Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_K23
(824 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O70351|HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type II ... 260 4e-69
sp|O02691|HCD2_BOVIN 3-hydroxyacyl-CoA dehydrogenase type I... 256 7e-68
sp|O18404|HCD2_DROME 3-hydroxyacyl-CoA dehydrogenase type I... 254 2e-67
sp|Q99714|HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type I... 253 4e-67
sp|O08756|HCD2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type I... 251 1e-66
sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reduc... 94 3e-19
sp|P99120|BUTA_STAAN Acetoin(diacetyl) reductase (Acetoin d... 88 2e-17
sp|P46331|YXBG_BACSU Hypothetical oxidoreductase yxbG 85 3e-16
sp|P51831|FABG_BACSU 3-oxoacyl-[acyl-carrier-protein] reduc... 84 4e-16
sp|P66781|YD50_MYCTU Putative oxidoreductase Rv1350/MT1393 ... 84 6e-16
>sp|O70351|HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein)
Length = 261
Score = 260 bits (664), Expect = 4e-69
Identities = 126/236 (53%), Positives = 167/236 (70%), Gaps = 6/236 (2%)
Frame = +2
Query: 77 TVERLTEQGCKVAICDIQ------EPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKL 238
T +RL QG + D+ E KKL N + +V+ +V+ A+T K + ++
Sbjct: 26 TAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQAALTLAKEKFGRI 85
Query: 239 DILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFN 418
D+ VNCAGI VA+K Y+ KKN H L+ F+R++ VN +GTFN+IRL + NEP++
Sbjct: 86 DVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIRLVAGVMGQNEPDQGG 145
Query: 419 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 598
QRG++INT+S+AAFEGQ GQ+AYSAS+G IV MTLP+ARDL +G+RV+TIAPG+F TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVVTIAPGLFATPL 205
Query: 599 LENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQSIIENPMLNGEVIRIDGALRMMP 766
L +PD R L+ VPFPSRLG P E+AHLVQ +IENP LNGEVIR+DGA+RM P
Sbjct: 206 LTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQMVIENPFLNGEVIRLDGAIRMQP 261
>sp|O02691|HCD2_BOVIN 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH)
Length = 261
Score = 256 bits (653), Expect = 7e-68
Identities = 128/236 (54%), Positives = 165/236 (69%), Gaps = 6/236 (2%)
Frame = +2
Query: 77 TVERLTEQGCKVAICDIQ------EPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKL 238
T ERL QG + D+ + KKL + + DV+ DV+ A+T + + ++
Sbjct: 26 TAERLVGQGATAVLLDLPNSDGETQAKKLGKSCAFAPADVTSEKDVQAALTLAREKFGRV 85
Query: 239 DILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFN 418
D+ VNCAGI VA K YN KK+ H L+ F+R++ VN +GTFN+IRL NEP++
Sbjct: 86 DVAVNCAGIAVASKTYNLKKSQAHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGG 145
Query: 419 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 598
QRG++INT+S+AAFEGQ GQ+AYSAS+G IV MTLP+ARDL MG+RVMTIAPG+F TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVMTIAPGLFGTPL 205
Query: 599 LENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQSIIENPMLNGEVIRIDGALRMMP 766
L +PD R L+ VPFPSRLG P E+AHLVQ+IIEN LNGEVIR+DGA+RM P
Sbjct: 206 LTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQAIIENSFLNGEVIRLDGAIRMQP 261
>sp|O18404|HCD2_DROME 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Scully
protein)
Length = 255
Score = 254 bits (649), Expect = 2e-67
Identities = 122/236 (51%), Positives = 165/236 (69%), Gaps = 6/236 (2%)
Frame = +2
Query: 77 TVERLTEQGCKVAICDI------QEPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKL 238
T ERL +QG V + D+ + K+L ++ DV+ DV A+ K + +L
Sbjct: 20 TAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVTSEKDVSAALQTAKDKFGRL 79
Query: 239 DILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFN 418
D+ VNCAG AVK +N KN H L+ F+R++ +N VGTFN+IRL + +NEPN+
Sbjct: 80 DLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFNVIRLSAGLMGANEPNQDG 139
Query: 419 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 598
QRG+++NT+S+AAF+GQ GQ+AYSAS+ A+V MTLP+ARDL G+R+ TIAPG+F TP+
Sbjct: 140 QRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPGLFNTPM 199
Query: 599 LENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQSIIENPMLNGEVIRIDGALRMMP 766
L +P+ R L+K +PFP RLG P E+AHLVQ+I ENP+LNGEVIRIDGALRMMP
Sbjct: 200 LAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQAIYENPLLNGEVIRIDGALRMMP 255
>sp|Q99714|HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein) (Short-chain type dehydrogenase/reductase
XH98G2)
Length = 261
Score = 253 bits (646), Expect = 4e-67
Identities = 127/236 (53%), Positives = 164/236 (69%), Gaps = 6/236 (2%)
Frame = +2
Query: 77 TVERLTEQGCKVAICDIQ------EPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKL 238
T ERL QG + D+ + KKL N + DV+ DV+ A+ K + ++
Sbjct: 26 TAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRV 85
Query: 239 DILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFN 418
D+ VNCAGI VA K YN KK H L+ F+R++ VN +GTFN+IRL NEP++
Sbjct: 86 DVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGG 145
Query: 419 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 598
QRG++INT+S+AAFEGQ GQ+AYSAS+G IV MTLP+ARDL +G+RVMTIAPG+F TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPL 205
Query: 599 LENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQSIIENPMLNGEVIRIDGALRMMP 766
L ++P+ L+ VPFPSRLG P E+AHLVQ+IIENP LNGEVIR+DGA+RM P
Sbjct: 206 LTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP 261
>sp|O08756|HCD2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein)
Length = 261
Score = 251 bits (642), Expect = 1e-66
Identities = 122/236 (51%), Positives = 166/236 (70%), Gaps = 6/236 (2%)
Frame = +2
Query: 77 TVERLTEQGCKVAICDI------QEPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKL 238
T +RL QG + D+ + KKL + + +V+ +++ A+T K + ++
Sbjct: 26 TAKRLVGQGATAVLLDVPDSEGESQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRI 85
Query: 239 DILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFN 418
D+ VNCAGI VA+K Y++KKN H L+ F+R++ VN +GTFN+IRL NEP++
Sbjct: 86 DVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGG 145
Query: 419 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 598
QRG++INT+S+AAFEGQ GQ+AYSAS+G I MTLP+ARDL G+RV+TIAPG+F TPL
Sbjct: 146 QRGVIINTASVAAFEGQVGQAAYSASKGGIDGMTLPIARDLAPTGIRVVTIAPGLFATPL 205
Query: 599 LENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQSIIENPMLNGEVIRIDGALRMMP 766
L +P+ R L+ VPFPSRLG P E+AHLVQ+IIENP LNGEVIR+DGA+RM P
Sbjct: 206 LTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP 261
>sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 94.4 bits (233), Expect = 3e-19
Identities = 59/213 (27%), Positives = 107/213 (50%), Gaps = 3/213 (1%)
Frame = +2
Query: 125 IQEPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKLDILVNCAGIGVAVKVYNRKKNS 304
++E + LP +V+ + ++ + ++ + ++D+LVN AGI + K+
Sbjct: 46 VKEAEGLPGKVDPYVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKE-- 103
Query: 305 PHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFNQR-GIVINTSSIAAFEGQCGQS 481
+ ++ ++ VN G FN+ ++ P QR G ++N SS+ G GQ+
Sbjct: 104 ----EDWDAVINVNLKGVFNVTQMVV-------PYMIKQRNGSIVNVSSVVGIYGNPGQT 152
Query: 482 AYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSR 661
Y+AS+ ++ MT A++L +RV +APG TP+ E +P+ AR +P R
Sbjct: 153 NYAASKAGVIGMTKTWAKELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSRIPL-GR 211
Query: 662 LGHPDEFAHLVQSII--ENPMLNGEVIRIDGAL 754
G P+E A ++ + E+ + G+VI IDG L
Sbjct: 212 FGKPEEVAQVILFLASDESSYVTGQVIGIDGGL 244
>sp|P99120|BUTA_STAAN Acetoin(diacetyl) reductase (Acetoin dehydrogenase) (AR)
(Meso-2,3-butanediol dehydrogenase)
sp|P66776|BUTA_STAAW Acetoin(diacetyl) reductase (Acetoin dehydrogenase) (AR)
(Meso-2,3-butanediol dehydrogenase)
sp|P66775|BUTA_STAAM Acetoin(diacetyl) reductase (Acetoin dehydrogenase) (AR)
(Meso-2,3-butanediol dehydrogenase)
sp|Q6GKH9|BUTA_STAAR Acetoin(diacetyl) reductase (Acetoin dehydrogenase) (AR)
(Meso-2,3-butanediol dehydrogenase)
sp|Q6GCZ8|BUTA_STAAS Acetoin(diacetyl) reductase (Acetoin dehydrogenase) (AR)
(Meso-2,3-butanediol dehydrogenase)
Length = 258
Score = 88.2 bits (217), Expect = 2e-17
Identities = 70/251 (27%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Frame = +2
Query: 83 ERLTEQGCKVAICDIQEPKKLPA---------NSYYIKTDVSCANDVENAITQIKSEAKK 235
ERL E G KVA+ D E A + IK DVS +DV NA+ Q ++
Sbjct: 22 ERLVEDGFKVAVVDFNEEGAKAAALKLSSDGTKAIAIKADVSNRDDVFNAVRQTAAQFGD 81
Query: 236 LDILVNCAGIGVAVKVYNRKKNSPHPLDT-----FERIVKVNAVGTFNMIRLCCSMFNSN 400
++VN AG+G P+DT F+ + VN G I+ F
Sbjct: 82 FHVMVNNAGLGPTT-----------PIDTITEEQFKTVYGVNVAGVLWGIQAAHEQFK-- 128
Query: 401 EPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPG 580
+FN G +IN +S A EG G S Y +++ A+ +T A+DL + G+ V APG
Sbjct: 129 ---KFNHGGKIINATSQAGVEGNPGLSLYCSTKFAVRGLTQVAAQDLASEGITVNAFAPG 185
Query: 581 IFLTPLLENVPDSARLNLSKIVPFP----------SRLGHPDEFAHLVQSII--ENPMLN 724
I TP++E++ + K + R+ P++ +++V + ++ +
Sbjct: 186 IVQTPMMESIAVATAEEAGKPEAWGWEQFTSQIALGRVSQPEDVSNVVSFLAGKDSDYIT 245
Query: 725 GEVIRIDGALR 757
G+ I +DG +R
Sbjct: 246 GQTIIVDGGMR 256
>sp|P46331|YXBG_BACSU Hypothetical oxidoreductase yxbG
Length = 273
Score = 84.7 bits (208), Expect = 3e-16
Identities = 76/265 (28%), Positives = 114/265 (43%), Gaps = 19/265 (7%)
Frame = +2
Query: 77 TVERLTEQGCKVAICDIQEP---------KKLPANSYYIKTDVSCANDVENAITQIKSEA 229
T E +G +V I DI + +K + DVS N V+ QIK
Sbjct: 22 TAEVFANEGARVIIGDINKDQMEETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDAC 81
Query: 230 KKLDILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPN 409
+DIL N AG+ K +P+D F+RI+ V+ GTF CS + P
Sbjct: 82 GTIDILFNNAGVD-----QEGGKVHEYPVDLFDRIIAVDLRGTF-----LCSKYLI--PL 129
Query: 410 EFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFL 589
G +INTSS++ +S Y+A++G I +T +A D G+RV +I+PG
Sbjct: 130 MLENGGSIINTSSMSGRAADLDRSGYNAAKGGITNLTKAMAIDYARNGIRVNSISPGTIE 189
Query: 590 TPLLENVPDSARLNLSK--------IVPFPSRLGHPDEFAHLVQSII--ENPMLNGEVIR 739
TPL++ + + + + I P RLG P E A + + ++ + GE I
Sbjct: 190 TPLIDKLAGTKEQEMGEQFREANKWITPL-GRLGQPKEMATVALFLASDDSSYVTGEDIT 248
Query: 740 IDGALRMMP*LLFWYNKTCIRFKMK 814
DG + W K I K K
Sbjct: 249 ADGGIMAYT----WPGKMLIEEKWK 269
>sp|P51831|FABG_BACSU 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 84.3 bits (207), Expect = 4e-16
Identities = 56/214 (26%), Positives = 98/214 (45%), Gaps = 2/214 (0%)
Frame = +2
Query: 125 IQEPKKLPANSYYIKTDVSCANDVENAITQIKSEAKKLDILVNCAGIGVAVKVYNRKKNS 304
+ E K + + +K DVS DV+N I + S +DILVN AGI + K+
Sbjct: 46 VDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMKE-- 103
Query: 305 PHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSA 484
D ++ ++ +N G FN + + G +IN SSI G GQ+
Sbjct: 104 ----DEWDDVININLKGVFNCTKAVTRQMMKQ------RSGRIINVSSIVGVSGNPGQAN 153
Query: 485 YSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRL 664
Y A++ ++ +T A++L + + V IAPG T + + + + + K +P +R
Sbjct: 154 YVAAKAGVIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPL-ARF 212
Query: 665 GHPDEFAHLVQSIIEN--PMLNGEVIRIDGALRM 760
G P + + +V + + G+ + IDG + M
Sbjct: 213 GEPSDVSSVVTFLASEGARYMTGQTLHIDGGMVM 246
>sp|P66781|YD50_MYCTU Putative oxidoreductase Rv1350/MT1393
sp|P66782|YD85_MYCBO Putative oxidoreductase Mb1385
Length = 247
Score = 83.6 bits (205), Expect = 6e-16
Identities = 63/233 (27%), Positives = 113/233 (48%), Gaps = 11/233 (4%)
Frame = +2
Query: 83 ERLTEQGCKVAICDIQ------EPKKLPAN--SYYIKTDVSCANDVENAITQIKSEAKKL 238
+R +G +V + D+ K+L + + ++ DV+ A+DV+ I L
Sbjct: 25 QRFVAEGARVVLGDVNLEATEVAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGL 84
Query: 239 DILVNCAGIGVAVKVYNRKKNSPHPLDTFERIVKVNAVGTFNMIRLCCSMFNSNEPNEFN 418
D++VN AGI + + + F++++ V+ GT+N RL ++ +
Sbjct: 85 DVMVNNAGITRDATMRTMTE------EQFDQVIAVHLKGTWNGTRLAAAIMRERK----- 133
Query: 419 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 598
RG ++N SS++ G GQ+ YSA++ IV MT A++L +G+RV IAPG+ + +
Sbjct: 134 -RGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRSAM 192
Query: 599 LENVPDSARLNLSKIVPFP-SRLGHPDEFAHLVQSIIE--NPMLNGEVIRIDG 748
E +P R+ K+ P R G P E A + + + + G V+ + G
Sbjct: 193 TEAMPQ--RIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTG 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,709,166
Number of Sequences: 369166
Number of extensions: 1791975
Number of successful extensions: 5419
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5123
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5279
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7956112725
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)