Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_M21
(378 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 ... 70 1e-12
sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p... 69 3e-12
sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 ... 68 6e-12
sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p... 68 7e-12
sp|Q03497|STE20_YEAST Serine/threonine-protein kinase STE20 68 7e-12
sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 ... 68 7e-12
sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 ... 68 7e-12
sp|Q29502|PAK2_RABIT Serine/threonine-protein kinase PAK 2 ... 68 7e-12
sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinas... 68 7e-12
sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinas... 67 1e-11
>sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK)
Length = 545
Score = 70.5 bits (171), Expect = 1e-12
Identities = 34/93 (36%), Positives = 52/93 (55%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K S
Sbjct: 432 APEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 491
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F++ CLD + KR + K+L++H+FL A
Sbjct: 492 AIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIA 524
>sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2)
Length = 544
Score = 68.9 bits (167), Expect = 3e-12
Identities = 33/93 (35%), Positives = 52/93 (55%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K S
Sbjct: 431 APEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 490
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F++ CL+ + KR + K+L++H+FL A
Sbjct: 491 AIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIA 523
>sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase
PAK-A)
Length = 545
Score = 68.2 bits (165), Expect = 6e-12
Identities = 33/93 (35%), Positives = 51/93 (54%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K S
Sbjct: 432 APEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 491
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F+ CL+ + KR + K+L++H+FL A
Sbjct: 492 AIFRDFLQCCLEMDVEKRGSAKELLQHQFLKIA 524
>sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p62-PAK)
Length = 524
Score = 67.8 bits (164), Expect = 7e-12
Identities = 32/93 (34%), Positives = 51/93 (54%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P K S
Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F++ CL+ + KR + K+L++H FL A
Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLA 503
>sp|Q03497|STE20_YEAST Serine/threonine-protein kinase STE20
Length = 939
Score = 67.8 bits (164), Expect = 7e-12
Identities = 33/97 (34%), Positives = 53/97 (54%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV++ + YG DIWS G +++E+I G+ P +A+Y + T + P S
Sbjct: 782 APEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLS 841
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSAMEAD 291
+LK F+D CL EP R + +L+ E++ EA+
Sbjct: 842 SSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEAN 878
>sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2)
Length = 524
Score = 67.8 bits (164), Expect = 7e-12
Identities = 32/93 (34%), Positives = 51/93 (54%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P K S
Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F++ CL+ + KR + K+L++H FL A
Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLA 503
>sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase)
Length = 524
Score = 67.8 bits (164), Expect = 7e-12
Identities = 32/93 (34%), Positives = 51/93 (54%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P K S
Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F++ CL+ + KR + K+L++H FL A
Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLA 503
>sp|Q29502|PAK2_RABIT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p21-activated protein kinase I)
(PAKI)
Length = 524
Score = 67.8 bits (164), Expect = 7e-12
Identities = 32/93 (34%), Positives = 51/93 (54%)
Frame = +1
Query: 1 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 180
APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P K S
Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470
Query: 181 DALKSFVDPCLDPEPLKRPTVKDLMKHEFLNSA 279
+ F++ CL+ + KR + K+L++H FL A
Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLA 503
>sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1)
Length = 1607
Score = 67.8 bits (164), Expect = 7e-12
Identities = 38/94 (40%), Positives = 55/94 (58%), Gaps = 4/94 (4%)
Frame = +1
Query: 1 APEVIN---GEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYP 168
APEVI GEG+G +ADIWS G V++E++TGK P + +FQ +Y++G K P
Sbjct: 1509 APEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--P 1566
Query: 169 LKCSDALKSFVDPCLDPEPLKRPTVKDLMKHEFL 270
+ S K F+ CL+ +P R T L+ H F+
Sbjct: 1567 ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1600
>sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4)
Length = 1597
Score = 67.0 bits (162), Expect = 1e-11
Identities = 38/94 (40%), Positives = 56/94 (59%), Gaps = 4/94 (4%)
Frame = +1
Query: 1 APEVIN---GEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYP 168
APEVI GEG+G +ADIWS G V++E++TGK P + +FQ +Y++G K P
Sbjct: 1499 APEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--P 1556
Query: 169 LKCSDALKSFVDPCLDPEPLKRPTVKDLMKHEFL 270
+ S K+F+ CL+ +P R T L+ H F+
Sbjct: 1557 ERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFV 1590
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,685,520
Number of Sequences: 369166
Number of extensions: 809462
Number of successful extensions: 3542
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3237
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3348
length of database: 68,354,980
effective HSP length: 92
effective length of database: 51,359,360
effective search space used: 1694858880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)