Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_O15
(612 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P14088|CYPH_ECHGR Peptidyl-prolyl cis-trans isomerase (P... 227 2e-59
sp|P91791|CYPH_HEMPU Peptidyl-prolyl cis-trans isomerase (P... 222 7e-58
sp|P18253|CYPH_SCHPO Peptidyl-prolyl cis-trans isomerase (P... 221 9e-58
sp|P30405|PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase, m... 218 1e-56
sp|P22011|CYPH_CANAL Peptidyl-prolyl cis-trans isomerase (P... 218 1e-56
sp|Q99KR7|PPIF_MOUSE Peptidyl-prolyl cis-trans isomerase, m... 214 1e-55
sp|P29117|PPIF_RAT Peptidyl-prolyl cis-trans isomerase, mit... 214 1e-55
sp|P17742|PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A ... 214 1e-55
sp|P10111|PPIA_RAT Peptidyl-prolyl cis-trans isomerase A (P... 214 2e-55
sp|P14851|PPIA_CRIGR Peptidyl-prolyl cis-trans isomerase A ... 213 3e-55
>sp|P14088|CYPH_ECHGR Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein) (EGCyP-1)
Length = 162
Score = 227 bits (579), Expect = 2e-59
Identities = 113/160 (70%), Positives = 123/160 (76%)
Frame = +3
Query: 6 KTYFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQX 185
K +FDI K GRIVF L+ DDVPKTVENFRALCTGEKGFGYKGSKFHR+IP FM Q
Sbjct: 4 KCFFDISIGGKPAGRIVFALF-DDVPKTVENFRALCTGEKGFGYKGSKFHRIIPGFMCQG 62
Query: 186 XXXXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDG 365
SIYG KF DENF +KH+KP +LSMANAG NTNGSQFFITT VT+WLDG
Sbjct: 63 GDFTAGNGTGGKSIYGSKFEDENFNHKHSKPMMLSMANAGKNTNGSQFFITTAVTSWLDG 122
Query: 366 KHVVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
KHVVFGEVE G D+VK +E +GS SGK SQEVLI DCGQL
Sbjct: 123 KHVVFGEVESGEDVVKDMEAVGSSSGKTSQEVLITDCGQL 162
>sp|P91791|CYPH_HEMPU Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein)
Length = 164
Score = 222 bits (565), Expect = 7e-58
Identities = 107/160 (66%), Positives = 122/160 (76%)
Frame = +3
Query: 6 KTYFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQX 185
+ +FD+ AN + LGRIV L AD VPKT ENFRALCTGEKGFGYKGS FHRVIP FM Q
Sbjct: 5 QVFFDLQANGENLGRIVMELRADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPGFMCQG 64
Query: 186 XXXXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDG 365
SIYGEKF DENF KHT+PG+LSMANAG NTNGSQFFI T VT+WLDG
Sbjct: 65 GDFTRHNGTGGKSIYGEKFADENFTLKHTQPGILSMANAGVNTNGSQFFICTAVTSWLDG 124
Query: 366 KHVVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
KHVVFG V +G+DI+K++E GSDSGK S+++ I DCGQL
Sbjct: 125 KHVVFGAVTQGLDIIKKVESYGSDSGKTSKKITIADCGQL 164
>sp|P18253|CYPH_SCHPO Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein) (CPH)
Length = 162
Score = 221 bits (564), Expect = 9e-58
Identities = 106/156 (67%), Positives = 120/156 (76%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
+FD++AN + LGRIVF L+ D VPKT NFRALCTGEKG+GY GS FHRVIP FMLQ
Sbjct: 5 FFDVIANGQPLGRIVFKLFDDVVPKTAANFRALCTGEKGYGYAGSTFHRVIPQFMLQGGD 64
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYGEKF DENF KH KPGLLSMANAGPNTNGSQFFITTVVT WLDGKH
Sbjct: 65 FTRGNGTGGKSIYGEKFPDENFALKHNKPGLLSMANAGPNTNGSQFFITTVVTPWLDGKH 124
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCG 479
VVFGEV EGMD+VK++E +GS+SG ++I+ CG
Sbjct: 125 VVFGEVTEGMDVVKKVESLGSNSGATRARIVIDKCG 160
>sp|P30405|PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase, mitochondrial precursor
(PPIase) (Rotamase) (Cyclophilin F)
Length = 207
Score = 218 bits (555), Expect = 1e-56
Identities = 105/158 (66%), Positives = 120/158 (75%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
Y D+ AN K LGR+V L AD VPKT ENFRALCTGEKGFGYKGS FHRVIP+FM Q
Sbjct: 49 YLDVDANGKPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGD 108
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYG +F DENF KH PG+LSMANAGPNTNGSQFFI T+ T+WLDGKH
Sbjct: 109 FTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKH 168
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFG V+EGMD+VK+IE GS SG+ S++++I DCGQL
Sbjct: 169 VVFGHVKEGMDVVKKIESFGSKSGRTSKKIVITDCGQL 206
>sp|P22011|CYPH_CANAL Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein) (CPH)
Length = 162
Score = 218 bits (554), Expect = 1e-56
Identities = 107/158 (67%), Positives = 121/158 (76%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
YFD+ A+ +KLG+I F LY D VPKT ENFRALCTGEKGFGYKGS FHRVIP FMLQ
Sbjct: 5 YFDVSADGQKLGKITFKLYDDVVPKTAENFRALCTGEKGFGYKGSIFHRVIPQFMLQGGD 64
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYG KF DENF +H +PGLLSMANAGPNTNGSQFFITTV WLDGKH
Sbjct: 65 FTNFNGTGGKSIYGTKFADENFVKRHDRPGLLSMANAGPNTNGSQFFITTVPCPWLDGKH 124
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFGEV +G+DIVK+IE GS SG S++++IE+ GQL
Sbjct: 125 VVFGEVTDGLDIVKKIESFGSGSGATSKKIVIEESGQL 162
>sp|Q99KR7|PPIF_MOUSE Peptidyl-prolyl cis-trans isomerase, mitochondrial precursor
(PPIase) (Rotamase) (Cyclophilin F)
Length = 206
Score = 214 bits (546), Expect = 1e-55
Identities = 104/158 (65%), Positives = 119/158 (75%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
Y D+ A+ + LGR+V L AD VPKT ENFRALCTGEKGFGYKGS FHRVIP FM Q
Sbjct: 48 YLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFMCQAGD 107
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYG +F DENF KH PG+LSMANAGPNTNGSQFFI T+ T+WLDGKH
Sbjct: 108 FTNHNGTGGRSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKH 167
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFG V+EGMD+VK+IE GS SGK S++++I DCGQL
Sbjct: 168 VVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQL 205
>sp|P29117|PPIF_RAT Peptidyl-prolyl cis-trans isomerase, mitochondrial precursor
(PPIase) (Rotamase) (Cyclophilin F)
Length = 206
Score = 214 bits (546), Expect = 1e-55
Identities = 104/158 (65%), Positives = 119/158 (75%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
Y D+ A+ + LGR+V L AD VPKT ENFRALCTGEKGFGYKGS FHRVIP FM Q
Sbjct: 48 YLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFMCQAGD 107
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYG +F DENF KH PG+LSMANAGPNTNGSQFFI T+ T+WLDGKH
Sbjct: 108 FTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKH 167
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFG V+EGMD+VK+IE GS SGK S++++I DCGQL
Sbjct: 168 VVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQL 205
>sp|P17742|PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein) (SP18)
Length = 164
Score = 214 bits (545), Expect = 1e-55
Identities = 103/158 (65%), Positives = 120/158 (75%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
+FDI A+ + LGR+ F L+AD VPKT ENFRAL TGEKGFGYKGS FHR+IP FM Q
Sbjct: 7 FFDITADDEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGD 66
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYGEKF DENF KHT PG+LSMANAGPNTNGSQFFI T T WLDGKH
Sbjct: 67 FTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFG+V+EGM+IV+ +E+ GS +GK S+++ I DCGQL
Sbjct: 127 VVFGKVKEGMNIVEAMERFGSRNGKTSKKITISDCGQL 164
>sp|P10111|PPIA_RAT Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein) (P31)
(p1B15)
Length = 164
Score = 214 bits (544), Expect = 2e-55
Identities = 103/158 (65%), Positives = 119/158 (75%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
+FDI A+ + LGR+ F L+AD VPKT ENFRAL TGEKGFGYKGS FHR+IP FM Q
Sbjct: 7 FFDITADGEPLGRVCFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGD 66
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYGEKF DENF KHT PG+LSMANAGPNTNGSQFFI T T WLDGKH
Sbjct: 67 FTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFG+V+EGM IV+ +E+ GS +GK S+++ I DCGQL
Sbjct: 127 VVFGKVKEGMSIVEAMERFGSRNGKTSKKITISDCGQL 164
>sp|P14851|PPIA_CRIGR Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
Length = 164
Score = 213 bits (542), Expect = 3e-55
Identities = 103/158 (65%), Positives = 120/158 (75%)
Frame = +3
Query: 12 YFDIVANKKKLGRIVFVLYADDVPKTVENFRALCTGEKGFGYKGSKFHRVIPNFMLQXXX 191
+FDI A+ + LGR+ F L+AD VPKT ENFRAL TGEKGFGYKGS FHR+IP FM Q
Sbjct: 7 FFDISADGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGD 66
Query: 192 XXXXXXXXXXSIYGEKFGDENFKYKHTKPGLLSMANAGPNTNGSQFFITTVVTNWLDGKH 371
SIYGEKF DENF KHT PG+LSMANAGPNTNGSQFFI T T WLDGKH
Sbjct: 67 FTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 372 VVFGEVEEGMDIVKQIEKMGSDSGKPSQEVLIEDCGQL 485
VVFG+V+EGM+IV+ +E+ GS +GK S+++ I DCGQL
Sbjct: 127 VVFGKVKEGMNIVEAMERFGSRNGKTSKKITISDCGQL 164
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,078,902
Number of Sequences: 369166
Number of extensions: 1652639
Number of successful extensions: 4566
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4348
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4455
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4797864890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)