Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_M15
(889 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q27433|MEC2_CAEEL Mechanosensory protein 2 310 5e-84
sp|P27105|STOM_HUMAN Erythrocyte band 7 integral membrane p... 294 2e-79
sp|P54116|STOM_MOUSE Erythrocyte band 7 integral membrane p... 294 3e-79
sp|Q19958|STO2_CAEEL Stomatin protein 2 286 5e-77
sp|Q22165|STO4_CAEEL Stomatin protein 4 285 1e-76
sp|Q8TAV4|STML3_HUMAN Stomatin-like protein 3 265 1e-70
sp|Q21190|UNC1_CAEEL Uncoordinated protein 1 (Protein unc-1) 265 1e-70
sp|Q6PE84|STML3_MOUSE Stomatin-like protein 3 (Stomatin-rel... 264 3e-70
sp|Q19200|STO1_CAEEL Stomatin protein 1 250 3e-66
sp|Q20657|STO3_CAEEL Stomatin protein 3 219 8e-57
>sp|Q27433|MEC2_CAEEL Mechanosensory protein 2
Length = 481
Score = 310 bits (793), Expect = 5e-84
Identities = 160/254 (62%), Positives = 194/254 (76%), Gaps = 2/254 (0%)
Frame = +3
Query: 129 KEEPSSAGANF--CGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSP 302
KEE ++ F CG +L +LS L+ T PIS CIKVV EYERAV+FRLGR++PG
Sbjct: 104 KEEKANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGA 163
Query: 303 KGPGLLFIFPCMDQLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNV 482
KGPG+ FI PC+D R VDLR ++F+VPPQE+L+KDSVTVAVDAVVY+RI N +SVTNV
Sbjct: 164 KGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNV 223
Query: 483 ENADRSTRLLAATTLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXX 662
E+A RST+LLA TTLRN+LGTK LAE+LS+R++IS+ MQ LDEAT PWG
Sbjct: 224 EDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKD 283
Query: 663 XXLPVQLQRXXXXXXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTL 842
LPVQLQR RE++AKVI A GEQK+++ALKEAA+VI++SP ALQLRYLQTL
Sbjct: 284 VRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTL 343
Query: 843 NAISAEKNSTIIFP 884
N+ISAEKNSTIIFP
Sbjct: 344 NSISAEKNSTIIFP 357
>sp|P27105|STOM_HUMAN Erythrocyte band 7 integral membrane protein (Stomatin) (Protein
7.2b)
Length = 288
Score = 294 bits (753), Expect = 2e-79
Identities = 147/253 (58%), Positives = 186/253 (73%)
Frame = +3
Query: 129 KEEPSSAGANFCGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKG 308
K+ PS G CG +L+ S +ITFPIS+ CIK++ EYERA++FRLGRIL G KG
Sbjct: 20 KDSPSK-GLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKG 78
Query: 309 PGLLFIFPCMDQLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVEN 488
PGL FI PC D VD+RT++FD+PPQE+LTKDSVT++VD VVYYR+ N ++V N+ N
Sbjct: 79 PGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITN 138
Query: 489 ADRSTRLLAATTLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXX 668
AD +TRLLA TTLRNVLGTKNL++ILS+R+ I++ MQ+ LD+AT WG
Sbjct: 139 ADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVK 198
Query: 669 LPVQLQRXXXXXXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNA 848
LPVQLQR RE++AKVIAA GE +++ALKEA+ VI++SP ALQLRYLQTL
Sbjct: 199 LPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTT 258
Query: 849 ISAEKNSTIIFPL 887
I+AEKNSTI+FPL
Sbjct: 259 IAAEKNSTIVFPL 271
>sp|P54116|STOM_MOUSE Erythrocyte band 7 integral membrane protein (Stomatin) (Protein
7.2b)
Length = 284
Score = 294 bits (752), Expect = 3e-79
Identities = 152/267 (56%), Positives = 191/267 (71%), Gaps = 1/267 (0%)
Frame = +3
Query: 90 RKYSVVNPQGMP-SKEEPSSAGANFCGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAV 266
R+ S V Q +P S E S CG +L+ +S V+ITFPIS+ CIK+V EYER +
Sbjct: 5 RQSSHVQSQRIPESFRENSKTELGACGWILVAVSFIFVLITFPISIWICIKIVKEYERVI 64
Query: 267 VFRLGRILPGSPKGPGLLFIFPCMDQLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYY 446
+FRLGRIL G KGPGL FI PC D VD+RT++FD+PPQEVLTKDSVT++VD VVYY
Sbjct: 65 IFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYY 124
Query: 447 RIYNPIVSVTNVENADRSTRLLAATTLRNVLGTKNLAEILSERDSISNMMQALLDEATHP 626
R+ N ++V N+ NAD +TRLLA TTLRN LGTKNL++ILS+R+ I++ MQ+ LD+AT
Sbjct: 125 RVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDD 184
Query: 627 WGXXXXXXXXXXXXLPVQLQRXXXXXXXXDRESKAKVIAALGEQKSAKALKEAADVISQS 806
WG LPVQLQR RE++AKVIAA GE +++ALKEA+ VI++S
Sbjct: 185 WGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITES 244
Query: 807 PMALQLRYLQTLNAISAEKNSTIIFPL 887
P ALQLRYLQTL I+AEKNSTI+FPL
Sbjct: 245 PAALQLRYLQTLTTIAAEKNSTIVFPL 271
>sp|Q19958|STO2_CAEEL Stomatin protein 2
Length = 314
Score = 286 bits (732), Expect = 5e-77
Identities = 144/243 (59%), Positives = 181/243 (74%)
Frame = +3
Query: 135 EPSSAGANFCGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKGPG 314
E G FCG LM LS +VI TFP+S+ FC+KVV EYERAV+FRLGR++ G KGPG
Sbjct: 60 EHYDTGLGFCGWFLMGLSWIMVISTFPVSIYFCMKVVQEYERAVIFRLGRLIGGGAKGPG 119
Query: 315 LLFIFPCMDQLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVENAD 494
+ F+ PC++ VDLRTV+F VPPQE+LTKDSVT +VDAV+YYRI N VSV NVENA
Sbjct: 120 IFFVLPCIESYTKVDLRTVSFSVPPQEILTKDSVTTSVDAVIYYRISNATVSVANVENAH 179
Query: 495 RSTRLLAATTLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXXLP 674
STRLLA TTLRN+LGT++L+EILS+R++++ MQ +LDEAT WG LP
Sbjct: 180 HSTRLLAQTTLRNMLGTRSLSEILSDRETLAASMQTILDEATESWGIKVERVEIKDVRLP 239
Query: 675 VQLQRXXXXXXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNAIS 854
+QLQR RE++AKVIAA GEQK+++AL++AA VI+QSP ALQLRYLQTLN+++
Sbjct: 240 IQLQRAMAAEAEATREARAKVIAAEGEQKASRALRDAASVIAQSPAALQLRYLQTLNSVA 299
Query: 855 AEK 863
EK
Sbjct: 300 REK 302
>sp|Q22165|STO4_CAEEL Stomatin protein 4
Length = 281
Score = 285 bits (729), Expect = 1e-76
Identities = 142/241 (58%), Positives = 181/241 (75%)
Frame = +3
Query: 162 CGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKGPGLLFIFPCMD 341
CG ++ ++S +V+ T P+S FC+KVV EYERAV+FRLGR+ G +GPG+ FI PC++
Sbjct: 26 CGWIITIISYLVVLFTLPLSAFFCLKVVQEYERAVIFRLGRLKHGGARGPGIFFIIPCIE 85
Query: 342 QLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVENADRSTRLLAAT 521
+ +DLR V+FDVPPQE+L+KDSVTV+VDAV+Y+RI N VSV NVE+A RST+LLA T
Sbjct: 86 SFKKIDLRVVSFDVPPQEILSKDSVTVSVDAVIYFRISNATVSVINVEDAARSTKLLAQT 145
Query: 522 TLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXXLPVQLQRXXXX 701
TLRN LGT+ LAE+LS RD+IS MQA LDEAT PWG LP+QLQR
Sbjct: 146 TLRNFLGTRTLAEMLSSRDAISMQMQAALDEATDPWGVKVERVEIKDVRLPIQLQRAMAA 205
Query: 702 XXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNAISAEKNSTIIF 881
R + AK+IAA GEQ +++AL +AADVI+ SP A+QLRYLQTLN+IS+EKN+TIIF
Sbjct: 206 EAEAARAAGAKIIAAEGEQLASRALADAADVIATSPCAIQLRYLQTLNSISSEKNNTIIF 265
Query: 882 P 884
P
Sbjct: 266 P 266
>sp|Q8TAV4|STML3_HUMAN Stomatin-like protein 3
Length = 291
Score = 265 bits (678), Expect = 1e-70
Identities = 133/242 (54%), Positives = 176/242 (72%)
Frame = +3
Query: 162 CGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKGPGLLFIFPCMD 341
CG +L LS LVIITFPIS+ C+K++ EYERAVVFRLGRI KGPGL+ + PC+D
Sbjct: 27 CGWILFSLSFLLVIITFPISIWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCID 86
Query: 342 QLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVENADRSTRLLAAT 521
VDLRTVT ++PPQE+LT+DSVT VD VVYYRIY+ + +V NV + ++T LLA T
Sbjct: 87 VFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQT 146
Query: 522 TLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXXLPVQLQRXXXX 701
TLRNVLGT+ L++IL+ R+ I++ +Q LLD+AT WG +PVQLQR
Sbjct: 147 TLRNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAA 206
Query: 702 XXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNAISAEKNSTIIF 881
RE++AKV+AA GE ++K+LK A+ V+++SP+ALQLRYLQTL+ ++ EKNSTI+F
Sbjct: 207 EAEATREARAKVLAAEGEMNASKSLKSASMVLAESPIALQLRYLQTLSTVATEKNSTIVF 266
Query: 882 PL 887
PL
Sbjct: 267 PL 268
>sp|Q21190|UNC1_CAEEL Uncoordinated protein 1 (Protein unc-1)
Length = 285
Score = 265 bits (678), Expect = 1e-70
Identities = 131/241 (54%), Positives = 176/241 (73%)
Frame = +3
Query: 165 GSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKGPGLLFIFPCMDQ 344
G L LS L+I+TFP S+ C+KV+ EYER V+FR+GR++ G +GPG++FI PC+D
Sbjct: 32 GYALQALSWILIIVTFPFSMCVCLKVIKEYERVVIFRIGRLVFGGARGPGMIFIIPCIDT 91
Query: 345 LRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVENADRSTRLLAATT 524
R +DLR V++ VPPQE+L+KDSVTV+VDAVVY+R +PI SV NV++A ST+LLA TT
Sbjct: 92 YRKIDLRVVSYAVPPQEILSKDSVTVSVDAVVYFRTSDPIASVNNVDDAIYSTKLLAQTT 151
Query: 525 LRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXXLPVQLQRXXXXX 704
LRN LG K L E+L+ER++I+ + + +LDE T WG LP QL R
Sbjct: 152 LRNALGMKTLTEMLTEREAIAQLCETILDEGTEHWGVKVERVEVKDIRLPQQLTRAMAAE 211
Query: 705 XXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNAISAEKNSTIIFP 884
RE++AKV+AA GEQK+++ALKEAADVI +P+ALQLR+LQ LN+I+AE NSTI+FP
Sbjct: 212 AEAAREARAKVVAAEGEQKASRALKEAADVIQANPVALQLRHLQALNSIAAEHNSTIVFP 271
Query: 885 L 887
+
Sbjct: 272 V 272
>sp|Q6PE84|STML3_MOUSE Stomatin-like protein 3 (Stomatin-related olfactory protein)
Length = 287
Score = 264 bits (674), Expect = 3e-70
Identities = 131/242 (54%), Positives = 175/242 (72%)
Frame = +3
Query: 162 CGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKGPGLLFIFPCMD 341
CG +L LS L+++TFPIS+ C+K++ EYERAVVFRLGRI KGPGL+ + PC+D
Sbjct: 23 CGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCID 82
Query: 342 QLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVENADRSTRLLAAT 521
VDLRTVT ++PPQE+LT+DSVT VD VVYYRIY+ + +V NV + ++T LLA T
Sbjct: 83 VFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQT 142
Query: 522 TLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXXLPVQLQRXXXX 701
TLRNVLGT+ L++ILS R+ I++ +Q LLD+AT WG +PVQLQR
Sbjct: 143 TLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAA 202
Query: 702 XXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNAISAEKNSTIIF 881
RE++AKV+AA GE ++K+LK A+ V+++SP+ALQLRYLQTL ++ EKNSTI+F
Sbjct: 203 EAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVF 262
Query: 882 PL 887
PL
Sbjct: 263 PL 264
>sp|Q19200|STO1_CAEEL Stomatin protein 1
Length = 330
Score = 250 bits (639), Expect = 3e-66
Identities = 136/276 (49%), Positives = 186/276 (67%), Gaps = 6/276 (2%)
Frame = +3
Query: 75 ETDEIRKYSVVNPQGMPSKEEPSSAGANF-----CGSVLMV-LSLFLVIITFPISLIFCI 236
ET E+++ + + Q + SA AN C + + +S L+ +TFP+S+ CI
Sbjct: 5 ETVEMQEMAQPSGQQRDVEARVQSAPANHSHDAGCTEMFCIAMSYVLIFLTFPVSVFMCI 64
Query: 237 KVVVEYERAVVFRLGRILPGSPKGPGLLFIFPCMDQLRSVDLRTVTFDVPPQEVLTKDSV 416
K+V EY+RAVVFRLGR++P KGPG+ FI PC+D ++DLR +++VP QE+L++DSV
Sbjct: 65 KIVQEYQRAVVFRLGRLVP-DVKGPGIFFIIPCIDTFLNIDLRVASYNVPSQEILSRDSV 123
Query: 417 TVAVDAVVYYRIYNPIVSVTNVENADRSTRLLAATTLRNVLGTKNLAEILSERDSISNMM 596
TV+VDAVVY+++++PI SV V NA ST+LLA TTLR +LGT L+EILS+R+ IS M
Sbjct: 124 TVSVDAVVYFKVFDPITSVVGVGNATDSTKLLAQTTLRTILGTHTLSEILSDREKISADM 183
Query: 597 QALLDEATHPWGXXXXXXXXXXXXLPVQLQRXXXXXXXXDRESKAKVIAALGEQKSAKAL 776
+ LDEAT PWG LP Q+QR R++ AK+IAA GE +++ AL
Sbjct: 184 KISLDEATEPWGIKVERVELRDVRLPSQMQRAMAAEAEATRDAGAKIIAAEGELRASAAL 243
Query: 777 KEAADVISQSPMALQLRYLQTLNAISAEKNSTIIFP 884
EAA +IS+S A+QLRYL TLNAIS+EK STIIFP
Sbjct: 244 AEAATIISKSEGAMQLRYLHTLNAISSEKTSTIIFP 279
>sp|Q20657|STO3_CAEEL Stomatin protein 3
Length = 267
Score = 219 bits (558), Expect = 8e-57
Identities = 110/242 (45%), Positives = 162/242 (66%)
Frame = +3
Query: 159 FCGSVLMVLSLFLVIITFPISLIFCIKVVVEYERAVVFRLGRILPGSPKGPGLLFIFPCM 338
F V ++ + +++TFP+S+ FC+K+V EY+R V+FRLGR+ +P+GPG++ + P +
Sbjct: 14 FFDFVALICAWAFLLLTFPVSIFFCVKIVKEYDRMVIFRLGRLWQDNPRGPGIVLVLPFI 73
Query: 339 DQLRSVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVSVTNVENADRSTRLLAA 518
D ++VDLR +++DVP QE+LT+DSVT+ VDA VYYR +PI S+ V +A STR LA
Sbjct: 74 DSHKTVDLRVMSYDVPTQEMLTRDSVTIGVDAAVYYRTSDPIASLARVNDAHMSTRQLAQ 133
Query: 519 TTLRNVLGTKNLAEILSERDSISNMMQALLDEATHPWGXXXXXXXXXXXXLPVQLQRXXX 698
++LRNVLGT++LAE++++R I+ ++ +LD AT WG LP ++ R
Sbjct: 134 SSLRNVLGTRSLAELMTDRHGIAVQVKYILDSATLFWGIHVERVEIKDIRLpreMCRAMA 193
Query: 699 XXXXXDRESKAKVIAALGEQKSAKALKEAADVISQSPMALQLRYLQTLNAISAEKNSTII 878
RES AKV+ A GE ++ A ++AAD ++ SP ALQLRYLQTL ISA N TI+
Sbjct: 194 AEAEAQRESDAKVVTAQGELDASMAFQKAADELAGSPTALQLRYLQTLVKISAHDNHTIV 253
Query: 879 FP 884
P
Sbjct: 254 VP 255
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,657,138
Number of Sequences: 369166
Number of extensions: 1767128
Number of successful extensions: 4755
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4435
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4746
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8886314050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)