Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_E07
(637 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I ... 140 4e-33
sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I ... 139 5e-33
sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II... 137 2e-32
sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (... 137 2e-32
sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II... 137 3e-32
sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase II... 133 4e-31
sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (... 119 5e-27
sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (... 109 7e-24
sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetas... 108 1e-23
sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetas... 106 4e-23
>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I) (PPRibP)
sp|P60892|PRPS1_RAT Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 140 bits (352), Expect = 4e-33
Identities = 72/173 (41%), Positives = 112/173 (64%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + WI++NIS+W TI S + A+RV ++A+ L V F LI+ E+K+A+E
Sbjct: 144 NLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVD 203
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S + +++
Sbjct: 204 RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINN 263
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 513
+ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 264 ACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 139 bits (351), Expect = 5e-33
Identities = 72/173 (41%), Positives = 111/173 (64%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + WI++NIS+W TI S + A+RV ++A L V F LI+ E+K+A+E
Sbjct: 144 NLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIAERLNVDFALIHKERKKANEVD 203
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S + +++
Sbjct: 204 RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINN 263
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 513
+ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 264 ACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
sp|P11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II) (PPRibP)
Length = 318
Score = 137 bits (345), Expect = 2e-32
Identities = 70/173 (40%), Positives = 112/173 (64%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + WI++NI++W+ I S + A+RV ++A+ L V F LI+ E+K+A+E
Sbjct: 144 NLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVD 203
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S + +++
Sbjct: 204 RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINN 263
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 513
+ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 264 AAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 137 bits (345), Expect = 2e-32
Identities = 70/173 (40%), Positives = 111/173 (64%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + WI++NI++W I S + A+RV ++A+ L V F LI+ E+K+A+E
Sbjct: 144 NLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVD 203
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S + +++
Sbjct: 204 RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINN 263
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 513
+ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 264 AAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 137 bits (344), Expect = 3e-32
Identities = 70/173 (40%), Positives = 110/173 (63%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + WI++NI++W I S + A+RV ++A+ L V F LI+ E+K+A+E
Sbjct: 144 NLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVD 203
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S + ++
Sbjct: 204 RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINS 263
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 513
+ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 264 AAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase III (Phosphoribosyl
pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl
pyrophosphate synthetase 1-like 1)
Length = 318
Score = 133 bits (334), Expect = 4e-31
Identities = 70/173 (40%), Positives = 110/173 (63%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQ- 177
NL +E + WI++NI +W+ I S + A+RV ++A+ L V F LI+ E+K+A+E
Sbjct: 144 NLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERKKANEVD 203
Query: 178 -IILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
I+LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S + ++
Sbjct: 204 CIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAGATRVYAILTHGIFSGPAISRINT 263
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 513
+ +VVTNTI Q++ +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 264 ACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (Phosphoribosyl pyrophosphate
synthetase 3)
Length = 320
Score = 119 bits (299), Expect = 5e-27
Identities = 64/172 (37%), Positives = 110/172 (63%), Gaps = 2/172 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + +IK+N++ + I I S + A+R A +A+ L + F LI+ E+ A+E
Sbjct: 147 NLYAEPSVVRYIKENVNYMDSI-IISPDAGGAKRAATLADRLDLNFALIHKERARANEVS 205
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LVGDV +I +I+ D+ D C + + + L E A V I THG+LS R ++ +++
Sbjct: 206 RMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINN 265
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNN 510
S + ++V TNT+ E+ +K+ K+A +D+S + AE+IRR+H GES+S L+ N
Sbjct: 266 SKLDRVVCTNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNGESISYLFKN 317
>sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (Phosphoribosyl pyrophosphate
synthetase 1)
Length = 321
Score = 109 bits (272), Expect = 7e-24
Identities = 63/172 (36%), Positives = 103/172 (59%), Gaps = 2/172 (1%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE-- 174
NL +E + +IK+ I + E I S + A+R A +A+ L + F LI+ E+ A+E
Sbjct: 147 NLYAEPSVVRYIKETID-YSEAIIISSDAGGAKRAAGLADRLDLNFELIHKERARANEVS 205
Query: 175 QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDD 354
+++LV DV +I VI+ D+ D C + + + L + A V I THG+LS +K +++
Sbjct: 206 RMVLVVDVTDKICVIVDDMADTCGTLAKAAEVLLDNNAKDVIAIVTHGILSGNAIKNINN 265
Query: 355 SIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNN 510
S + K+V TNT+ E +K K+ +D+S + AE+IRR+H GES+S L+ N
Sbjct: 266 SKLKKVVCTNTVPFEDKLKLCLKLDTIDISAVIAESIRRLHNGESISYLFKN 317
>sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 108 bits (269), Expect = 1e-23
Identities = 66/204 (32%), Positives = 109/204 (53%), Gaps = 33/204 (16%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQI 180
NL + + +I++ I + I + + SA+R + A L++ +I+ E ++A +
Sbjct: 162 NLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDL 221
Query: 181 I---------------------------------LVGDVVSRIAVILLDIIDNCDLVISS 261
+ +VGDV RIA+I+ DIID+ D +++
Sbjct: 222 VDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAA 281
Query: 262 VKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDV 441
+ LKE GA ++V+ATHG+LS + +++S I ++VVTNTI E Q KI +D+
Sbjct: 282 AETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKTVDI 341
Query: 442 SVIFAEAIRRIHYGESVSCLYNNL 513
S+I +EAIRRIH GES+S L+ N+
Sbjct: 342 SMILSEAIRRIHNGESMSYLFRNI 365
>sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 106 bits (265), Expect = 4e-23
Identities = 66/204 (32%), Positives = 109/204 (53%), Gaps = 33/204 (16%)
Frame = +1
Query: 1 NLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQI 180
NL + + +I++ I + I + + SA+R + A L++ +I+ E ++A +
Sbjct: 162 NLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDL 221
Query: 181 I---------------------------------LVGDVVSRIAVILLDIIDNCDLVISS 261
+ +VGDV RIA+I+ DIID+ D +++
Sbjct: 222 VDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAA 281
Query: 262 VKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDV 441
+ LKE GA ++V+ATHG+LS + +++S I ++VVTNTI E Q KI +D+
Sbjct: 282 AETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKTVDI 341
Query: 442 SVIFAEAIRRIHYGESVSCLYNNL 513
S+I +EAIRRIH GES+S L+ N+
Sbjct: 342 SMILSEAIRRIHNGESMSYLFRNI 365
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,813,643
Number of Sequences: 369166
Number of extensions: 1299122
Number of successful extensions: 3781
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3525
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3726
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5121172350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)