Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_M18
(466 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 163 2e-40
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 158 6e-39
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 156 2e-38
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 156 2e-38
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 155 3e-38
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 155 4e-38
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 153 2e-37
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 151 8e-37
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 148 5e-36
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 148 7e-36
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 163 bits (412), Expect = 2e-40
Identities = 71/127 (55%), Positives = 96/127 (75%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y A DG+C+ + + + C+G T+I S +ET L AV +GP+SV IDA H+SFQ Y SG
Sbjct: 197 YEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSG 256
Query: 197 IYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAT 376
+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT
Sbjct: 257 VYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIAT 316
Query: 377 MASYPLV 397
+ASYPLV
Sbjct: 317 VASYPLV 323
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 158 bits (399), Expect = 6e-39
Identities = 78/128 (60%), Positives = 88/128 (68%), Gaps = 1/128 (0%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y ATD +C P K TGF DI Q E L AVATVGP+SVAIDAGH+SFQ YKSG
Sbjct: 91 YEATDTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQFYKSG 149
Query: 197 IYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIA 373
IY + CS+ LDHGVL VGYG + K+WIVKNSW WG GY+KM+KD+ N CGIA
Sbjct: 150 IYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIA 209
Query: 374 TMASYPLV 397
T ASYP V
Sbjct: 210 TAASYPTV 217
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 156 bits (394), Expect = 2e-38
Identities = 74/128 (57%), Positives = 87/128 (67%), Gaps = 1/128 (0%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y D +C N + I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G
Sbjct: 212 YEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEG 271
Query: 197 IYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIA 373
+YNE C LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQCGIA
Sbjct: 272 VYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIA 331
Query: 374 TMASYPLV 397
T +SYP V
Sbjct: 332 TASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 156 bits (394), Expect = 2e-38
Identities = 73/128 (57%), Positives = 89/128 (69%), Gaps = 1/128 (0%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y A D +C N + GFTDI +E +A AVATVGPVSVAIDA H SFQ Y G
Sbjct: 214 YEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEG 273
Query: 197 IYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIA 373
+YNE C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA
Sbjct: 274 VYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIA 333
Query: 374 TMASYPLV 397
+ +SYPLV
Sbjct: 334 SASSYPLV 341
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 155 bits (393), Expect = 3e-38
Identities = 76/131 (58%), Positives = 86/131 (65%), Gaps = 4/131 (3%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y A D CK P V TGFT + E L AVATVGP+SVA+DAGH+SFQ YKSG
Sbjct: 204 YVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG 263
Query: 197 IYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQC 364
IY E CS+ LDHGVL VGYG KYW+VKNSW WG +GY+K++KDK N C
Sbjct: 264 IYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHC 323
Query: 365 GIATMASYPLV 397
GIAT ASYP V
Sbjct: 324 GIATAASYPNV 334
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 155 bits (392), Expect = 4e-38
Identities = 70/127 (55%), Positives = 91/127 (71%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y A D TC+ N + I CTG+ I +E+ L A +GP+SVAIDA H SFQ Y +G
Sbjct: 196 YEARDNTCRFNSNTIGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRSFQSYYTG 255
Query: 197 IYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAT 376
+Y E SCS++QLDH VLAVGYG++ G+ +W+VKNSW +WGESGYIKM++++ N CGIAT
Sbjct: 256 VYYEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATSWGESGYIKMARNRNNNCGIAT 315
Query: 377 MASYPLV 397
A YP V
Sbjct: 316 DACYPTV 322
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 153 bits (387), Expect = 2e-37
Identities = 76/131 (58%), Positives = 88/131 (67%), Gaps = 4/131 (3%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF YK G
Sbjct: 204 YEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEG 262
Query: 197 IYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMSKDKKNQC 364
IY E CS+ +DHGVL VGYG + KYW+VKNSW WG GY+KM+KD++N C
Sbjct: 263 IYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHC 322
Query: 365 GIATMASYPLV 397
GIA+ ASYP V
Sbjct: 323 GIASAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 151 bits (381), Expect = 8e-37
Identities = 71/127 (55%), Positives = 91/127 (71%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y A D +C+ + + I CTG ++Q E L AV+ VGP+SVAIDA H SFQ Y SG
Sbjct: 196 YEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSG 254
Query: 197 IYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAT 376
+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++ N CGIA+
Sbjct: 255 VYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIAS 314
Query: 377 MASYPLV 397
SYP V
Sbjct: 315 EPSYPTV 321
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 148 bits (374), Expect = 5e-36
Identities = 76/131 (58%), Positives = 87/131 (66%), Gaps = 4/131 (3%)
Frame = +2
Query: 17 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSG 196
Y A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S Q Y SG
Sbjct: 204 YEAKDGSCKYRAEYAVANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSG 262
Query: 197 IYNEESCSTTQLDHGVLAVGY---GTQIGK-KYWIVKNSWDVTWGESGYIKMSKDKKNQC 364
IY E +CS+ LDHGVL VGY GT K KYW+VKNSW WG GYIK++KD+ N C
Sbjct: 263 IYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHC 322
Query: 365 GIATMASYPLV 397
G+AT ASYP+V
Sbjct: 323 GLATAASYPIV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 148 bits (373), Expect = 7e-36
Identities = 77/132 (58%), Positives = 86/132 (65%), Gaps = 5/132 (3%)
Frame = +2
Query: 17 YTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKS 193
Y ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SFQ YKS
Sbjct: 204 YLATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSFQFYKS 262
Query: 194 GIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQ 361
GIY + CS LDHGVL VGYG + K+WIVKNSW WG +GY+KM+KD+ N
Sbjct: 263 GIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNH 322
Query: 362 CGIATMASYPLV 397
CGIAT ASYP V
Sbjct: 323 CGIATAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,109,480
Number of Sequences: 369166
Number of extensions: 1103914
Number of successful extensions: 3324
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3039
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3108
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2633927485
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)