Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_O22
(809 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 83 8e-16
sp|P16591|FER_HUMAN Proto-oncogene tyrosine-protein kinase ... 82 2e-15
sp|P09760|FLK_RAT Tyrosine-protein kinase FLK 81 4e-15
sp|Q9Y7J6|KOIA_SCHPO Putative serine/threonine-protein kina... 80 5e-15
sp|Q61083|M3K2_MOUSE Mitogen-activated protein kinase kinas... 80 5e-15
sp|O14299|WIS4_SCHPO MAP kinase kinase kinase wis4 (MAP kin... 80 7e-15
sp|P42687|SPK1_DUGTI Tyrosine-protein kinase SPK-1 79 1e-14
sp|P16092|FGFR1_MOUSE Basic fibroblast growth factor recept... 79 1e-14
sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor recept... 79 1e-14
sp|Q04589|FGFR1_RAT Basic fibroblast growth factor receptor... 79 1e-14
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 618
Score = 83.2 bits (204), Expect = 8e-16
Identities = 57/174 (32%), Positives = 93/174 (53%), Gaps = 6/174 (3%)
Frame = +2
Query: 305 NTNRKILIKK--YEVESSKTWKDEEFMLKELITFQMTKS--HRRFIQLLGVYID--DATL 466
+T R++ +K+ ++ +S +T K+ + E+ Q+ K+ H R +Q G D + TL
Sbjct: 376 DTGRELAVKQVQFDPDSPETSKEVNALECEI---QLLKNFLHERIVQYYGCLRDPQEKTL 432
Query: 467 YVVMENMDGGNLKTFLQENYDKLDKNKIYKWSAQILEGLKFLHENKVIHRDLNPSSILVD 646
+ ME M GG++K L+ Y L +N K++ QILEG+ +LH N ++HRD+ ++IL D
Sbjct: 433 SIFMEYMPGGSIKDQLKA-YGALTENGTRKYTRQILEGVHYLHSNMILHRDIKGANILRD 491
Query: 647 GNEDLKLSSFNLSIYLNIYTTSSINAKRDKNRELPVRYMAPEILSGQIYGEACD 808
++KL F S L S K +M+PE++SGQ YG D
Sbjct: 492 STGNVKLGDFGASKRLQTICLSGTGMKSVTGTPY---WMSPEVISGQGYGRKAD 542
>sp|P16591|FER_HUMAN Proto-oncogene tyrosine-protein kinase FER (p94-FER) (c-FER)
Length = 822
Score = 82.0 bits (201), Expect = 2e-15
Identities = 53/189 (28%), Positives = 95/189 (50%), Gaps = 4/189 (2%)
Frame = +2
Query: 254 DYITKGNFSELKRGTFENTNRKILIKKYEVESSKTWKDEEFMLKELITFQMTKS--HRRF 427
+ + KGNF E+ +GT ++ V++ K +E +K L ++ K H
Sbjct: 567 ELLGKGNFGEVYKGTLKDKT------SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNI 620
Query: 428 IQLLGVYIDDATLYVVMENMDGGNLKTFLQENYDKLDKNKIYKWSAQILEGLKFLHENKV 607
++L+GV +Y++ME + GG+ TFL+ D+L ++ K+S G+ +L
Sbjct: 621 VKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNC 680
Query: 608 IHRDLNPSSILVDGNEDLKLSSFNLSIYLN--IYTTSSINAKRDKNRELPVRYMAPEILS 781
IHRDL + LV N LK+S F +S + +Y++S + +++P+++ APE L+
Sbjct: 681 IHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGL-------KQIPIKWTAPEALN 733
Query: 782 GQIYGEACD 808
Y D
Sbjct: 734 YGRYSSESD 742
>sp|P09760|FLK_RAT Tyrosine-protein kinase FLK
Length = 323
Score = 80.9 bits (198), Expect = 4e-15
Identities = 55/202 (27%), Positives = 102/202 (50%), Gaps = 8/202 (3%)
Frame = +2
Query: 227 KWAGINMND----DYITKGNFSELKRGTFENTNRKILIKKYEVESSKTWKDEEFMLKELI 394
KW +N D + + KGNF E+ +GT ++ V++ K +E +K L
Sbjct: 56 KWV-LNHEDVSLGELLGKGNFGEVYKGTLKDKT------PVAVKTCKEDLPQELKIKFLQ 108
Query: 395 TFQMTKS--HRRFIQLLGVYIDDATLYVVMENMDGGNLKTFLQENYDKLDKNKIYKWSAQ 568
++ K H ++L+GV +Y++ME + GG+ +FL++ D+L ++ ++S
Sbjct: 109 EAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLD 168
Query: 569 ILEGLKFLHENKVIHRDLNPSSILVDGNEDLKLSSFNLSIYLN--IYTTSSINAKRDKNR 742
+ G+ +L IHRDL + LV N LK+S F +S + +Y++S + +
Sbjct: 169 VAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGL-------K 221
Query: 743 ELPVRYMAPEILSGQIYGEACD 808
++P+++ APE L+ Y D
Sbjct: 222 QIPIKWTAPEALNYGRYSSESD 243
>sp|Q9Y7J6|KOIA_SCHPO Putative serine/threonine-protein kinase C1778.10c
Length = 550
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/190 (29%), Positives = 98/190 (51%), Gaps = 5/190 (2%)
Frame = +2
Query: 254 DYITKGNFSELKRGTFENTNR----KILIKKYEVESSKTWKDEEFMLKELITFQMTKSHR 421
D I G+FS+++R T + + + K+L KKY V+ +K +++ E +
Sbjct: 58 DIIGDGSFSKVRRATDKKSWKEYAIKVLDKKYIVKENKV----KYVNIERDSMMRLNGFP 113
Query: 422 RFIQLLGVYIDDATLYVVMENMDGGNLKTFLQENYDKLDKNKIYKWSAQILEGLKFLHEN 601
+L + DD LY V+E G L ++++ Y LD+N + ++A+IL ++++H
Sbjct: 114 GISRLFHTFQDDLKLYYVLELAPNGELLQYIKK-YRFLDENCVRFYAAEILSSIEYMHSC 172
Query: 602 KVIHRDLNPSSILVDGNEDLKLSSFNLS-IYLNIYTTSSINAKRDKNRELPVRYMAPEIL 778
+IHRDL P +IL DGN +K++ F + I Y S + Y+APE+L
Sbjct: 173 GIIHRDLKPENILFDGNMHVKITDFGTAKILPPKYVNSPDYTTFPSSFVGTAEYVAPELL 232
Query: 779 SGQIYGEACD 808
S Q+ ++ D
Sbjct: 233 SRQVVSKSSD 242
>sp|Q61083|M3K2_MOUSE Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 619
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/174 (32%), Positives = 91/174 (52%), Gaps = 6/174 (3%)
Frame = +2
Query: 305 NTNRKILIKK--YEVESSKTWKDEEFMLKELITFQMTKS--HRRFIQLLGVYID--DATL 466
+T R++ +K+ + ES +T K+ + E+ Q+ K+ H R +Q G D + TL
Sbjct: 377 DTGRELAVKQVQFNPESPETSKEVNALECEI---QLLKNLLHERIVQYYGCLRDPQEKTL 433
Query: 467 YVVMENMDGGNLKTFLQENYDKLDKNKIYKWSAQILEGLKFLHENKVIHRDLNPSSILVD 646
+ ME GG++K L+ Y L +N K++ QILEG+ +LH N ++HRD+ ++IL D
Sbjct: 434 SIFMELSPGGSIKDQLKA-YGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRD 492
Query: 647 GNEDLKLSSFNLSIYLNIYTTSSINAKRDKNRELPVRYMAPEILSGQIYGEACD 808
++KL F S L S K +M+PE++SG+ YG D
Sbjct: 493 STGNIKLGDFGASKRLQTICLSGTGMKSVTGTPY---WMSPEVISGEGYGRKAD 543
>sp|O14299|WIS4_SCHPO MAP kinase kinase kinase wis4 (MAP kinase kinase kinase wak1) (MAP
kinase kinase kinase wik1)
Length = 1401
Score = 80.1 bits (196), Expect = 7e-15
Identities = 49/186 (26%), Positives = 92/186 (49%), Gaps = 5/186 (2%)
Frame = +2
Query: 257 YITKGNFSELKRGTFENTNRKILIKKYEVESSKTWKDEEFMLKELITFQMTKSHRRFIQL 436
++ G F ++ G T + +K+ +++ S+T++ + +T +H +
Sbjct: 1042 FVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTY 1101
Query: 437 LGVYIDDATLYVVMENMDGGNLKTFLQENYDKLDKNKIYKWSAQILEGLKFLHENKVIHR 616
GV + +Y+ ME GG+L L + D+N + + Q+LEGL ++H ++HR
Sbjct: 1102 YGVEVHREKVYIFMEFCQGGSLADLLAHGRIE-DENVLKVYVVQLLEGLAYIHSQHILHR 1160
Query: 617 DLNPSSILVDGNEDLKLSSFNLSIYLNIYTTSSINAKRDKNREL-----PVRYMAPEILS 781
D+ P++IL+D +K S F ++Y++ T + + D EL YMAPEI+
Sbjct: 1161 DIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYE-DIQPELQHLAGTPMYMAPEIIL 1219
Query: 782 GQIYGE 799
G G+
Sbjct: 1220 GTKKGD 1225
>sp|P42687|SPK1_DUGTI Tyrosine-protein kinase SPK-1
Length = 497
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/201 (28%), Positives = 104/201 (51%), Gaps = 11/201 (5%)
Frame = +2
Query: 239 INMNDDYITKGNF---SELKRGTFENTNRKILIKKYEV-----ESSKTWKDEEFMLKELI 394
++ D I + N +E+ RG F + +R + YEV +SSK + E+F+L+ I
Sbjct: 208 VHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAER-EKFVLEAKI 266
Query: 395 TFQMTKSHRRFIQLLGVYID--DATLYVVMENMDGGNLKTFLQE-NYDKLDKNKIYKWSA 565
++ HR+ ++LLGV + D + +++E M G+LK +L+ + K + N++ A
Sbjct: 267 MHKLR--HRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMA 324
Query: 566 QILEGLKFLHENKVIHRDLNPSSILVDGNEDLKLSSFNLSIYLNIYTTSSINAKRDKNRE 745
+I EG+ +L KV+HRDL +ILV + K++ F L+ T S+ + K
Sbjct: 325 EISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGLT----ELTDGSLGDQEKKTLR 380
Query: 746 LPVRYMAPEILSGQIYGEACD 808
P ++ APE +++ D
Sbjct: 381 FPYKWTAPEAAKSKVFTSKSD 401
>sp|P16092|FGFR1_MOUSE Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R)
(MFR)
Length = 822
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 18/187 (9%)
Frame = +2
Query: 302 ENTNRKILIKKYEVESSKTWKDEEFMLKELITFQMTKSHRRFIQLLGVYIDDATLYVVME 481
+ NR + ++S T KD ++ E+ +M H+ I LLG D LYV++E
Sbjct: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562
Query: 482 NMDGGNLKTFLQEN---------------YDKLDKNKIYKWSAQILEGLKFLHENKVIHR 616
GNL+ +LQ ++L + + Q+ G+++L K IHR
Sbjct: 563 YASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHR 622
Query: 617 DLNPSSILVDGNEDLKLSSFNLS---IYLNIYTTSSINAKRDKNRELPVRYMAPEILSGQ 787
DL ++LV + +K++ F L+ +++ Y K+ N LPV++MAPE L +
Sbjct: 623 DLAARNVLVTEDNVMKIADFGLARDIHHIDYY-------KKTTNGRLPVKWMAPEALFDR 675
Query: 788 IYGEACD 808
IY D
Sbjct: 676 IYTHQSD 682
>sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R)
(Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen)
Length = 822
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 18/187 (9%)
Frame = +2
Query: 302 ENTNRKILIKKYEVESSKTWKDEEFMLKELITFQMTKSHRRFIQLLGVYIDDATLYVVME 481
+ NR + ++S T KD ++ E+ +M H+ I LLG D LYV++E
Sbjct: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562
Query: 482 NMDGGNLKTFLQEN---------------YDKLDKNKIYKWSAQILEGLKFLHENKVIHR 616
GNL+ +LQ ++L + + Q+ G+++L K IHR
Sbjct: 563 YASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHR 622
Query: 617 DLNPSSILVDGNEDLKLSSFNLS---IYLNIYTTSSINAKRDKNRELPVRYMAPEILSGQ 787
DL ++LV + +K++ F L+ +++ Y K+ N LPV++MAPE L +
Sbjct: 623 DLAARNVLVTEDNVMKIADFGLARDIHHIDYY-------KKTTNGRLPVKWMAPEALFDR 675
Query: 788 IYGEACD 808
IY D
Sbjct: 676 IYTHQSD 682
>sp|Q04589|FGFR1_RAT Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R)
(MFR)
Length = 822
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 18/187 (9%)
Frame = +2
Query: 302 ENTNRKILIKKYEVESSKTWKDEEFMLKELITFQMTKSHRRFIQLLGVYIDDATLYVVME 481
+ NR + ++S T KD ++ E+ +M H+ I LLG D LYV++E
Sbjct: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562
Query: 482 NMDGGNLKTFLQEN---------------YDKLDKNKIYKWSAQILEGLKFLHENKVIHR 616
GNL+ +LQ ++L + + Q+ G+++L K IHR
Sbjct: 563 YASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHR 622
Query: 617 DLNPSSILVDGNEDLKLSSFNLS---IYLNIYTTSSINAKRDKNRELPVRYMAPEILSGQ 787
DL ++LV + +K++ F L+ +++ Y K+ N LPV++MAPE L +
Sbjct: 623 DLAARNVLVTEDNVMKIADFGLARDIHHIDYY-------KKTTNGRLPVKWMAPEALFDR 675
Query: 788 IYGEACD 808
IY D
Sbjct: 676 IYTHQSD 682
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,682,597
Number of Sequences: 369166
Number of extensions: 1770653
Number of successful extensions: 7229
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6077
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6362
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)