Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_O11
(808 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9H4M9|EHD1_HUMAN EH-domain containing protein 1 (Testil... 236 4e-62
sp|Q9WVK4|EHD1_MOUSE EH-domain containing protein 1 (mPAST1) 234 3e-61
sp|Q9NZN3|EHD3_HUMAN EH-domain containing protein 3 230 4e-60
sp|Q9QXY6|EHD3_MOUSE EH-domain containing protein 3 229 7e-60
sp|Q9H223|EHD4_HUMAN EH-domain containing protein 4 (Hepato... 213 6e-55
sp|Q9EQP2|EHD4_MOUSE EH-domain containing protein 4 (mPAST2) 206 6e-53
sp|Q9NZN4|EHD2_HUMAN EH-domain containing protein 2 206 8e-53
sp|Q60902|EP15R_MOUSE Epidermal growth factor receptor subs... 83 1e-15
sp|P42566|EP15_HUMAN Epidermal growth factor receptor subst... 82 2e-15
sp|Q9UBC2|EP15R_HUMAN Epidermal growth factor receptor subs... 80 5e-15
>sp|Q9H4M9|EHD1_HUMAN EH-domain containing protein 1 (Testilin) (hPAST1)
Length = 534
Score = 236 bits (603), Expect = 4e-62
Identities = 120/212 (56%), Positives = 148/212 (69%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IISSL+ EMP++ GKESKKKEL+ NL IY KI R H ISPGDFP + +MQ LL
Sbjct: 307 HAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQ 366
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTPVKGGAFEVQHDNPFGI 362
DF F +K KL+D VDDMLANDIA+LM M+ +E++ S VKGGAF+ + PFG
Sbjct: 367 DFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMP--SQVVKGGAFDGTMNGPFGH 424
Query: 363 GASEGINRGRFDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKI 542
G EG G D EW V K K YD IF L PVNGKI G AK MV++KLP +LGKI
Sbjct: 425 GYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKI 484
Query: 543 WKLSDIDLDGALDEDEFALALYLVRLKLDNEE 638
WKL+D+D DG LD++EFALA +L+++KL+ E
Sbjct: 485 WKLADVDKDGLLDDEEFALANHLIKVKLEGHE 516
>sp|Q9WVK4|EHD1_MOUSE EH-domain containing protein 1 (mPAST1)
Length = 534
Score = 234 bits (596), Expect = 3e-61
Identities = 119/212 (56%), Positives = 147/212 (69%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IISSL+ EMP++ GKESKKKEL+ NL IY KI R H IS GDFP + +MQ LL
Sbjct: 307 HAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISSGDFPSLRKMQELLQTQ 366
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTPVKGGAFEVQHDNPFGI 362
DF F +K KL+D VDDMLANDIA+LM M+ +E++ S VKGGAF+ + PFG
Sbjct: 367 DFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMP--SQAVKGGAFDGTMNGPFGH 424
Query: 363 GASEGINRGRFDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKI 542
G EG G D EW V K K YD IF L PVNGKI G AK MV++KLP +LGKI
Sbjct: 425 GYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKI 484
Query: 543 WKLSDIDLDGALDEDEFALALYLVRLKLDNEE 638
WKL+D+D DG LD++EFALA +L+++KL+ E
Sbjct: 485 WKLADVDKDGLLDDEEFALANHLIKVKLEGHE 516
>sp|Q9NZN3|EHD3_HUMAN EH-domain containing protein 3
Length = 546
Score = 230 bits (586), Expect = 4e-60
Identities = 116/212 (54%), Positives = 150/212 (70%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IISSL+ EMPS+ GK++KKKEL+ NL IY +I R H ISPGDFP ++RMQ+ L
Sbjct: 307 HAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQLQAQ 366
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTPVKGGAFEVQHDNPFGI 362
DF F P+K KL++ VDDMLA+DIA+LM ++ +E++ + VKGGAFE PFG
Sbjct: 367 DFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRP--IQMVKGGAFEGTLHGPFGH 424
Query: 363 GASEGINRGRFDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKI 542
G EG G D EW V + K YD IF L PV+GKI G AK MV++KLP ++LGKI
Sbjct: 425 GYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKI 484
Query: 543 WKLSDIDLDGALDEDEFALALYLVRLKLDNEE 638
WKL+DID DG LD+DEFALA +L+++KL+ E
Sbjct: 485 WKLADIDKDGMLDDDEFALANHLIKVKLEGHE 516
>sp|Q9QXY6|EHD3_MOUSE EH-domain containing protein 3
Length = 535
Score = 229 bits (584), Expect = 7e-60
Identities = 115/212 (54%), Positives = 150/212 (70%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IISSL+ EMPS+ GK++KKKEL+ NL IY +I R H ISPGDFP +++MQ+ L
Sbjct: 307 HAYIISSLKKEMPSVFGKDTKKKELVNNLAEIYGRIEREHQISPGDFPNLKKMQDQLQAQ 366
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTPVKGGAFEVQHDNPFGI 362
DF F P+K KL++ VDDMLA+DIA+LM ++ +E+T + VKGGAFE PFG
Sbjct: 367 DFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEETQRP--VQMVKGGAFEGTLQGPFGH 424
Query: 363 GASEGINRGRFDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKI 542
G EG G D EW V + K YD IF L PV+GKI G AK MV++KLP ++LGKI
Sbjct: 425 GYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKI 484
Query: 543 WKLSDIDLDGALDEDEFALALYLVRLKLDNEE 638
WKL+DID DG LD++EFALA +L+++KL+ E
Sbjct: 485 WKLADIDKDGMLDDEEFALANHLIKVKLEGHE 516
>sp|Q9H223|EHD4_HUMAN EH-domain containing protein 4 (Hepatocellular carcinoma-associated
protein 10/11)
Length = 541
Score = 213 bits (541), Expect = 6e-55
Identities = 110/215 (51%), Positives = 147/215 (68%), Gaps = 3/215 (1%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IIS L+ EMPS+ GKE+KK+ELI L IY ++ R + IS GDFP+++ MQ L ++
Sbjct: 310 HAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPEVKAMQEQLENY 369
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTP---VKGGAFEVQHDNP 353
DF F +K KLI+AVD+ML+N I+ LM +I +E+T STP V+GGAF+ + P
Sbjct: 370 DFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEET-----STPTQLVQGGAFDGTTEGP 424
Query: 354 FGIGASEGINRGRFDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNIL 533
F G EG G + EW V K K YD +F L P+NGKI+G AK MV +KLP ++L
Sbjct: 425 FNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVL 484
Query: 534 GKIWKLSDIDLDGALDEDEFALALYLVRLKLDNEE 638
GKIWKL+D D DG LDE+EFALA +L+++KLD E
Sbjct: 485 GKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYE 519
>sp|Q9EQP2|EHD4_MOUSE EH-domain containing protein 4 (mPAST2)
Length = 541
Score = 206 bits (524), Expect = 6e-53
Identities = 105/212 (49%), Positives = 143/212 (67%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IIS L+ EMP++ GKE+KK+ELI L IY ++ R + IS GDFP+++ MQ L ++
Sbjct: 310 HAYIISYLKKEMPNMFGKENKKRELIYRLPEIYVQLQREYQISAGDFPEVKAMQEQLENY 369
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTPVKGGAFEVQHDNPFGI 362
DF F +K KLI+AVD+ML N I+ LM +I +E+ + V+GGAF+ + PF
Sbjct: 370 DFTKFHSLKPKLIEAVDNMLTNKISSLMGLISQEEMNMP--TQMVQGGAFDGTTEGPFNQ 427
Query: 363 GASEGINRGRFDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKI 542
G EG G + EW V K K YD +F L P+NGKI+G AK MV +KLP ++LGKI
Sbjct: 428 GYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKI 487
Query: 543 WKLSDIDLDGALDEDEFALALYLVRLKLDNEE 638
WKL+D D DG LDE+EFALA +L+++KLD E
Sbjct: 488 WKLADCDCDGMLDEEEFALAKHLIKIKLDGYE 519
>sp|Q9NZN4|EHD2_HUMAN EH-domain containing protein 2
Length = 543
Score = 206 bits (523), Expect = 8e-53
Identities = 108/214 (50%), Positives = 145/214 (67%), Gaps = 5/214 (2%)
Frame = +3
Query: 3 HAFIISSLQSEMPSILGKESKKKELIQNLQGIYDKISRMHSISPGDFPKIERMQNLLPDH 182
HA+IIS L+ EMPS+ GKE+KKK+LI L I+ KI H ISPGDFP ++MQ LL H
Sbjct: 307 HAYIISYLKKEMPSVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAH 366
Query: 183 DFKAFSPMKQKLIDAVDDMLANDIAKLMQMIPKEQTTQVEFSTPVKGGAFEVQHDNPF-G 359
DF F +K KL++A+D+ML +DIAKLM ++ +E+ E V+GGAFE H PF
Sbjct: 367 DFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTEVG--VQGGAFEGTHMGPFVE 424
Query: 360 IGASEGINRGR----FDTEWAVLKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYN 527
G E + G + EW V K K++YD IF L P +GK++G+ AK +MV TKLP +
Sbjct: 425 RGPDEAMEDGEEGSDDEAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNS 484
Query: 528 ILGKIWKLSDIDLDGALDEDEFALALYLVRLKLD 629
+LG+IWKLSD+D DG LD++EFALA +L+ KL+
Sbjct: 485 VLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLE 518
>sp|Q60902|EP15R_MOUSE Epidermal growth factor receptor substrate 15-like 1 (Eps15-related
protein) (Eps15R) (Epidermal growth factor receptor
pathway substrate 15-related sequence) (Eps15-rs)
Length = 907
Score = 82.8 bits (203), Expect = 1e-15
Identities = 39/81 (48%), Positives = 58/81 (71%), Gaps = 1/81 (1%)
Frame = +3
Query: 396 DTEWAV-LKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDG 572
+T WAV ++ K ++D IF+ L PVNG ++G K ++ +KLP ++LG++W LSDID DG
Sbjct: 118 ETHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDG 177
Query: 573 ALDEDEFALALYLVRLKLDNE 635
LD DEFA+A++LV L+ E
Sbjct: 178 HLDRDEFAVAMHLVYRALEKE 198
Score = 45.8 bits (107), Expect = 1e-04
Identities = 23/69 (33%), Positives = 40/69 (57%), Gaps = 1/69 (1%)
Frame = +3
Query: 423 KNEYDRIF-KGLQPVNGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALDEDEFAL 599
K +D IF K ++G ++G K+ + + L N+L IW L+D G L +++FAL
Sbjct: 274 KMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFAL 333
Query: 600 ALYLVRLKL 626
A+Y ++ K+
Sbjct: 334 AMYFIQQKV 342
Score = 38.9 bits (89), Expect = 0.017
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 1/62 (1%)
Frame = +3
Query: 432 YDRIFKGLQPV-NGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALDEDEFALALY 608
Y+ +K + P G++ + A ++ ++ L ILGKIW L+D + G LD+ F +AL
Sbjct: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Query: 609 LV 614
LV
Sbjct: 79 LV 80
>sp|P42566|EP15_HUMAN Epidermal growth factor receptor substrate 15 (Protein Eps15)
(AF-1p protein)
Length = 896
Score = 82.0 bits (201), Expect = 2e-15
Identities = 40/78 (51%), Positives = 55/78 (70%), Gaps = 1/78 (1%)
Frame = +3
Query: 405 WAVL-KYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALD 581
WAV + K +YD IF L PVNG ++G K ++ +KLP +ILG++W+LSDID DG LD
Sbjct: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
Query: 582 EDEFALALYLVRLKLDNE 635
DEFA+A++LV L+ E
Sbjct: 182 RDEFAVAMFLVYCALEKE 199
Score = 48.9 bits (115), Expect = 2e-05
Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 1/69 (1%)
Frame = +3
Query: 423 KNEYDRIF-KGLQPVNGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALDEDEFAL 599
K +YD IF K + ++G ++G ++ ++T LP +L IW L D G L +D+FAL
Sbjct: 225 KAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFAL 284
Query: 600 ALYLVRLKL 626
A +L+ KL
Sbjct: 285 AFHLISQKL 293
Score = 43.1 bits (100), Expect = 9e-04
Identities = 23/62 (37%), Positives = 39/62 (62%), Gaps = 1/62 (1%)
Frame = +3
Query: 432 YDRIFKGLQPVN-GKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALDEDEFALALY 608
Y++ ++ + N G++ + A ++ ++ LP ILGKIW L+D D G L++ EF +AL
Sbjct: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 609 LV 614
LV
Sbjct: 79 LV 80
>sp|Q9UBC2|EP15R_HUMAN Epidermal growth factor receptor substrate 15-like 1 (Eps15-related
protein) (Eps15R)
Length = 864
Score = 80.5 bits (197), Expect = 5e-15
Identities = 37/81 (45%), Positives = 57/81 (70%), Gaps = 1/81 (1%)
Frame = +3
Query: 396 DTEWAV-LKYKNEYDRIFKGLQPVNGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDG 572
+ WAV ++ K ++D IF+ L P+NG ++G K ++ +KLP ++LG++W LSDID DG
Sbjct: 118 EAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDG 177
Query: 573 ALDEDEFALALYLVRLKLDNE 635
LD DEFA+A++LV L+ E
Sbjct: 178 HLDRDEFAVAMHLVYRALEKE 198
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 2/109 (1%)
Frame = +3
Query: 306 STPVKGGAFEVQHDNPFGIGASEGINRGRFDTEWAV-LKYKNEYDRIF-KGLQPVNGKIN 479
STP G + + + + + W V + K +D IF K ++G ++
Sbjct: 238 STPSHGSVSSLNSTG--SLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVS 295
Query: 480 GTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALDEDEFALALYLVRLKL 626
G K+ + + L N+L IW L+D G L +D+FALA+Y ++ K+
Sbjct: 296 GQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKV 344
Score = 38.9 bits (89), Expect = 0.017
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 1/62 (1%)
Frame = +3
Query: 432 YDRIFKGLQPV-NGKINGTTAKDYMVQTKLPYNILGKIWKLSDIDLDGALDEDEFALALY 608
Y+ +K + P G++ + A ++ ++ L ILGKIW L+D + G LD+ F +AL
Sbjct: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Query: 609 LV 614
LV
Sbjct: 79 LV 80
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,434,195
Number of Sequences: 369166
Number of extensions: 1785141
Number of successful extensions: 5130
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4902
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5119
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)