSGLTFLN 207
>sp|Q07283|TRHY_HUMAN Trichohyalin
Length = 1898
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/122 (22%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Frame = -1
Query: 821 RREAENRVYREHDFWSWRRR--VVGERQTRVEHVNEQDGAEF-HEGSRLVRLGHEHVERD 651
RRE ++RV++E + WR+R V+ + + +++ Q E E +L +L + + R+
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 650 VEQHDEQRLGGVKIDEISRLAEISERSGASQRDQHVQRGEQARHQAESEASDIREHRHVE 471
++ ++Q+ + ++ R E R +R + +R EQ + E + +E R +
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 470 NV 465
+
Sbjct: 350 QL 351
>sp|Q8BVF7|APH1A_MOUSE Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha)
Length = 265
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/251 (20%), Positives = 73/251 (29%), Gaps = 9/251 (3%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXYAVVPLK 212
M GC +FG L L T+ PLRVI + +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 213 SK---------LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLIMFDLKSSEPSTDRSLT 365
+ L FG SV+ QE RF + L K D G+ +
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASL---------------- 104
Query: 366 SNIDIATTSNNINYHRDGEEGNKPLIASDKSTEDIFNVTMFAYVXXXXXXXXXXXXXXXN 545
E+G P+ ++ AYV N
Sbjct: 105 -----------------SEDGRSPI-----------SIRQMAYVSGLSFGIISGVFSVIN 136
Query: 546 MLVALRGPGTLGYFGQSADFIDFYAAQTXXXXXXXXXXXXXMSKAYQARSLVKFGAILLV 725
+L GPG +G G S + A T A + R G ++
Sbjct: 137 ILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGS 196
Query: 726 HMLYSCLTLAN 758
H+L S LT N
Sbjct: 197 HLLTSGLTFLN 207
>sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C
Length = 258
Score = 39.7 bits (91), Expect = 0.010
Identities = 59/276 (21%), Positives = 78/276 (28%), Gaps = 9/276 (3%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXYAVVPLK 212
M GC +FG L LFTI T PLRVI + V +
Sbjct: 1 MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVIT 60
Query: 213 SK---------LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLIMFDLKSSEPSTDRSLT 365
+ L FG + SV QE R + L K G+K S+
Sbjct: 61 NNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLK---------------SIN 105
Query: 366 SNIDIATTSNNINYHRDGEEGNKPLIASDKSTEDIFNVTMFAYVXXXXXXXXXXXXXXXN 545
DIA ++ + AYV N
Sbjct: 106 PEEDIAP-----------------------------SMRLLAYVSGLGFGIMSGVFSFVN 136
Query: 546 MLVALRGPGTLGYFGQSADFIDFYAAQTXXXXXXXXXXXXXMSKAYQARSLVKFGAILLV 725
L GPGT+G G S F A T + +LL
Sbjct: 137 TLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLT 196
Query: 726 HMLYSCLTLANNSPSPAPEIVLAVNAVLCFSSCCWA 833
H++ S T SP E+ L ++ WA
Sbjct: 197 HLVVSTQTFL----SPYYEVNLVTAYIIMVLMGIWA 228
>sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)
Length = 257
Score = 39.3 bits (90), Expect = 0.014
Identities = 29/104 (27%), Positives = 38/104 (36%), Gaps = 9/104 (8%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXYAVVPLK 212
M GC +FG + L +FTI T PLRVI + V +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60
Query: 213 SK---------LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLI 317
L FG++ SV QE R + L K G+K I
Sbjct: 61 DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSI 104
>sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)
(Presenilin-stabilization factor-like)
Length = 257
Score = 39.3 bits (90), Expect = 0.014
Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 9/104 (8%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXY-AVVPL 209
M GC +FG + L +FTI T PLR+I + A V +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 210 KSK--------LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLI 317
+K L FG SV QE RF + L K G+K I
Sbjct: 61 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSI 104
>sp|Q5RDM3|APH1B_PONPY Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)
Length = 257
Score = 39.3 bits (90), Expect = 0.014
Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 9/104 (8%)
Frame = +3
Query: 33 MACDELIGCLLTSFGIPIVLVLFTIITHPLRVITXXXXXXXXXXXXXXXXXXXY-AVVPL 209
M GC +FG + L +FTI T PLR+I + A V +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 210 KSK--------LAFGLVFSVIFQEAIRFLFIYCLHKIDRGIKLI 317
+K L FG SV QE RF + L K G+K I
Sbjct: 61 DNKDGPTQKYLLIFGTFVSVYIQEMFRFAYYRLLKKASEGLKSI 104
>sp|Q87M02|IF2_VIBPA Translation initiation factor IF-2
Length = 905
Score = 35.8 bits (81), Expect = 0.15
Identities = 32/106 (30%), Positives = 47/106 (44%)
Frame = -1
Query: 827 AARREAENRVYREHDFWSWRRRVVGERQTRVEHVNEQDGAEFHEGSRLVRLGHEHVERDV 648
AA+REAE+ V RE + +R E+ R N Q AE E +RD
Sbjct: 138 AAKREAEDAVKREAE--EKAKREAEEKAKRDADTNAQRNAE------------EKAKRDA 183
Query: 647 EQHDEQRLGGVKIDEISRLAEISERSGASQRDQHVQRGEQARHQAE 510
E+ +Q + DE+ R E + A + Q ++ E+AR AE
Sbjct: 184 EEKIKQEAARKEADELKRRQEEEAKRKAEEESQ--RKLEEARELAE 227
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,365,268
Number of Sequences: 369166
Number of extensions: 1666991
Number of successful extensions: 5479
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5179
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5462
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8100769320
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)