Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_O22
(503 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q25378|KPC1_LYTPI Protein kinase C 104 1e-22
sp|P90980|KPC2_CAEEL Protein kinase C-like 2 (PKC2) 101 9e-22
sp|P68404|KPCB_MOUSE Protein kinase C, beta type (PKC-beta)... 99 4e-21
sp|P10829|KPCG_RABIT Protein kinase C, gamma type (PKC-gamm... 99 4e-21
sp|P05126|KPCB_BOVIN Protein kinase C, beta type (PKC-beta)... 99 4e-21
sp|P05772|KPCB_RABIT Protein kinase C, beta type (PKC-beta)... 99 4e-21
sp|P68403|KPCB_RAT Protein kinase C, beta type (PKC-beta) (... 99 4e-21
sp|P05771|KPCB_HUMAN Protein kinase C, beta type (PKC-beta)... 99 4e-21
sp|P05129|KPCG_HUMAN Protein kinase C, gamma type (PKC-gamma) 99 6e-21
sp|P63319|KPCG_RAT Protein kinase C, gamma type (PKC-gamma)... 99 6e-21
>sp|Q25378|KPC1_LYTPI Protein kinase C
Length = 658
Score = 104 bits (260), Expect = 1e-22
Identities = 49/114 (42%), Positives = 68/114 (59%), Gaps = 5/114 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCCKMFP-----PPKNEHEFKP 194
P+ C+ C FI+G KQG +C C VVH RC V C + P P+N+H+FK
Sbjct: 38 PTFCSHCKDFIWGFGKQGFQCKVCSFVVHKRCHEFVTFQCPGLDPGVDSDDPRNKHKFKV 97
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSNPHVE 356
++ +PT+CD CG+L+YG+Y QG+KC A C + H RC VP CG++ H E
Sbjct: 98 HSYNSPTFCDHCGSLLYGLYHQGMKCGA--CDMNVHKRCQKSVPNLCGAD-HTE 148
Score = 52.4 bits (124), Expect = 6e-07
Identities = 25/60 (41%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC-GSNPHVE 356
H+F P+ F PT+C C I+G KQG +C C V H RC V F C G +P V+
Sbjct: 28 HKFIPRFFKQPTFCSHCKDFIWGFGKQGFQCKV--CSFVVHKRCHEFVTFQCPGLDPGVD 85
Score = 44.3 bits (103), Expect = 2e-04
Identities = 19/48 (39%), Positives = 26/48 (54%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K + SP+ C C ++G+ QGMKC C VH RC+ SV C
Sbjct: 95 FKVHSYNSPTFCDHCGSLLYGLYHQGMKCGACDMNVHKRCQKSVPNLC 142
>sp|P90980|KPC2_CAEEL Protein kinase C-like 2 (PKC2)
Length = 682
Score = 101 bits (252), Expect = 9e-22
Identities = 46/110 (41%), Positives = 64/110 (58%), Gaps = 5/110 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCCKM-----FPPPKNEHEFKP 194
P+ C+ C F++GI KQG +C C VVH RC V C P+ +H++K
Sbjct: 49 PTFCSHCKDFLWGITKQGFQCQVCTLVVHKRCHEFVNFACPGADKGVDTDDPRQQHKWKV 108
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSN 344
QT+ +PT+CD CG+L+YG+ QG+KC SC HHRC VP CG++
Sbjct: 109 QTYSSPTFCDHCGSLLYGILHQGMKC--QSCDTNVHHRCVKNVPNMCGTD 156
Score = 51.2 bits (121), Expect = 1e-06
Identities = 21/48 (43%), Positives = 29/48 (60%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K T +SP+ C C ++GI+ QGMKC +C VHHRC +V C
Sbjct: 106 WKVQTYSSPTFCDHCGSLLYGILHQGMKCQSCDTNVHHRCVKNVPNMC 153
Score = 50.4 bits (119), Expect = 2e-06
Identities = 23/60 (38%), Positives = 30/60 (50%), Gaps = 5/60 (8%)
Frame = +3
Query: 171 KNEHEFKPQTFFT-----PTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC 335
KN HE K F PT+C C ++G+ KQG +C C +V H RC V F+C
Sbjct: 31 KNVHEIKSHKFIARFFKQPTFCSHCKDFLWGITKQGFQCQV--CTLVVHKRCHEFVNFAC 88
>sp|P68404|KPCB_MOUSE Protein kinase C, beta type (PKC-beta) (PKC-B)
Length = 673
Score = 99.4 bits (246), Expect = 4e-21
Identities = 47/114 (41%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+G KQG +C CC VVH RC V +C P+++H+FK
Sbjct: 47 PTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKI 106
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSNPHVE 356
T+ +PT+CD CG+L+YG+ QG+KC +C + H RC VP CG++ H E
Sbjct: 107 HTYSSPTFCDHCGSLLYGLIHQGMKC--DTCMMNVHKRCVMNVPSLCGTD-HTE 157
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/52 (42%), Positives = 27/52 (51%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC 335
H+F + F PT+C C I+G KQG +C C V H RC V FSC
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV--CCFVVHKRCHEFVTFSC 86
Score = 47.4 bits (111), Expect = 2e-05
Identities = 20/48 (41%), Positives = 27/48 (56%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K T +SP+ C C ++G+I QGMKC C VH RC +V C
Sbjct: 104 FKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>sp|P10829|KPCG_RABIT Protein kinase C, gamma type (PKC-gamma) (PKC-delta)
Length = 697
Score = 99.4 bits (246), Expect = 4e-21
Identities = 45/108 (41%), Positives = 64/108 (59%), Gaps = 5/108 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+GI KQG++C C VVH RC V C P+N+H+F+
Sbjct: 46 PTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRL 105
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCG 338
++ +PT+CD CG+L+YG+ QG+KCS C++ H RC VP CG
Sbjct: 106 HSYSSPTFCDHCGSLLYGLVHQGMKCSC--CEMNVHRRCVRTVPSLCG 151
Score = 51.6 bits (122), Expect = 1e-06
Identities = 23/62 (37%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC---GSNPH 350
H+F + F PT+C C I+G+ KQG++C C V H RC V F C G P
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQV--CSFVVHRRCHEFVTFECPGAGKGPQ 93
Query: 351 VE 356
+
Sbjct: 94 TD 95
Score = 43.9 bits (102), Expect = 2e-04
Identities = 18/48 (37%), Positives = 28/48 (58%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
++ + +SP+ C C ++G++ QGMKCS C VH RC +V C
Sbjct: 103 FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRTVPSLC 150
>sp|P05126|KPCB_BOVIN Protein kinase C, beta type (PKC-beta) (PKC-B)
Length = 673
Score = 99.4 bits (246), Expect = 4e-21
Identities = 47/114 (41%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+G KQG +C CC VVH RC V +C P+++H+FK
Sbjct: 47 PTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKI 106
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSNPHVE 356
T+ +PT+CD CG+L+YG+ QG+KC +C + H RC VP CG++ H E
Sbjct: 107 HTYSSPTFCDHCGSLLYGLIHQGMKC--DTCMMNVHKRCVMNVPSLCGTD-HTE 157
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/52 (42%), Positives = 27/52 (51%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC 335
H+F + F PT+C C I+G KQG +C C V H RC V FSC
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV--CCFVVHKRCHEFVTFSC 86
Score = 47.4 bits (111), Expect = 2e-05
Identities = 20/48 (41%), Positives = 27/48 (56%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K T +SP+ C C ++G+I QGMKC C VH RC +V C
Sbjct: 104 FKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>sp|P05772|KPCB_RABIT Protein kinase C, beta type (PKC-beta) (PKC-B)
Length = 671
Score = 99.4 bits (246), Expect = 4e-21
Identities = 47/114 (41%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+G KQG +C CC VVH RC V +C P+++H+FK
Sbjct: 47 PTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKI 106
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSNPHVE 356
T+ +PT+CD CG+L+YG+ QG+KC +C + H RC VP CG++ H E
Sbjct: 107 HTYSSPTFCDHCGSLLYGLIHQGMKC--DTCMMNVHKRCVMNVPSLCGTD-HTE 157
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/52 (42%), Positives = 27/52 (51%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC 335
H+F + F PT+C C I+G KQG +C C V H RC V FSC
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV--CCFVVHKRCHEFVTFSC 86
Score = 47.4 bits (111), Expect = 2e-05
Identities = 20/48 (41%), Positives = 27/48 (56%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K T +SP+ C C ++G+I QGMKC C VH RC +V C
Sbjct: 104 FKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>sp|P68403|KPCB_RAT Protein kinase C, beta type (PKC-beta) (PKC-B)
Length = 671
Score = 99.4 bits (246), Expect = 4e-21
Identities = 47/114 (41%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+G KQG +C CC VVH RC V +C P+++H+FK
Sbjct: 47 PTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKI 106
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSNPHVE 356
T+ +PT+CD CG+L+YG+ QG+KC +C + H RC VP CG++ H E
Sbjct: 107 HTYSSPTFCDHCGSLLYGLIHQGMKC--DTCMMNVHKRCVMNVPSLCGTD-HTE 157
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/52 (42%), Positives = 27/52 (51%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC 335
H+F + F PT+C C I+G KQG +C C V H RC V FSC
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV--CCFVVHKRCHEFVTFSC 86
Score = 47.4 bits (111), Expect = 2e-05
Identities = 20/48 (41%), Positives = 27/48 (56%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K T +SP+ C C ++G+I QGMKC C VH RC +V C
Sbjct: 104 FKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>sp|P05771|KPCB_HUMAN Protein kinase C, beta type (PKC-beta) (PKC-B)
Length = 671
Score = 99.4 bits (246), Expect = 4e-21
Identities = 47/114 (41%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+G KQG +C CC VVH RC V +C P+++H+FK
Sbjct: 47 PTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKI 106
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCGSNPHVE 356
T+ +PT+CD CG+L+YG+ QG+KC +C + H RC VP CG++ H E
Sbjct: 107 HTYSSPTFCDHCGSLLYGLIHQGMKC--DTCMMNVHKRCVMNVPSLCGTD-HTE 157
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/52 (42%), Positives = 27/52 (51%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC 335
H+F + F PT+C C I+G KQG +C C V H RC V FSC
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV--CCFVVHKRCHEFVTFSC 86
Score = 47.4 bits (111), Expect = 2e-05
Identities = 20/48 (41%), Positives = 27/48 (56%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
+K T +SP+ C C ++G+I QGMKC C VH RC +V C
Sbjct: 104 FKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>sp|P05129|KPCG_HUMAN Protein kinase C, gamma type (PKC-gamma)
Length = 697
Score = 99.0 bits (245), Expect = 6e-21
Identities = 45/108 (41%), Positives = 64/108 (59%), Gaps = 5/108 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+GI KQG++C C VVH RC V C P+N+H+F+
Sbjct: 46 PTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRL 105
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCG 338
++ +PT+CD CG+L+YG+ QG+KCS C++ H RC VP CG
Sbjct: 106 HSYSSPTFCDHCGSLLYGLVHQGMKCSC--CEMNVHRRCVRSVPSLCG 151
Score = 51.6 bits (122), Expect = 1e-06
Identities = 23/62 (37%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC---GSNPH 350
H+F + F PT+C C I+G+ KQG++C C V H RC V F C G P
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQV--CSFVVHRRCHEFVTFECPGAGKGPQ 93
Query: 351 VE 356
+
Sbjct: 94 TD 95
Score = 45.1 bits (105), Expect = 1e-04
Identities = 19/48 (39%), Positives = 28/48 (58%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
++ + +SP+ C C ++G++ QGMKCS C VH RC SV C
Sbjct: 103 FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
>sp|P63319|KPCG_RAT Protein kinase C, gamma type (PKC-gamma)
sp|P63318|KPCG_MOUSE Protein kinase C, gamma type (PKC-gamma)
Length = 697
Score = 99.0 bits (245), Expect = 6e-21
Identities = 45/108 (41%), Positives = 64/108 (59%), Gaps = 5/108 (4%)
Frame = +3
Query: 30 PSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINCC-----KMFPPPKNEHEFKP 194
P+ C+ C FI+GI KQG++C C VVH RC V C P+N+H+F+
Sbjct: 46 PTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRL 105
Query: 195 QTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSCG 338
++ +PT+CD CG+L+YG+ QG+KCS C++ H RC VP CG
Sbjct: 106 HSYSSPTFCDHCGSLLYGLVHQGMKCSC--CEMNVHRRCVRSVPSLCG 151
Score = 51.6 bits (122), Expect = 1e-06
Identities = 23/62 (37%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Frame = +3
Query: 180 HEFKPQTFFTPTYCDQCGALIYGVYKQGVKCSASSCQIVTHHRCSSLVPFSC---GSNPH 350
H+F + F PT+C C I+G+ KQG++C C V H RC V F C G P
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQV--CSFVVHRRCHEFVTFECPGAGKGPQ 93
Query: 351 VE 356
+
Sbjct: 94 TD 95
Score = 45.1 bits (105), Expect = 1e-04
Identities = 19/48 (39%), Positives = 28/48 (58%)
Frame = +3
Query: 6 YKSTTLTSPSICTVCHGFIFGIIKQGMKCSNCCNVVHHRCRASVKINC 149
++ + +SP+ C C ++G++ QGMKCS C VH RC SV C
Sbjct: 103 FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,110,255
Number of Sequences: 369166
Number of extensions: 1297584
Number of successful extensions: 3173
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2821
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3042
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3218280650
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)