Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_N21
(871 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9CR62|M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate ca... 313 5e-85
sp|Q02978|M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate ca... 312 7e-85
sp|P22292|M2OM_BOVIN Mitochondrial 2-oxoglutarate/malate ca... 311 1e-84
sp|P97700|M2OM_RAT Mitochondrial 2-oxoglutarate/malate carr... 301 1e-81
sp|Q9UBX3|DIC_HUMAN Mitochondrial dicarboxylate carrier 166 1e-40
sp|Q9QZD8|DIC_MOUSE Mitochondrial dicarboxylate carrier 161 3e-39
sp|O95258|UCP5_HUMAN Brain mitochondrial carrier protein 1 ... 140 5e-33
sp|Q9Z2B2|UCP5_MOUSE Brain mitochondrial carrier protein 1 ... 139 8e-33
sp|P14271|UCP1_RABIT Mitochondrial brown fat uncoupling pro... 138 2e-32
sp|P12242|UCP1_MOUSE Mitochondrial brown fat uncoupling pro... 135 1e-31
>sp|Q9CR62|M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute
carrier family 25 member 11)
Length = 314
Score = 313 bits (801), Expect = 5e-85
Identities = 154/233 (66%), Positives = 184/233 (78%), Gaps = 1/233 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTRLG 278
PLDLVKNRMQ+SG+ + YK+SF A+ I K EGL IY+GLSAGLLRQATYTTTRLG
Sbjct: 41 PLDLVKNRMQLSGEGAKTREYKTSFHALTSILKTEGLKGIYTGLSAGLLRQATYTTTRLG 100
Query: 279 VYTCLFEKFSTKD-KPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRRN 455
+YT LFE+ + D PP F KA IG+TAG G+F+GTP EVALIRMT+DGRLP DQRR
Sbjct: 101 IYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRG 160
Query: 456 YRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGIF 635
Y+NVF+AL RI REEGV TLWRGC+PTM RA VVN AQLASYSQ+KQ +L+SGYFSD I
Sbjct: 161 YKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNIL 220
Query: 636 VHFGASMISGFITTVASMPVDIVKTRIQNMKVVNGVAEYSGAINAFVRIAKTE 794
HF ASMISG +TT ASMPVDIVKTRIQNM++++G EY ++ +++ + E
Sbjct: 221 CHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLLKVVRYE 273
Score = 47.8 bits (112), Expect = 4e-05
Identities = 41/181 (22%), Positives = 79/181 (43%), Gaps = 9/181 (4%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGA--KKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTR 272
P ++ RM G+ A ++ YK+ F+A+ +I + EG+ ++ G + R +
Sbjct: 139 PAEVALIRMTADGRLPADQRRGYKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNAAQ 198
Query: 273 LGVYT----CLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPM 440
L Y+ L + D + + +GLV + P ++ R+ + +
Sbjct: 199 LASYSQSKQFLLDSGYFSD---NILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMI-- 253
Query: 441 DQRRNYRNVFHALARIVREEGVLTLWRGCLP---TMGRAAVVNLAQLASYSQAKQVILES 611
D + Y+N L ++VR EG +LW+G P +G V+ L ++A + + S
Sbjct: 254 DGKPEYKNGLDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLS 313
Query: 612 G 614
G
Sbjct: 314 G 314
Score = 47.8 bits (112), Expect = 4e-05
Identities = 18/22 (81%), Positives = 21/22 (95%)
Frame = +2
Query: 803 SLWKGFTPYFLRLGPHTVITFV 868
SLWKGFTPY+ RLGPHTV+TF+
Sbjct: 277 SLWKGFTPYYARLGPHTVLTFI 298
Score = 30.4 bits (67), Expect = 6.7
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +2
Query: 35 PNYVKFLFGGSAGMIATLF 91
P VKFLFGG AGM AT+F
Sbjct: 20 PKSVKFLFGGLAGMGATVF 38
>sp|Q02978|M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute
carrier family 25 member 11)
Length = 314
Score = 312 bits (800), Expect = 7e-85
Identities = 154/233 (66%), Positives = 183/233 (78%), Gaps = 1/233 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTRLG 278
PLDLVKNRMQ+SG+ + YK+SF A+ I K EGL IY+GLSAGLLRQATYTTTRLG
Sbjct: 41 PLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLG 100
Query: 279 VYTCLFEKFSTKD-KPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRRN 455
+YT LFE+ + D PP F KA IG+TAG G+F+GTP EVALIRMT+DGRLP DQRR
Sbjct: 101 IYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRG 160
Query: 456 YRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGIF 635
Y+NVF+AL RI REEGVLTLWRGC+PTM RA VVN AQLASYSQ+KQ +L+SGYFSD I
Sbjct: 161 YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNIL 220
Query: 636 VHFGASMISGFITTVASMPVDIVKTRIQNMKVVNGVAEYSGAINAFVRIAKTE 794
HF ASMISG +TT ASMPVDI KTRIQNM++++G EY ++ ++ + E
Sbjct: 221 CHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYE 273
Score = 53.5 bits (127), Expect = 7e-07
Identities = 44/181 (24%), Positives = 82/181 (45%), Gaps = 9/181 (4%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGA--KKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTR 272
P ++ RM G+ A ++ YK+ F+A+ +IT+ EG+L ++ G + R +
Sbjct: 139 PAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQ 198
Query: 273 LGVYT----CLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPM 440
L Y+ L + D + + +GLV + P ++A R+ + +
Sbjct: 199 LASYSQSKQFLLDSGYFSD---NILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMI-- 253
Query: 441 DQRRNYRNVFHALARIVREEGVLTLWRGCLP---TMGRAAVVNLAQLASYSQAKQVILES 611
D + Y+N L ++VR EG +LW+G P +G V+ L ++A + + S
Sbjct: 254 DGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLS 313
Query: 612 G 614
G
Sbjct: 314 G 314
Score = 47.8 bits (112), Expect = 4e-05
Identities = 18/22 (81%), Positives = 21/22 (95%)
Frame = +2
Query: 803 SLWKGFTPYFLRLGPHTVITFV 868
SLWKGFTPY+ RLGPHTV+TF+
Sbjct: 277 SLWKGFTPYYARLGPHTVLTFI 298
Score = 30.4 bits (67), Expect = 6.7
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +2
Query: 35 PNYVKFLFGGSAGMIATLF 91
P VKFLFGG AGM AT+F
Sbjct: 20 PKSVKFLFGGLAGMGATVF 38
>sp|P22292|M2OM_BOVIN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP)
Length = 314
Score = 311 bits (798), Expect = 1e-84
Identities = 154/233 (66%), Positives = 186/233 (79%), Gaps = 1/233 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTRLG 278
PLDLVKNRMQ+SG+ + YK+SF A+ I + EGL IY+GLSAGLLRQATYTTTRLG
Sbjct: 41 PLDLVKNRMQLSGEGAKTREYKTSFHALISILRAEGLRGIYTGLSAGLLRQATYTTTRLG 100
Query: 279 VYTCLFEKFSTKD-KPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRRN 455
+YT LFE+ + D PP F KA IG+TAG G+F+GTP EVALIRMT+DGRLP+DQRR
Sbjct: 101 IYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPVDQRRG 160
Query: 456 YRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGIF 635
Y+NVF+AL RIV+EEGV TLWRGC+PTM RA VVN AQLASYSQ+KQ +L+SGYFSD I
Sbjct: 161 YKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNIL 220
Query: 636 VHFGASMISGFITTVASMPVDIVKTRIQNMKVVNGVAEYSGAINAFVRIAKTE 794
HF ASMISG +TT ASMPVDIVKTRIQNM++++G EY ++ V++ + E
Sbjct: 221 CHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLVKVVRYE 273
Score = 47.8 bits (112), Expect = 4e-05
Identities = 18/22 (81%), Positives = 21/22 (95%)
Frame = +2
Query: 803 SLWKGFTPYFLRLGPHTVITFV 868
SLWKGFTPY+ RLGPHTV+TF+
Sbjct: 277 SLWKGFTPYYARLGPHTVLTFI 298
Score = 46.6 bits (109), Expect = 9e-05
Identities = 40/181 (22%), Positives = 78/181 (43%), Gaps = 9/181 (4%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQ--DGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTR 272
P ++ RM G+ ++ YK+ F+A+ +I + EG+ ++ G + R +
Sbjct: 139 PAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQ 198
Query: 273 LGVYT----CLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPM 440
L Y+ L + D + + +GLV + P ++ R+ + +
Sbjct: 199 LASYSQSKQFLLDSGYFSD---NILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMI-- 253
Query: 441 DQRRNYRNVFHALARIVREEGVLTLWRGCLP---TMGRAAVVNLAQLASYSQAKQVILES 611
D + Y+N L ++VR EG +LW+G P +G V+ L ++A + + S
Sbjct: 254 DGKPEYKNGLDVLVKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLS 313
Query: 612 G 614
G
Sbjct: 314 G 314
Score = 30.4 bits (67), Expect = 6.7
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +2
Query: 35 PNYVKFLFGGSAGMIATLF 91
P VKFLFGG AGM AT+F
Sbjct: 20 PKSVKFLFGGLAGMGATVF 38
>sp|P97700|M2OM_RAT Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute
carrier family 25 member 11)
Length = 314
Score = 301 bits (772), Expect = 1e-81
Identities = 150/233 (64%), Positives = 180/233 (77%), Gaps = 1/233 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTRLG 278
PLDLV NRMQ+SG+ + YK+SF A+ I K EGL IY+GLSAGLLRQATYTTTRLG
Sbjct: 41 PLDLVXNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLG 100
Query: 279 VYTCLFEKFSTKD-KPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRRN 455
+YT LFE+ + D PP F KA IG+TAG G+F+G P EVALIRMT+DGRLP DQRR
Sbjct: 101 IYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFVGPPAEVALIRMTADGRLPADQRRG 160
Query: 456 YRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGIF 635
Y+NVF+AL RI REEGV TLWRGC+PTM RA VVN AQLASYSQ+KQ +L+SGYFSD I
Sbjct: 161 YKNVFNALIRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNIL 220
Query: 636 VHFGASMISGFITTVASMPVDIVKTRIQNMKVVNGVAEYSGAINAFVRIAKTE 794
HF A MISG +TT ASMPVDIVKTRIQNM++++ EY ++ +++ + E
Sbjct: 221 CHFCAIMISGLVTTAASMPVDIVKTRIQNMRMIDEKPEYKNGLDVLLKVVRYE 273
Score = 47.8 bits (112), Expect = 4e-05
Identities = 41/181 (22%), Positives = 80/181 (44%), Gaps = 9/181 (4%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGA--KKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTR 272
P ++ RM G+ A ++ YK+ F+A+ +I + EG+ ++ G + R +
Sbjct: 139 PAEVALIRMTADGRLPADQRRGYKNVFNALIRIAREEGVPTLWRGCIPTMARAVVVNAAQ 198
Query: 273 LGVYT----CLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPM 440
L Y+ L + D + + +GLV + P ++ R+ + +
Sbjct: 199 LASYSQSKQFLLDSGYFSD---NILCHFCAIMISGLVTTAASMPVDIVKTRIQNMRMI-- 253
Query: 441 DQRRNYRNVFHALARIVREEGVLTLWRGCLP---TMGRAAVVNLAQLASYSQAKQVILES 611
D++ Y+N L ++VR EG +LW+G P +G V+ L ++A + + S
Sbjct: 254 DEKPEYKNGLDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLS 313
Query: 612 G 614
G
Sbjct: 314 G 314
Score = 47.8 bits (112), Expect = 4e-05
Identities = 18/22 (81%), Positives = 21/22 (95%)
Frame = +2
Query: 803 SLWKGFTPYFLRLGPHTVITFV 868
SLWKGFTPY+ RLGPHTV+TF+
Sbjct: 277 SLWKGFTPYYARLGPHTVLTFI 298
Score = 30.4 bits (67), Expect = 6.7
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +2
Query: 35 PNYVKFLFGGSAGMIATLF 91
P VKFLFGG AGM AT+F
Sbjct: 20 PKSVKFLFGGLAGMGATVF 38
>sp|Q9UBX3|DIC_HUMAN Mitochondrial dicarboxylate carrier
Length = 287
Score = 166 bits (419), Expect = 1e-40
Identities = 91/231 (39%), Positives = 133/231 (57%), Gaps = 1/231 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTRLG 278
PLDL+K +Q + + + A+R + + +G+LA+YSGLSA L RQ TY+ TR
Sbjct: 26 PLDLLKVHLQTQQE----VKLRMTGMALR-VVRTDGILALYSGLSASLCRQMTYSLTRFA 80
Query: 279 VYTCLFEKFSTKDKPP-SFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRRN 455
+Y + ++ + + P F K +G +GL G F+GTP ++ +RM +D +LP QRRN
Sbjct: 81 IYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRN 140
Query: 456 YRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGIF 635
Y + L R+ REEG+ L+ G R A+V + QL+ Y QAKQ++L +GY SD IF
Sbjct: 141 YAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIF 200
Query: 636 VHFGASMISGFITTVASMPVDIVKTRIQNMKVVNGVAEYSGAINAFVRIAK 788
HF AS I+G T P+D++KTR+ N K EY G + V AK
Sbjct: 201 THFVASFIAGGCATFLCQPLDVLKTRLMNSK-----GEYQGVFHCAVETAK 246
Score = 30.8 bits (68), Expect = 5.1
Identities = 13/23 (56%), Positives = 17/23 (73%)
Frame = +2
Query: 800 LSLWKGFTPYFLRLGPHTVITFV 868
L+ +KG P +RL PHTV+TFV
Sbjct: 250 LAFYKGLVPAGIRLIPHTVLTFV 272
>sp|Q9QZD8|DIC_MOUSE Mitochondrial dicarboxylate carrier
Length = 287
Score = 161 bits (407), Expect = 3e-39
Identities = 89/232 (38%), Positives = 130/232 (56%), Gaps = 2/232 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTRLG 278
PLDL+K +Q + + + Q+ + +G LA+Y+GLSA L RQ TY+ TR
Sbjct: 25 PLDLLKVHLQTQQEVKLRMTGMAL-----QVVRTDGFLALYNGLSASLCRQMTYSLTRFA 79
Query: 279 VYTCLFEKFSTKDK--PPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRR 452
+Y + + + TKD P F K +G +GL G F+GTP ++ +RM +D +LP QRR
Sbjct: 80 IYETMRD-YMTKDSQGPLPFYNKVLLGGISGLTGGFVGTPADLVNVRMQNDMKLPPSQRR 138
Query: 453 NYRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGI 632
NY + L R+ REE + L+ G R A+V + QL+ Y QAKQ++L +GY SD I
Sbjct: 139 NYSHALDGLYRVAREESLRKLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNI 198
Query: 633 FVHFGASMISGFITTVASMPVDIVKTRIQNMKVVNGVAEYSGAINAFVRIAK 788
F HF +S I+G T P+D++KTR+ N K EY G + + AK
Sbjct: 199 FTHFVSSFIAGGCATFLCQPLDVLKTRLMNSK-----GEYQGVFHCAMETAK 245
>sp|O95258|UCP5_HUMAN Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial
uncoupling protein 5) (UCP 5) (Solute carrier family 25
member 14)
Length = 325
Score = 140 bits (353), Expect = 5e-33
Identities = 84/237 (35%), Positives = 130/237 (54%), Gaps = 5/237 (2%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQ--DGAKKA--YKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTT 266
P+DL K R+Q+ GQ D K Y+ F A+ +I K EG+LA+YSG++ LLRQA+Y T
Sbjct: 60 PVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGT 119
Query: 267 TRLGVYTCLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQ 446
++G+Y L F + + + G+ +G++ S I PT+V IRM + G L
Sbjct: 120 IKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQG- 178
Query: 447 RRNYRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSD 626
++ + I ++EG LWRG +PT RAA+V +L Y K+ ++ SG D
Sbjct: 179 -----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGD 233
Query: 627 GIFVHFGASMISGFITTVASMPVDIVKTRIQNMKVVNG-VAEYSGAINAFVRIAKTE 794
I HF +S G +AS PVD+V+TR+ N + + G V Y G ++ +++ K E
Sbjct: 234 TILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHE 290
Score = 32.0 bits (71), Expect = 2.3
Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 1/51 (1%)
Frame = +3
Query: 99 PLDLVKNRMQ-MSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLR 248
P+D+V+ RM G YK + D I ++ K+EG A+Y G LR
Sbjct: 255 PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLR 305
Score = 30.0 bits (66), Expect = 8.7
Identities = 12/22 (54%), Positives = 17/22 (77%)
Frame = +2
Query: 803 SLWKGFTPYFLRLGPHTVITFV 868
+L+KGF P +LRLGP +I F+
Sbjct: 294 ALYKGFWPNWLRLGPWNIIFFI 315
>sp|Q9Z2B2|UCP5_MOUSE Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial
uncoupling protein 5) (UCP 5) (Solute carrier family 25
member 14)
Length = 325
Score = 139 bits (351), Expect = 8e-33
Identities = 82/237 (34%), Positives = 129/237 (54%), Gaps = 5/237 (2%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKK----AYKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTT 266
P+DL K R+Q+ GQ + Y+ F A+ +I K EG+LA+YSG++ LLRQA+Y T
Sbjct: 60 PVDLTKTRLQVQGQSIDVRFKEIKYRGMFHALFRIYKEEGILALYSGIAPALLRQASYGT 119
Query: 267 TRLGVYTCLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQ 446
++G+Y L F + + + G+ +G++ S I PT+V IRM + G L
Sbjct: 120 IKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQG- 178
Query: 447 RRNYRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSD 626
++ + I ++EG LWRG +PT RAA+V +L Y K+ ++ SG D
Sbjct: 179 -----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLIVSGMLGD 233
Query: 627 GIFVHFGASMISGFITTVASMPVDIVKTRIQNMKVVNG-VAEYSGAINAFVRIAKTE 794
I HF +S G +AS PVD+V+TR+ N + + G V Y G ++ +++ K E
Sbjct: 234 TILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTLDGILKMWKHE 290
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 1/51 (1%)
Frame = +3
Query: 99 PLDLVKNRMQ-MSGQDGAKKAYKSSFDAIRQITKNEGLLAIYSGLSAGLLR 248
P+D+V+ RM G YK + D I ++ K+EG A+Y G LR
Sbjct: 255 PVDVVRTRMMNQRAIVGHVDLYKGTLDGILKMWKHEGFFALYKGFWPNWLR 305
Score = 30.0 bits (66), Expect = 8.7
Identities = 12/22 (54%), Positives = 17/22 (77%)
Frame = +2
Query: 803 SLWKGFTPYFLRLGPHTVITFV 868
+L+KGF P +LRLGP +I F+
Sbjct: 294 ALYKGFWPNWLRLGPWNIIFFI 315
>sp|P14271|UCP1_RABIT Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Thermogenin)
Length = 306
Score = 138 bits (348), Expect = 2e-32
Identities = 75/210 (35%), Positives = 116/210 (55%), Gaps = 2/210 (0%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKA--YKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTR 272
PLD K R Q+ G+ YK I + K EG L +YSGL AGL RQ ++ + R
Sbjct: 33 PLDTAKVRQQIQGEFPITSGIRYKGVLGTITTLAKTEGPLKLYSGLPAGLQRQISFASLR 92
Query: 273 LGVYTCLFEKFSTKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRR 452
+G+Y + E F++ ++ PS +K + GLT G V FIG PTEV +R+ + L +
Sbjct: 93 IGLYDTVQEFFTSGEETPSLGSKISAGLTTGGVAVFIGQPTEVVKVRLQAQSHL-HGLKP 151
Query: 453 NYRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGI 632
Y ++A I E + +LW+G P + R ++N +L +Y K ++ + +D +
Sbjct: 152 RYTGTYNAYRIIATTESLTSLWKGTTPNLLRNVIINCTELVTYDLMKGALVRNEILADDV 211
Query: 633 FVHFGASMISGFITTVASMPVDIVKTRIQN 722
HF +++I+GF TT+ S PVD+VKTR N
Sbjct: 212 PCHFVSALIAGFCTTLLSSPVDVVKTRFIN 241
Score = 58.9 bits (141), Expect = 2e-08
Identities = 39/164 (23%), Positives = 68/164 (41%), Gaps = 1/164 (0%)
Frame = +3
Query: 306 STKDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQRRNYRNVFHALAR 485
+T D PP+ K A + I P + A +R G P+ Y+ V +
Sbjct: 5 TTTDVPPTMGVKIFSAGVAACLADVITFPLDTAKVRQQIQGEFPITSGIRYKGVLGTITT 64
Query: 486 IVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDGIFVHFGASMISG 665
+ + EG L L+ G + R ++ Y ++ SG + + A + +G
Sbjct: 65 LAKTEGPLKLYSGLPAGLQRQISFASLRIGLYDTVQE-FFTSGEETPSLGSKISAGLTTG 123
Query: 666 FITTVASMPVDIVKTRIQNMKVVNGV-AEYSGAINAFVRIAKTE 794
+ P ++VK R+Q ++G+ Y+G NA+ IA TE
Sbjct: 124 GVAVFIGQPTEVVKVRLQAQSHLHGLKPRYTGTYNAYRIIATTE 167
>sp|P12242|UCP1_MOUSE Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Thermogenin)
Length = 307
Score = 135 bits (340), Expect = 1e-31
Identities = 75/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Frame = +3
Query: 99 PLDLVKNRMQMSGQDGAKKA--YKSSFDAIRQITKNEGLLAIYSGLSAGLLRQATYTTTR 272
PLD K R+Q+ G+ A YK I + K EGL +YSGL AG+ RQ ++ + R
Sbjct: 33 PLDTAKVRLQIQGEGQASSTIRYKGVLGTITTLAKTEGLPKLYSGLPAGIQRQISFASLR 92
Query: 273 LGVYTCLFEKFST-KDKPPSFATKAAIGLTAGLVGSFIGTPTEVALIRMTSDGRLPMDQR 449
+G+Y + E FS+ ++ P S K + GL G V FIG PTEV +RM + L +
Sbjct: 93 IGLYDSVQEYFSSGRETPASLGNKISAGLMTGGVAVFIGQPTEVVKVRMQAQSHLHGIKP 152
Query: 450 RNYRNVFHALARIVREEGVLTLWRGCLPTMGRAAVVNLAQLASYSQAKQVILESGYFSDG 629
R Y ++A I E + TLW+G P + R ++N +L +Y K ++ + +D
Sbjct: 153 R-YTGTYNAYRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKGALVNNKILADD 211
Query: 630 IFVHFGASMISGFITTVASMPVDIVKTRIQN 722
+ H +++++GF TT+ + PVD+VKTR N
Sbjct: 212 VPCHLLSALVAGFCTTLLASPVDVVKTRFIN 242
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,631,287
Number of Sequences: 369166
Number of extensions: 2166921
Number of successful extensions: 6261
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5496
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5989
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)