Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_C15
(435 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q01705|NOTC1_MOUSE Neurogenic locus notch homolog protei... 37 0.018
sp|Q07008|NOTC1_RAT Neurogenic locus notch homolog protein ... 37 0.024
sp|P11976|PSTA_DICDI Prestalk protein precursor 36 0.031
sp|P10039|TENA_CHICK Tenascin precursor (TN) (Hexabrachion)... 35 0.053
sp|Q03376|BAR3_CHITE Balbiani ring protein 3 precursor 35 0.053
sp|P46531|NOTC1_HUMAN Neurogenic locus notch homolog protei... 35 0.069
sp|P24348|LET23_CAEEL Let-23 receptor tyrosine-protein kina... 35 0.090
sp|P24821|TENA_HUMAN Tenascin precursor (TN) (Hexabrachion)... 33 0.20
sp|Q9UKF5|ADA29_HUMAN ADAM 29 precursor (A disintegrin and ... 33 0.20
sp|P21783|NOTCH_XENLA Neurogenic locus notch protein homolo... 33 0.20
>sp|Q01705|NOTC1_MOUSE Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch
A) (mT14) (p300) [Contains: Notch 1 extracellular
truncation; Notch 1 intracellular domain]
Length = 2531
Score = 37.0 bits (84), Expect = 0.018
Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 35/141 (24%)
Frame = +3
Query: 75 DC---WNKGISCD---KECDDNP--------DGSGIAVTLCRKV-----CRKELRQCVDD 197
DC W+ G +CD EC+ NP D + V CR+ C+ + +C +
Sbjct: 740 DCAPGWS-GTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN 798
Query: 198 GCKKKKEVVAD--------PVPKKG-NCKVICWENATT-CHDK--CMKGDDKRSSTVINC 341
C + + D P+P G C+V+ AT+ C + C + +D S + +
Sbjct: 799 PCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCP 858
Query: 342 T----KTCKKELNNCVNIQCQ 392
T +TC+ ++N CV C+
Sbjct: 859 TGWQGQTCEVDINECVKSPCR 879
>sp|Q07008|NOTC1_RAT Neurogenic locus notch homolog protein 1 precursor (Notch 1)
[Contains: Notch 1 extracellular truncation; Notch 1
intracellular domain]
Length = 2531
Score = 36.6 bits (83), Expect = 0.024
Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 35/141 (24%)
Frame = +3
Query: 75 DC---WNKGISCD---KECDDNP--------DGSGIAVTLCRKV-----CRKELRQCVDD 197
DC W+ G +CD EC+ NP D + V CR+ C+ + +C +
Sbjct: 740 DCAPGWS-GTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN 798
Query: 198 GCKKKKEVVAD--------PVPKKG-NCKVICWENATT-CHDK--CMKGDDKRSSTVINC 341
C + + D P+P G C+V+ AT+ C + C + +D S + +
Sbjct: 799 PCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCP 858
Query: 342 T----KTCKKELNNCVNIQCQ 392
T +TC+ ++N CV C+
Sbjct: 859 TGWQGQTCEIDINECVKSPCR 879
>sp|P11976|PSTA_DICDI Prestalk protein precursor
Length = 1046
Score = 36.2 bits (82), Expect = 0.031
Identities = 30/107 (28%), Positives = 42/107 (39%), Gaps = 8/107 (7%)
Frame = +3
Query: 78 CWNKGISCDKECDDNP---DGSGIAVTLCRKVCR-KELRQCVDDGCKKKKEVVADPVPKK 245
C + ISCD D+NP D + C + C +D C + V P+
Sbjct: 859 CCHTPISCD---DNNPCTVDSCSNSTGCCHTPINVDDNNPCTEDKCTQSGGVTHTPIGCN 915
Query: 246 GN--CKVICWENATTCHDKCMKGDDKRSSTVINCTKT--CKKELNNC 374
N C V N+T C MK DD T+ +C+ + C NC
Sbjct: 916 DNNACTVDSCSNSTGCTHTPMKCDDNNPCTIDSCSNSTGCVHTPMNC 962
Score = 33.5 bits (75), Expect = 0.20
Identities = 34/124 (27%), Positives = 45/124 (36%), Gaps = 13/124 (10%)
Frame = +3
Query: 57 KPFCLVD-CWNKGISCDKE--CDDNPDGSGIAVTLCRKVCRKELR-----QCVDDGCKKK 212
K C D C N SC CDDN + + + C + C +D C +
Sbjct: 245 KNACTADSCSNSTGSCHTPITCDDNNACTVDSCSNSTGCCHTPINVDDNNACTEDKCTQS 304
Query: 213 KEVVADPVP--KKGNCKVICWENATTCHDKCMKGDDKRSSTVINC---TKTCKKELNNCV 377
V P+ K C V N+T C + DDK TV +C T C +N
Sbjct: 305 GGVTHTPIACDDKNACTVDSCSNSTGCVHTPLPCDDKNPCTVDSCSNSTGCCHTPINVDD 364
Query: 378 NIQC 389
N C
Sbjct: 365 NNAC 368
Score = 32.7 bits (73), Expect = 0.34
Identities = 28/111 (25%), Positives = 40/111 (36%), Gaps = 13/111 (11%)
Frame = +3
Query: 57 KPFCLVDCWNKGISC---DKECDDNPDGSGIAVTLCRK--------VCRKELRQCVDDGC 203
K C VD + C CDDN + V C + + C +D C
Sbjct: 677 KNACTVDSCSNSTGCCHTPLSCDDN---NACTVDSCSNSTGCVHTPINVDDNNACTEDKC 733
Query: 204 KKKKEVVADPVP--KKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKT 350
+ V P+ K C V N+T C +K DD TV +C+ +
Sbjct: 734 TQNGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLKCDDNNPCTVDSCSNS 784
Score = 32.0 bits (71), Expect = 0.58
Identities = 27/108 (25%), Positives = 40/108 (37%), Gaps = 13/108 (12%)
Frame = +3
Query: 66 CLVDCWNKGISCDK---ECDDNPDGSGIAVTLCRK--------VCRKELRQCVDDGCKKK 212
C VD + C CDDN + V C + + C +D C +
Sbjct: 392 CTVDSCSNSTGCCHTPIRCDDN---NPCTVDSCSNSTGCVHTPINVDDNNACTEDKCTQN 448
Query: 213 KEVVADPVP--KKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKT 350
V P+ K C V N+T C +K DD + TV +C+ +
Sbjct: 449 GGVTHTPIACDDKNACTVDSCSNSTGCCHTPLKCDDNNACTVDSCSNS 496
Score = 30.4 bits (67), Expect = 1.7
Identities = 25/97 (25%), Positives = 38/97 (39%), Gaps = 6/97 (6%)
Frame = +3
Query: 78 CWNKGISCDKECDDNP---DGSGIAVTLCRKVCRKELRQ-CVDDGCKKKKEVVADPVP-- 239
C + +SCD D+NP D + C + C +D C + V P+
Sbjct: 115 CCHTPLSCD---DNNPCTVDSCSNSTGCCHTPINVVVHNACTEDKCIQLGVVTHTPIACD 171
Query: 240 KKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKT 350
K C V N+T C + DD TV +C+ +
Sbjct: 172 DKNACTVDSCSNSTGCCHTPLSCDDNNPCTVDSCSNS 208
Score = 29.6 bits (65), Expect = 2.9
Identities = 17/57 (29%), Positives = 23/57 (40%), Gaps = 2/57 (3%)
Frame = +3
Query: 186 CVDDGCKKKKEVVADPVP--KKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKT 350
C D C V P+P K C V N+T C + DD + T CT++
Sbjct: 320 CTVDSCSNSTGCVHTPLPCDDKNPCTVDSCSNSTGCCHTPINVDDNNACTEDKCTQS 376
Score = 28.1 bits (61), Expect = 8.4
Identities = 26/105 (24%), Positives = 36/105 (34%), Gaps = 10/105 (9%)
Frame = +3
Query: 66 CLVDCWNKGISC---DKECDD-NPDGSGIAVTL--CRKVCRK--ELRQCVDDGCKKKKEV 221
C +D + C CDD NP S C+ V + C D C
Sbjct: 536 CTIDSCSNSTGCVHTPMSCDDRNPCTSDFCSWEKGCQHVALSCNDFNACTMDSCSNSTGC 595
Query: 222 VADPVP--KKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKT 350
P+ K C V N+T C + DD TV +C+ +
Sbjct: 596 THTPIACDDKNACTVDSCSNSTGCVHTPLTCDDNNPCTVDSCSNS 640
>sp|P10039|TENA_CHICK Tenascin precursor (TN) (Hexabrachion) (Cytotactin) (Neuronectin)
(GMEM) (JI) (Miotendinous antigen)
(Glioma-associated-extracellular matrix antigen) (GP
150-225)
Length = 1808
Score = 35.4 bits (80), Expect = 0.053
Identities = 34/129 (26%), Positives = 50/129 (38%), Gaps = 11/129 (8%)
Frame = +3
Query: 36 FINEAEAKPFCLVDCWNKGISCDKE--CDDNPDGSGIAVTLCRKVCRKELRQCVDDGCKK 209
F E +P C +C N+G D E CD+ G +C C R C++ C
Sbjct: 275 FTGEDCNEPLCPNNCHNRGRCVDNECVCDEGYTGEDCGELICPNDCFDRGR-CINGTCFC 333
Query: 210 KKEVVAD-----PVPKKGNCKVICWENATTCHDKCMKGDDKRSSTVINCT-KTCKKELNN 371
++ + P N C CH+ + GDD C+ K C K+ NN
Sbjct: 334 EEGYTGEDCGELTCPNNCNGNGRCENGLCVCHEGFV-GDD--------CSQKRCPKDCNN 384
Query: 372 ---CVNIQC 389
CV+ +C
Sbjct: 385 RGHCVDGRC 393
>sp|Q03376|BAR3_CHITE Balbiani ring protein 3 precursor
Length = 1700
Score = 35.4 bits (80), Expect = 0.053
Identities = 31/121 (25%), Positives = 47/121 (38%), Gaps = 19/121 (15%)
Frame = +3
Query: 60 PFCLVDCWNKGISCDKECDDNPDGSGI------AVTLCRKVCRKELRQCVDDGCKKKK-- 215
P C + +SC C+ +G CR VC K + + D+ CK K
Sbjct: 1208 PTCSNNQKYSNVSCSCGCNPGKPKNGCPGNQIWCDNTCRCVCPKNMEKPADN-CKTKWWN 1266
Query: 216 ----EVVADPVPKKGNCKVICWENATTCHDKC-------MKGDDKRSSTVINCTKTCKKE 362
+ V P +G CK + NA TC +C DK+S +C+ CK +
Sbjct: 1267 DEMCQCVCKPGCPEGGCKGVMKWNANTCSCECPADKAKPASCGDKKSWNDDSCSCQCKSK 1326
Query: 363 L 365
+
Sbjct: 1327 M 1327
>sp|P46531|NOTC1_HUMAN Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1)
(Translocation-associated notch protein TAN-1) [Contains:
Notch 1 extracellular truncation; Notch 1 intracellular
domain]
Length = 2556
Score = 35.0 bits (79), Expect = 0.069
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 37/143 (25%)
Frame = +3
Query: 75 DC---WNKGISCD---KECDDNP--------DGSGIAVTLCRKV-----CRKELRQCVDD 197
DC W+ G +CD EC+ NP D + V CR+ C+ + +C +
Sbjct: 740 DCDPGWS-GTNCDINNNECESNPCVNGGTCKDMTSGIVCTCREGFSGPNCQTNINECASN 798
Query: 198 GCKKKKEVVADPVPKKGNCKVICWENATT-----------CHD--KCMKGDDKRSSTVIN 338
C K + D K NC ++ + AT C + +C + +D S + +
Sbjct: 799 PCLNKGTCIDDVAGYKCNC-LLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVC 857
Query: 339 CT-----KTCKKELNNCVNIQCQ 392
T +TC+ ++N CV C+
Sbjct: 858 PTAGAKGQTCEVDINECVLSPCR 880
>sp|P24348|LET23_CAEEL Let-23 receptor tyrosine-protein kinase precursor (Lethal protein
23)
Length = 1367
Score = 34.7 bits (78), Expect = 0.090
Identities = 26/86 (30%), Positives = 35/86 (40%)
Frame = +3
Query: 117 DNPDGSGIAVTLCRKVCRKELRQCVDDGCKKKKEVVADPVPKKGNCKVICWENATTCHDK 296
DN IA K+C E R C D C K+ +P CK W++ TC +K
Sbjct: 541 DNKPSLAIAENRDSKLCETEQRVC-DKNCNKRGCWGKEPEDCL-ECKT--WKSVGTCVEK 596
Query: 297 CMKGDDKRSSTVINCTKTCKKELNNC 374
C R+ T + C + C E C
Sbjct: 597 CDTKGFLRNQTSMKCER-CSPECETC 621
>sp|P24821|TENA_HUMAN Tenascin precursor (TN) (Hexabrachion) (Cytotactin) (Neuronectin)
(GMEM) (JI) (Miotendinous antigen)
(Glioma-associated-extracellular matrix antigen) (GP
150-225) (Tenascin-C) (TN-C)
Length = 2201
Score = 33.5 bits (75), Expect = 0.20
Identities = 27/118 (22%), Positives = 50/118 (42%), Gaps = 6/118 (5%)
Frame = +3
Query: 57 KPFCLVDCWNKGISCDKE--CDDNPDGSGIAVTLCRKVCRKELRQCVDDGCKKKKEVVAD 230
KP CL +C+N+G + E CD+ G + +C C R C++ C ++ +
Sbjct: 281 KPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGR-CINGTCYCEEGFTGE 339
Query: 231 PVPKKGNCKVICWENATTCHDKCMKGDDKRSSTVINCT-KTCKKELNN---CVNIQCQ 392
K C C +C+ + ++C+ K C + +N CV+ +C+
Sbjct: 340 DCGKP-TCPHACHTQGRCEEGQCVCDE---GFAGLDCSEKRCPADCHNRGRCVDGRCE 393
Score = 29.6 bits (65), Expect = 2.9
Identities = 28/114 (24%), Positives = 42/114 (36%), Gaps = 6/114 (5%)
Frame = +3
Query: 66 CLVDCWNKGISCDKE--CDDNPDGSGIAVTLCRKVCRKELR----QCVDDGCKKKKEVVA 227
C DC N+G+ D + C+D G A C C + R QCV K+
Sbjct: 501 CPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKE 560
Query: 228 DPVPKKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKTCKKELNNCVNIQC 389
P + + C + CH+ D + S +C L CV+ +C
Sbjct: 561 QRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDC-----NNLGQCVSGRC 609
>sp|Q9UKF5|ADA29_HUMAN ADAM 29 precursor (A disintegrin and metalloproteinase domain 29)
Length = 820
Score = 33.5 bits (75), Expect = 0.20
Identities = 33/116 (28%), Positives = 48/116 (41%), Gaps = 13/116 (11%)
Frame = +3
Query: 60 PFCLVDCWNKGIS------CDKECDDNPDGSGIAVTLCRKVCRKELRQC-VDDGCKKKKE 218
P CL +C S C K+C P G KVCRKE+ +C + + C
Sbjct: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSG---------KVCRKEVNECDLPEWCNGTSH 473
Query: 219 ------VVADPVPKKGNCKVICWENATTCHDKCMKGDDKRSSTVINCTKTCKKELN 368
V D +P K + C+E +CHD+ + + ++TC KELN
Sbjct: 474 KCPDDFYVEDGIPCKE--RGYCYEK--SCHDRNEQCRRIFGAGANTASETCYKELN 525
>sp|P21783|NOTCH_XENLA Neurogenic locus notch protein homolog precursor (XOTCH protein)
Length = 2524
Score = 33.5 bits (75), Expect = 0.20
Identities = 34/141 (24%), Positives = 53/141 (37%), Gaps = 35/141 (24%)
Frame = +3
Query: 75 DC---WNKGISCD---KECDDNP--------DGSGIAVTLCRKV-----CRKELRQCVDD 197
DC W+ G +CD EC+ NP D +G + C+ C+ + +C +
Sbjct: 739 DCEAGWS-GSNCDINNNECESNPCMNGGTCKDMTGAYICTCKAGFSGPNCQTNINECSSN 797
Query: 198 GCKKKKEVVADPVPKKGNCKV-----ICWENATTCHDK-CMKGDDKRSST---VINCT-- 344
C + D K NC + IC C C G + S +C
Sbjct: 798 PCLNHGTCIDDVAGYKCNCMLPYTGAICEAVLAPCAGSPCKNGGRCKESEDFETFSCECP 857
Query: 345 -----KTCKKELNNCVNIQCQ 392
+TC+ ++N CVN C+
Sbjct: 858 PGWQGQTCEIDMNECVNRPCR 878
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,059,923
Number of Sequences: 369166
Number of extensions: 971182
Number of successful extensions: 2758
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2613
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2751
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2194785120
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)