Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_P09
(888 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8R4V2|DUS15_MOUSE Dual specificity protein phosphatase ... 102 2e-21
sp|Q9H1R2|DUS15_HUMAN Dual specificity protein phosphatase 15 99 2e-20
sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9... 90 7e-18
sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6... 89 2e-17
sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (... 89 2e-17
sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6... 89 2e-17
sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7... 86 2e-16
sp|Q63340|DUS7_RAT Dual specificity protein phosphatase 7 (... 86 2e-16
sp|Q91Z46|DUS7_MOUSE Dual specificity protein phosphatase 7 86 2e-16
sp|Q8WUJ0|STYX_HUMAN Serine/threonine/tyrosine interacting ... 81 4e-15
>sp|Q8R4V2|DUS15_MOUSE Dual specificity protein phosphatase 15 (Dual specificity protein
phosphatase T-DSP10)
Length = 125
Score = 102 bits (253), Expect = 2e-21
Identities = 52/126 (41%), Positives = 72/126 (57%)
Frame = +3
Query: 63 MGKEMSKILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKD 242
MG M+K+LPGLYLG ITH++S+HE + LQ YL I+V D
Sbjct: 1 MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIISIHESPQPLLQDIT---YLRISVSD 57
Query: 243 EDTACISKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNC 422
I K+F + FIH R+ GN L+HC AG+SR+ TIV+AY+M+V L +Q+
Sbjct: 58 TPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTIVIAYVMTVTGLGWQEVLEA 117
Query: 423 LRAVRP 440
++A RP
Sbjct: 118 IKASRP 123
>sp|Q9H1R2|DUS15_HUMAN Dual specificity protein phosphatase 15
Length = 295
Score = 98.6 bits (244), Expect = 2e-20
Identities = 53/134 (39%), Positives = 73/134 (54%)
Frame = +3
Query: 84 ILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACIS 263
+LPGLYLG ITH++S+HE + LQ YL I V D I
Sbjct: 5 VLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDIT---YLRIPVADTPEVPIK 61
Query: 264 KYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRPN 443
K+F + +FIH R+ GN L+HC AG+SR+ TIV AY+M+V L ++D ++A RP
Sbjct: 62 KHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPI 121
Query: 444 IKPIATFVKQLNDF 485
P F +QL +F
Sbjct: 122 ANPNPGFRQQLEEF 135
>sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9 (Mitogen-activated protein
kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)
Length = 384
Score = 90.1 bits (222), Expect = 7e-18
Identities = 50/144 (34%), Positives = 78/144 (54%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + +K + Y +I + D + +
Sbjct: 206 QILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNL 265
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + +FI E +N VL+HCLAGVSR+ T+ +AYLM LS DA++ ++ +
Sbjct: 266 SRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKS 325
Query: 441 NIKPIATFVKQLNDFETNEVIVER 512
NI P F+ QL DFE + + ER
Sbjct: 326 NISPNFNFMGQLLDFERSLRLEER 349
>sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
(Dual specificity protein phosphatase PYST1)
Length = 381
Score = 88.6 bits (218), Expect = 2e-17
Identities = 48/136 (35%), Positives = 75/136 (55%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + + ++Y +I + D + +
Sbjct: 209 EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNL 268
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + FI E R KN VL+HCLAG+SR+ T+ +AYLM +LS DA++ ++ +
Sbjct: 269 SQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS 328
Query: 441 NIKPIATFVKQLNDFE 488
NI P F+ QL DFE
Sbjct: 329 NISPNFNFMGQLLDFE 344
>sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 88.6 bits (218), Expect = 2e-17
Identities = 48/136 (35%), Positives = 75/136 (55%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + + ++Y +I + D + +
Sbjct: 209 EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNL 268
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + FI E R KN VL+HCLAG+SR+ T+ +AYLM +LS DA++ ++ +
Sbjct: 269 SQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS 328
Query: 441 NIKPIATFVKQLNDFE 488
NI P F+ QL DFE
Sbjct: 329 NISPNFNFMGQLLDFE 344
>sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 88.6 bits (218), Expect = 2e-17
Identities = 48/136 (35%), Positives = 75/136 (55%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + + ++Y +I + D + +
Sbjct: 209 EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNL 268
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + FI E R KN VL+HCLAG+SR+ T+ +AYLM +LS DA++ ++ +
Sbjct: 269 SQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS 328
Query: 441 NIKPIATFVKQLNDFE 488
NI P F+ QL DFE
Sbjct: 329 NISPNFNFMGQLLDFE 344
>sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7 (Dual specificity protein
phosphatase PYST2)
Length = 368
Score = 85.5 bits (210), Expect = 2e-16
Identities = 47/136 (34%), Positives = 73/136 (53%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + + + Y +I + D + +
Sbjct: 196 QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNL 255
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + FI E R K VL+HCLAG+SR+ T+ +AYLM +LS DA++ ++ +
Sbjct: 256 SQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS 315
Query: 441 NIKPIATFVKQLNDFE 488
NI P F+ QL DFE
Sbjct: 316 NISPNFNFMGQLLDFE 331
>sp|Q63340|DUS7_RAT Dual specificity protein phosphatase 7 (Dual specificity protein
phosphatase MKP-X)
Length = 280
Score = 85.5 bits (210), Expect = 2e-16
Identities = 47/136 (34%), Positives = 73/136 (53%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + + + Y +I + D + +
Sbjct: 108 QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNL 167
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + FI E R K VL+HCLAG+SR+ T+ +AYLM +LS DA++ ++ +
Sbjct: 168 SQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS 227
Query: 441 NIKPIATFVKQLNDFE 488
NI P F+ QL DFE
Sbjct: 228 NISPNFNFMGQLLDFE 243
>sp|Q91Z46|DUS7_MOUSE Dual specificity protein phosphatase 7
Length = 358
Score = 85.5 bits (210), Expect = 2e-16
Identities = 47/136 (34%), Positives = 73/136 (53%)
Frame = +3
Query: 81 KILPGLYLGRLXXXXXXXXXXXXCITHVLSVHEPVKQKLQKFNSYEYLEINVKDEDTACI 260
+ILP LYLG I ++L+V + + + Y +I + D + +
Sbjct: 186 QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNL 245
Query: 261 SKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLSFQDAFNCLRAVRP 440
S++F + FI E R K VL+HCLAG+SR+ T+ +AYLM +LS DA++ ++ +
Sbjct: 246 SQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS 305
Query: 441 NIKPIATFVKQLNDFE 488
NI P F+ QL DFE
Sbjct: 306 NISPNFNFMGQLLDFE 321
>sp|Q8WUJ0|STYX_HUMAN Serine/threonine/tyrosine interacting protein (Protein tyrosine
phosphatase-like protein)
Length = 223
Score = 80.9 bits (198), Expect = 4e-15
Identities = 48/149 (32%), Positives = 77/149 (51%), Gaps = 5/149 (3%)
Frame = +3
Query: 57 YIMGKEMSKILPGLYLGRLXXXXXXXXXXXXC--ITHVLSVHEPVKQKLQKFNS---YEY 221
Y M +EM +ILPGL+LG ITH++ + + ++ K N + Y
Sbjct: 23 YPMRREMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQLFRY 82
Query: 222 LEINVKDEDTACISKYFSKTNDFIHEGRIKNGNVLIHCLAGVSRAPTIVLAYLMSVYDLS 401
L +++ D I ++F T +FI G VL+H AG+SR+ V+AY+M + +
Sbjct: 83 LVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMK 142
Query: 402 FQDAFNCLRAVRPNIKPIATFVKQLNDFE 488
++DAF ++ R I P A FV QL ++E
Sbjct: 143 YRDAFAYVQERRFCINPNAGFVHQLQEYE 171
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,821,963
Number of Sequences: 369166
Number of extensions: 1931087
Number of successful extensions: 5174
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4944
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5158
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8886314050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)