Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_M20
(555 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitoc... 251 8e-67
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 250 2e-66
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 250 2e-66
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 231 9e-61
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 228 8e-60
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 228 8e-60
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplas... 228 1e-59
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 226 3e-59
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytopl... 225 5e-59
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 216 4e-56
>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 251 bits (641), Expect = 8e-67
Identities = 118/150 (78%), Positives = 132/150 (88%), Gaps = 1/150 (0%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
SSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQ
Sbjct: 300 SSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQ 359
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ ++E+ CV+TV+SG MTKDLA CI
Sbjct: 360 KGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCI 419
Query: 361 HGLKNVQPN-HYLVTMDFLDAIAENFESKL 447
HGL NV+ N H+L T DFLD I N + L
Sbjct: 420 HGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 250 bits (638), Expect = 2e-66
Identities = 118/150 (78%), Positives = 131/150 (87%), Gaps = 1/150 (0%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
SSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQ
Sbjct: 300 SSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQ 359
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV+TV+SG MTKDLA CI
Sbjct: 360 KGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCI 419
Query: 361 HGLKNVQPN-HYLVTMDFLDAIAENFESKL 447
HGL NV+ N H+L T DFLD I N + L
Sbjct: 420 HGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 421
Score = 250 bits (638), Expect = 2e-66
Identities = 118/150 (78%), Positives = 131/150 (87%), Gaps = 1/150 (0%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
SSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQ
Sbjct: 269 SSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQ 328
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV+TV+SG MTKDLA CI
Sbjct: 329 KGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCI 388
Query: 361 HGLKNVQPN-HYLVTMDFLDAIAENFESKL 447
HGL NV+ N H+L T DFLD I N + L
Sbjct: 389 HGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 523
Score = 231 bits (589), Expect = 9e-61
Identities = 113/150 (75%), Positives = 124/150 (82%), Gaps = 1/150 (0%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
SSGGFVW CKNYDGDVQSDI+A +GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQ
Sbjct: 372 SSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQ 431
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+PTST IASIFAWTRGLEHRGKLD NQ+LIR+ E+ CV TV+ G MTKDLA CI
Sbjct: 432 KGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFAQTREKVCVQTVE-GAMTKDLAGCI 490
Query: 361 HGLKNVQPN-HYLVTMDFLDAIAENFESKL 447
HGL NV+ N H+L T DFLD I N + L
Sbjct: 491 HGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 520
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 228 bits (581), Expect = 8e-60
Identities = 104/149 (69%), Positives = 124/149 (83%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
S GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR HQ
Sbjct: 261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMHQ 320
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E C++T+++G MTKDLAACI
Sbjct: 321 KGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIETIEAGFMTKDLAACI 380
Query: 361 HGLKNVQPNHYLVTMDFLDAIAENFESKL 447
GL NVQ + YL T +F+D + EN ++KL
Sbjct: 381 KGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 228 bits (581), Expect = 8e-60
Identities = 104/149 (69%), Positives = 124/149 (83%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
S GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR HQ
Sbjct: 261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMHQ 320
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E C++T+++G MTKDLAACI
Sbjct: 321 KGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIETIEAGFMTKDLAACI 380
Query: 361 HGLKNVQPNHYLVTMDFLDAIAENFESKL 447
GL NVQ + YL T +F+D + EN ++KL
Sbjct: 381 KGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 228 bits (580), Expect = 1e-59
Identities = 104/149 (69%), Positives = 125/149 (83%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
S GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +Q
Sbjct: 261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQ 320
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+ TSTNPIASIFAW+RGL HR KLDNN EL + + +E C++T+++G MTKDLAACI
Sbjct: 321 KGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIETIEAGFMTKDLAACI 380
Query: 361 HGLKNVQPNHYLVTMDFLDAIAENFESKL 447
GL NVQ + YL T +F+D + EN ++KL
Sbjct: 381 KGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 226 bits (576), Expect = 3e-59
Identities = 104/149 (69%), Positives = 124/149 (83%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
S GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +Q
Sbjct: 261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQ 320
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+ TSTNPIASIFAW+RGL HR KLDNN EL + +E C++T+++G MTKDLAACI
Sbjct: 321 KGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACI 380
Query: 361 HGLKNVQPNHYLVTMDFLDAIAENFESKL 447
GL NVQ + YL T +F+D + EN ++KL
Sbjct: 381 KGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 225 bits (574), Expect = 5e-59
Identities = 104/149 (69%), Positives = 124/149 (83%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
S GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +Q
Sbjct: 261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQ 320
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG+ TSTNPIASIFAWTRGL HR KLDNN+EL + + +E ++T+++G MTKDLAACI
Sbjct: 321 KGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACI 380
Query: 361 HGLKNVQPNHYLVTMDFLDAIAENFESKL 447
GL NVQ + YL T +F+D + EN + KL
Sbjct: 381 KGLPNVQRSDYLNTFEFMDKLGENLKIKL 409
>sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase)
(IDH) (NADP(+)-specific ICDH) (IDP)
Length = 415
Score = 216 bits (549), Expect = 4e-56
Identities = 102/149 (68%), Positives = 121/149 (81%)
Frame = +1
Query: 1 SSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQ 180
S GG+VW CKNYDGDVQSD +AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYR HQ
Sbjct: 263 SEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQ 322
Query: 181 KGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACI 360
KG TSTN IASIFAWTRGL HR LDNN+ L+ + +E AC+ V+SGKMTKDLA I
Sbjct: 323 KGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALII 382
Query: 361 HGLKNVQPNHYLVTMDFLDAIAENFESKL 447
HG K + +HYL T +F+DA+A+ +++L
Sbjct: 383 HGSK-LSRDHYLNTEEFIDAVADELKARL 410
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,298,231
Number of Sequences: 369166
Number of extensions: 1368414
Number of successful extensions: 3371
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3276
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3356
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3931403200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)