Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_M03
(905 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 293 3e-79
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 289 8e-78
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 286 6e-77
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 286 7e-77
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 274 3e-73
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 273 5e-73
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 259 9e-69
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 217 4e-56
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 211 2e-54
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 206 7e-53
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 293 bits (751), Expect = 3e-79
Identities = 146/265 (55%), Positives = 175/265 (66%)
Frame = +1
Query: 88 PLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLGVIKDPNNFKLPKRKPLLNRVRLP 267
PLS +L+N+VN TTWKA +S ++K+ G I KLP+R V LP
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAIL--GGPKLPQRDAFAADVVLP 81
Query: 268 TTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTX 447
+FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 82 ESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTC 141
Query: 448 XXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPYPNCTGE 627
PS AW FW GLV+GG Y H+GC+ Y+ P C HHV G P CTGE
Sbjct: 142 CGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGE 201
Query: 628 FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPN 807
TPKC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE AFSVY+DF
Sbjct: 202 GDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLL 261
Query: 808 YKSGVYQHVTGGMLGGHAIKILGLG 882
YKSGVYQHV+G ++GGHAI+ILG G
Sbjct: 262 YKSGVYQHVSGEIMGGHAIRILGWG 286
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 289 bits (739), Expect = 8e-78
Identities = 143/271 (52%), Positives = 177/271 (65%)
Frame = +1
Query: 70 SIPMHTPLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLGVIKDPNNFKLPKRKPLL 249
S P PLS +L+NYVN TTW+A +S ++++ G K P+R
Sbjct: 19 SRPSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFT 75
Query: 250 NRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISA 429
++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SA
Sbjct: 76 EDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 430 EDLLTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPY 609
EDLLT P+ AW FW GLV+GG Y H+GC+ Y+ P C HHV G
Sbjct: 136 EDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSR 195
Query: 610 PNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSV 789
P CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE AFSV
Sbjct: 196 PPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV 255
Query: 790 YADFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
Y+DF YKSGVYQHVTG M+GGHAI+ILG G
Sbjct: 256 YSDFLLYKSGVYQHVTGEMMGGHAIRILGWG 286
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 286 bits (732), Expect = 6e-77
Identities = 142/269 (52%), Positives = 172/269 (63%)
Frame = +1
Query: 76 PMHTPLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLGVIKDPNNFKLPKRKPLLNR 255
P PLS DLINY+N TTW+A IS ++K+ G + KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVL--GGPKLPGRVAFGED 77
Query: 256 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 435
+ LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAED
Sbjct: 78 IDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAED 137
Query: 436 LLTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPYPN 615
LLT PS AW FW GLV+GG Y H+GC Y P C HHV G P
Sbjct: 138 LLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPP 197
Query: 616 CTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 795
CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE AF+V++
Sbjct: 198 CTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFS 257
Query: 796 DFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
DF YKSGVY+H G M+GGHAI+ILG G
Sbjct: 258 DFLTYKSGVYKHEAGDMMGGHAIRILGWG 286
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 286 bits (731), Expect = 7e-77
Identities = 141/270 (52%), Positives = 173/270 (64%), Gaps = 1/270 (0%)
Frame = +1
Query: 76 PMHTPLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLG-VIKDPNNFKLPKRKPLLN 252
P PLS D+INY+N TTW+A IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 253 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 432
+ LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 433 DLLTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPYP 612
DLLT PS AW FW GLV+GG Y H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRP 196
Query: 613 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 792
CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVF 256
Query: 793 ADFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
+DF YKSGVY+H G ++GGHAI+ILG G
Sbjct: 257 SDFLTYKSGVYKHEAGDVMGGHAIRILGWG 286
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 274 bits (700), Expect = 3e-73
Identities = 136/272 (50%), Positives = 171/272 (62%), Gaps = 1/272 (0%)
Frame = +1
Query: 70 SIPMHTPLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLGVIKDPNNFKLPKRKPLL 249
SIP + PLS DL+N++N + TT +A +S ++K+ G K P+R
Sbjct: 19 SIPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFA 75
Query: 250 NRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISA 429
+ LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SA
Sbjct: 76 EDMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSA 135
Query: 430 EDLLTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPY 609
EDLL+ PS AWR+W GLV+GG Y H+GC+ Y P C HHV G
Sbjct: 136 EDLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSR 195
Query: 610 PNCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFS 786
P CTGE TP+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE AF
Sbjct: 196 PPCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFI 255
Query: 787 VYADFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
VY DF YKSGVYQHV+G +GGHAI+ILG G
Sbjct: 256 VYEDFLMYKSGVYQHVSGEQVGGHAIRILGWG 287
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 273 bits (698), Expect = 5e-73
Identities = 132/274 (48%), Positives = 175/274 (63%), Gaps = 5/274 (1%)
Frame = +1
Query: 88 PLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLGVIKDPNNFKLPKRKPLLNR---- 255
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 256 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 435
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 436 LLTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPYPN 615
L++ P AW +W G+VTGG H GCQ Y FPKC HH G YP
Sbjct: 148 LISCCKDCGDGCQGGF-PGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 616 C-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 792
C T + TP+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEAAF VY
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVY 266
Query: 793 ADFPNYKSGVYQHVTGGMLGGHAIKILGLGCRKQ 894
DF NYKSG+Y+HVTG ++GGHAI+I+G G K+
Sbjct: 267 EDFLNYKSGIYRHVTGSIVGGHAIRIIGWGVEKR 300
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 259 bits (661), Expect = 9e-69
Identities = 126/270 (46%), Positives = 170/270 (62%), Gaps = 5/270 (1%)
Frame = +1
Query: 88 PLSFDLINYVNYVARTTWKAAPTTRFQSISDIRKVLGVIKDPNNFKLPKRKPLLNR---- 255
PLS D+I+Y+N W+A + RF S+ D R +G ++ + + KR+P ++
Sbjct: 28 PLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWN 86
Query: 256 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 435
V +P+ FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S G Q +SA D
Sbjct: 87 VEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVD 146
Query: 436 LLTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPYPN 615
LLT AW +W G+VT H GC+ Y FPKC HH G YP
Sbjct: 147 LLTCCESCGLGCEGGIL-GPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPP 205
Query: 616 CTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 792
C + + TP+CK+ CQ Y Y +DK GKSSY+V ++++AI +EI+ GPVEA+F+VY
Sbjct: 206 CGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVY 265
Query: 793 ADFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
DF NYKSG+Y+H+TG LGGHAI+I+G G
Sbjct: 266 EDFLNYKSGIYKHITGEALGGHAIRIIGWG 295
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 217 bits (552), Expect = 4e-56
Identities = 120/273 (43%), Positives = 163/273 (59%), Gaps = 12/273 (4%)
Frame = +1
Query: 100 DLINYVNYVARTTWKAAPTTRFQSI-SDIRKVLGVIKDPNNFKLP-KRKPLLNRVR---- 261
DLI+YVN + W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 262 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDL 438
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 439 LTXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHV----IGP 606
L+ P AWR+W G+VTG Y + GC+ Y FP C HH P
Sbjct: 164 LS-CCKSCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDP 222
Query: 607 YPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAF 783
P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+GP+E AF
Sbjct: 223 CPH--DLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAF 280
Query: 784 SVYADFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
VY DF NY GVY H G + GGHA+K++G G
Sbjct: 281 EVYEDFLNYDGGVYVHTGGKLGGGHAVKLIGWG 313
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 211 bits (537), Expect = 2e-54
Identities = 106/207 (51%), Positives = 131/207 (63%)
Frame = +1
Query: 262 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 441
+P TFD+R QW +CKSI IRDQ+ CGSCWAFGA E I+DR CI + G Q P IS +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 442 TXXXXXXXXXXXXXSPSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIGPYPNCT 621
+ P +A R+W++ G+VTGG+Y GC+ Y C+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDY-HGAGCKPYPIAPCTSG------NCP 197
Query: 622 GEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADF 801
E TP C +CQ+GYS YA+DK +G S+Y+V N +I EI NGPVEAAFSVY DF
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256
Query: 802 PNYKSGVYQHVTGGMLGGHAIKILGLG 882
YKSGVY+H G LGGHAIKI+G G
Sbjct: 257 YKYKSGVYKHTAGKYLGGHAIKIIGWG 283
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 206 bits (524), Expect = 7e-53
Identities = 103/213 (48%), Positives = 129/213 (60%), Gaps = 6/213 (2%)
Frame = +1
Query: 262 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 441
+P FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL
Sbjct: 82 IPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLL 141
Query: 442 TXXXXXXXXXXXXXS--PSRAWRFWNTHGLVTGGEYGEHLGCQDYAFPKCSHHVIG-PYP 612
+ P +AW++W HGLVTGG Y GC+ Y+ C V G +P
Sbjct: 142 SCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWP 201
Query: 613 NCTGEF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAF 783
C + PTPKC +C + Y+ Y +DK +G ++Y+V + I EILTNGP+E AF
Sbjct: 202 ACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAF 261
Query: 784 SVYADFPNYKSGVYQHVTGGMLGGHAIKILGLG 882
+VY DF Y +GVY H G LGGHA+KILG G
Sbjct: 262 TVYEDFYQYTTGVYVHTAGASLGGHAVKILGWG 294
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,653,028
Number of Sequences: 369166
Number of extensions: 2351265
Number of successful extensions: 6641
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6233
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6576
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9174518830
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)