Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_P01
(488 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 (Preseni... 60 4e-09
sp|Q8JHE9|APH1B_BRARE Gamma-secretase subunit Aph-1b (Anter... 41 0.002
sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B (APH-1... 38 0.011
sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C 37 0.019
sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B (APH-1... 37 0.019
sp|Q5RDM3|APH1B_PONPY Gamma-secretase subunit APH-1B (APH-1... 37 0.019
sp|O75712|CXB3_HUMAN Gap junction beta-3 protein (Connexin-... 30 2.3
sp|Q661K1|KAD_BORGA Adenylate kinase (ATP-AMP transphosphor... 29 5.1
sp|P04766|IF2_BACST Translation initiation factor IF-2 28 8.8
sp|Q10130|DHS5_CAEEL Putative oxidoreductase dhs-5 28 8.8
>sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor)
Length = 238
Score = 59.7 bits (143), Expect = 4e-09
Identities = 33/90 (36%), Positives = 49/90 (54%)
Frame = +1
Query: 1 FGIPIVLVLFTIITHPLRVITLINXXXXXXXXXXXXXILGYAVVPLKSKLAFGLLFSVIF 180
FG P L +FTI P+R+I LI L YA++PLK LAFG++FSV F
Sbjct: 14 FGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISS-LWYALIPLKEFLAFGVVFSVCF 72
Query: 181 QEAIRFLFIYCLHEIDRGIKLIMFDLKSSE 270
QEA R++ L ++G+ + D + ++
Sbjct: 73 QEAFRYIIYRILRSTEQGLHAVAEDTRVTD 102
>sp|Q8JHE9|APH1B_BRARE Gamma-secretase subunit Aph-1b (Anterior-pharynx-defective protein
1b)
Length = 258
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Frame = +1
Query: 1 FGIPIVLVLFTIITHPLRVITLINXXXXXXXXXXXXXILGYAVVPLKSK---------LA 153
FG I L +FTI PLRVI LI ++ + V + +K L
Sbjct: 14 FGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQISNKNSATQQRGLLI 73
Query: 154 FGLLFSVIFQEAIRFLFIYCLHEIDRGI 237
FG++ SV+ QEA R+ + L + + G+
Sbjct: 74 FGVVLSVLLQEAFRYGYYRLLKKANEGL 101
>sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)
Length = 257
Score = 38.1 bits (87), Expect = 0.011
Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 9/91 (9%)
Frame = +1
Query: 1 FGIPIVLVLFTIITHPLRVITLINXXXXXXXXXXXXXILGYAVVPLKSK---------LA 153
FG + L +FTI T PLRVI LI + + V + L
Sbjct: 14 FGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLI 73
Query: 154 FGLLFSVIFQEAIRFLFIYCLHEIDRGIKLI 246
FG+L SV QE R + L + G+K I
Sbjct: 74 FGVLLSVCIQELFRLAYYKLLKKASEGLKSI 104
>sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C
Length = 258
Score = 37.4 bits (85), Expect = 0.019
Identities = 29/91 (31%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Frame = +1
Query: 1 FGIPIVLVLFTIITHPLRVITLINXXXXXXXXXXXXXILGYAVVPLKSK---------LA 153
FG L LFTI T PLRVI LI + + V + + L
Sbjct: 14 FGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVITNNRDESVQNYLLI 73
Query: 154 FGLLFSVIFQEAIRFLFIYCLHEIDRGIKLI 246
FG L SV QE R + L + G+K I
Sbjct: 74 FGALLSVCIQELFRLAYYKLLKKASEGLKSI 104
>sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)
(Presenilin-stabilization factor-like)
Length = 257
Score = 37.4 bits (85), Expect = 0.019
Identities = 29/91 (31%), Positives = 40/91 (43%), Gaps = 9/91 (9%)
Frame = +1
Query: 1 FGIPIVLVLFTIITHPLRVITLINXXXXXXXXXXXXXILGY-AVVPLKSK--------LA 153
FG + L +FTI T PLR+I LI ++ + A V + +K L
Sbjct: 14 FGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLI 73
Query: 154 FGLLFSVIFQEAIRFLFIYCLHEIDRGIKLI 246
FG SV QE RF + L + G+K I
Sbjct: 74 FGAFVSVYIQEMFRFAYYKLLKKASEGLKSI 104
>sp|Q5RDM3|APH1B_PONPY Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)
Length = 257
Score = 37.4 bits (85), Expect = 0.019
Identities = 29/91 (31%), Positives = 40/91 (43%), Gaps = 9/91 (9%)
Frame = +1
Query: 1 FGIPIVLVLFTIITHPLRVITLINXXXXXXXXXXXXXILGY-AVVPLKSK--------LA 153
FG + L +FTI T PLR+I LI ++ + A V + +K L
Sbjct: 14 FGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLI 73
Query: 154 FGLLFSVIFQEAIRFLFIYCLHEIDRGIKLI 246
FG SV QE RF + L + G+K I
Sbjct: 74 FGTFVSVYIQEMFRFAYYRLLKKASEGLKSI 104
>sp|O75712|CXB3_HUMAN Gap junction beta-3 protein (Connexin-31) (Cx31)
Length = 270
Score = 30.4 bits (67), Expect = 2.3
Identities = 13/27 (48%), Positives = 18/27 (66%)
Frame = +1
Query: 163 LFSVIFQEAIRFLFIYCLHEIDRGIKL 243
LFS+IF+ I FLF+Y LH + G +
Sbjct: 132 LFSLIFKLIIEFLFLYLLHTLWHGFNM 158
>sp|Q661K1|KAD_BORGA Adenylate kinase (ATP-AMP transphosphorylase)
Length = 211
Score = 29.3 bits (64), Expect = 5.1
Identities = 21/54 (38%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Frame = -2
Query: 229 DRFREDNK*IENVLLLGKSLKKVIQKQV*ILMEPQHTPKLMKIKMKP-PRNSNY 71
D FRE+ I N LGK +KK+++K L+ Q T K++K K+K +N N+
Sbjct: 33 DLFREN---ILNSTTLGKEIKKIVEKGE--LVPDQITIKIVKDKIKAIKKNDNF 81
>sp|P04766|IF2_BACST Translation initiation factor IF-2
Length = 741
Score = 28.5 bits (62), Expect = 8.8
Identities = 13/29 (44%), Positives = 19/29 (65%)
Frame = -3
Query: 477 HVQRGEQARHQAESEASDIREHRLVENVL 391
+V+ A+ AESE DIR HR++ NV+
Sbjct: 600 NVRPDANAKRAAESEKVDIRLHRIIYNVI 628
>sp|Q10130|DHS5_CAEEL Putative oxidoreductase dhs-5
Length = 378
Score = 28.5 bits (62), Expect = 8.8
Identities = 17/49 (34%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
Frame = +1
Query: 226 DRGIKLIMFDLKSSEPSTDRSLTSNIDIATTSNNINYHRDGEE--GNKP 366
D IK +FD S + S+ R S+ID+ N++ RD E G+ P
Sbjct: 139 DAQIKTFVFDFGSGDFSSLRDYISDIDVGFVVNSVGTGRDNLERYGDNP 187
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,575,944
Number of Sequences: 369166
Number of extensions: 972976
Number of successful extensions: 2359
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2277
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2350
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2970720600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)