Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_F24
(839 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P49900|ARGI_RANCA Arginase, hepatic 235 1e-61
sp|O08691|ARGI2_MOUSE Arginase-2, mitochondrial precursor (... 221 2e-57
sp|O08701|ARGI2_RAT Arginase-2, mitochondrial precursor (Ar... 219 6e-57
sp|P78540|ARGI2_HUMAN Arginase-2, mitochondrial precursor (... 217 4e-56
sp|Q58DL1|ARGI2_BOVIN Arginase-2, mitochondrial precursor (... 215 1e-55
sp|P05089|ARGI1_HUMAN Arginase-1 (Type I arginase) (Liver-t... 213 5e-55
sp|Q91554|ARGN2_XENLA Arginase, non-hepatic 2 211 2e-54
sp|Q95JC8|ARGI1_PIG Arginase-1 (Type I arginase) (Liver-typ... 209 6e-54
sp|Q91553|ARGN1_XENLA Arginase, non-hepatic 1 209 8e-54
sp|Q61176|ARGI1_MOUSE Arginase-1 (Type I arginase) (Liver-t... 209 8e-54
>sp|P49900|ARGI_RANCA Arginase, hepatic
Length = 323
Score = 235 bits (600), Expect = 1e-61
Identities = 116/225 (51%), Positives = 153/225 (68%)
Frame = +3
Query: 162 DLEFHDFGNIDTNLIGNDNNIFNAKYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSI 341
+ E D+G++ + D N K PR K+A+ + E+ + LT+GGDHS+
Sbjct: 45 EYEVRDYGDLHFPELPCDEPFQNVKNPRTVGQAAEKVANAVSEVKRSGRVCLTLGGDHSL 104
Query: 342 TTGTILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFK 521
GTI GHA+ H DLCV+WVDAHADINTP++S SGN+HG P+SFLI E+Q ++P I F
Sbjct: 105 AVGTITGHAKVHPDLCVVWVDAHADINTPITSPSGNLHGQPVSFLIRELQTKVPAIPGFS 164
Query: 522 DIPPVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNL 701
+ P +SAK+IVYIGLR VDP E ++L IKS+SM D+DR IN V+++ I+ +
Sbjct: 165 WVQPSLSAKDIVYIGLRDVDPGEHYILKTLGIKSYSMSDVDRLTINKVMEETIEFLVGKK 224
Query: 702 DRYFHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
R HLSFDID LDP AP+TGT VPGGLT REG+Y+ EQL+NTG
Sbjct: 225 KRPIHLSFDIDGLDPSVAPATGTPVPGGLTYREGMYITEQLYNTG 269
Score = 33.9 bits (76), Expect = 0.57
Identities = 14/33 (42%), Positives = 22/33 (66%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
+LG PF KGQ+ GV GP IR +++++E+
Sbjct: 11 VLGAPFSKGQARGGVEEGPIYIRRAGLIEKLEE 43
>sp|O08691|ARGI2_MOUSE Arginase-2, mitochondrial precursor (Arginase II) (Non-hepatic
arginase) (Kidney-type arginase)
Length = 354
Score = 221 bits (563), Expect = 2e-57
Identities = 112/221 (50%), Positives = 146/221 (66%), Gaps = 1/221 (0%)
Frame = +3
Query: 177 DFGNIDTNLIGNDNNIFN-AKYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSITTGT 353
DFG++ + D+ N YPR ++A+ + + Y +T+GGDHS+ GT
Sbjct: 67 DFGDLSFTNVPQDDPYNNLVVYPRSVGLANQELAEVVSRAVSGGYSCVTMGGDHSLAIGT 126
Query: 354 ILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFKDIPP 533
I+GHAR DLCVIWVDAHADINTPL++ SGN+HG PLSFLI E+Q+++P + F I P
Sbjct: 127 IIGHARHRPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIKELQDKVPQLPGFSWIKP 186
Query: 534 VISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNLDRYF 713
+S NIVYIGLR V+P E +L Y+I+ FSM +IDR GI V++Q + R
Sbjct: 187 CLSPPNIVYIGLRDVEPPEHFILKNYDIQYFSMREIDRLGIQKVMEQTFDRLIGKRQRPI 246
Query: 714 HLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
HLSFDIDA DP AP+TGT V GGLT REGVY+ E++ NTG
Sbjct: 247 HLSFDIDAFDPKLAPATGTPVVGGLTYREGVYITEEIHNTG 287
>sp|O08701|ARGI2_RAT Arginase-2, mitochondrial precursor (Arginase II) (Non-hepatic
arginase) (Kidney-type arginase)
Length = 354
Score = 219 bits (559), Expect = 6e-57
Identities = 110/221 (49%), Positives = 146/221 (66%), Gaps = 1/221 (0%)
Frame = +3
Query: 177 DFGNIDTNLIGNDNNIFN-AKYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSITTGT 353
DFG++ + D+ N YPR ++A+ + + Y +T+GGDHS+ GT
Sbjct: 67 DFGDLSFTNVPKDDPYNNLVVYPRSVGIANQELAEVVSRAVSGGYSCVTLGGDHSLAIGT 126
Query: 354 ILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFKDIPP 533
I GHAR H DLCVIWVDAHADINTPL++ SGN+HG PLSFLI E+Q+++P + F I P
Sbjct: 127 ISGHARHHPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIRELQDKVPQLPGFSWIKP 186
Query: 534 VISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNLDRYF 713
+S N+VYIGLR V+P E +L ++I+ FSM DIDR GI V++Q + R
Sbjct: 187 CLSPPNLVYIGLRDVEPAEHFILKSFDIQYFSMRDIDRLGIQKVMEQTFDRLIGKRKRPI 246
Query: 714 HLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
HLSFDIDA DP AP+TGT V GGLT REG+Y+ E++ +TG
Sbjct: 247 HLSFDIDAFDPKLAPATGTPVVGGLTYREGLYITEEIHSTG 287
>sp|P78540|ARGI2_HUMAN Arginase-2, mitochondrial precursor (Arginase II) (Non-hepatic
arginase) (Kidney-type arginase)
Length = 354
Score = 217 bits (552), Expect = 4e-56
Identities = 112/230 (48%), Positives = 150/230 (65%), Gaps = 3/230 (1%)
Frame = +3
Query: 156 ISDLEFH--DFGNIDTNLIGNDNNIFNAKY-PRMFLYNTMKIADKIEEMLDKNYIPLTIG 326
+S L H DFG++ + D+ N PR ++A+ + + Y +T+G
Sbjct: 58 LSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLG 117
Query: 327 GDHSITTGTILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPW 506
GDHS+ GTI GHAR DLCV+WVDAHADINTPL++SSGN+HG P+SFL+ E+Q+++P
Sbjct: 118 GDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQ 177
Query: 507 IEEFKDIPPVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKA 686
+ F I P IS+ +IVYIGLR VDP E +L Y+I+ FSM DIDR GI V+++
Sbjct: 178 LPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDL 237
Query: 687 VNPNLDRYFHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
+ R HLSFDIDA DP AP+TGT V GGLT REG+Y+ E++ NTG
Sbjct: 238 LIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTG 287
>sp|Q58DL1|ARGI2_BOVIN Arginase-2, mitochondrial precursor (Arginase II)
Length = 354
Score = 215 bits (548), Expect = 1e-55
Identities = 113/230 (49%), Positives = 151/230 (65%), Gaps = 3/230 (1%)
Frame = +3
Query: 156 ISDLEFH--DFGNIDTNLIGNDNNIFNAKY-PRMFLYNTMKIADKIEEMLDKNYIPLTIG 326
+SDL H DFG+++ + D+ N PR ++A+ + + Y +T+G
Sbjct: 58 LSDLGCHLKDFGDLNFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSGGYSCVTVG 117
Query: 327 GDHSITTGTILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPW 506
GDHS+ GTI GHAR DL VIWVDAHADINTPL++SSGN+HG P+SFL+ E+Q+++P
Sbjct: 118 GDHSLAIGTISGHARHCPDLGVIWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQ 177
Query: 507 IEEFKDIPPVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKA 686
+ F I P IS+ +IVYIGLR VDP E +L Y+I+ FSM DIDR GI V++Q
Sbjct: 178 LPGFSWIKPCISSPSIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMEQTFDL 237
Query: 687 VNPNLDRYFHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
+ R HLSFDIDA DP AP+TGT V GGLT REG+Y+ E++ +TG
Sbjct: 238 LIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGIYITEEIHSTG 287
Score = 30.8 bits (68), Expect = 4.9
Identities = 11/33 (33%), Positives = 20/33 (60%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
++G PF +GQ GV GP +R +++++ D
Sbjct: 28 VIGAPFSQGQKRKGVEYGPAAVRXAGLMKRLSD 60
>sp|P05089|ARGI1_HUMAN Arginase-1 (Type I arginase) (Liver-type arginase)
Length = 322
Score = 213 bits (542), Expect = 5e-55
Identities = 105/225 (46%), Positives = 149/225 (66%)
Frame = +3
Query: 162 DLEFHDFGNIDTNLIGNDNNIFNAKYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSI 341
+ + D+G++ I ND+ K PR + ++A K+ E+ I L +GGDHS+
Sbjct: 44 ECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSL 103
Query: 342 TTGTILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFK 521
G+I GHAR H DL VIWVDAH DINTPL+++SGN+HG P+SFL+ E++ ++P + F
Sbjct: 104 AIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFS 163
Query: 522 DIPPVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNL 701
+ P ISAK+IVYIGLR VDP E ++L IK FSM ++DR GI V+++ + +
Sbjct: 164 WVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRK 223
Query: 702 DRYFHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
R HLSFD+D LDP + P+TGT V GGLT REG+Y+ E+++ TG
Sbjct: 224 KRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTG 268
Score = 31.2 bits (69), Expect = 3.7
Identities = 11/33 (33%), Positives = 22/33 (66%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
++G PF KGQ GV GP ++R +++++++
Sbjct: 10 IIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKE 42
>sp|Q91554|ARGN2_XENLA Arginase, non-hepatic 2
Length = 360
Score = 211 bits (537), Expect = 2e-54
Identities = 106/222 (47%), Positives = 150/222 (67%), Gaps = 2/222 (0%)
Frame = +3
Query: 177 DFGNIDTNLIGNDNNIFNA--KYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSITTG 350
DFG++ + + ND ++N+ K+PR +A+++ + + + +T+GGDHS+ G
Sbjct: 69 DFGDLHFSKVPNDE-LYNSIVKHPRTVGLACKVLAEEVSKAVGAGHTCVTLGGDHSLAFG 127
Query: 351 TILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFKDIP 530
+I GHA++ DLCVIWVDAHADINTPL++ SGN+HG P+SFL+ E+Q+++P I F
Sbjct: 128 SITGHAQQCPDLCVIWVDAHADINTPLTTPSGNLHGQPVSFLLRELQDKVPPIPGFSWAK 187
Query: 531 PVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNLDRY 710
P +S +IVYIGLR +DP E+ +L YNI +SM ID GI V+++ + DR
Sbjct: 188 PCLSKSDIVYIGLRDLDPAEQFILKNYNISYYSMRHIDCMGIKKVMEKTFDQLLGRRDRP 247
Query: 711 FHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
HLSFDIDA DP AP+TGT V GGLT REGVY+ E++ NTG
Sbjct: 248 IHLSFDIDAFDPALAPATGTPVIGGLTYREGVYITEEIHNTG 289
Score = 32.0 bits (71), Expect = 2.2
Identities = 12/33 (36%), Positives = 21/33 (63%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
++G PF KGQ GV GP IR+ +++++ +
Sbjct: 30 VIGAPFSKGQKRRGVEHGPAAIRSAGLIERLSN 62
>sp|Q95JC8|ARGI1_PIG Arginase-1 (Type I arginase) (Liver-type arginase)
Length = 322
Score = 209 bits (533), Expect = 6e-54
Identities = 100/225 (44%), Positives = 146/225 (64%)
Frame = +3
Query: 162 DLEFHDFGNIDTNLIGNDNNIFNAKYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSI 341
+ + D+G++ + ND K PR ++AD + E+ L +GGDHS+
Sbjct: 44 ECDVKDYGDLCFADVPNDTPFQIVKNPRSVGKANQQLADVVAEIKKNGRTSLVLGGDHSM 103
Query: 342 TTGTILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFK 521
G+I GHAR H DLCVIWVDAH DINTPL++++GN+HG P+SFL+ E++ ++P +
Sbjct: 104 AIGSISGHARVHPDLCVIWVDAHTDINTPLTTTTGNLHGQPVSFLLKELKEKIPEVPGLS 163
Query: 522 DIPPVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNL 701
+ P +SAK+IVYIGLR VDP E ++L IK FSM ++D+ GI V+++A +
Sbjct: 164 WVTPCLSAKDIVYIGLRDVDPAEHYILKTLGIKYFSMIEVDKLGIGKVMEEAFSYLLGRK 223
Query: 702 DRYFHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
R HLSFD+D LDP + P+TGT V GGL+ REG+Y+ E+++ TG
Sbjct: 224 KRPIHLSFDVDGLDPFFTPATGTPVHGGLSYREGIYITEEIYKTG 268
Score = 30.4 bits (67), Expect = 6.4
Identities = 11/33 (33%), Positives = 21/33 (63%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
++G PF KGQ GV GP +R +++++++
Sbjct: 10 IIGAPFSKGQPRGGVEEGPTALRKAGLLEKLKE 42
>sp|Q91553|ARGN1_XENLA Arginase, non-hepatic 1
Length = 360
Score = 209 bits (532), Expect = 8e-54
Identities = 105/222 (47%), Positives = 150/222 (67%), Gaps = 2/222 (0%)
Frame = +3
Query: 177 DFGNIDTNLIGNDNNIFNA--KYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHSITTG 350
DFG++ + + ND ++N+ K+PR +A+++ + + + +T+GGDHS+ G
Sbjct: 69 DFGDLHFSQVPNDE-LYNSIVKHPRTVGLACKVLAEEVSKAVGAGHTCVTLGGDHSLAFG 127
Query: 351 TILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEFKDIP 530
+I GHA++ DLCVIWVDAHADINTPL++ SGN+HG P+SFL+ E+Q+++P I F
Sbjct: 128 SITGHAQQCPDLCVIWVDAHADINTPLTTPSGNLHGQPVSFLLRELQDKVPPIPGFSWAK 187
Query: 531 PVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPNLDRY 710
P +S +IVYIGLR +DP E+ +L Y+I +SM ID GI V+++ + DR
Sbjct: 188 PCLSKSDIVYIGLRDLDPAEQFILKNYDISYYSMRHIDCMGIKKVMEKTFDQLLGRRDRP 247
Query: 711 FHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
HLSFDIDA DP AP+TGT V GGLT REGVY+ E++ NTG
Sbjct: 248 IHLSFDIDAFDPALAPATGTPVIGGLTYREGVYITEEIHNTG 289
Score = 32.0 bits (71), Expect = 2.2
Identities = 12/33 (36%), Positives = 21/33 (63%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
++G PF KGQ GV GP IR+ +++++ +
Sbjct: 30 VIGAPFSKGQKRRGVEHGPAAIRSAGLIERLSN 62
>sp|Q61176|ARGI1_MOUSE Arginase-1 (Type I arginase) (Liver-type arginase)
Length = 323
Score = 209 bits (532), Expect = 8e-54
Identities = 100/226 (44%), Positives = 147/226 (65%)
Frame = +3
Query: 159 SDLEFHDFGNIDTNLIGNDNNIFNAKYPRMFLYNTMKIADKIEEMLDKNYIPLTIGGDHS 338
++ + D G++ + ND++ K PR ++A + E+ + + +GGDHS
Sbjct: 43 TEYDVRDHGDLAFVDVPNDSSFQIVKNPRSVGKANEELAGVVAEVQKNGRVSVVLGGDHS 102
Query: 339 ITTGTILGHARRHEDLCVIWVDAHADINTPLSSSSGNMHGMPLSFLIHEMQNEMPWIEEF 518
+ G+I GHAR H DLCVIWVDAH DINTPL++SSGN+HG P+SFL+ E++ + P + F
Sbjct: 103 LAVGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVSFLLKELKGKFPDVPGF 162
Query: 519 KDIPPVISAKNIVYIGLRSVDPYERHVLNKYNIKSFSMEDIDRDGINCVIQQAIKAVNPN 698
+ P ISAK+IVYIGLR VDP E +++ IK FSM ++D+ GI V+++ +
Sbjct: 163 SWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGR 222
Query: 699 LDRYFHLSFDIDALDPLYAPSTGTAVPGGLTLREGVYLCEQLFNTG 836
R HLSFD+D LDP + P+TGT V GGL+ REG+Y+ E+++ TG
Sbjct: 223 KKRPIHLSFDVDGLDPAFTPATGTPVLGGLSYREGLYITEEIYKTG 268
Score = 30.8 bits (68), Expect = 4.9
Identities = 11/33 (33%), Positives = 21/33 (63%)
Frame = +2
Query: 2 LLGVPFEKGQSLSGVSCGPKLIRTKKIVQQIED 100
++G PF KGQ GV GP +R +++++++
Sbjct: 10 IIGAPFSKGQPRGGVEKGPAALRKAGLLEKLKE 42
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,853,151
Number of Sequences: 369166
Number of extensions: 1728395
Number of successful extensions: 4895
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4669
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4829
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)