Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_C07
(857 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P35224|CTNB_URECA Beta-catenin 139 1e-32
sp|P18824|ARM_DROME Armadillo segment polarity protein 137 4e-32
sp|Q02453|ARM_MUSDO Armadillo segment polarity protein 135 2e-31
sp|P35223|CTNB_TRIGR Beta-catenin 133 6e-31
sp|P26233|CTNB_XENLA Beta-catenin 133 6e-31
sp|Q02248|CTNB1_MOUSE Beta-catenin 133 7e-31
sp|P35222|CTNB1_HUMAN Beta-catenin 133 7e-31
sp|Q9WU82|CTNB1_RAT Beta-catenin 133 7e-31
sp|P14923|PLAK_HUMAN Junction plakoglobin (Desmoplakin III) 126 7e-29
sp|Q8SPJ1|PLAK_BOVIN Junction plakoglobin (Desmoplakin III) 126 7e-29
>sp|P35224|CTNB_URECA Beta-catenin
Length = 818
Score = 139 bits (349), Expect = 1e-32
Identities = 85/251 (33%), Positives = 138/251 (54%), Gaps = 4/251 (1%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP +C LRH++SRH EAE AQ ++ GL +L++++ H P
Sbjct: 484 EPAVCALRHLTSRHGEAEMAQNAVRLHYGLPVLVKLL-------------HPPS------ 524
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA++GLIRNLA+ P N P+RE G ++ L+ RA D + S +
Sbjct: 525 -----RWPLIKAVVGLIRNLALCPANHAPLREHGAIPRIVQLLIRAHQDTQRRATAGSGN 579
Query: 365 PKDKL----LEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIA 532
+ +EEI+E + GALH++A++ R+ I + +C+ + A
Sbjct: 580 TSAYVDGVRMEEIVEGTVGALHIMAREAHNRAVIRGL----------------NCISLFA 623
Query: 533 SLLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAIL 712
LL++ +++IQRV AG+L E++ ++ G E+ I Q T L+E++HS NE ++TYA+A+L
Sbjct: 624 QLLYSPIDNIQRVAAGVLCELAADKEGAEM-IEQEGTTAPLTELLHSRNEGVATYAAAVL 682
Query: 713 IRATEEKNKRY 745
R +E+K + Y
Sbjct: 683 FRMSEDKPQDY 693
>sp|P18824|ARM_DROME Armadillo segment polarity protein
Length = 843
Score = 137 bits (345), Expect = 4e-32
Identities = 90/282 (31%), Positives = 147/282 (52%), Gaps = 12/282 (4%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP +C LRH++SRH ++E AQ ++ GL ++++++ H P
Sbjct: 470 EPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLL-------------HPPS------ 510
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA+IGLIRNLA+ P N P+RE G ++ L+ RA D + + + +
Sbjct: 511 -----RWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATT 565
Query: 365 PKDK--------LLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCV 520
+ +EEI+E + GALH+LA++ R+ I QS +
Sbjct: 566 GSQQPSAYADGVRMEEIVEGTVGALHILARESHNRA----------------LIRQQSVI 609
Query: 521 FVIASLLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYA 700
+ LLFN +E+IQRV AG+L E++ ++ G E II Q T L++++HS NE ++TYA
Sbjct: 610 PIFVRLLFNEIENIQRVAAGVLCELAADKEGAE-IIEQEGATGPLTDLLHSRNEGVATYA 668
Query: 701 SAILIRATEEK----NKRYATSHNYNVAQNPNNLRNNLSISL 814
+A+L R +E+K KR + ++ + NN+ N + +
Sbjct: 669 AAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGM 710
>sp|Q02453|ARM_MUSDO Armadillo segment polarity protein
Length = 813
Score = 135 bits (339), Expect = 2e-31
Identities = 89/283 (31%), Positives = 145/283 (51%), Gaps = 13/283 (4%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP +C LRH+++RH ++E AQ ++ GL ++++++ H P
Sbjct: 460 EPAVCALRHLTTRHADSEMAQNAVRLNYGLSVIVKLL-------------HPPS------ 500
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA IGL+RNLA+ P N P+RE G ++ L+ RA D + + + +
Sbjct: 501 -----RWPLIKAAIGLVRNLALCPANAAPLREHGAIHHLVRLLMRAFQDTERQRSSVATT 555
Query: 365 PKDK--------LLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCV 520
+ +EEI+E + GALH+LA++ R+ I QS +
Sbjct: 556 GSQQPAAYADGVRMEEIVEGTVGALHILARESHNRA----------------LIRQQSVI 599
Query: 521 FVIASLLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYA 700
+ LLFN +E+IQRV AG+L E++ ++ G E II Q T L++++HS NE ++TYA
Sbjct: 600 PIFVRLLFNEIENIQRVAAGVLCELAADKEGAE-IIEQEGATGPLTDLLHSRNEGVATYA 658
Query: 701 SAILIRATEEKNKRYATSHNYNVAQN-----PNNLRNNLSISL 814
+A+L R +E+K + Y + + N NN+ N + L
Sbjct: 659 AAVLFRMSEDKPQDYKKRLSIELTTNSLLREDNNIWGNADLGL 701
>sp|P35223|CTNB_TRIGR Beta-catenin
Length = 820
Score = 133 bits (335), Expect = 6e-31
Identities = 83/253 (32%), Positives = 136/253 (53%), Gaps = 6/253 (2%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP +C LRH++SRH AE Q ++ G+ ++++++ H P
Sbjct: 478 EPAVCALRHVTSRHPGAEMGQNTVRLNYGIPVIVKLL-------------HPPS------ 518
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA +GLIRNLA+ N P+RE+G ++ L+ RA D +++ S
Sbjct: 519 -----RWPLIKATVGLIRNLALCSANHAPLREQGALHRLVQLLMRAHQDTQRRSSMGSTG 573
Query: 365 PK------DKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFV 526
+ +E+I+E + GALH+LA+D R+ I + +C+ +
Sbjct: 574 SQGGNYADGVRMEDIVEGTTGALHILARDSHNRALIQGL----------------NCIPL 617
Query: 527 IASLLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASA 706
LL+N++E+IQRV AG+L E+S E+ G E+ I Q T L+E++HS NE ++TYA+A
Sbjct: 618 FVQLLYNNIENIQRVAAGVLSELSLEKQGAEM-IEQEGATAPLTELLHSRNEGVATYAAA 676
Query: 707 ILIRATEEKNKRY 745
+L R +++K + Y
Sbjct: 677 VLYRMSDDKPQDY 689
>sp|P26233|CTNB_XENLA Beta-catenin
Length = 781
Score = 133 bits (335), Expect = 6e-31
Identities = 86/250 (34%), Positives = 138/250 (55%), Gaps = 3/250 (1%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP IC LRH++SRH+EAE AQ ++ GL ++++++ H SH
Sbjct: 462 EPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL---------HPPSH--------- 503
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA +GLIRNLA+ P N P+RE+G ++ L+ RA D +T+
Sbjct: 504 ------WPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSIGGTQ 557
Query: 365 P---KDKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIAS 535
+ +EEI+E GALH+LA+D I ++I+ I + + +
Sbjct: 558 QQFVEGVRMEEIVEGCTGALHILARD--IHNRIV--------------IRGLNTIPLFVQ 601
Query: 536 LLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAILI 715
LL++ +E+IQRV AG+L +V+ ++ E I ++ T L+E++HS NE ++TYA+A+L
Sbjct: 602 LLYSPIENIQRVAAGVLCDVAQDKEAAEAIEAE-GATAPLTELLHSRNEGVATYAAAVLF 660
Query: 716 RATEEKNKRY 745
R +E+K + Y
Sbjct: 661 RMSEDKPQDY 670
>sp|Q02248|CTNB1_MOUSE Beta-catenin
Length = 781
Score = 133 bits (334), Expect = 7e-31
Identities = 85/250 (34%), Positives = 138/250 (55%), Gaps = 3/250 (1%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP IC LRH++SRH+EAE AQ ++ GL ++++++ H SH
Sbjct: 462 EPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL---------HPPSH--------- 503
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA +GLIRNLA+ P N P+RE+G ++ L+ RA D +T+
Sbjct: 504 ------WPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ 557
Query: 365 P---KDKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIAS 535
+ +EEI+E GALH+LA+D + ++I+ I + + +
Sbjct: 558 QQFVEGVRMEEIVEGCTGALHILARD--VHNRIV--------------IRGLNTIPLFVQ 601
Query: 536 LLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAILI 715
LL++ +E+IQRV AG+L E++ ++ E I ++ T L+E++HS NE ++TYA+A+L
Sbjct: 602 LLYSPIENIQRVAAGVLCELAQDKEAAEAIEAE-GATAPLTELLHSRNEGVATYAAAVLF 660
Query: 716 RATEEKNKRY 745
R +E+K + Y
Sbjct: 661 RMSEDKPQDY 670
>sp|P35222|CTNB1_HUMAN Beta-catenin
Length = 781
Score = 133 bits (334), Expect = 7e-31
Identities = 85/250 (34%), Positives = 138/250 (55%), Gaps = 3/250 (1%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP IC LRH++SRH+EAE AQ ++ GL ++++++ H SH
Sbjct: 462 EPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL---------HPPSH--------- 503
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA +GLIRNLA+ P N P+RE+G ++ L+ RA D +T+
Sbjct: 504 ------WPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ 557
Query: 365 P---KDKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIAS 535
+ +EEI+E GALH+LA+D + ++I+ I + + +
Sbjct: 558 QQFVEGVRMEEIVEGCTGALHILARD--VHNRIV--------------IRGLNTIPLFVQ 601
Query: 536 LLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAILI 715
LL++ +E+IQRV AG+L E++ ++ E I ++ T L+E++HS NE ++TYA+A+L
Sbjct: 602 LLYSPIENIQRVAAGVLCELAQDKEAAEAIEAE-GATAPLTELLHSRNEGVATYAAAVLF 660
Query: 716 RATEEKNKRY 745
R +E+K + Y
Sbjct: 661 RMSEDKPQDY 670
>sp|Q9WU82|CTNB1_RAT Beta-catenin
Length = 781
Score = 133 bits (334), Expect = 7e-31
Identities = 85/250 (34%), Positives = 138/250 (55%), Gaps = 3/250 (1%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP IC LRH++SRH+EAE AQ ++ GL ++++++ H SH
Sbjct: 462 EPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL---------HPPSH--------- 503
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W LIKA +GLIRNLA+ P N P+RE+G ++ L+ RA D +T+
Sbjct: 504 ------WPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ 557
Query: 365 P---KDKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIAS 535
+ +EEI+E GALH+LA+D + ++I+ I + + +
Sbjct: 558 QQFVEGVRMEEIVEGCTGALHILARD--VHNRIV--------------IRGLNTIPLFVQ 601
Query: 536 LLFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAILI 715
LL++ +E+IQRV AG+L E++ ++ E I ++ T L+E++HS NE ++TYA+A+L
Sbjct: 602 LLYSPIENIQRVAAGVLCELAQDKEAAEAIEAE-GATAPLTELLHSRNEGVATYAAAVLF 660
Query: 716 RATEEKNKRY 745
R +E+K + Y
Sbjct: 661 RMSEDKPQDY 670
>sp|P14923|PLAK_HUMAN Junction plakoglobin (Desmoplakin III)
Length = 744
Score = 126 bits (317), Expect = 7e-29
Identities = 84/249 (33%), Positives = 129/249 (51%), Gaps = 2/249 (0%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP +C LRH++SRH EAE AQ S+ G+ +++++ PN
Sbjct: 452 EPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQ----------------PN--- 492
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W L+KA IGLIRNLA+ P N P++E ++ L+ +A D A +
Sbjct: 493 -----QWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQ 547
Query: 365 P--KDKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIASL 538
P +EEI+E GALH+LA+DP R +I RL P + L
Sbjct: 548 PYTDGVRMEEIVEGCTGALHILARDPMNRMEIF------RLNTIP----------LFVQL 591
Query: 539 LFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAILIR 718
L++ +E+IQRV AG+L E++ ++ + I ++ + L E++HS NE +TYA+A+L R
Sbjct: 592 LYSSVENIQRVAAGVLCELAQDKEAADAIDAE-GASAPLMELLHSRNEGTATYAAAVLFR 650
Query: 719 ATEEKNKRY 745
+E+KN Y
Sbjct: 651 ISEDKNPDY 659
>sp|Q8SPJ1|PLAK_BOVIN Junction plakoglobin (Desmoplakin III)
Length = 745
Score = 126 bits (317), Expect = 7e-29
Identities = 84/249 (33%), Positives = 129/249 (51%), Gaps = 2/249 (0%)
Frame = +2
Query: 5 EPCICTLRHISSRHEEAEAAQASILHFQGLQILIRIIEMQLGPDLFHMQSHQPIMPNLFL 184
EP +C LRH++SRH EAE AQ S+ G+ +++++ PN
Sbjct: 453 EPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQ----------------PN--- 493
Query: 185 SYYKINWSLIKAIIGLIRNLAMSPCNFVPIREKGFGWPMIVLINRAQIDLLNKTACASIS 364
W L+KA IGLIRNLA+ P N P++E ++ L+ +A D A +
Sbjct: 494 -----QWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQ 548
Query: 365 P--KDKLLEEIIEVSCGALHMLAKDPGIRSQIISMKIWQRLINYPQQIGTQSCVFVIASL 538
P +EEI+E GALH+LA+DP R +I RL P + L
Sbjct: 549 PYTDGVRMEEIVEGCTGALHILARDPMNRMEIF------RLNTIP----------LFVQL 592
Query: 539 LFNHLESIQRVTAGLLVEVSGERMGLELIISQIVITNKLSEMVHSNNEAISTYASAILIR 718
L++ +E+IQRV AG+L E++ ++ + I ++ + L E++HS NE +TYA+A+L R
Sbjct: 593 LYSSVENIQRVAAGVLCELAQDKEAADAIDAE-GASAPLMELLHSRNEGTATYAAAVLFR 651
Query: 719 ATEEKNKRY 745
+E+KN Y
Sbjct: 652 ISEDKNPDY 660
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,412,575
Number of Sequences: 369166
Number of extensions: 1853492
Number of successful extensions: 4563
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4374
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4518
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)