Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_E08
(869 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 47 9e-05
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 46 1e-04
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 45 3e-04
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 44 4e-04
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 44 6e-04
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 41 0.005
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 41 0.005
sp|Q02084|A33_PLEWA Zinc-binding protein A33 41 0.005
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 40 0.011
sp|Q99PQ1|TRI12_MOUSE Tripartite motif protein 12 39 0.014
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/122 (24%), Positives = 52/122 (42%)
Frame = +1
Query: 454 TSEMSSSKFKPMFNFISQYKNVINKNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEM 633
T +SSS + I Y + + +C C L A PCG +C C+ +
Sbjct: 42 TGNLSSSFMEE----IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKS 97
Query: 634 LENGVVNCPGEAEDCKEELISNSHLDCKTNRAISNVVIKCPEAMCLFECAIINMEEHMRV 813
+ + CP + E E + + R I ++++KCP CL + + ++E+H
Sbjct: 98 IRDAGHKCPVDNEILLENQLFPDNF---AKREILSLMVKCPNEGCLHKMELRHLEDHQAH 154
Query: 814 CE 819
CE
Sbjct: 155 CE 156
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 1/129 (0%)
Frame = +1
Query: 454 TSEMSSSKFKPMFNFISQYKNVINKNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEM 633
T +SSS + I Y + + +C C L A PCG +C C+ +
Sbjct: 42 TGNLSSSFMEE----IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKS 97
Query: 634 LENGVVNCPGEAEDCKEELISNSHLDCKTNRAISNVVIKCPEAMCLFECAIINMEEHMRV 813
+ + CP + E E + + R I ++ +KCP CL + + ++E+H
Sbjct: 98 IRDAGHKCPVDNEILLENQLFPDNF---AKREILSLTVKCPNKGCLQKMELRHLEDHQVH 154
Query: 814 CE-KNVKCP 837
CE V CP
Sbjct: 155 CEFALVNCP 163
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 44.7 bits (104), Expect = 3e-04
Identities = 33/119 (27%), Positives = 47/119 (39%), Gaps = 3/119 (2%)
Frame = +1
Query: 508 YKNVINKNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLENGVVNCPGEAEDCKEE 687
YK K V D KC KCR +L N CG +C C+ +L + C C+E
Sbjct: 38 YKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTA----CQES 93
Query: 688 LISNSHLD---CKTNRAISNVVIKCPEAMCLFECAIINMEEHMRVCEKNVKCPFDNLGC 855
+I + CK V + C + + H+ V KN +C F+ L C
Sbjct: 94 IIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTL----GHLLVHLKN-ECQFEELPC 147
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/136 (25%), Positives = 56/136 (41%), Gaps = 6/136 (4%)
Frame = +1
Query: 451 ITSEMSSSKFKPMFNFISQYKNVINKNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNE 630
+TS S +P F+ K ++ + C C+NIL + CG YC C+
Sbjct: 6 VTSPGSLELLQPGFS-----KTLLGTRLEAKYLCSACKNILRRPFQAQCGHRYCSFCLTS 60
Query: 631 MLENGVVNCPG-EAEDCKEELI-----SNSHLDCKTNRAISNVVIKCPEAMCLFECAIIN 792
+L +G NC E EE I S++ D R + ++ CP C ++ +
Sbjct: 61 ILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKE 120
Query: 793 MEEHMRVCEKNVKCPF 840
E C + + CPF
Sbjct: 121 YES----CHEGL-CPF 131
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 43.9 bits (102), Expect = 6e-04
Identities = 28/107 (26%), Positives = 50/107 (46%), Gaps = 3/107 (2%)
Frame = +1
Query: 526 KNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLE-NGVVNCPGEAEDCKEELISNS 702
+ + + KC C ++L N + CG +C C+ + E N V CP + E K + +
Sbjct: 37 EQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVFKD 96
Query: 703 HLDCKTNRAISNVVIKCPEAM-CLFECAIINMEEHMRVCE-KNVKCP 837
+ CK R + N+ + C A C + ++H++ C + V CP
Sbjct: 97 NC-CK--REVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCP 140
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 40.8 bits (94), Expect = 0.005
Identities = 29/115 (25%), Positives = 47/115 (40%), Gaps = 6/115 (5%)
Frame = +1
Query: 511 KNVINKNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLENGVVNCPG-EAEDCKEE 687
K ++ + C CRN+L + CG YC C+ +L +G NC E EE
Sbjct: 21 KTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEE 80
Query: 688 LI-----SNSHLDCKTNRAISNVVIKCPEAMCLFECAIINMEEHMRVCEKNVKCP 837
I S++ D R + ++ CP C ++ + E C + +CP
Sbjct: 81 GISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYES----CHEG-RCP 130
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/99 (25%), Positives = 47/99 (47%), Gaps = 2/99 (2%)
Frame = +1
Query: 526 KNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLE-NGVVNCPGEAEDCKEELISNS 702
+ + + KC C ++L N + CG +C C+ + E N V CP + E K + +
Sbjct: 37 ERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKD 96
Query: 703 HLDCKTNRAISNVVIKCPEAM-CLFECAIINMEEHMRVC 816
+ CK R + N+ + C A C + + ++H++ C
Sbjct: 97 NC-CK--REVLNLYVYCSNAPGCNAKVILGRYQDHLQQC 132
>sp|Q02084|A33_PLEWA Zinc-binding protein A33
Length = 624
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/72 (30%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Frame = +1
Query: 538 DNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLEN-GVVNCPGEAEDCKEELISNSHLDC 714
++L C CR++ L CG ++C C+++ E+ +CP +CKE L +
Sbjct: 158 EDLTCPLCRSLFKEPVILECGHNFCKHCIDKSWESASAFSCP----ECKEVLTERKY--- 210
Query: 715 KTNRAISNVVIK 750
TNR ++N+V K
Sbjct: 211 TTNRVLANLVKK 222
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/117 (28%), Positives = 46/117 (39%), Gaps = 1/117 (0%)
Frame = +1
Query: 508 YKNVINKNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLENGVVNCPGEAEDCKEE 687
YK K V D KC KC +L + CG +C C+ +L + C C+E
Sbjct: 39 YKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQES 94
Query: 688 LISNS-HLDCKTNRAISNVVIKCPEAMCLFECAIINMEEHMRVCEKNVKCPFDNLGC 855
++ + D R I + I C CA H+ V KN C F+ L C
Sbjct: 95 IVKDKVFKDNCCKREILALQIYCRNES--RGCAEQLTLGHLLVHLKN-DCHFEELPC 148
>sp|Q99PQ1|TRI12_MOUSE Tripartite motif protein 12
Length = 284
Score = 39.3 bits (90), Expect = 0.014
Identities = 18/73 (24%), Positives = 35/73 (47%)
Frame = +1
Query: 526 KNVPDNLKCGKCRNILINAYCLPCGCSYCGDCVNEMLENGVVNCPGEAEDCKEELISNSH 705
KN+ + + C C N+++ CG ++C C+ E+ + C + C IS
Sbjct: 7 KNLKEEVTCPVCLNLMVKPVSADCGHTFCQGCITLYFES--IKCDKKVFICPVCRISYQF 64
Query: 706 LDCKTNRAISNVV 744
+ + NR ++N+V
Sbjct: 65 SNLRPNRNVANIV 77
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,753,273
Number of Sequences: 369166
Number of extensions: 1373836
Number of successful extensions: 3454
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3313
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3447
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)