Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_B17
(881 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BXW6|OSR1_HUMAN Oxysterol binding protein-related prot... 272 8e-73
sp|Q9H1P3|OSR2_HUMAN Oxysterol binding protein-related prot... 271 2e-72
sp|Q91XL9|OSR1_MOUSE Oxysterol binding protein-related prot... 267 3e-71
sp|Q8BX94|OSR2_MOUSE Oxysterol binding protein-related prot... 263 6e-70
sp|Q9BZF3|OSR6_HUMAN Oxysterol binding protein-related prot... 198 1e-50
sp|Q8BXR9|OSR6_MOUSE Oxysterol binding protein-related prot... 197 2e-50
sp|Q9BZF2|OSR7_HUMAN Oxysterol binding protein-related prot... 196 9e-50
sp|Q9H4L5|OSR3_HUMAN Oxysterol binding protein-related prot... 194 4e-49
sp|Q9DBS9|OSR3_MOUSE Oxysterol binding protein-related prot... 189 9e-48
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F1... 186 1e-46
>sp|Q9BXW6|OSR1_HUMAN Oxysterol binding protein-related protein 1 (OSBP-related protein 1)
(ORP-1)
Length = 950
Score = 272 bits (696), Expect = 8e-73
Identities = 146/298 (48%), Positives = 187/298 (62%), Gaps = 7/298 (2%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IG ELSKITMP++FNEP+SFLQRLTEY+E++ LI +A S DP++RM+ + AFAVS AS
Sbjct: 557 IGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVAS 616
Query: 181 NWGRIGKPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVE--SSTFKFYGAIHPK 348
W R GKPFNPLLGETYEL R + F+ +S Q+ HHPPISAFH E ++ F F+G+I+PK
Sbjct: 617 QWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPK 676
Query: 349 LSFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNN 528
L FWGKSV PKG +TLELL +E YTW N TC VHN+I+GK+WIE G + IINH
Sbjct: 677 LKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTG 736
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSP---DVWNXX 699
L F G FGK +H+V+G Y Q KSK +YGKWTE L+SV P D +
Sbjct: 737 DKCVLNFKPCGLFGKELHKVEG---YIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKN 793
Query: 700 XXXXXXXXXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENS 873
Q++ E+ D +P ++ + L+W+ RP NS
Sbjct: 794 DKKNTEEKKNSKQMSTSEE--------LDEMPVPDSESVFIIPGSVLLWRIAPRPPNS 843
>sp|Q9H1P3|OSR2_HUMAN Oxysterol binding protein-related protein 2 (OSBP-related protein
2) (ORP-2)
Length = 480
Score = 271 bits (693), Expect = 2e-72
Identities = 142/296 (47%), Positives = 186/296 (62%), Gaps = 5/296 (1%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
+G ELSKITMPI FNEP+SFLQR+TEY+E+ LI +A +P P++RM+ + AFAVS AS
Sbjct: 84 VGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVAS 143
Query: 181 NWGRIGKPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVE--SSTFKFYGAIHPK 348
W R GKPFNPLLGETYEL R + F+++S Q+ HHPPISAFH E + F F+G+I+PK
Sbjct: 144 QWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPK 203
Query: 349 LSFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNN 528
L FWGKSV P+G +TLELL +E YTW N TC VHNVIIGK+WIE G + I+NH
Sbjct: 204 LKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTG 263
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXX 708
L F G FGK +H+V+G I Q K+K IYGKWTE L+ + P +
Sbjct: 264 HKCVLHFKPCGLFGKELHKVEGHI---QDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQ 320
Query: 709 XXXXXXXXXQITNVEKGDINENDIDD-PLPQDNTPCDMKLLNQRLIWKAKSRPENS 873
+ + G + + DD P+ Q+ + +L+W+ +RP NS
Sbjct: 321 ERRGDHLRKAKLDEDSGKADSDVADDVPVAQETV---QVIPGSKLLWRINTRPPNS 373
>sp|Q91XL9|OSR1_MOUSE Oxysterol binding protein-related protein 1 (OSBP-related protein
1) (ORP-1)
Length = 437
Score = 267 bits (683), Expect = 3e-71
Identities = 143/298 (47%), Positives = 185/298 (62%), Gaps = 7/298 (2%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IG ELSKITMP++FNEP+SFLQRLTEY+E++ LI +A S DP++RM+ + AFAVS AS
Sbjct: 44 IGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVAS 103
Query: 181 NWGRIGKPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVE--SSTFKFYGAIHPK 348
W R GKPFNPLLGETYEL R + F+ +S Q+ HHPPISAFH E ++ F F+G+I+PK
Sbjct: 104 QWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPK 163
Query: 349 LSFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNN 528
L FWGKSV PKG +TLEL +E YTW N TC V N+I+GK+WIE G + II H
Sbjct: 164 LKFWGKSVKAEPKGTITLELFVHNEAYTWTNPTCCVQNIIVGKLWIEQYGNVEIITHKTG 223
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSP---DVWNXX 699
L F+ G FGK +H+V+G I Q KSK +YGKWTE L+SV P D +
Sbjct: 224 DKCVLNFNPCGLFGKELHKVEGSI---QDKSKKKLCALYGKWTECLYSVDPATFDAYKKN 280
Query: 700 XXXXXXXXXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENS 873
Q ++ E+ D +P ++ + L+W+ RP NS
Sbjct: 281 DKKNTEEKKNSKQTSSSEE--------SDEMPVPDSESVFIIPGSVLLWRIAPRPPNS 330
>sp|Q8BX94|OSR2_MOUSE Oxysterol binding protein-related protein 2 (OSBP-related protein
2) (ORP-2)
Length = 484
Score = 263 bits (671), Expect = 6e-70
Identities = 140/300 (46%), Positives = 186/300 (62%), Gaps = 9/300 (3%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IG ELSKITMPI FNEP+SFLQR+TEY+E+ LI +A S+ P++RM+ + AFAVS AS
Sbjct: 84 IGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHKASSQSQPLERMQSVAAFAVSAVAS 143
Query: 181 NWGRIGKPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVE--SSTFKFYGAIHPK 348
W R GKPFNPLLGETYEL R + F+++S Q+ HHPPISAF+ E + F+F+G+I+PK
Sbjct: 144 QWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFYSEGLNQDFRFHGSIYPK 203
Query: 349 LSFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNN 528
L FWGKSV P+G +TLELL +E YTW N TC VHNVI+G++WIE G + I+NH
Sbjct: 204 LKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIVEIVNHRTG 263
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXX 708
L F G FGK +HRV+G I RK + +YGKWTE L+ + P +
Sbjct: 264 DKCILHFKPCGLFGKELHRVEGYIQDKNRKKLFI---MYGKWTECLWGIDPASYE--SFK 318
Query: 709 XXXXXXXXXQITNVEKGDINEN-----DIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENS 873
+ ++ G N D+ D +P + + +L+W+ SRP NS
Sbjct: 319 KQEKRGDQARKAKMDDGPEKANSDVPGDVADDVPVAQETVQV-IPGSKLLWRINSRPPNS 377
>sp|Q9BZF3|OSR6_HUMAN Oxysterol binding protein-related protein 6 (OSBP-related protein 6)
(ORP-6)
Length = 934
Score = 198 bits (504), Expect = 1e-50
Identities = 105/227 (46%), Positives = 144/227 (63%), Gaps = 4/227 (1%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IGK+LSK++MP+ NEP++ LQ L E +EYSEL+D+A DP +RM + AFAVSG S
Sbjct: 579 IGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCS 638
Query: 181 NWGRIG-KPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVESSTFKFYGAIHPKL 351
+ R G KPFNP+LGETYE R + F++ S Q+ HHPPISA H ES F F+ I K
Sbjct: 639 TYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKN 698
Query: 352 SFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNN 528
FWGKS+ I P G L + L + + Y W VT +HN++ G+ WIEH G + I N S+
Sbjct: 699 KFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSV 758
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF 669
CI LTF V ++ NM+ V G + + K+ + +++GKW E L+
Sbjct: 759 CICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVY---RLFGKWHEGLY 802
>sp|Q8BXR9|OSR6_MOUSE Oxysterol binding protein-related protein 6 (OSBP-related protein 6)
(ORP-6)
Length = 959
Score = 197 bits (502), Expect = 2e-50
Identities = 104/227 (45%), Positives = 143/227 (62%), Gaps = 4/227 (1%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IGK+LSK++MP+ NEP++ LQ L E +EYSEL+D+A DP +RM + AFAVSG S
Sbjct: 604 IGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCS 663
Query: 181 NWGRIG-KPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVESSTFKFYGAIHPKL 351
+ R G KPFNP+LGETYE R + F++ S Q+ HHPPISA H ES F F+ I K
Sbjct: 664 TYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKN 723
Query: 352 SFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNN 528
FWGKS+ I P G L + L + + Y W VT +HN++ G+ WIEH G + + N S+
Sbjct: 724 KFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTLRNTKSSV 783
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF 669
CI LTF V ++ N++ V G + + K H +++GKW E L+
Sbjct: 784 CICKLTFVKVNYWNSNVNEVQGVVIDQEGKVVH---RLFGKWHEGLY 827
>sp|Q9BZF2|OSR7_HUMAN Oxysterol binding protein-related protein 7 (OSBP-related protein 7)
(ORP-7)
Length = 842
Score = 196 bits (497), Expect = 9e-50
Identities = 102/227 (44%), Positives = 143/227 (62%), Gaps = 4/227 (1%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IGK+LSK++MP+ NEP++ LQRL E +EYS L+DQA DP +RM I AFAVS +S
Sbjct: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
Query: 181 NWGRIG-KPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVESSTFKFYGAIHPKL 351
+ R G KPFNP+LGETYE RP+ F+++S Q+ HHPPISA H ES F F+ + K
Sbjct: 547 TYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQDMKWKN 606
Query: 352 SFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNN 528
FWGKS+ I P G + + L + + + W VT +HNV+ G+ WIEH G + I N ++
Sbjct: 607 KFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSS 666
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF 669
C +TF ++ N+H V G + +S V +++GKW E L+
Sbjct: 667 CHCKITFCKAKYWSSNVHEVQGAVL---SRSGRVLHRLFGKWHEGLY 710
>sp|Q9H4L5|OSR3_HUMAN Oxysterol binding protein-related protein 3 (OSBP-related protein 3)
(ORP-3)
Length = 887
Score = 194 bits (492), Expect = 4e-49
Identities = 101/238 (42%), Positives = 148/238 (62%), Gaps = 8/238 (3%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IGK+LSK+ MP+ NEP++ LQRL E +EYSEL+D+A P P++RM + AFA+S AS
Sbjct: 536 IGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYAS 595
Query: 181 NWGRIG-KPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVESSTFKFYGAIHPKL 351
++ R G KPFNP+LGETYE R + F++ S Q+ HHPPISA H ES F F+ + K
Sbjct: 596 SYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKN 655
Query: 352 SFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNN 528
FWGKS+ I P G + L + + + W VT +HN++ G+ WIEH G + I N H ++
Sbjct: 656 KFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDS 715
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF----SVSPDVW 690
C + F ++ N H ++G ++ K+ H +++GKW E+++ S S VW
Sbjct: 716 CYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVH---RLFGKWHESIYCGGGSSSACVW 770
>sp|Q9DBS9|OSR3_MOUSE Oxysterol binding protein-related protein 3 (OSBP-related protein 3)
(ORP-3)
Length = 855
Score = 189 bits (480), Expect = 9e-48
Identities = 99/238 (41%), Positives = 148/238 (62%), Gaps = 8/238 (3%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IGK+LSK+ MP+ NEP++ LQRL E +EYSEL+D+A P P++RM + AFA+S AS
Sbjct: 504 IGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAAFAISAYAS 563
Query: 181 NWGRIG-KPFNPLLGETYELHRPN--FKYVSVQICHHPPISAFHVESSTFKFYGAIHPKL 351
++ R G KPFNP+LGETYE R + F++ + Q+ HHPPISA H ES F F+ + K
Sbjct: 564 SYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVFWQDVRWKN 623
Query: 352 SFWGKSVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNN 528
FWGKS+ I P G + L + + + W VT +HN++ G+ WIEH G + I N + ++
Sbjct: 624 KFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIDIKNLNDDS 683
Query: 529 CIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF----SVSPDVW 690
C + F ++ N H ++G ++ K+ H +++GKW E+++ S S VW
Sbjct: 684 CHCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVH---RLFGKWHESIYCGGASSSTCVW 738
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
Length = 1310
Score = 186 bits (471), Expect = 1e-46
Identities = 101/235 (42%), Positives = 142/235 (60%), Gaps = 7/235 (2%)
Frame = +1
Query: 1 IGKELSKITMPIVFNEPISFLQRLTEYVEYSELIDQAVSEPDPIKRMEKICAFAVSGGAS 180
IGK+++K+T+P+ FNEP S LQR+ E +EY+EL+DQA DP +R+ + AFA S AS
Sbjct: 946 IGKDMTKMTLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQRILYVAAFAASEYAS 1005
Query: 181 NWGRIGKPFNPLLGETYELHRP--NFKYVSVQICHHPPISAFHVESSTFKFYGAIHPKLS 354
R+ KPFNPLLGETYE P F+++ Q+ HHPP+ A + ES+ +K+YG K
Sbjct: 1006 TLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSESANWKYYGESSVKSK 1065
Query: 355 FWGKSVVINPKGNLTLELL-PWDEV--YTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSN 525
F+GKS I+P G LEL P EV YTW+ VT +V +I+G +++ G M I+NHS+
Sbjct: 1066 FYGKSFDISPLGTWFLELRHPSGEVELYTWKKVTSSVVGIILGSPSVDNYGQMHIVNHSS 1125
Query: 526 --NCIADLTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSPD 684
NC+ D F GW G N H V G + Q + + G W + +F P+
Sbjct: 1126 GINCVLD--FKPRGWRGTNAHEVKGSV---QSTDDTPKWMVNGHWNDKIFGQQPN 1175
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,525,116
Number of Sequences: 369166
Number of extensions: 2338976
Number of successful extensions: 6145
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5948
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6081
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8790245790
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)